Anti Angiogenesis Strategies In Cancer Therapies PDF Download
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| Author | : Shaker Mousa |
| Publisher | : Academic Press |
| Total Pages | : 212 |
| Release | : 2016-11-28 |
| Genre | : Medical |
| ISBN | : 0128026731 |
Download Anti-Angiogenesis Strategies in Cancer Therapies Book in PDF, ePub and Kindle
Anti-angiogenesis Strategies in Cancer Therapeutics provides a detailed look at the current status and future directions in the discovery and development of novel anti-angiogenesis strategies in oncology. This book highlights the different mechanisms involved in the modulation of angiogenesis, including inflammation, thrombosis, and microRNA, and shows how nanotechnology can further enhance the potential of existing and new anti-angiogenesis approaches. Written for industry scientists, researchers, oncologists, hematologists, and professors and students in the field, this comprehensive book covers all aspects of anti-angiogenesis strategies and their differences. Covers important preclinical models and clinical trials in the discovery and development of novel anti-angiogenesis agents Reviews FDA-approved anti-angiogenesis agents Illustrates the value of nanotechnology in improving the utility of anti-angiogenesis agents Offers insight into the development of novel anti-angiogenesis agents and future direction in this area
| Author | : Darren W. Davis |
| Publisher | : CRC Press |
| Total Pages | : 878 |
| Release | : 2007-07-25 |
| Genre | : Medical |
| ISBN | : 1420004298 |
Download Antiangiogenic Cancer Therapy Book in PDF, ePub and Kindle
Top Investigators Explore the Complexities of Angiogenesis Cancer Research The targeting of tumor angiogenesis has evolved into one of the most widely pursued therapeutic strategies. However, as of yet, no antiangiogenic agent used as a monotherapy has demonstrated a survival benefit in a randomized Phase III trial. The combination of bev
| Author | : Sudip Mukherjee |
| Publisher | : Springer Nature |
| Total Pages | : 85 |
| Release | : 2022-09-27 |
| Genre | : Technology & Engineering |
| ISBN | : 3031112849 |
Download Nanoparticles in Angiogenesis and Cancer Book in PDF, ePub and Kindle
This book highlights recent developments of organic and inorganic nanomedicine that play a major role in anti-angiogenic cancer therapy. In addition, the authors present examples of nanomedicine based anti-angiogenic agents and their applications in cancer therapy. Angiogenesis is a pathophysiological phenomenon that modulates cell proliferation and cell migration and plays important roles in cancer. Anti-angiogenic nanotherapies have gained immense attention in recent times as alternative cost-effective therapies that opened a new dimension in cancer theranostics. Further the challenges of the anti-angiogenic nanotherapies and possible future perspective are detailed.
| Author | : Dieter Marmé |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 840 |
| Release | : 2007-12-05 |
| Genre | : Medical |
| ISBN | : 3540331778 |
Download Tumor Angiogenesis Book in PDF, ePub and Kindle
Tumor angiogenesis is one of the most prominent mechanisms driving tumor development and progression. This book is written by internationally renowned experts. Part 1 describes the basic mechanisms. Tumor-angiogenic signaling pathways are presented as new potential targets for anti-angiogenic therapy. Part 2 reviews the efforts made to validate new targets and to show efficacy in animals. Part 3 is devoted to the clinical development of the novel anti-angiogenic drugs and their use in clinical practice.
| Author | : Beverly A. Teicher |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 585 |
| Release | : 2008-01-08 |
| Genre | : Medical |
| ISBN | : 1597451843 |
Download Antiangiogenic Agents in Cancer Therapy Book in PDF, ePub and Kindle
This volume represents a compendium of scientific findings and approaches to the study of angiogenesis in cancer. The second edition of Antiangiogenic Agents in Cancer Therapy is intended to give a current perspective on the state-of-the-art of angiogenensis and therapy directed at this process. Antiangiogenesis is a dynamic and evolving field in oncology. New therapeutic targets continue to emerge followed by the rapid development of new therapeutic agents to be investigated in clinical trials. Optimizing the therapeutic potential of antiangiogenic agents in combination with the other therapies in the armamentarium to fight cancer will be an on-going challenge.
| Author | : Domenico Ribatti |
| Publisher | : Academic Press |
| Total Pages | : 198 |
| Release | : 2020-01-21 |
| Genre | : Science |
| ISBN | : 0128194944 |
Download Tumor Vascularization Book in PDF, ePub and Kindle
Tumor Vascularization discusses the different types of growth of tumor blood vessels and their implications on research and healthcare. The book is divided into three parts: the first one, General Mechanisms, discusses different vessel growth mechanisms, such as sprouting angiogenesis, non-angiogenesis dependent growth, intussusceptive microvascular growth, vascular co-option and vasculogenic mimicry. The second and third parts, entitled Clinical Implications and Therapeutic Implications are dedicated to translating recent findings in this field to patient treatment and healthcare. This book is a valuable source for cancer researchers, oncologists, graduate students and members of the biomedical field who are interested in tumor progression and blood vessels. Explains new, non-orthodox concepts recently developed and related to the modality of growth of tumor blood vessels Provides information on the types of angiogenesis, non-angiogenesis dependent growth and vascular co-option, discussing both their similarities and differences Encompasses a discussion on clinical implications of tumor vascularization to translate research findings into treatment
| Author | : |
| Publisher | : Academic Press |
| Total Pages | : 296 |
| Release | : 2022-01-14 |
| Genre | : Science |
| ISBN | : 0323905560 |
Download Antiangiogenic Drugs as Chemosensitizers in Cancer Therapy Book in PDF, ePub and Kindle
Anti-angiogenic Drugs as Chemosensitizers in Cancer Therapy, Volume 19 focuses on the use of anti-angiogenic drugs as sensitizers of tumor cells to the inhibitory activity of antitumor agents. Conventional and novel anti-neoplastic agents (cytotoxic molecules, hormones/antihormones, immunotherapies) are taken into consideration, along with advances made in combination therapies. The book encompasses examples of studies on the use of antiangiogenic compounds—molecules that inhibit the growth of vessels inside a tumor—together with antineoplastic drugs in order to sensitize the resistant tumor to their cytotoxic effects, thus reducing adverse side reactions and resistance and improving the therapeutic response of cancer patients. In addition, the book discusses clinical applications in various types of cancer, such as colorectal, lung, breast, renal, genitourinary, skin and brain and circulating tumors. It is a valuable resource for cancer researchers, clinicians and members of the biomedical field who wants to be up-to-date on the most recent and promising developments in the field. Provides the most updated reviews on anti-angiogenic drugs as chemosensitizers by leaders in the field Encompasses summarized tables and schematic diagrams in each chapter to give a clear overview on recent findings in a didactic manner Brings not only relevant information of current research but also new ideas and suggestions for further investigations to help advance the field
| Author | : Atta-ur-Rahman |
| Publisher | : Bentham Science Publishers |
| Total Pages | : 212 |
| Release | : 2020-10-05 |
| Genre | : Medical |
| ISBN | : 9811432864 |
Download Anti-Angiogenesis Drug Discovery and Development: Volume 5 Book in PDF, ePub and Kindle
The inhibition of angiogenesis is an effective mechanism of slowing down tumor growth and malignancies. The process of induction or pro-angiogenesis is highly desirable for the treatment of cardiovascular diseases, and wound healing disorders. Efforts to understand the molecular basis, both for inhibition and induction, have yielded fascinating results. Anti-angiogenesis Drug Discovery and Development provides an excellent compilation of well-written reviews on various aspects of the anti-angiogenesis process. These reviews have been contributed by leading practitioners in drug discovery science and highlight the major developments in this exciting field in the last two decades. The feast of these reader-friendly reviews on topics of great scientific importance – many of which are considered significant medical breakthroughs, makes this series excellent reading both for the novice as well as for expert medicinal chemists and clinicians. The fifth volume brings together reviews on the following topics: - Targeted therapy for tumor vasculature - Anti-angiogenic therapy for breast and prostate cancers (including information updates on clinical trials) - Microbe-based and other novel antiangiogenesis therapies such as chromene-based agents
| Author | : |
| Publisher | : |
| Total Pages | : 14 |
| Release | : 2000 |
| Genre | : |
| ISBN | : |
Download Anti-Angiogenesis by a Novel VEGF-Intrakine Strategy for Breast Cancer Therapy Book in PDF, ePub and Kindle
Angiogenesis plays a pivotal role in tumor growth and metastasis. VEGF, an endothelial specific mitogen and an angiogenesis inducer in vivo, is one of the most important tumor angiogenesis growth factor. KDR, a VEGF receptor, appears to be the major transducer of VEGF signals in endothelial cells. A tethered intracellular antibody ("intrabody") strategy has been used successfully for both phenotypic and functional knockouts of target molecules. In this study, we have targeted a KDR single chain antibody (scFv) p3S5 to the endoplasmic reticulum (ER) using a c-terminal endoplasmic retention signal (KDEL). We hypothesized that the tethered KDR intrabody would bind newly synthesized KDR and block its transport to the surface of endothelial cells, thereby inhibiting VEGF-induced proliferation. The tethered intrabody significantly reduced KDR expression (from 82.5 % 12.5% to 27.9 + 13.6%, P
| Author | : Thomas H. Adair |
| Publisher | : Morgan & Claypool Publishers |
| Total Pages | : 85 |
| Release | : 2011 |
| Genre | : Medical |
| ISBN | : 1615043306 |
Download Angiogenesis Book in PDF, ePub and Kindle
Angiogenesis is the growth of blood vessels from the existing vasculature. The field of angiogenesis has grown enormously in the past 30 years, with only 40 papers published in 1980 and nearly 6000 in 2010. Why has there been this explosive growth in angiogenesis research? Angiogenic therapies provide a potential to conquer cancer, heart diseases, and more than 70 of life's most threatening medical conditions. The lives of at least 1 billion people worldwide could be improved with angiogenic therapy, according to the Angiogenesis Foundation. In this little book, we provide a simple approach to understand the essential elements of the angiogenic process, we critique the most powerful angiogenesis assays that are used to discover proangiogenic and antiangiogenic substances, and we provide an in-depth physiological perspective on how angiogenesis is regulated in normal, healthy tissues of the human body. All tissues of the body require a continuous supply of oxygen to burn metabolic substrates that are needed for energy. Oxygen is conducted to these tissues by blood capillaries: more capillaries can improve tissue oxygenation and thus enhance energy production; fewer capillaries can lead to hypoxia and even anoxia in the tissues. This means that angiogenic therapies designed to control the growth and regression of blood capillaries can be used to improve the survival of poorly perfused tissues that are essential to the body (heart, brain, skeletal muscle, etc.) and to rid the body of unwanted tissues (tumors). Table of Contents: Overview of Angiogenesis / Angiogenesis Assays / Regulation: Metabolic Factors / Regulation: Mechanical Factors / Glossary / References / Author Biographies
