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Applied Statistics for Network Biology

Applied Statistics for Network Biology
Author: Matthias Dehmer
Publisher: John Wiley & Sons
Total Pages: 441
Release: 2011-04-08
Genre: Medical
ISBN: 3527638083

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The book introduces to the reader a number of cutting edge statistical methods which can e used for the analysis of genomic, proteomic and metabolomic data sets. In particular in the field of systems biology, researchers are trying to analyze as many data as possible in a given biological system (such as a cell or an organ). The appropriate statistical evaluation of these large scale data is critical for the correct interpretation and different experimental approaches require different approaches for the statistical analysis of these data. This book is written by biostatisticians and mathematicians but aimed as a valuable guide for the experimental researcher as well computational biologists who often lack an appropriate background in statistical analysis.


Computational Network Analysis with R

Computational Network Analysis with R
Author: Matthias Dehmer
Publisher: John Wiley & Sons
Total Pages: 364
Release: 2016-12-12
Genre: Medical
ISBN: 3527339582

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This new title in the well-established "Quantitative Network Biology" series includes innovative and existing methods for analyzing network data in such areas as network biology and chemoinformatics. With its easy-to-follow introduction to the theoretical background and application-oriented chapters, the book demonstrates that R is a powerful language for statistically analyzing networks and for solving such large-scale phenomena as network sampling and bootstrapping. Written by editors and authors with an excellent track record in the field, this is the ultimate reference for R in Network Analysis.


Analyzing Network Data in Biology and Medicine

Analyzing Network Data in Biology and Medicine
Author: Nataša Pržulj
Publisher: Cambridge University Press
Total Pages: 647
Release: 2019-03-28
Genre: Science
ISBN: 1108386245

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The increased and widespread availability of large network data resources in recent years has resulted in a growing need for effective methods for their analysis. The challenge is to detect patterns that provide a better understanding of the data. However, this is not a straightforward task because of the size of the data sets and the computer power required for the analysis. The solution is to devise methods for approximately answering the questions posed, and these methods will vary depending on the data sets under scrutiny. This cutting-edge text introduces biological concepts and biotechnologies producing the data, graph and network theory, cluster analysis and machine learning, before discussing the thought processes and creativity involved in the analysis of large-scale biological and medical data sets, using a wide range of real-life examples. Bringing together leading experts, this text provides an ideal introduction to and insight into the interdisciplinary field of network data analysis in biomedicine.


Statistical and Machine Learning Approaches for Network Analysis

Statistical and Machine Learning Approaches for Network Analysis
Author: Matthias Dehmer
Publisher: John Wiley & Sons
Total Pages: 269
Release: 2012-06-26
Genre: Mathematics
ISBN: 111834698X

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Explore the multidisciplinary nature of complex networks through machine learning techniques Statistical and Machine Learning Approaches for Network Analysis provides an accessible framework for structurally analyzing graphs by bringing together known and novel approaches on graph classes and graph measures for classification. By providing different approaches based on experimental data, the book uniquely sets itself apart from the current literature by exploring the application of machine learning techniques to various types of complex networks. Comprised of chapters written by internationally renowned researchers in the field of interdisciplinary network theory, the book presents current and classical methods to analyze networks statistically. Methods from machine learning, data mining, and information theory are strongly emphasized throughout. Real data sets are used to showcase the discussed methods and topics, which include: A survey of computational approaches to reconstruct and partition biological networks An introduction to complex networks—measures, statistical properties, and models Modeling for evolving biological networks The structure of an evolving random bipartite graph Density-based enumeration in structured data Hyponym extraction employing a weighted graph kernel Statistical and Machine Learning Approaches for Network Analysis is an excellent supplemental text for graduate-level, cross-disciplinary courses in applied discrete mathematics, bioinformatics, pattern recognition, and computer science. The book is also a valuable reference for researchers and practitioners in the fields of applied discrete mathematics, machine learning, data mining, and biostatistics.


Discriminative Pattern Discovery on Biological Networks

Discriminative Pattern Discovery on Biological Networks
Author: Fabio Fassetti
Publisher: Springer
Total Pages: 45
Release: 2017-09-01
Genre: Computers
ISBN: 3319634771

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This work provides a review of biological networks as a model for analysis, presenting and discussing a number of illuminating analyses. Biological networks are an effective model for providing insights about biological mechanisms. Networks with different characteristics are employed for representing different scenarios. This powerful model allows analysts to perform many kinds of analyses which can be mined to provide interesting information about underlying biological behaviors. The text also covers techniques for discovering exceptional patterns, such as a pattern accounting for local similarities and also collaborative effects involving interactions between multiple actors (for example genes). Among these exceptional patterns, of particular interest are discriminative patterns, namely those which are able to discriminate between two input populations (for example healthy/unhealthy samples). In addition, the work includes a discussion on the most recent proposal on discovering discriminative patterns, in which there is a labeled network for each sample, resulting in a database of networks representing a sample set. This enables the analyst to achieve a much finer analysis than with traditional techniques, which are only able to consider an aggregated network of each population.


Handbook of Statistical Bioinformatics

Handbook of Statistical Bioinformatics
Author: Henry Horng-Shing Lu
Publisher: Springer Nature
Total Pages: 406
Release: 2022-12-08
Genre: Science
ISBN: 3662659026

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Now in its second edition, this handbook collects authoritative contributions on modern methods and tools in statistical bioinformatics with a focus on the interface between computational statistics and cutting-edge developments in computational biology. The three parts of the book cover statistical methods for single-cell analysis, network analysis, and systems biology, with contributions by leading experts addressing key topics in probabilistic and statistical modeling and the analysis of massive data sets generated by modern biotechnology. This handbook will serve as a useful reference source for students, researchers and practitioners in statistics, computer science and biological and biomedical research, who are interested in the latest developments in computational statistics as applied to computational biology.


Networks of Networks in Biology

Networks of Networks in Biology
Author: Narsis A. Kiani
Publisher: Cambridge University Press
Total Pages: 215
Release: 2021-04
Genre: Computers
ISBN: 1108428878

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Introduces network inspired approaches for the analysis and integration of large, heterogeneous data sets in the life sciences.


Foundational and Applied Statistics for Biologists Using R

Foundational and Applied Statistics for Biologists Using R
Author: Ken A. Aho
Publisher: CRC Press
Total Pages: 598
Release: 2016-03-09
Genre: Mathematics
ISBN: 1439873399

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Full of biological applications, exercises, and interactive graphical examples, this text presents comprehensive coverage of both modern analytical methods and statistical foundations. The author harnesses the inherent properties of the R environment to enable students to examine the code of complicated procedures step by step and thus better understand the process of obtaining analysis results. The graphical capabilities of R are used to provide interactive demonstrations of simple to complex statistical concepts. R code and other materials are available online.


Weighted Network Analysis

Weighted Network Analysis
Author: Steve Horvath
Publisher: Springer Science & Business Media
Total Pages: 433
Release: 2011-04-30
Genre: Science
ISBN: 144198819X

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High-throughput measurements of gene expression and genetic marker data facilitate systems biologic and systems genetic data analysis strategies. Gene co-expression networks have been used to study a variety of biological systems, bridging the gap from individual genes to biologically or clinically important emergent phenotypes.


Network Medicine

Network Medicine
Author: Joseph Loscalzo
Publisher: Harvard University Press
Total Pages: 500
Release: 2017-02-01
Genre: Medical
ISBN: 0674545524

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Big data, genomics, and quantitative approaches to network-based analysis are combining to advance the frontiers of medicine as never before. With contributions from leading experts, Network Medicine introduces this rapidly evolving field of research, which promises to revolutionize the diagnosis and treatment of human diseases.