Apoptosis In Cancer Pathogenesis And Anti Cancer Therapy PDF Download
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Author | : Christopher D. Gregory |
Publisher | : Springer |
Total Pages | : 260 |
Release | : 2016-08-24 |
Genre | : Medical |
ISBN | : 3319394061 |
Download Apoptosis in Cancer Pathogenesis and Anti-cancer Therapy Book in PDF, ePub and Kindle
This book discusses properties of apoptosis and other cell death modalities in cancer pathogenesis and treatment. Its nine chapters discuss modulation of anti-tumor inflammatory and immune responses, effects on the tumor microenvironment, to strategies for improving pro-apoptotic therapies, mechanisms and implications for disease pathogenesis, axl and mer receptor tyrosine kinases, immunogenic apoptotic cell death and anti-cancer immunity and cancer cell death-inducing radiotherapy. This book places the onco-biology of apoptosis in clear and objective perspective through an expertly synthesized series of reviews. Apoptosis in Cancer Pathogenesis and Anti-cancer Therapy is a deft and thorough exploration of cutting-edge research in apoptosis and anti-cancer mechanisms from basic biology to oncology. It highlights a rapidly growing field within cancer research and is essential reading for oncologists, biochemists and advanced graduate students alike.
Author | : George G. Chen |
Publisher | : Springer Science & Business Media |
Total Pages | : 396 |
Release | : 2009-02-22 |
Genre | : Medical |
ISBN | : 140209597X |
Download Apoptosis in Carcinogenesis and Chemotherapy Book in PDF, ePub and Kindle
Although research on carcinogenesis has focused more on cellular proliferation than on cell death, yet understanding the mechanism of apoptosis may have important implications for cancer therapy. This book brings together experts from around the world who will discuss the common cancers encountered in clinical practice in the laboratory setting. During the induction of these common cancers, the role of apoptosis in cellular and molecular changes is emphasized, critically highlighting possible anti-cancer strategies. For those who are interested in carcinogenesis and for those who are seeking new approaches to anti-cancer therapy, this book is an important reference. It serves not only as a reference of the current understanding of apoptosis in common cancers but also an important bridge between the laboratory and clinical practice. The editors and contributors are to be congratulated in bringing together an important pool of up-to-date knowledge to light and further our interest in this exciting and expanding ?eld. Arthur K. C. Li Emeritus Professor of Surgery The Chinese University of Hong Kong v Preface The role of apoptosis in cancer development and emerging treatment strategies has rapidly expanded over the past few years. The novel discovery in the apoptotic pa- ways and their relevant molecules provides us not only the knowledge how tumors develop but also the opportunity to design new therapeutic tools to prevent or inhibit the growth of tumors with minimal side-effects. Undoubtedly, understanding the events involved at a molecular level can permit the manipulation of apoptosis for therapeutic purposes.
Author | : Rafiq A. A Rather |
Publisher | : |
Total Pages | : 0 |
Release | : 2020 |
Genre | : Science |
ISBN | : |
Download Insights Into the Role of Defective Apoptosis in Cancer Pathogenesis and Therapy Book in PDF, ePub and Kindle
One form of programmed cell death (PCD) is apoptosis. Defective apoptosis is an indispensable causative factor in the development of cancer that allows cancer cells to survive longer and favors the accumulation of oncogenic mutations. Further, upregulation of antiapoptotic proteins (e.g., Bcl-2, Mcl-1) and loss of pro-apoptotic proteins (e.g., Bid, Bad, Bax, Bak) strongly favors apoptosis evasion. The ability of cancer cells to evade apoptosis is critical for the progression and clonal expansion of malignantly transformed cells. Defective apoptosis imparts proliferative advantage to cancer cells or cells with the potential to become cancerous. The mechanisms employed by cancer cells to evade apoptosis can be used in the strategic design of therapeutic regimens aimed at exploiting apoptotic signaling networks to ensure tumor-specific cell death. Therefore, to ensure tumor-specific cell death, we may need to exploit the expression and/or function of different components of apoptotic signaling that are critical for maintaining cell survival and are regulated differently in tumor cells than normal cells. Both inhibitors of anti-apoptotic proteins and activators of pro-apoptotic proteins can be used for cancer therapy. In this chapter, we attempted to summarize the knowledge about the molecular mechanisms of defective apoptosis that could be translated into the development of novel therapeutic agents and therapeutic modalities for cancer treatment.
Author | : Roya Khosravi-Far |
Publisher | : Springer Science & Business Media |
Total Pages | : 362 |
Release | : 2007-12-29 |
Genre | : Medical |
ISBN | : 140206554X |
Download Programmed Cell Death in Cancer Progression and Therapy Book in PDF, ePub and Kindle
Programmed cell death (PCD) plays pivotal roles in tumor progression, cancer therapeutics and resistance of tumor cells to therapy. This book examines the mechanisms involved in mediating and regulating PCD in cancer. It also provides a detailed indication of the utility of PCD in cancer therapy. The book features chapters on the current and future of RNA interference in therapeutics and Pathways involved in Stem Cell Survival and Death.
Author | : Mels Sluyser |
Publisher | : Springer Science & Business Media |
Total Pages | : 388 |
Release | : 2005-04-14 |
Genre | : Medical |
ISBN | : 9781402033032 |
Download Application of Apoptosis to Cancer Treatment Book in PDF, ePub and Kindle
Novel drugs are being developed which interact with the programmed cell death (apoptotic) machinery in cancer cells, thereby causing these cells to commit suicide and to be removed from the body. Research is also directed to investigate why the cancer cells sometimes lose the ability to undergo apoptosis after a certain period of time and methods are being developed to reactivate this cell death process. This book is intended for workers in the field and clinicians as a useful guide of the state of affairs in this exciting field which may offer more effective possibilities for treatment of cancer patients. Mels Sluyser is the Editor of the journals APOPTOSIS and ANTI-CANCER DRUGS. He brings together a collection of papers written by the world’s leading experts in these fields.
Author | : Seamus J. Martin |
Publisher | : S. Karger AG (Switzerland) |
Total Pages | : 0 |
Release | : 1997 |
Genre | : Apoptosis |
ISBN | : 9783805565790 |
Download Apoptosis and Cancer Book in PDF, ePub and Kindle
The past five years have witnessed an explosion of research efforts in the study of how cells die. This book provides an up-to-date overview of our current knowledge of apoptosis and how discoveries in this area impact on our understanding of cancer. By synthesizing many of the recent developments in this area and placing them in perspective, it fulfills an important need. All the contributions are written by experts in their respective fields. The first two chapters give a basic introduction to the cell death machinery and its role in tumor development and progression; subsequent chapters cover current aspects of apoptosis research, including the involvement of cell cycle-related proteins (e.g. cyclin-dependent kinases) in apoptosis, the role of Bcl-2, Bcr-Abl, Rb, p53 and myc in the regulation of cell death, and apoptosis in the context of specific neoplasms such as cancer of the prostate, kidney, leukemia and neuroblastoma. It is also discussed how insights into the regulation of apoptosis may be exploited for designing new drugs aimed at eliminating malignant cells. Compiling the most recent research results on the relationship between apoptosis and cancer in one handy volume, this book will provide a valuable reference for scientists working in cancer research as well as newcomers to the field.
Author | : Albina W. Taylor |
Publisher | : Nova Publishers |
Total Pages | : 208 |
Release | : 2007 |
Genre | : Apoptosis |
ISBN | : 9781600215063 |
Download Cell Apoptosis and Cancer Book in PDF, ePub and Kindle
Apoptosis is the regulated form of cell death. It is a complex process defined by a set of characteristic morphological and biochemical features that involves the active participation of affected cells in a self-destruction cascade. This programmed cell death plays a critical role in physiological functions such as cell deletion during embryonic development, balancing cell number in continuously renewing tissues and immune system development. Additionally, a dysregulation of apoptosis is underlying in numerous pathological situations such as Parkinson, Alzheimer's disease and cancer. A number of studies have pointed out an association between consumption of fruits and vegetables, and certain beverages such as tea and wine, which are rich in polyphenols, with reduced risk of chronic diseases, including cancer. Apoptosis is also the regulatory mechanism involved in the removal of unnecessary cells during development and in tissue homeostasis in a wide range of organisms from insects to mammals. Cancer and cell apoptosis is the central focus of this significant book.
Author | : K. M. Debatin |
Publisher | : |
Total Pages | : 504 |
Release | : 2006 |
Genre | : Apoptosis |
ISBN | : |
Download Apoptosis and Cancer Therapy Book in PDF, ePub and Kindle
Author | : Hugo Barcenilla |
Publisher | : Springer Nature |
Total Pages | : 215 |
Release | : 2022-09-10 |
Genre | : Medical |
ISBN | : 1071625535 |
Download Apoptosis and Cancer Book in PDF, ePub and Kindle
This volume discusses methods used in the fields of molecular and cellular biology for detecting and studying cell death, especially in cancer and cancer therapy. Chapters in this book cover topics such as non-destructive, real-time Annexin V apoptosis assay; assessment of the immune response to tumor cell apoptosis and efferocytosis; mass cytometry assessment of cell phenotypes and signaling states in human whole blood; cell cycle analysis of ER stress and autophagy; and simultaneous detection of inflammasome activation and membrane damage during pyroptosis. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and practical, Apoptosis and Cancer: Methods and Protocols is a valuable resource and practical guide for both novice and expert researchers looking into the “meaning of death.”
Author | : John A. Hickman |
Publisher | : Springer Science & Business Media |
Total Pages | : 347 |
Release | : 1999-04-08 |
Genre | : Medical |
ISBN | : 1592597203 |
Download Apoptosis and Cancer Chemotherapy Book in PDF, ePub and Kindle
The past few years have witnessed an astonishing international effort that established the role of some 20 new molecules in apoptosis and added activation or suppression of apoptosis to the accepted biological functions of a great many others already familiar in cancer biology. Some of these molecules are receptors, transducing cytokine-mediated signals; others appear to intensify or diminish the risk that a compro mised cell will fire its apoptosis effector mechanism. All are of interest as potential targets for tumor therapy, and some may prove to be control points influenced in the pathogenesis of cancer and other diseases as diverse as viral infection, neurodegenerative disorders, and stroke. Sometimes, in the midst of these developments, a kind of euphoria ap pears to have gripped the research community, with the expectation that apoptosis will afford explanations to many unsolved questions in cellu lar regulation. This book, in a series of thoughtful and provocative ar ticles--some from established leaders in the field, and others from younger scientists--seeks to redress the balance.