Animal Models Of Neuropsychiatric Diseases PDF Download
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Author | : Kurt Leroy Hoffman |
Publisher | : Woodhead Publishing |
Total Pages | : 325 |
Release | : 2015-08-28 |
Genre | : Medical |
ISBN | : 0081001061 |
Download Modeling Neuropsychiatric Disorders in Laboratory Animals Book in PDF, ePub and Kindle
Modeling Neuropsychiatric Disorders in Laboratory Animals serves as a guide for students and basic investigators in the fields of behavioral sciences, psychology, neuroscience, psychiatry, and other professionals interested in the use of animal models in preclinical research related to human neuropsychiatric disorders. The text focuses on the rationale and theory of using animal behavior, both pathological and normal, as a tool for understanding the neural underpinnings of neuropsychiatric disorders. Chapters contain discussions on both classical and modern views on the validation of animal models for neuropsychiatric disorders, also discussing the utility of endophenotypes in modeling neuropsychiatric disease. Subsequent chapters deal with four specific classes of disorders, including anxiety disorders, depressive disorders, obsessive-compulsive and related disorders. Final sections discuss the future for the development, validation, and use of animal models in basic and preclinical research. Focuses on the rationale and theory of using animal behavior, both pathological and normal, as a tool for understanding the neural underpinnings of neuropsychiatric disorders Serves as a guide for students and basic investigators in the fields of behavioral sciences, psychology, neuroscience, psychiatry, and other professionals Discusses specific classes of disorders, including anxiety disorders, depressive disorders, obsessive-compulsive and related disorders
Author | : Michael Koch |
Publisher | : World Scientific |
Total Pages | : 426 |
Release | : 2006-05-11 |
Genre | : Medical |
ISBN | : 1783260068 |
Download Animal Models Of Neuropsychiatric Diseases Book in PDF, ePub and Kindle
Animal models of neuro- and psychopathological states in humans are an indispensable part of both experimental neurology and biological psychiatry. Written by a team of experts, this book provides an up-to-date detailed overview of the current approaches to the design of viable animal models for eight prominent neuropsychiatric diseases. The book is specifically written with the research-oriented reader in mind — both in academia and the pharmaceutical industry. It contains first-hand information on how to design viable animal models for Alzheimer's disease, epilepsy, Huntington's disease, Parkinson's disease, addiction, depression, fear and anxiety, and schizophrenia. Each chapter also critically discusses the limitations of the animal experimental approach towards an understanding of human neuropsychiatric disorders.The book is an essential source of reference for researchers who seek to successfully continue and elaborate the experimental work that will finally lead to a better understanding of the neurobiological basis of the diseases, as well as to an improvement of both diagnosis and therapy.
Author | : Alan A. Boulton |
Publisher | : Springer Science & Business Media |
Total Pages | : 440 |
Release | : 1991-08-20 |
Genre | : Medical |
ISBN | : |
Download Animal Models in Psychiatry, I Book in PDF, ePub and Kindle
Annotation The first of two volumes on animal models of neuropsychiatric disorders. This initial volume opens with an introductory chapter on criteria for assessing the validity of animal models in psychiatry, providing a framework in which to evaluate subsequent chapters in both volumes. Chapters are devoted to specific psychiatric disorders, along with various procedures that have been proposed as potential animal models for understanding their etiology and management. Annotation(c) 2003 Book News, Inc., Portland, OR (booknews.com)
Author | : Gene S. Fisch |
Publisher | : Springer Science & Business Media |
Total Pages | : 295 |
Release | : 2007-11-06 |
Genre | : Medical |
ISBN | : 1597450588 |
Download Transgenic and Knockout Models of Neuropsychiatric Disorders Book in PDF, ePub and Kindle
In this up-to-date survey and critical assessment of transgenic and knockout models in neuropsychiatry and behavior, a panel of leading researchers comprehensively assesses how and whether the genetic abnormalities produced from these models manifest the neuropsychiatric disorders to which they correspond. The authors focus on transgenic and knockout models of neurocognitive dysfunction and neuropsychiatric dysfunction. The discussion of neurobiological problems covers mental retardation, polyglutamate, and speech disorders, as well as disorders that involve cognitive, social, speech, and language dysfunction. The neuropsychiatric dysfunctions examined include psychosis and schizophrenia, anxiety, depression, and bipolar disorder.
Author | : Joshua A. Gordon |
Publisher | : |
Total Pages | : |
Release | : 2015 |
Genre | : |
ISBN | : |
Download Animal Models of Neuropsychiatric Disease Book in PDF, ePub and Kindle
Author | : Eva Tvrdá |
Publisher | : BoD – Books on Demand |
Total Pages | : 248 |
Release | : 2020-04-08 |
Genre | : Science |
ISBN | : 1838800115 |
Download Animal Models in Medicine and Biology Book in PDF, ePub and Kindle
Thanks to animal models, our knowledge of biology and medicine has increased enormously over the past decades, leading to significant breakthroughs that have had a direct impact on the prevention, management and treatment of a wide array of diseases.This book presents a comprehensive reference that reflects the latest scientific research being done in a variety of medical and biological fields utilizing animal models. Chapters on Drosophila, rat, pig, rabbit, and other animal models reflect frontier research in neurology, psychiatry, cardiology, musculoskeletal disorders, reproduction, chronic diseases, epidemiology, and pain and inflammation management. Animal Models in Medicine and Biology offers scientists, clinicians, researchers and students invaluable insights into a wide range of issues at the forefront of medical and biological progress.
Author | : Robert A. McArthur |
Publisher | : Academic Press |
Total Pages | : 413 |
Release | : 2008-11-18 |
Genre | : Medical |
ISBN | : 0080920381 |
Download Animal and Translational Models for CNS Drug Discovery: Neurological Disorders Book in PDF, ePub and Kindle
Neurological Disorders is written for researchers in both academia and the pharmaceutical industry who use animal models in research and development of drugs for neurological disorders such as neurofibromatosis, Alzheimer’s disease, Parkinson’s disease, Huntington disease, ALS, and the epilepsies. Neurological Disorders has introductory chapters expressing the view of the role and relevance of animal models for drug discovery and development for the treatment of psychiatric disorders from the perspective of (a) academic basic neuroscientific research, (b) applied pharmaceutical drug discovery and development, and (c) issues of clinical trial design and regulatory agencies limitations. Each volume examines the rationale, use, robustness and limitations of animal models in each therapeutic area covered and discuss the use of animal models for target identification and validation. The clinical relevance of animal models is discussed in terms of major limitations in cross-species comparisons, clinical trial design of drug candidates, and how clinical trial endpoints could be improved. The aim of this series of volumes on Animal and Translational Models for CNS Drug Discovery is to identify and provide common endpoints between species that can serve to inform both the clinic and the bench with the information needed to accelerate clinically-effective CNS drug discovery. This is the second volume in the three volume-set, Animal and Translational Models for CNS Drug Discovery 978-0-12-373861-5, which is also available for purchase individually. Clinical, academic, government and industry perspectives fostering integrated communication between principle participants at all stages of the drug discovery process Critical evaluation of animal and translational models improving transition from drug discovery and clinical development Emphasis on what results mean to the overall drug discovery process Exploration of issues in clinical trial design and conductance in each therapeutic area
Author | : Alan A. Boulton |
Publisher | : Humana |
Total Pages | : 373 |
Release | : 2013-08-11 |
Genre | : Medical |
ISBN | : 9781489943897 |
Download Animal Models of Neurological Disease, II Book in PDF, ePub and Kindle
to the Animal Models Volumes This and several other volumes in the Neuromethods series will describe a number of animal models of neuropsychiatric disorders. Because of increasing public concern over the ethical treatment of animals in research, we felt it incumbent upon us to include this general preface to these volumes in order to indicate why we think further - search using animals is necessary and why animal models of psychiatric disorders, in particular, are so important. We recognize that animals should only be used when suitable alternatives are not available. We think it self-e- dent, however, that humans can only be experimented upon in severely proscribed circumstances and alternative pro- dures using cell or tissue culture are inadequate in any models requiring assessments of behavioral change or of complex in vivo processes. However, when the distress, discomfort, or pain to the animals outweighs the anticipated gains for human welfare, then the research is not ethical and should not be carried out. It is imperative that each individual researcher examine his/her own research from a critical moral standpoint - fore engaging in it, taking into consideration the animals’ welfare as well as the anticipated gains. Furthermore, once a decision to proceed with research is made, it is the researcher’s responsibility to ensure that the animals’ w- fare is of prime concern in terms of appropriate housing, feeding, and maximum reduction of any uncomfortable or distressing effects of the experimental conditions, and that these conditions undergo frequent formalized monitoring.
Author | : Jim J. Hagan |
Publisher | : Springer Science & Business Media |
Total Pages | : 400 |
Release | : 2011-04-02 |
Genre | : Medical |
ISBN | : 3642197035 |
Download Molecular and Functional Models in Neuropsychiatry Book in PDF, ePub and Kindle
The development of more effective treatments for neuropsychiatric disorders requires scientific progress on a broad front. Animal models have a vital role to play in advancing the field. When deployed in conjunction with detailed study of these diseases in man they bring the power to make controlled experimental interventions which allow the functional consequences of genetic variations and polymorphisms to be understood in terms of their cellular, systems and behavioural effects. Further, they provide a means by which complex cognitive and behavioural phenomena may be dissected and understood. Finally, they provide a bridge to understanding the effects of drugs on the functioning of the central nervous system, thereby improving our understanding of the actions of those drugs in man.
Author | : J. D. Keehn |
Publisher | : Routledge |
Total Pages | : 373 |
Release | : 2018-02-19 |
Genre | : Psychology |
ISBN | : 135136278X |
Download Animal Models for Psychiatry Book in PDF, ePub and Kindle
Originally published in 1986, in this work Professor Keehn assesses the contributions of experimental psychology and ethology to psychiatric theory and practice at the time. He discusses the status of animals in psychopathology, and describes a number of animal clinical pictures, covering both abnormal movements and convulsions, and spontaneous behavioural disorders. He also includes animal models of such psychiatric illnesses as neurosis, psychosis, drug addiction and disorders of childhood, and examines the nature of mental illness and the status of psychiatric diagnosis. The book includes an evaluation of the ethics of experimental research with animals and a summary of humane experimental procedures. Animal Models for Psychiatry will be of special interest to psychiatrists, clinical and physiological psychologists, behavioural pharmacologists, and to veterinarians.