Autophagy Dysfunction In Alzheimers Disease And Dementia PDF Download
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Author | : Tadanori Hamano |
Publisher | : Academic Press |
Total Pages | : 360 |
Release | : 2022-08-20 |
Genre | : Medical |
ISBN | : 0323899145 |
Download Autophagy Dysfunction in Alzheimer's Disease and Dementia Book in PDF, ePub and Kindle
Autophagy Dysfunction in Alzheimer’s Disease and Dementia provides an overview for researchers and clinicians on the mechanisms involved in protein degradation in Alzheimer’s. The book discusses the implication of autophagy dysfunction in these diseases and how it causes degenerated proteins, including aggregated tau and aggregated amyloid protein. Other sections explores the possibilities of potential drug development through autophagy modulation, making this a great resource on the study of how autophagy dysfunction has been linked to the accumulation of misfolded proteins that cause death of neurons in Alzheimer’s and other neurodegenerative diseases. Discusses the implication of autophagy dysfunction in neurodegenerative diseases Highlights the mechanisms involved in protein degradation Explores the possibilities of drug development through autophagy modulation
Author | : Vee P. Prasher |
Publisher | : Radcliffe Publishing |
Total Pages | : 206 |
Release | : 2006 |
Genre | : Alzheimer's disease |
ISBN | : 9781857756371 |
Download Down Syndrome and Alzheimer's Disease Book in PDF, ePub and Kindle
Addresses the underlying biological abnormalities of Dementia in Alzheimer's Disease (DAD) in people with Down syndrome. Brings together recent research findings relating to the neuropathology, genetics, blood markers and neurophysiology of Alzheimer's disease in older adults with Down syndrome.
Author | : Lawrence H. Lash |
Publisher | : Elsevier |
Total Pages | : 527 |
Release | : 2013-10-22 |
Genre | : Science |
ISBN | : 1483218619 |
Download Mitochondrial Dysfunction Book in PDF, ePub and Kindle
Methods in Toxicology, Volume 2: Mitochondrial Dysfunction provides a source of methods, techniques, and experimental approaches for studying the role of abnormal mitochondrial function in cell injury. The book discusses the methods for the preparation and basic functional assessment of mitochondria from liver, kidney, muscle, and brain; the methods for assessing mitochondrial dysfunction in vivo and in intact organs; and the structural aspects of mitochondrial dysfunction are addressed. The text also describes chemical detoxification and metabolism as well as specific metabolic reactions that are especially important targets or indicators of damage. The methods for measurement of alterations in fatty acid and phospholipid metabolism and for the analysis and manipulation of oxidative injury and antioxidant systems are also considered. The book further tackles additional methods on mitochondrial energetics and transport processes; approaches for assessing impaired function of mitochondria; and genetic and developmental aspects of mitochondrial disease and toxicology. The text also looks into mitochondrial DNA synthesis, covalent binding to mitochondrial DNA, DNA repair, and mitochondrial dysfunction in the context of developing individuals and cellular differentiation. Microbiologists, toxicologists, biochemists, and molecular pharmacologists will find the book invaluable.
Author | : Athanasios Alexiou |
Publisher | : Frontiers Media SA |
Total Pages | : 501 |
Release | : 2019-12-04 |
Genre | : |
ISBN | : 2889631281 |
Download The Alzheimer's Disease Challenge Book in PDF, ePub and Kindle
Alzheimer’s disease is undoubtedly the major health challenge of our Century with significant social and economic consequences. This Frontiers eBook offers a contribution of 39 innovative papers on the multidimensional and crucial problem of Alzheimer’s disease management and treatment. Several perspectives, research updates, and trials describing methods on potential diagnosis and treatment are presented including biological mechanisms, biomarkers and risk factors for an early and efficient prognosis, diagnosis and prevention. Additionally, while the rapidly increasing Alzheimer’s disease population demands holistic solutions and clinical studies with new therapeutic target approaches, several of the contributive papers present promising drugs targeting Alzheimer’s disease treatment. We give our deepest acknowledgment to all the authors for their important and innovative contributions, to the reviewers for their valuable recommendations on improving the submitting studies and all the Frontiers Editorial team for continuous support.
Author | : Heather M. Wilkins |
Publisher | : Frontiers Media SA |
Total Pages | : 183 |
Release | : 2022-02-11 |
Genre | : Science |
ISBN | : 2889743616 |
Download Metabolism in Alzheimer’s Disease Book in PDF, ePub and Kindle
Author | : Study Group on the Pharmacology of Memory Disorders Associated with Aging. Meeting |
Publisher | : |
Total Pages | : 460 |
Release | : 1996 |
Genre | : Medical |
ISBN | : |
Download The Neurobiology of Alzheimer's Disease Book in PDF, ePub and Kindle
The overall goal of the International Study Group on the Pharmacology of Memory Disorders Associated with Ageing is to point out discoveries that shed light on the potential causes of Alzheimer's disease, its pathogenesis, and the biological mechanisms that could underlie its cure. This eighth meeting in the series, aims to stimulate research in dementia and increase the transfer of information from the basic sciences to physicians and the pharmaceutical industry."
Author | : José M. Fuentes |
Publisher | : Springer |
Total Pages | : 277 |
Release | : 2015-05-04 |
Genre | : Medical |
ISBN | : 3319139398 |
Download Toxicity and Autophagy in Neurodegenerative Disorders Book in PDF, ePub and Kindle
Comprehensive overview of different aspects of autophagy as it relates to neurodegenerative diseases. The pathogenesis of the main neurodegenerative disorders includes either the accumulation of altered or misfolded proteins or exposure to several toxics. Autophagy constitute one of the two principal cellular pathways implicate in the clearance of these material and can serve as a neuroprotective mechanism. Topics include: the role of autophagy in the brain, the role of autophagy in the principal neurodegenerative disorders, and the mechanism by which different molecules cause neurotoxicity and the role autophagy plays.
Author | : Zhenyu Yue |
Publisher | : World Scientific |
Total Pages | : 441 |
Release | : 2012 |
Genre | : Medical |
ISBN | : 9814350443 |
Download Autophagy of the Nervous System Book in PDF, ePub and Kindle
What is autophagy? Why would neurons digest parts of themselves through autophagy? How can autophagy save the lives of cells under some conditions, but act as an accomplice to cell death in others? By what mechanisms are autophagy-related processes dysregulated in neurological diseases, and are there therapeutic strategies to correct or compensate for their dysfunction? This book provides an expert view of major concepts in autophagy research with a focus on autophagy in neurons. Experimental evidence for evolutionarily conserved and specialized regulatory mechanisms for autophagy in the mammalian nervous system will be presented, including recent data on braking mechanisms. Areas of intersection with cell death, the ubiquitin-proteasome system, chaperone-mediated autophagy, and the endocytic pathway will be reviewed, along with emerging areas of mitochondrial autophagy (mitophagy) and the autophagic regulation of neuritic/synaptic processes. Advances in delineating mechanisms by which autophagy is involved in the pathophysiology of neurological disorders, including Alzheimer's, Parkinson's, Huntington's, amyotrophic lateral sclerosis, ischemia/hypoxia and lysosomal storage diseases, will be discussed along with current drug development strategies targeting autophagy.
Author | : Thimmaiah Govindaraju |
Publisher | : Royal Society of Chemistry |
Total Pages | : 531 |
Release | : 2022-01-04 |
Genre | : Medical |
ISBN | : 1839162740 |
Download Alzheimer's Disease Book in PDF, ePub and Kindle
Alzheimer’s disease is an increasingly common form of dementia and despite rising interest in discovery of novel treatments and investigation into aetiology, there are no currently approved treatments that directly tackle the causes of the condition. Due to its multifactorial pathogenesis, current treatments are directed against symptoms and even precise diagnosis remains difficult as the majority of cases are diagnosed symptomatically and usually confirmed only by autopsy. Alzheimer’s Disease: Recent Findings in Pathophysiology, Diagnostic and Therapeutic Modalities provides a comprehensive overview from aetiology and neurochemistry to diagnosis, evaluation and management of Alzheimer's disease, and latest therapeutic approaches. Intended to provide an introduction to all aspects of the disease and latest developments, this book is ideal for students, postgraduates and researchers in neurochemistry, neurological drug discovery and Alzheimer’s disease.
Author | : Davide Moretti |
Publisher | : BoD – Books on Demand |
Total Pages | : 560 |
Release | : 2016-09-28 |
Genre | : Medical |
ISBN | : 9535126547 |
Download Update on Dementia Book in PDF, ePub and Kindle
The dementia challenge is the largest health effort of the times we live in. The whole society has to move to a realization of the significance of prioritization to make an attempt in the direction of mental health promotion and dementia risk reduction. New priorities for research are needed to go far beyond the usual goal of constructing a disease course-modifying medication. Moreover, a full empowerment and engagement of men and women living with dementia and their caregivers, overcoming stigma and discrimination should be promoted. The common efforts and the final aim will have to be the progress of a ''dementia-constructive'' world, where people with dementia can take advantage of equal opportunities.