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| Author | : National Research Council |
| Publisher | : National Academies Press |
| Total Pages | : 58 |
| Release | : 2006-05-24 |
| Genre | : Science |
| ISBN | : 0309100844 |
Download Application of Toxicogenomics to Cross-Species Extrapolation Book in PDF, ePub and Kindle
Some of what we know about the health effects of exposure to chemicals from food, drugs, and the environment come from studies of occupational, inadvertent, or accident-related exposures. When there is not enough human data, scientists rely on animal data to assess risk from chemical exposure and make health and safety decisions. However, humans and animals can respond differently to chemicals, including the types of adverse effects experienced and the dosages at which they occur. Scientists in the field of toxicogenomics are using new technologies to study the effects of chemicals. For example, in response to a particular chemical exposure, they can study gene expression ("transcriptomics"), proteins ("proteomics") and metabolites ("metabolomics"), and they can also look at how individual and species differences in the underlying DNA sequence itself can result in different responses to the environment. Based on a workshop held in August 2004, this report explores how toxicogenomics could enhance scientists' ability to make connections between data from experimental animal studies and human health.
| Author | : William H. Benson |
| Publisher | : CRC Press |
| Total Pages | : 218 |
| Release | : 2006-12-13 |
| Genre | : Mathematics |
| ISBN | : 1420043641 |
Download Genomic Approaches for Cross-Species Extrapolation in Toxicology Book in PDF, ePub and Kindle
The latest tools for investigating stress response in organisms, genomic technologies provide great insight into how different organisms respond to environmental conditions. However, their usefulness needs to be tested, verified, and codified. Genomic Approaches for Cross-Species Extrapolation in Toxicology provides a balanced discussion drawn from
| Author | : Society of Environmental Toxicology & Chemistry |
| Publisher | : S E T A C Press |
| Total Pages | : 187 |
| Release | : 2006-12 |
| Genre | : |
| ISBN | : 9781880611883 |
Download Genomic Approaches for Cross-Species Extrapolation in Toxicology Book in PDF, ePub and Kindle
| Author | : Darrell R. Boverhof |
| Publisher | : John Wiley & Sons |
| Total Pages | : 470 |
| Release | : 2011-10-11 |
| Genre | : Science |
| ISBN | : 1118008987 |
Download Applications of Toxicogenomics in Safety Evaluation and Risk Assessment Book in PDF, ePub and Kindle
This book provides a timely overview of toxicogenomics, with special emphasis on the practical applications of this technology to the risk assessment process. Introductory sections are followed by a series of chapters highlighting practical and systematic applications of toxicogenomics in informing the risk assessment process – including the areas of mutagenicity, carcinogenicity, endocrine toxicity, organ-specific toxicity, population monitoring, and ecotoxicology. The book concludes with approaches for the integration of this technology in safety evaluation studies, and an outlook on how toxicogenomics and complementary technologies can reframe the current risk assessment paradigm.
| Author | : National Research Council |
| Publisher | : National Academies Press |
| Total Pages | : 58 |
| Release | : 2006-04-24 |
| Genre | : Science |
| ISBN | : 0309181682 |
Download Application of Toxicogenomics to Cross-Species Extrapolation Book in PDF, ePub and Kindle
Some of what we know about the health effects of exposure to chemicals from food, drugs, and the environment come from studies of occupational, inadvertent, or accident-related exposures. When there is not enough human data, scientists rely on animal data to assess risk from chemical exposure and make health and safety decisions. However, humans and animals can respond differently to chemicals, including the types of adverse effects experienced and the dosages at which they occur. Scientists in the field of toxicogenomics are using new technologies to study the effects of chemicals. For example, in response to a particular chemical exposure, they can study gene expression ("transcriptomics"), proteins ("proteomics") and metabolites ("metabolomics"), and they can also look at how individual and species differences in the underlying DNA sequence itself can result in different responses to the environment. Based on a workshop held in August 2004, this report explores how toxicogenomics could enhance scientists' ability to make connections between data from experimental animal studies and human health.
| Author | : National Research Council |
| Publisher | : National Academies Press |
| Total Pages | : 300 |
| Release | : 2007-12-19 |
| Genre | : Science |
| ISBN | : 0309112982 |
Download Applications of Toxicogenomic Technologies to Predictive Toxicology and Risk Assessment Book in PDF, ePub and Kindle
The new field of toxicogenomics presents a potentially powerful set of tools to better understand the health effects of exposures to toxicants in the environment. At the request of the National Institute of Environmental Health Sciences, the National Research Council assembled a committee to identify the benefits of toxicogenomics, the challenges to achieving them, and potential approaches to overcoming such challenges. The report concludes that realizing the potential of toxicogenomics to improve public health decisions will require a concerted effort to generate data, make use of existing data, and study data in new waysâ€"an effort requiring funding, interagency coordination, and data management strategies.
| Author | : National Research Council |
| Publisher | : National Academies Press |
| Total Pages | : 422 |
| Release | : 2009-03-24 |
| Genre | : Political Science |
| ISBN | : 0309120462 |
Download Science and Decisions Book in PDF, ePub and Kindle
Risk assessment has become a dominant public policy tool for making choices, based on limited resources, to protect public health and the environment. It has been instrumental to the mission of the U.S. Environmental Protection Agency (EPA) as well as other federal agencies in evaluating public health concerns, informing regulatory and technological decisions, prioritizing research needs and funding, and in developing approaches for cost-benefit analysis. However, risk assessment is at a crossroads. Despite advances in the field, risk assessment faces a number of significant challenges including lengthy delays in making complex decisions; lack of data leading to significant uncertainty in risk assessments; and many chemicals in the marketplace that have not been evaluated and emerging agents requiring assessment. Science and Decisions makes practical scientific and technical recommendations to address these challenges. This book is a complement to the widely used 1983 National Academies book, Risk Assessment in the Federal Government (also known as the Red Book). The earlier book established a framework for the concepts and conduct of risk assessment that has been adopted by numerous expert committees, regulatory agencies, and public health institutions. The new book embeds these concepts within a broader framework for risk-based decision-making. Together, these are essential references for those working in the regulatory and public health fields.
| Author | : Helena Röcklinsberg |
| Publisher | : Cambridge University Press |
| Total Pages | : 199 |
| Release | : 2017-10-26 |
| Genre | : Law |
| ISBN | : 1108420613 |
Download Animal Ethics in Animal Research Book in PDF, ePub and Kindle
An interdisciplinary in-depth analysis of the ethical issues raised by using animals in research and the related regulatory issues.
| Author | : Akhileshwar Kumar Srivastava |
| Publisher | : Academic Press |
| Total Pages | : 328 |
| Release | : 2022-02-17 |
| Genre | : Science |
| ISBN | : 0323906818 |
Download Xenobiotics in Chemical Carcinogenesis Book in PDF, ePub and Kindle
Xenobiotics in Chemical Carcinogenesis: Translational Aspects in Toxicology covers the translational toxicology of xenobiotics substances in carcinogenesis by explaining the toxicokinetic and toxicodynamic, toxicogenomic, biotransformation, and resistance mechanisms in the human body. The book begins with a historical review and link to future prospects for chemical carcinogenesis. It discusses major environmental xenobiotics and their risks in inducing cancer, along with content on toxic xenobiotics and their routes of exposure in humans, the role of xenobiotic metabolism in carcinogenesis, and the toxicokinetic and toxicodynamic of xenobiotics in cancer development. Lastly, the book explores current achievements such as using toxicogenomics for predicting the carcinogenicity of xenobiotic substances and the challenges posed by carcinogenic xenobiotic substances when examining preventive methods, diagnosis, and the development of anticancer drugs for specific toxicants. Covers the exposure and transmission of various toxic xenobiotics substances, including nanomaterials, to humans and their interaction with specific tissues in precipitating the development of cancers Unravels the toxicokinetic and toxicodynamic processes of toxic xenobiotics in bioaccumulation Examines the genetic aberrations in cancer genomes by genetic-environmental interactions in carcinogenesis Explains the biotransformation mechanisms of toxic xenobiotics by gut microbes in humans
| Author | : Samreen Siddiqui |
| Publisher | : Springer Nature |
| Total Pages | : 174 |
| Release | : |
| Genre | : |
| ISBN | : 3031531302 |
Download Aquatic Ecotoxicology Book in PDF, ePub and Kindle
