Axonopathy In Neurodegenerative Disease PDF Download
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| Author | : Samuel D. Crish |
| Publisher | : Frontiers Media SA |
| Total Pages | : 248 |
| Release | : 2019-02-05 |
| Genre | : |
| ISBN | : 2889456803 |
Download Axonopathy in Neurodegenerative Disease Book in PDF, ePub and Kindle
Axons are the major output processes of neurons, responsible for transmitting information to other neurons and tissues throughout the body. The 150,000+ kilometers of axons make up half of the brain's volume and require a large amount of energy. Normal axon function is the product of a massive number of intra- and extra-cellular mechanisms working in concert. Perhaps not surprisingly, the axon is a site of vulnerability during normal aging and in disease states, although this has only been recently appreciated. Axonopathy, broadly defined as functional or structural defects in the axon or its terminal, is common across a wide range of neurodegenerative conditions, including amyotrophic lateral sclerosis, Huntington’s, Parkinson’s, and Alzheimer’s diseases, glaucoma, and as a result of neurotoxin exposure or drug treatment. This Research Topic assembles a series of original research papers, reviews, and commentaries that will illustrate both the commonalities and important differences across neurodegenerative disorders. Though this collection cannot address all aspects of this topic, it is our hope that these manuscripts will educate other scientists and inspire new investigations into axon dysfunction and degeneration.
| Author | : Gorazd B. Stokin |
| Publisher | : |
| Total Pages | : 7 |
| Release | : 2005 |
| Genre | : Alzheimer's disease |
| ISBN | : |
Download Axonopathy and Transport Deficits Early in the Pathogenesis of Alzheimer's Disease Book in PDF, ePub and Kindle
| Author | : Elisabetta Babetto |
| Publisher | : Humana |
| Total Pages | : 0 |
| Release | : 2020-06-11 |
| Genre | : Science |
| ISBN | : 9781071605844 |
Download Axon Degeneration Book in PDF, ePub and Kindle
This book is a collection of classical as well as innovative methods used to investigate axon degeneration with a particular focus on addressing the common challenges encountered while performing these procedures. Particular attention is devoted to the study of axon loss in several model organisms, as each poses unique challenges and provides powerful advantages. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Axon Degeneration: Methods and Protocols is an ideal guide for facilitating the application and further development of these protocols, which will help the scientific community tackle important questions regarding axon degeneration. Chapters 2, 3, and 20 are available Open Access under a Creative Commons Attribution 4.0 International License via link.springer.com.
| Author | : Cláudio M. Gomes |
| Publisher | : Frontiers Media SA |
| Total Pages | : 153 |
| Release | : 2022-02-02 |
| Genre | : Science |
| ISBN | : 2889742512 |
Download The Biochemistry of Amyloids in Neurodegenerative Diseases, Volume I Book in PDF, ePub and Kindle
| Author | : Daniel Laskowitz |
| Publisher | : CRC Press |
| Total Pages | : 412 |
| Release | : 2015-12-01 |
| Genre | : Medical |
| ISBN | : 1498766579 |
Download Translational Research in Traumatic Brain Injury Book in PDF, ePub and Kindle
Traumatic brain injury (TBI) remains a significant source of death and permanent disability, contributing to nearly one-third of all injury related deaths in the United States and exacting a profound personal and economic toll. Despite the increased resources that have recently been brought to bear to improve our understanding of TBI, the development of new diagnostic and therapeutic approaches has been disappointingly slow. Translational Research in Traumatic Brain Injury attempts to integrate expertise from across specialties to address knowledge gaps in the field of TBI. Its chapters cover a wide scope of TBI research in five broad areas: Epidemiology Pathophysiology Diagnosis Current treatment strategies and sequelae Future therapies Specific topics discussed include the societal impact of TBI in both the civilian and military populations, neurobiology and molecular mechanisms of axonal and neuronal injury, biomarkers of traumatic brain injury and their relationship to pathology, neuroplasticity after TBI, neuroprotective and neurorestorative therapy, advanced neuroimaging of mild TBI, neurocognitive and psychiatric symptoms following mild TBI, sports-related TBI, epilepsy and PTSD following TBI, and more. The book integrates the perspectives of experts across disciplines to assist in the translation of new ideas to clinical practice and ultimately to improve the care of the brain injured patient.
| Author | : Uday Kishore |
| Publisher | : BoD – Books on Demand |
| Total Pages | : 642 |
| Release | : 2013-05-15 |
| Genre | : Medical |
| ISBN | : 9535110888 |
Download Neurodegenerative Diseases Book in PDF, ePub and Kindle
This book highlights the pathophysiological complexities of the mechanisms and factors that are likely to be involved in a range of neuroinflammatory and neurodegenerative diseases including Alzheimer's disease, other Dementia, Parkinson Diseases and Multiple Sclerosis. The spectrum of diverse factors involved in neurodegeneration, such as protein aggregation, oxidative stress, caspases and secretase, regulators, cholesterol, zinc, microglia, astrocytes, oligodendrocytes, etc, have been discussed in the context of disease progression. In addition, novel approaches to therapeutic interventions have also been presented. It is hoped that students, scientists and clinicians shall find this very informative book immensely useful and thought-provoking.
| Author | : Stephen G. Waxman |
| Publisher | : |
| Total Pages | : 710 |
| Release | : 1995 |
| Genre | : Axons |
| ISBN | : 0195082931 |
Download The Axon Book in PDF, ePub and Kindle
The axon, interposed between the cell body and the synaptic terminals in most neurons, plays a crucial role in connecting neurons and acting as a conduit for the transmission of information between them. This book provides a comprehensive and up-to-date compendium that brings together chapterson the structure, function, and pathophysiology of axons in both the PNS and CNS. Carefully written, well-illustrated with superb illustrations, and generously referenced, the 33 chapters and introduction have been authored by 49 world-renowned authorities. Recent advances in the molecularneurobiology of axons are carefully reviewed, and new areas, such as the molecular biology of ion channels and myelination, the role of calcium in pathophysiology and regeneration, cell adhesion molecules and their roles in axo-glial interactions and axonal guidance, and optical recording methods,are highlighted. This book will provide an essential reference for neuroscientists as well as clinicians such as neurologists, neurosurgeons, and clinical electrophysiologists interested in axons.
| Author | : Gabor G. Kovacs |
| Publisher | : Cambridge University Press |
| Total Pages | : 320 |
| Release | : 2017-12-13 |
| Genre | : Medical |
| ISBN | : 1316337650 |
Download Neuropathology of Neurodegenerative Diseases Book in PDF, ePub and Kindle
This practical guide to the diagnosis of neurodegenerative diseases discusses modern molecular techniques, morphological classification, fundamentals of clinical symptomology, diagnostic pitfalls and immunostaining protocols. It is based on the proteinopathy concept of neurodegenerative disease, which has influenced classification and provides new strategies for therapy. Numerous high-quality images, including histopathology photomicrographs and neuroradiology scans, accompany the description of morphologic alterations and interpretation of immunoreactivities. Diagnostic methods and criteria are placed within recent developments in neuropathology, including the now widespread application of immunohistochemistry. To aid daily practice, the guide includes diagnostic algorithms and offers personal insights from experienced experts in the field. Special focus is given to the way brain tissue should be handled during diagnosis. This is a must-have reference for medical specialists and specialist medical trainees in the fields of pathology, neuropathology and neurology working with neuropathologic features of neurodegenerative diseases.
| Author | : Michael S. Wolfe |
| Publisher | : Academic Press |
| Total Pages | : 560 |
| Release | : 2018-03-29 |
| Genre | : Medical |
| ISBN | : 0128113057 |
Download The Molecular and Cellular Basis of Neurodegenerative Diseases Book in PDF, ePub and Kindle
The Molecular and Cellular Basis of Neurodegenerative Diseases: Underlying Mechanisms presents the pathology, genetics, biochemistry and cell biology of the major human neurodegenerative diseases, including Alzheimer’s, Parkinson’s, frontotemporal dementia, ALS, Huntington’s, and prion diseases. Edited and authored by internationally recognized leaders in the field, the book's chapters explore their pathogenic commonalities and differences, also including discussions of animal models and prospects for therapeutics. Diseases are presented first, with common mechanisms later. Individual chapters discuss each major neurodegenerative disease, integrating this information to offer multiple molecular and cellular mechanisms that diseases may have in common. This book provides readers with a timely update on this rapidly advancing area of investigation, presenting an invaluable resource for researchers in the field. Covers the spectrum of neurodegenerative diseases and their complex genetic, pathological, biochemical and cellular features Focuses on leading hypotheses regarding the biochemical and cellular dysfunctions that cause neurodegeneration Details features, advantages and limitations of animal models, as well as prospects for therapeutic development Authored by internationally recognized leaders in the field Includes illustrations that help clarify and consolidate complex concepts
| Author | : Juan M. Pascual |
| Publisher | : Cambridge University Press |
| Total Pages | : 507 |
| Release | : 2017-04-20 |
| Genre | : Medical |
| ISBN | : 1107042054 |
Download Progressive Brain Disorders in Childhood Book in PDF, ePub and Kindle
A review of childhood neurodegenerative and other progressive but non-degenerative disorders to guide their diagnosis and management.
