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Applications of Statistical and Machine Learning Methods in Bioinformatics

Applications of Statistical and Machine Learning Methods in Bioinformatics
Author: Jaroslaw Meller
Publisher: Peter Lang Gmbh, Internationaler Verlag Der Wissenschaften
Total Pages: 136
Release: 2007
Genre: Computers
ISBN:

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Statistical and machine learning approaches play an increasingly important role in biomedical research. In the absence of fundamental (first principle-based) models, or because of the computational complexity of such models, statistical and machine learning approaches are being used to identify interesting structures in the data (e.g. patterns in gene expression profiles), correlate these patterns and other «input» attributes with (e.g. medically) relevant outcomes, and to develop predictors that can generalize from known data and make predictions for new data instances. Examples of important applications include structural bioinformatics, in which one of the goals is to predict elements of protein structure from amino acid sequence, or microarray gene expression profiling, in which the goal is to discover interesting patterns in gene expression data and correlate them with clinically relevant phenotypes. This volume includes papers submitted to the BIT 2005 workshop on the Applications of Machine and Statistical Learning Methods in Bioinformatics that took place in September 2005 in Torun, Poland.


Applications of Statistical and Machine Learning Methods in Bioinformatics

Applications of Statistical and Machine Learning Methods in Bioinformatics
Author: Jaroslaw Meller
Publisher: Peter Lang Pub Incorporated
Total Pages: 128
Release: 2007-01-01
Genre: Computers
ISBN: 9780820487939

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Statistical and machine learning approaches play an increasingly important role in biomedical research. In the absence of fundamental (first principle-based) models, or because of the computational complexity of such models, statistical and machine learning approaches are being used to identify interesting structures in the data (e.g. patterns in gene expression profiles), correlate these patterns and other -input attributes with (e.g. medically) relevant outcomes, and to develop predictors that can generalize from known data and make predictions for new data instances. Examples of important applications include structural bioinformatics, in which one of the goals is to predict elements of protein structure from amino acid sequence, or microarray gene expression profiling, in which the goal is to discover interesting patterns in gene expression data and correlate them with clinically relevant phenotypes. This volume includes papers submitted to the BIT 2005 workshop on the Applications of Machine and Statistical Learning Methods in Bioinformatics that took place in September 2005 in Torun, Poland."


Statistical Modelling and Machine Learning Principles for Bioinformatics Techniques, Tools, and Applications

Statistical Modelling and Machine Learning Principles for Bioinformatics Techniques, Tools, and Applications
Author: K. G. Srinivasa
Publisher: Springer Nature
Total Pages: 318
Release: 2020-01-30
Genre: Technology & Engineering
ISBN: 9811524459

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This book discusses topics related to bioinformatics, statistics, and machine learning, presenting the latest research in various areas of bioinformatics. It also highlights the role of computing and machine learning in knowledge extraction from biological data, and how this knowledge can be applied in fields such as drug design, health supplements, gene therapy, proteomics and agriculture.


Statistical Modelling and Machine Learning Principles for Bioinformatics Techniques, Tools, and Applications

Statistical Modelling and Machine Learning Principles for Bioinformatics Techniques, Tools, and Applications
Author: K. G. Srinivasa
Publisher:
Total Pages: 318
Release: 2020
Genre: Bioinformatics
ISBN: 9789811524462

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This book discusses topics related to bioinformatics, statistics, and machine learning, presenting the latest research in various areas of bioinformatics. It also highlights the role of computing and machine learning in knowledge extraction from biological data, and how this knowledge can be applied in fields such as drug design, health supplements, gene therapy, proteomics and agriculture.


Bioinformatics Applications Based On Machine Learning

Bioinformatics Applications Based On Machine Learning
Author: Pablo Chamoso
Publisher: MDPI
Total Pages: 206
Release: 2021-09-01
Genre: Technology & Engineering
ISBN: 3036507604

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The great advances in information technology (IT) have implications for many sectors, such as bioinformatics, and has considerably increased their possibilities. This book presents a collection of 11 original research papers, all of them related to the application of IT-related techniques within the bioinformatics sector: from new applications created from the adaptation and application of existing techniques to the creation of new methodologies to solve existing problems.


Handbook of Statistical Bioinformatics

Handbook of Statistical Bioinformatics
Author: Henry Horng-Shing Lu
Publisher: Springer Nature
Total Pages: 406
Release: 2022-12-08
Genre: Science
ISBN: 3662659026

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Now in its second edition, this handbook collects authoritative contributions on modern methods and tools in statistical bioinformatics with a focus on the interface between computational statistics and cutting-edge developments in computational biology. The three parts of the book cover statistical methods for single-cell analysis, network analysis, and systems biology, with contributions by leading experts addressing key topics in probabilistic and statistical modeling and the analysis of massive data sets generated by modern biotechnology. This handbook will serve as a useful reference source for students, researchers and practitioners in statistics, computer science and biological and biomedical research, who are interested in the latest developments in computational statistics as applied to computational biology.


Multivariate Statistical Machine Learning Methods for Genomic Prediction

Multivariate Statistical Machine Learning Methods for Genomic Prediction
Author: Osval Antonio Montesinos López
Publisher: Springer Nature
Total Pages: 707
Release: 2022-02-14
Genre: Technology & Engineering
ISBN: 3030890104

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This book is open access under a CC BY 4.0 license This open access book brings together the latest genome base prediction models currently being used by statisticians, breeders and data scientists. It provides an accessible way to understand the theory behind each statistical learning tool, the required pre-processing, the basics of model building, how to train statistical learning methods, the basic R scripts needed to implement each statistical learning tool, and the output of each tool. To do so, for each tool the book provides background theory, some elements of the R statistical software for its implementation, the conceptual underpinnings, and at least two illustrative examples with data from real-world genomic selection experiments. Lastly, worked-out examples help readers check their own comprehension.The book will greatly appeal to readers in plant (and animal) breeding, geneticists and statisticians, as it provides in a very accessible way the necessary theory, the appropriate R code, and illustrative examples for a complete understanding of each statistical learning tool. In addition, it weighs the advantages and disadvantages of each tool.


Statistical Data Modeling and Machine Learning with Applications

Statistical Data Modeling and Machine Learning with Applications
Author: Snezhana Gocheva-Ilieva
Publisher: Mdpi AG
Total Pages: 184
Release: 2021-12-21
Genre: Mathematics
ISBN: 9783036526928

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The modeling and processing of empirical data is one of the main subjects and goals of statistics. Nowadays, with the development of computer science, the extraction of useful and often hidden information and patterns from data sets of different volumes and complex data sets in warehouses has been added to these goals. New and powerful statistical techniques with machine learning (ML) and data mining paradigms have been developed. To one degree or another, all of these techniques and algorithms originate from a rigorous mathematical basis, including probability theory and mathematical statistics, operational research, mathematical analysis, numerical methods, etc. Popular ML methods, such as artificial neural networks (ANN), support vector machines (SVM), decision trees, random forest (RF), among others, have generated models that can be considered as straightforward applications of optimization theory and statistical estimation. The wide arsenal of classical statistical approaches combined with powerful ML techniques allows many challenging and practical problems to be solved. This Special Issue belongs to the section "Mathematics and Computer Science". Its aim is to establish a brief collection of carefully selected papers presenting new and original methods, data analyses, case studies, comparative studies, and other research on the topic of statistical data modeling and ML as well as their applications. Particular attention is given, but is not limited, to theories and applications in diverse areas such as computer science, medicine, engineering, banking, education, sociology, economics, among others. The resulting palette of methods, algorithms, and applications for statistical modeling and ML presented in this Special Issue is expected to contribute to the further development of research in this area. We also believe that the new knowledge acquired here as well as the applied results are attractive and useful for young scientists, doctoral students, and researchers from various scientific specialties.


Data Analytics in Bioinformatics

Data Analytics in Bioinformatics
Author: Rabinarayan Satpathy
Publisher: John Wiley & Sons
Total Pages: 544
Release: 2021-01-20
Genre: Computers
ISBN: 1119785618

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Machine learning techniques are increasingly being used to address problems in computational biology and bioinformatics. Novel machine learning computational techniques to analyze high throughput data in the form of sequences, gene and protein expressions, pathways, and images are becoming vital for understanding diseases and future drug discovery. Machine learning techniques such as Markov models, support vector machines, neural networks, and graphical models have been successful in analyzing life science data because of their capabilities in handling randomness and uncertainty of data noise and in generalization. Machine Learning in Bioinformatics compiles recent approaches in machine learning methods and their applications in addressing contemporary problems in bioinformatics approximating classification and prediction of disease, feature selection, dimensionality reduction, gene selection and classification of microarray data and many more.