Astrocytes In Pathophysiology Of The Nervous System PDF Download
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Author | : Vladimir Parpura |
Publisher | : Springer Science & Business Media |
Total Pages | : 701 |
Release | : 2008-12-11 |
Genre | : Medical |
ISBN | : 0387794921 |
Download Astrocytes in (Patho)Physiology of the Nervous System Book in PDF, ePub and Kindle
Astrocytes were the original neuroglia that Ramón y Cajal visualized in 1913 using a gold sublimate stain. This stain targeted intermediate filaments that we now know consist mainly of glial fibrillary acidic protein, a protein used today as an astrocytic marker. Cajal described the morphological diversity of these cells with some ast- cytes surrounding neurons, while the others are intimately associated with vasculature. We start the book by discussing the heterogeneity of astrocytes using contemporary tools and by calling into question the assumption by classical neuroscience that neurons and glia are derived from distinct pools of progenitor cells. Astrocytes have long been neglected as active participants in intercellular communication and information processing in the central nervous system, in part due to their lack of electrical excitability. The follow up chapters review the “nuts and bolts” of ast- cytic physiology; astrocytes possess a diverse assortment of ion channels, neu- transmitter receptors, and transport mechanisms that enable the astrocytes to respond to many of the same signals that act on neurons. Since astrocytes can detect chemical transmitters that are released from neurons and can release their own extracellular signals there is an increasing awareness that they play physiological roles in regulating neuronal activity and synaptic transmission. In addition to these physiological roles, it is becoming increasingly recognized that astrocytes play critical roles during pathophysiological states of the nervous system; these states include gliomas, Alexander disease, and epilepsy to mention a few.
Author | : Sergey Fedoroff |
Publisher | : Springer Science & Business Media |
Total Pages | : 452 |
Release | : 2013-06-29 |
Genre | : Science |
ISBN | : 147579486X |
Download Biology and Pathology of Astrocyte-Neuron Interactions Book in PDF, ePub and Kindle
This volume is made up of papers presented at the Second International Altschul Symposium: Biology and Pathology of Astrocyte-Neuron Interactions. The symposium was held in Saskatoon, Canada at the University of Saskatchewn in May, 1992 in memory of Rudolf Altschul, a graduate of the University of Prague and a pioneer in the fields of the biology of the vascular and nervous systems. Dr. Altschul was Professor and Head of the Department of Anatomy at the University of Saskatchewan from 1955 to 1963. The Altschul Symposia were made possible by an endowment left by Anni Altschul and by other contributions. The symposia are held biennially. One of the greatest challenges for present day scientists is to uncover the mechanisms of brain function. Although cellular anatomy of the nervous system has already been well outlined and indeed was delineated by the beginning of the century, experimental analysis of the function of the brain is relatively recent. The framework of the brain is made up of stellate cells, the astrocytes, which are interconnected by means of their processes, thus presenting a meshwork through which the neurons send their axons, accompanied by oligodendrocytes. Microglia are distributed throughout the brain.
Author | : Vladimir Parpura |
Publisher | : |
Total Pages | : 760 |
Release | : 2011-03-21 |
Genre | : |
ISBN | : 9780387571065 |
Download Astrocytes in (Patho)Physiology of the Nervous System Book in PDF, ePub and Kindle
Author | : Firas H. Kobeissy |
Publisher | : CRC Press |
Total Pages | : 718 |
Release | : 2015-02-25 |
Genre | : Medical |
ISBN | : 1466565993 |
Download Brain Neurotrauma Book in PDF, ePub and Kindle
With the contribution from more than one hundred CNS neurotrauma experts, this book provides a comprehensive and up-to-date account on the latest developments in the area of neurotrauma including biomarker studies, experimental models, diagnostic methods, and neurotherapeutic intervention strategies in brain injury research. It discusses neurotrauma mechanisms, biomarker discovery, and neurocognitive and neurobehavioral deficits. Also included are medical interventions and recent neurotherapeutics used in the area of brain injury that have been translated to the area of rehabilitation research. In addition, a section is devoted to models of milder CNS injury, including sports injuries.
Author | : Maria Teresa Gentile |
Publisher | : BoD – Books on Demand |
Total Pages | : 244 |
Release | : 2018-03-21 |
Genre | : Medical |
ISBN | : 9535138855 |
Download Astrocyte Book in PDF, ePub and Kindle
A team of authors from prestigious academic schools contributed to draw up a project that would give a detailed account of astrocyte's morphology and physiology, examining thoroughly all the astrocyte's types; giving an accurate description of their morphology, location, function in the brain; and illustrating their physiology and pathology in terms of dealing with neurons through "gliotransmitters," ionic channels, and membrane receptors expression. This book gives an overview of the crucial role of astrocytes in the physiology of the CNS and in the pathogenesis of several CNS disorders suggesting that the shift from a neurocentric view to one that incorporates astrocytes in disease models for drug discovery is a critical step in renewing drug development strategies to treat neurodegenerative diseases.
Author | : Jacqueline A. Hubbard |
Publisher | : Academic Press |
Total Pages | : 395 |
Release | : 2016-07-05 |
Genre | : Medical |
ISBN | : 0128026243 |
Download Astrocytes and Epilepsy Book in PDF, ePub and Kindle
Epilepsy is a devastating group of neurological disorders characterized by periodic and unpredictable seizure activity in the brain. There is a critical need for new drugs and approaches given than at least one-third of all epilepsy patients are not made free of seizures by existing medications and become "medically refractory". Much of epilepsy research has focused on neuronal therapeutic targets, but current antiepileptic drugs often cause severe cognitive, developmental, and behavioral side effects. Recent findings indicate a critical contribution of astrocytes, star-shaped glial cells in the brain, to neuronal and network excitability and seizure activity. Furthermore, many important cellular and molecular changes occur in astrocytes in epileptic tissue in both humans and animal models of epilepsy. The goal of Astrocytes and Epilepsy is to comprehensively review exciting findings linking changes in astrocytes to functional changes responsible for epilepsy for the first time in book format. These insights into astrocyte contribution to seizure susceptibility indicate that astrocytes may represent an important new therapeutic target in the control of epilepsy. Astrocytes and Epilepsy includes background explanatory text on astrocyte morphology and physiology, epilepsy models and syndromes, and evidence from both human tissue studies and animal models linking functional changes in astrocytes to epilepsy. Beautifully labelled diagrams are presented and relevant figures from the literature are reproduced to elucidate key findings and concepts in this rapidly emerging field. Astrocytes and Epilepsy is written for neuroscientists, epilepsy researchers, astrocyte investigators as well as neurologists and other specialists caring for patients with epilepsy. Presents the first comprehensive book to synthesize historical and recent research on astrocytes and epilepsy into one coherent volume Provides a great resource on the field of astrocyte biology and astrocyte-neuron interactions Details potential therapeutic targets, including chapters on gap junctions, water and potassium channels, glutamate and adenosine metabolism, and inflammation
Author | : Eliana Scemes |
Publisher | : CRC Press |
Total Pages | : 425 |
Release | : 2016-04-19 |
Genre | : Medical |
ISBN | : 1439825858 |
Download Astrocytes Book in PDF, ePub and Kindle
Astrocytes play diverse roles in central nervous system (CNS) function and dysfunction, and the connections that the astrocyte makes with other cells of the brain are essential for a variety of important neural tasks. Bringing together contributions from international experts at the top of their field, Astrocytes: Wiring the Brain emphasizes cellul
Author | : Howard Reisner |
Publisher | : McGraw Hill Professional |
Total Pages | : 622 |
Release | : 2014-09-22 |
Genre | : Medical |
ISBN | : 0071821236 |
Download Pathology: A Modern Case Study Book in PDF, ePub and Kindle
A unique case-based molecular approach to understanding pathology Pathology: A Modern Case Study is a concise, focused text that emphasizes the molecular and cellular biology essential to understanding the concepts of disease causation. The book includes numerous case studies designed to highlight the role of the pathologist in the team that provides patient care. Pathology: A Modern Case Study examines the role of anatomic, clinical, and molecular pathologists in dedicated chapters and in descriptions of the pathology of specific organ systems. Features Coverage of pathology focuses on modern approaches to common and important diseases Each chapter delivers the most up-to-date advances in pathology Learning aids include chapter summaries and overviews, bolded terms, and a glossary Common clinically relevant disease are highlighted Disease discussion is based on organ compartment and etiology Coverage includes: Disease and the Genome: Genetic, Developmental and Neoplastic Disease Cell Injury, Death and Aging and the Body's Response Environmental Injury Clinical Practice: Anatomic Pathology Clinical Practice: Molecular Pathology Clinical Practice: Molecular Pathology Organ-specific pathology covering all major body systems Molecular pathology Essential for undergraduate medical students and clinicians who wish to expand their knowledge pathology, Pathology: A Modern Case Study delivers valuable coverage that is directly related to a patient’s condition and the clinical practice of pathology.
Author | : Rommy von Bernhardi |
Publisher | : Springer |
Total Pages | : 349 |
Release | : 2016-10-06 |
Genre | : Medical |
ISBN | : 3319407643 |
Download Glial Cells in Health and Disease of the CNS Book in PDF, ePub and Kindle
A timely overview covering the three major types of glial cells in the central nervous system - astrocytes, microglia, and oligodendrocytes. New findings on glia biology are overturning a century of conventional thinking about how the brain operates and are expanding our knowledge about information processing in the brain. The book will present recent research findings on the role of glial cells in both healthy function and disease. It will comprehensively cover a broad spectrum of topics while remaining compact in size.
Author | : Sergey Fedorff |
Publisher | : Elsevier |
Total Pages | : 434 |
Release | : 2012-12-02 |
Genre | : Medical |
ISBN | : 0323150497 |
Download Astrocytes Pt 2: Biochemistry, Physiology, and Pharmacology of Astrocytes Book in PDF, ePub and Kindle
Astrocytes: Biochemistry, Physiology, and Pharmacology of Astrocytes, Volume 2 focuses on the physiological and pharmacological aspects of astrocytes. This volume gives specific attention to intracellular metabolic activity; membrane components and functions; responses to neurotransmitters and other intrinsic factors; and neuronal-glial interactions. Studies in this text establishe the astrocyte as an essential neuronal partner in the neuronal-glial interrelationship throughout the life-span of the neuron and also further explain the potential roles of astrocytes in brain function. Cell physiologists, neurophysiologists, neuropharmacologists, pediatric neurologists, and gerontologists will find the book interesting.