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Avian Diagnostic and Therapeutic Antibodies

Avian Diagnostic and Therapeutic Antibodies
Author:
Publisher:
Total Pages:
Release: 2012
Genre:
ISBN:
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A number of infectious agents have the potential of causing significant clinical symptomology and even death, but dispite this, the number of incidence remain below the level that supports producing a vaccine. Therapeutic antibodies provide a viable treatment option for many of these diseases. We proposed that antibodies derived from West Nile Virus (WNV) immunized geese would be able to treat WNV infection in mammals and potential humans. We demonstrated that WNV specific goose antibodies are indeed successful in treating WNV infection both prophylactically and therapeutically in a golden hamster model. We demonstrated that the goose derived antibodies are non-reactogenic, i.e. do not cause an inflammatory response with multiple exposures in mammals. We also developed both a specific pathogen free facility to house the geese during the antibody production phase and a patent-pending purification process to purify the antibodies to greater than 99% purity. Therefore, the success of these study will allow a cost effective rapidly producible therapeutic toward clinical testing with the necessary infrastructure and processes developed and in place.

Avian Diagnostic and Therapeutic Antibodies to Viral Emerging Pathogens

Avian Diagnostic and Therapeutic Antibodies to Viral Emerging Pathogens
Author:
Publisher:
Total Pages: 3
Release: 2011
Genre:
ISBN:
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During the current period the following key objectives were achieved: demonstration of high titer antibody production by geese following immunization with inactived H1N1 virus; completion of the epitope mapping of West Nile Virus-specific goose antibodies and initiation of epitope mapping of H1N1 flu-specific goose antibodies; advancement in scalable purification of goose antibodies.

Therapeutic Antibodies

Therapeutic Antibodies
Author: John Landon
Publisher: Springer Science & Business Media
Total Pages: 358
Release: 2012-12-06
Genre: Medical
ISBN: 1447119371
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Several aspects of clinical medicine are poised on the edge of a new era with the introduction of therapeutic antibodies. This revolution has been made possible by major advances in immune technology, which are now beginning to mature into clinical practice. This volume is aimed at all clinicians involved with this form of treatment, especially accident and emergency physicians, clinical immunologists, and pharmacologists. It covers both the basic technology, and also all the main clinical areas of application: septic shock, auto-immune disease, and cancer. The future of therapeutic antibodies is also discussed, including exciting new developments in "catalytic antibodies". This is the first occasion on which all these topics have been brought together in a single volume, thus making it an important reference source for physicians and researchers in this fast-moving area.

Current Therapy in Avian Medicine and Surgery

Current Therapy in Avian Medicine and Surgery
Author: Brian Speer
Publisher: Elsevier Health Sciences
Total Pages: 929
Release: 2015-12-04
Genre: Medical
ISBN: 1455746711
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A current and cutting-edge reference, Current Therapy in Avian Medicine and Surgery takes the popular Current Therapy approach in providing succinct and clear information pertinent to the medical care of avian species. Most chapters include an up-to-date delivery of the current state of knowledge on their subject material, and provide practical approaches and thought processes applicable to diagnosis and therapy where appropriate. Information is always easy to find, with topics including the latest advances in internal medicine; behavioral medicine; anesthesia, analgesia, and surgery. Sections dedicated to welfare, conservation, and practice risk management explore important, but less commonly discussed aspects of avian practice; and the pattern recognition portion of the text offers readers a view of what companion bird conditions are likely to be seen in practice in different parts of the world. Written by a team of highly regarded contributors from around the world, this text helps readers, regardless of location and current knowledge, develop and augment skills in the medical and surgical care of avian species. The Current Therapy format provides current, up-to-date, succinct and clear information pertinent to the medical and surgical care of avian species. Coverage of clinically significant topics includes current veterinary scientific literature and hot topics relating to today's avian medicine and surgery. Coverage of a wide variety of bird species includes psittacines, pigeons, raptors, ratites, waterfowl, gallinaceous birds, and less common species. More than 800 full-color images show avian disease, management strategies and thought processes, and aid in formulating guidelines to care. World-renowned, expert contributors provide cutting-edge information, offering authoritative, accurate, and sometimes controversial opinions in many areas of study. Summary tables simplify the lookup of key facts and treatment guidelines. References in each chapter facilitate further reading and research on specific topics.

The Use of Nanoparticles in the Diagnosis and Therapy of Infectious Disease in Animals

The Use of Nanoparticles in the Diagnosis and Therapy of Infectious Disease in Animals
Author: Gerson Nakazato
Publisher: Frontiers Media SA
Total Pages: 63
Release: 2023-09-28
Genre: Medical
ISBN: 2832531172
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Recently, nanoparticles have shown efficacy against antimicrobial activity, including several microorganisms and those that are multidrug-resistant. Nanosensors represent an advance in the diagnosis of infectious diseases, particularly those with zoonotic risk. Different strategies using nanoparticles have been examined for both diagnosis and treatment of these diseases, as well as prevention. The optimization of detection methods and antimicrobial activity is a challenge in microbiology. Advances using nanotechnology are an emerging alternative to solve some problems in the diagnosis and therapy of veterinary infectious diseases. There are implications for the application of nanoparticles to shape interactions with the microorganism itself, as well as influence the bioavailability, biocompatibility, and biodegradation of the system with low host toxicity. The time of detection and its ability to target pathogens can be improved with nanotechnology.

IgY-Technology: Production and Application of Egg Yolk Antibodies

IgY-Technology: Production and Application of Egg Yolk Antibodies
Author: Xiao-Ying Zhang
Publisher: Springer Nature
Total Pages: 316
Release: 2021-06-24
Genre: Medical
ISBN: 3030726886
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This first edited Volume on IgY-Technology, addresses the historical and dynamic development of IgY-applications. The authors cover the biological basis and theoretical context, methodological guidance, and applications of IgY-Technology. A focus is laid on the use of IgY-antibodies for prophylactic/therapeutic purposes in human and veterinary medicine. Aside from applications, the chapters also offer an evolutionary understanding of the IgY molecule, IgY receptors and practical prerequisites to produce IgY-antibodies. Guidance is given for every step of the process. Starting with an introduction to hens as a model species and including hen husbandry, hen egg-laying capacity and total IgY outcomes. Readers will also learn about immunization techniques, the advantages and limitations of different IgY extraction methods, as well as storage stability of the final product. The last part of the volume highlights hands-on aspects of applications, such as IgY delivery strategies, new methods to produce monoclonal IgY-antibodies or production of functional IgY fragments by phage-display as well as commercial exploitation of the technology. Thus, this book is a valuable resource and guide for Scientists, Clinicians and Health Product Developers in both human and veterinary medicine.

Viral Gastroenteritis

Viral Gastroenteritis
Author: Shunzo Chiba
Publisher: Springer Science & Business Media
Total Pages: 301
Release: 2012-12-06
Genre: Medical
ISBN: 3709165539
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Recently, rapid developments have occurred in the field of viral gastroenteritis. This book is an update of fundamental and practical aspects of viral gastroenteritis. Among the various agents that cause viral gastroenteritis, group A rotaviruses and caliciviruses are the focus of this volume because of their clinical impact and the significance of new findings about them.

Poultry Diseases,Diagnosis And Treatment

Poultry Diseases,Diagnosis And Treatment
Author: H. V. S. Chauhan
Publisher: New Age International
Total Pages: 442
Release: 1996
Genre: Poultry
ISBN: 9788122410235
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This Book Is First Of Its Kind On Poultry Diseases Written In India. It Is A Practical Manual On Poultry Diseases Which Every Practicing Veterinarian, Student, Poultry Farm Owner And Diagnostic Laboratory Would Like To Have. The Book Gives Practical Information On The Diseases Of Poultry Including Ducks In India. The Book Is Unique One Because It Not Only Gives Theoretical Information About Poultry Diseases But Also Practical Approach In The Form Ofdisease Tracing Charts On The Basis Of Symptoms Postmortem Findings, Biological Tests Etc. There Is Also A Section On The Modern Laboratory Methods Of Poultry Disease Diagnosis. The Third Section Deals With The Treatment Aspects. The Treatment Part Has Been Tabulated Into Various Groups Of Medicines Available In India And Their Doses Etc. A Section On The Vaccines Available In India Has Been Dealt With At Length To Give A Practical Approach To The Methods Of Vaccination, Methods Of Storage And Preparation Of Vaccines.