Aromatase Activity In The Brain Of Medaka And Its Regulation By Sex Steroids PDF Download

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Localization and Sex Steroid Regulation of Brain Aromatase Activity

Localization and Sex Steroid Regulation of Brain Aromatase Activity
Author: JSG Edmunds
Publisher:
Total Pages: 13
Release: 1999
Genre: Androgens
ISBN:

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We performed assays for aromatase activity in serial 200 ?m sections of the three orthogonal planes of the brain and produced a three dimensional reconstruction of aromatase levels in Medaka (Oryzias latipes) brain. The regulation of this brain aromatase activity by sex steroids was then examined by in vivo exposure bioassays. We demonstrate that the activity of brain aromatase is localized to an area that contains the hypothalamus, a region of the brain involved in the regulation of the reproductive function. The exposure of Medaka to estradiol lead to increased brain aromatase levels; whereas, exposure to methyl-testosterone lead to decreased brain aromatase levels. The regulation of brain aromatase levels by both product and substrate may provide a sensitive trigger for environmental cues to alter sex behavior.


Brain Aromatase, Estrogens, and Behavior

Brain Aromatase, Estrogens, and Behavior
Author: Jacques Balthazart
Publisher: Oxford University Press
Total Pages: 553
Release: 2012-11-15
Genre: Medical
ISBN: 0199841195

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This book concerns how estrogens are synthesized in the brain and their two modes of action on behavior: a slow process involving gene transcription and a faster action at the cell membrane. The significance of the regulation and distribution of the estrogen synthesizing enzyme aromatase in the brain is also highlighted.


Environmental Toxicology and Risk Assessment

Environmental Toxicology and Risk Assessment
Author: Diane Susan Henshel
Publisher: ASTM International
Total Pages: 500
Release: 1999
Genre: Biochemical markers
ISBN: 0803126182

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Spectrum of Sex

Spectrum of Sex
Author: Minoru Tanaka
Publisher: Springer Nature
Total Pages: 231
Release: 2022-11-07
Genre: Science
ISBN: 9811953597

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This book introduces cutting-edge studies on the spectrum of sex. The sex spectrum can be understood as an interwoven mechanism sustaining graded phenotypes between the two sexes. The book overviews three elements that develop the sex spectrum: genetics, the endocrine system, and the environment. Part I discusses the genetic regulation during sex determination, which often results in a mixture of two sexes or sex reversal. The evolutionary aspects of the genetic determinants are also discussed. Part II presents the involvement of endocrine regulation in the sex spectrum, which covers a broad range of phenotypic events, including sexual behavior and metabolism. Interestingly, sex hormones can also act as sex determinants. Finally, Part III shows that intrinsic factors, such as sex-determining genes and sex hormones, are not the only factors in sex development. The environment surrounding organisms, such as symbiosis and metabolism, act on the sex as critical factors, generating the sex spectrum. Determination and development of the two sexes have been a topic of great interest and a long-standing issue in biology. The book updates the conventional view that biological sex is fixed after birth and sets new perspectives for understanding sex as a spectrum manifested in multiple phenomena. Each chapter contributed by leading experts explains the sex spectrum in various organisms and their underlying mechanisms from the latest ongoing studies. The book provides a valuable resource for not only experts in developmental biology, physiology, and medical science, but also non-scientists and anyone interested in the topic.


Hormones and Reproduction of Vertebrates, Volume 1

Hormones and Reproduction of Vertebrates, Volume 1
Author: David Norris
Publisher: Academic Press
Total Pages: 297
Release: 2011-05-04
Genre: Technology & Engineering
ISBN: 0080962297

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This series of volumes represents a comprehensive and integrated treatment of reproduction in vertebrates from fishes of all sorts through mammals. It is designed to provide a readable, coordinated description of reproductive basics in each group of vertebrates as well as an introduction to the latest trends in reproductive research and our understanding of reproductive events. Whereas each chapter and each volume is intended to stand alone as a review of that topic or vertebrate group, respectively, the volumes are prepared so as to provide a thorough topical treatment across the vertebrates. Terminology has been standardized across the volumes to reduce confusion where multiple names exist in the literature, and a comprehensive glossary of these terms and their alternative names is provided. A complete, essential and up to date reference for research scientists working on vertebrate hormones and reproduction - and on animlals as models in human reproductive research Covers the endocrinology, neuroendocrinology, physiology, behaviour and anatomy of vertebrate reproduction Structured coverage of the major themes for all five vertebrate groups allows a consistent treatment for all Special chapters elaborate on features specific to individual vertebrate groups and to comparative aspects, similarities and differences between them