Applicability Of Bacterial Short Term Tests In The Assessment Of Genetic Toxicity Of Complex Mixtures PDF Download

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Mixture Toxicity

Mixture Toxicity
Author: Cornelis A. M. van Gestel
Publisher: CRC Press
Total Pages: 312
Release: 2016-04-19
Genre: Medical
ISBN: 1439830096

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In the last decade and a half, great progress has been made in the development of concepts and models for mixture toxicity, both in human and environmental toxicology. However, due to their different protection goals, developments have often progressed in parallel but with little integration. Arguably the first book to clearly link ecotoxicology an


Applications of Toxicogenomic Technologies to Predictive Toxicology and Risk Assessment

Applications of Toxicogenomic Technologies to Predictive Toxicology and Risk Assessment
Author: National Research Council
Publisher: National Academies Press
Total Pages: 300
Release: 2007-12-19
Genre: Science
ISBN: 0309112982

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The new field of toxicogenomics presents a potentially powerful set of tools to better understand the health effects of exposures to toxicants in the environment. At the request of the National Institute of Environmental Health Sciences, the National Research Council assembled a committee to identify the benefits of toxicogenomics, the challenges to achieving them, and potential approaches to overcoming such challenges. The report concludes that realizing the potential of toxicogenomics to improve public health decisions will require a concerted effort to generate data, make use of existing data, and study data in new waysâ€"an effort requiring funding, interagency coordination, and data management strategies.


Application of Short-Term Bioassays in the Fractionation and Analysis of Complex Environmental Mixtures

Application of Short-Term Bioassays in the Fractionation and Analysis of Complex Environmental Mixtures
Author: Michael D. Waters
Publisher: Springer Science & Business Media
Total Pages: 565
Release: 2012-12-06
Genre: Science
ISBN: 1468436112

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vi Williamsburg, Virginia, February 21-23, 1978. This symposium was sponsored by the U. S. Environmental Protection Agency, Office of Energy Minerals and Industry, Washington, DC, and Office of Health and Ecological Effects, Health Effects Re search Laboratory, Biochemistry Branch, Research Triangle Park, NC. The symposium consisted of 24 formal presentations that amplify the three major topics discussed during the symposium: an overview of short-term bioassay systems; current methodology involving the collection and chemical analysis of environmental samples; and current research in volving the use of short-term bioassays in the fractionation and analysis of complex environmental mixtures. The purpose of this symposium was to present the state-of-the-art tech niques in bioassay and chemical analysis as applied to com plex mixtures and to foster continued advancement of this important area. Complex mixtures discussed include ambient air and water, waste water, drinking water, shale oil, syn thetic fuels, automobile exhaust, diesel particulate, coal fly ash, cigarette smoke condensates, and food products. It is our hope that this volume will serve as a refer ence to catalyze and encourage further research in this field. Michael D. Waters, Ph. D. Stephen Nesnow, Ph. D. vii Acknowledgment We would like to thank Gerald Rausa, Office of Energy Minerals and Industry, for his advice, encouragement, and support of this program. We would also like to express our appreciation to Wendy A. Martin, Peter A. Murphy, and David F. Wright of Kappa Systems, Inc.


Toxicity Testing for Assessment of Environmental Agents

Toxicity Testing for Assessment of Environmental Agents
Author: National Research Council
Publisher: National Academies Press
Total Pages: 270
Release: 2006-04-07
Genre: Nature
ISBN: 0309164869

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Toxicity testing in laboratory animals provides much of the information used by the Environmental Protection Agency (EPA) to assess the hazards and risks associated with exposure to environmental agents that might harm public health or the environment. The data are used to establish maximum acceptable concentrations of environmental agents in drinking water, set permissible limits of exposure of workers, define labeling requirements, establish tolerances for pesticides residues on food, and set other kinds of limits on the basis of risk assessment. Because the number of regulations that require toxicity testing is growing, EPA called for a comprehensive review of established and emerging toxicity-testing methods and strategies. This interim report reviews current toxicity-testing methods and strategies and near-term improvements in toxicity-testing approaches proposed by EPA and others. It identifies several recurring themes and questions in the various reports reviewed. The final report will present a long-range vision and strategic plan to advance the practices of toxicity testing and human health assessment of environmental contaminants.


Energy Research Abstracts

Energy Research Abstracts
Author:
Publisher:
Total Pages: 852
Release: 1990
Genre: Power resources
ISBN:

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Genetic Toxicology Testing

Genetic Toxicology Testing
Author: Ray Proudlock
Publisher: Academic Press
Total Pages: 458
Release: 2016-05-28
Genre: Medical
ISBN: 0128010061

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Genetic Toxicology Testing: A Laboratory Manual presents a practical guide to genetic toxicology testing of chemicals in a GLP environment. The most commonly used assays are described, from laboratory and test design to results analysis. In a methodical manner, individual test methods are described step-by-step, along with equipment, suggested suppliers, recipes for reagents, and evaluation criteria. An invaluable resource in the lab, this book will help to troubleshoot any assay problems you may encounter to optimise quality and efficiency in your genetic toxicology tests. Genetic Toxicology Testing: A Laboratory Manual is an essential reference for those new to the genetic toxicology laboratory, or anyone involved in setting up their own. Offers practical and consistent guidance on the most commonly-performed tests and procedures in a genetic toxicology lab Describes standard genetic toxicology assays, their methodology, reagents, suppliers, and analysis of their results Includes guidance on general approaches: formulation for in vitro assays, study monitoring, and Good Laboratory Practice (GLP) Serves as an essential reference for those new to the genetic toxicology laboratory, or anyone involved in setting up their own lab


EPA Publications Bibliography

EPA Publications Bibliography
Author: United States. Environmental Protection Agency
Publisher:
Total Pages: 360
Release: 1987
Genre: Environmental protection
ISBN:

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Damp Indoor Spaces and Health

Damp Indoor Spaces and Health
Author: Institute of Medicine
Publisher: National Academies Press
Total Pages: 369
Release: 2004-10-01
Genre: Science
ISBN: 0309091934

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Almost all homes, apartments, and commercial buildings will experience leaks, flooding, or other forms of excessive indoor dampness at some point. Not only is excessive dampness a health problem by itself, it also contributes to several other potentially problematic types of situations. Molds and other microbial agents favor damp indoor environments, and excess moisture may initiate the release of chemical emissions from damaged building materials and furnishings. This new book from the Institute of Medicine examines the health impact of exposures resulting from damp indoor environments and offers recommendations for public health interventions. Damp Indoor Spaces and Health covers a broad range of topics. The book not only examines the relationship between damp or moldy indoor environments and adverse health outcomes but also discusses how and where buildings get wet, how dampness influences microbial growth and chemical emissions, ways to prevent and remediate dampness, and elements of a public health response to the issues. A comprehensive literature review finds sufficient evidence of an association between damp indoor environments and some upper respiratory tract symptoms, coughing, wheezing, and asthma symptoms in sensitized persons. This important book will be of interest to a wide-ranging audience of science, health, engineering, and building professionals, government officials, and members of the public.