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Principles & Practice of Pañcakarma is an essential text on the Pañcakarma, a branch of Medicine. The need for such a book results from scarcity of well written, critically reviewed and the less number of books on Pañcakarma in English language. In 4th edition of Principles & Practice of Pañcakarma, important topics have been added wherever necessary in order make the book complete. Current Practice of Pañcakarma in different diseases is updated. We are very much thankful to all those readers especially students for their overwhelming response & feedbacks. This incredible response increased the responsibility of Atreya Ayurveda Publications to come out with quality Ayurvedic Books. We hope the readers will continue to support in the same manner for this edition & other publications. Intended Audience A Comprehensive Book for BAMS students, M.D. scholars, Academicians, Practitioners and Researchers. This book will helps in precise & deeper understanding of the principles, concepts & practices of Pañcakarma therapy. Outstanding Features Description of fundamentals of Pañcakarma and fundamentals of Shodhana in separate chapters, which is the unique feature of book. All the Keraliya Pañcakarma therapies are covered in Snehana & Svedana chapters, in detail critically with current practices. In the chapter entitled “Fundamental principles of Shodhana”, the author has tried to explain the need, importance, utility, fundamentals, Basic considerations before bio-purification and practical considerations in vivid manner. Basic considerations before Pañcakarma and before Vamana etc. karma are the unique feature of this book. In the chapter therapeutic Pañcakarma the indications of Pañcakarma in different diseases with references has been described in tabular form. The research chapter deals with the problems of research, research methodology, researches done on Pañcakarma, standardization of Pañcakarma, area of research, Pañcakarma Record form, which is unique and first work. Experiences of the eminent physicians, research findings & my past 8 years experiences also included in order to make the book more practical & authentic. The heading ‘Critical notes’ in each Karma refers to the description of essential notes, which needs to be separated from the procedure to make the book reader friendly. The classifications, dose, indications, contraindications etc. subjects are presented in tabular form for easier and better understanding. The mode of action has been described both by Ayurvedic and Modern views in order to highlight the scientific substantiation of action of therapies.