Antiviral Strategies PDF Download
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Author | : Hans-Georg Kräusslich |
Publisher | : Springer Science & Business Media |
Total Pages | : 386 |
Release | : 2008-12-02 |
Genre | : Medical |
ISBN | : 3540790861 |
Download Antiviral Strategies Book in PDF, ePub and Kindle
A crucial issue for antiviral therapy is the fact that all antiviral substances rapidly select for resistance; thus, monitoring and overcoming resistance has become a most important clinical paradigm of antiviral therapy. This calls for cautious use of antiviral drugs and implementation of combination therapies. In parallel, efforts in drug discovery have to be continued to develop compounds with novel mode-of-action and activity against resistant strains. This book reviews the current status of antiviral therapy, from the roads to development of new compounds to their clinical use and cost effectiveness. Individual chapters address in more detail all available drug classes and outline new approaches currently under development.
Author | : Erik De Clercq |
Publisher | : John Wiley & Sons |
Total Pages | : 632 |
Release | : 2011-04-08 |
Genre | : Medical |
ISBN | : 3527635963 |
Download Antiviral Drug Strategies Book in PDF, ePub and Kindle
By focusing on general molecular mechanisms of antiviral drugs rather than therapies for individual viruses, this ready reference provides the critical knowledge needed to develop entirely novel therapeutics and to target new viruses. It begins with a general discussion of antiviral strategies, followed by a broad survey of known viral targets, such as reverse transcriptases, proteases, neuraminidases, RNA polymerases, helicases and primases, as well as their known inhibitors. The final section contains several cases studies of recent successful antiviral drug development. Edited by Erik de Clercq, the world authority on small molecule antiviral drugs, who has developed more new antivirals than anyone else.
Author | : Ann Arvin |
Publisher | : Cambridge University Press |
Total Pages | : 1325 |
Release | : 2007-08-16 |
Genre | : Medical |
ISBN | : 1139461648 |
Download Human Herpesviruses Book in PDF, ePub and Kindle
This comprehensive account of the human herpesviruses provides an encyclopedic overview of their basic virology and clinical manifestations. This group of viruses includes human simplex type 1 and 2, Epstein–Barr virus, Kaposi's Sarcoma-associated herpesvirus, cytomegalovirus, HHV6A, 6B and 7, and varicella-zoster virus. The viral diseases and cancers they cause are significant and often recurrent. Their prevalence in the developed world accounts for a major burden of disease, and as a result there is a great deal of research into the pathophysiology of infection and immunobiology. Another important area covered within this volume concerns antiviral therapy and the development of vaccines. All these aspects are covered in depth, both scientifically and in terms of clinical guidelines for patient care. The text is illustrated generously throughout and is fully referenced to the latest research and developments.
Author | : Manoj C. Desai |
Publisher | : Royal Society of Chemistry |
Total Pages | : 551 |
Release | : 2013 |
Genre | : Medical |
ISBN | : 184973657X |
Download Successful Strategies for the Discovery of Antiviral Drugs Book in PDF, ePub and Kindle
This volume will be aimed at medicinal chemistry and emerging drug discovery scientists.
Author | : |
Publisher | : BoD – Books on Demand |
Total Pages | : 156 |
Release | : 2023-12-20 |
Genre | : Medical |
ISBN | : 180356783X |
Download Antiviral Strategies in the Treatment of Human and Animal Viral Infections Book in PDF, ePub and Kindle
Antiviral Strategies in the Treatment of Human and Animal Viral Infections provides a comprehensive overview of the most recent discoveries in the field of antiviral research. It covers topics like viral replication, immunological reactions, medication discovery, vaccine development, and clinical applications. It also provides a summary of the difficulties and possibilities in battling viral infections that affect both humans and animals. Antiviral Strategies in the Treatment of Human and Animal Viral Infections is a useful resource for researchers, doctors, veterinarians, and students who are interested in the prevention and treatment of viral infections
Author | : Institute of Medicine |
Publisher | : National Academies Press |
Total Pages | : 132 |
Release | : 2008-07-11 |
Genre | : Medical |
ISBN | : 0309118662 |
Download Antivirals for Pandemic Influenza Book in PDF, ePub and Kindle
Planning for an influenza pandemic, whether it occurs in the near or distant future, will need to take into account many constantly evolving factors. The Institute of Medicine (IOM) Committee on Implementation of Antiviral Medication Strategies for an Influenza Pandemic was asked by the Department of Health and Human Services, (DHHS) to consider best practices and policies for providing antiviral treatment and prophylaxis during a pandemic event. The committee's report, entitled Antivirals for Pandemic Influenza: Guidance on Developing a Distribution and Dispensing Program, calls for a national and public process of creating an ethical framework for antiviral use within the context of uncertainty and scarcity. It is unclear whether antivirals will work against a pandemic strain as well as they work against seasonal influenza. Also, government stockpiles may not be sufficient for all possible uses in part because antivirals are costly and public health agencies must invest in other important activities, including other medical resources for pandemic influenza. Furthermore, the report identifies the lack of a science-based advisory body to guide decision making during the pandemic, including guidance on all dimensions of antiviral dispensing (for example, prioritization, drug safety, and antiviral resistance). The report also acknowledges the need for diverse methods and sites of dispensing, and discusses their advantages and disadvantages.
Author | : Gaëtan Ligat |
Publisher | : Frontiers Media SA |
Total Pages | : 173 |
Release | : 2023-12-27 |
Genre | : Science |
ISBN | : 2832541615 |
Download Recent highlights in the development of therapeutic antiviral strategies Book in PDF, ePub and Kindle
Author | : Xinyong Liu |
Publisher | : Springer Nature |
Total Pages | : 357 |
Release | : 2021-07-13 |
Genre | : Medical |
ISBN | : 9811602670 |
Download Antiviral Drug Discovery and Development Book in PDF, ePub and Kindle
This book summarizes state-of-the-art antiviral drug design and discovery approaches starting from natural products to de novo design, and provides a timely update on recently approved antiviral drugs and compounds in advanced clinical development. Special attention is paid to viral infections with a high impact on the world population or highly relevant from the public health perspective (HIV, hepatitis C, influenza virus, etc.). In these chapters, limitations associated with adverse effects and emergence of drug resistance are discussed in detail. In addition to classical antiviral strategies, chapters will be dedicated to discuss the non-classical drug development strategies to block viral infection, for instance, allosteric inhibitors, covalent antiviral agents, or antiviral compounds targeting protein–protein interactions. Finally, current prospects for producing broad-spectrum antiviral inhibitors will be also addressed. The book is distinctive in providing the most recent update in the rapidly evolving field of antiviral therapeutics. Authoritative reviews are written by international scientists well known for their contributions in their topics of research, which makes this book suitable for researchers not only within the antiviral research community but also attractive to a broad audience in the drug discovery field. This book covers molecular structures and biochemical mechanisms mediating the antiviral effects, while discussing various ligand design strategies, which include traditional medicinal chemistry, computational chemistry, and chemical biology approaches. The book provides a comprehensive review of antiviral drug discovery and development approaches, particularly focusing on current innovations and future trends.
Author | : Catherine Adamson |
Publisher | : MDPI |
Total Pages | : 386 |
Release | : 2021-01-21 |
Genre | : Science |
ISBN | : 3039289535 |
Download Antiviral Agents Book in PDF, ePub and Kindle
Antiviral agents are used for the treatment of viral diseases. Antiviral drugs have been successfully developed and used clinically for a limited number of important human viral diseases notably caused by human immunodeficiency virus (HIV), hepatitis C virus (HCV), hepatitis B virus (HBV), herpes, and influenza viruses. Despite the successes of these antiviral drugs, issues with drug resistance and toxicity remain challenging. These challenges are driving research to identify new drug candidates and to investigate novel drug targets to develop new mechanistic drug classes. Antiviral agents are not available against many viruses that cause human disease and economic burdens; in particular, the development of antiviral agents against emerging, re-emerging, and neglected viruses is increasingly becoming a priority. This book includes six review articles that discuss new antiviral strategies. The reviews either discuss advances relating to a specific virus or new therapeutic targets and approaches. The book includes 15 original research articles reporting new antiviral agents against a variety of clinically and economically important viruses and studies into the prevalence or acquisition of drug resistance. Overall, this book is an exciting collection of new research and ideas relating to the development of antiviral agents.
Author | : Elke Bogner |
Publisher | : Springer Science & Business Media |
Total Pages | : 543 |
Release | : 2007-01-31 |
Genre | : Medical |
ISBN | : 0387310479 |
Download New Concepts of Antiviral Therapy Book in PDF, ePub and Kindle
Antiviral drugs are vital - but imperfect - tools for treatment and prevention of viral infections. Undesirable effects, from drug resistant viruses to low oral bioavailability, toxicity and severe side effects limit clinical usefulness. These factors drive demand for improved antiviral strategies. This book offers an up-to-date review of new drugs and targets, novel modes of action, vector-based treatments and even the blocking of defined genes by inhibiting mRNA formation (siRNA). Includes contributions by acknowledged experts; the book will serve as a compendium for R&D and educational professionals, and be of value for students.