Analysis Of Human Genetic Linkage PDF Download
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| Author | : Jurg Ott |
| Publisher | : JHU Press |
| Total Pages | : 418 |
| Release | : 1999-04-16 |
| Genre | : Medical |
| ISBN | : 9780801861406 |
Download Analysis of Human Genetic Linkage Book in PDF, ePub and Kindle
Introduction and basic genetic principles; Genetic loci genetic polymorphisms; Aspects of statistical inference; Basics of linkage analysis; The informativeness of family data; Multipoint linkage analysis; Penetrance; Quantitative phenotypes; Numerical and computerized methods; Variability of the recombination fraction; Inconsistencies; Linkage analysis with mendelian disease loci; Nonparametric methods; Two-locus inheritance; Complex traits.
| Author | : William K. Scott |
| Publisher | : John Wiley & Sons |
| Total Pages | : 340 |
| Release | : 2021-12-06 |
| Genre | : Science |
| ISBN | : 1118123913 |
Download Genetic Analysis of Complex Disease Book in PDF, ePub and Kindle
Genetic Analysis of Complex Diseases An up-to-date and complete treatment of the strategies, designs and analysis methods for studying complex genetic disease in human beings In the newly revised Third Edition of Genetic Analysis of Complex Diseases, a team of distinguished geneticists delivers a comprehensive introduction to the most relevant strategies, designs and methods of analysis for the study of complex genetic disease in humans. The book focuses on concepts and designs, thereby offering readers a broad understanding of common problems and solutions in the field based on successful applications in the design and execution of genetic studies. This edited volume contains contributions from some of the leading voices in the area and presents new chapters on high-throughput genomic sequencing, copy-number variant analysis and epigenetic studies. Providing clear and easily referenced overviews of the considerations involved in genetic analysis of complex human genetic disease, including sampling, design, data collection, linkage and association studies and social, legal and ethical issues. Genetic Analysis of Complex Diseases also provides: A thorough introduction to study design for the identification of genes in complex traits Comprehensive explorations of basic concepts in genetics, disease phenotype definition and the determination of the genetic components of disease Practical discussions of modern bioinformatics tools for analysis of genetic data Reflecting on responsible conduct of research in genetic studies, as well as linkage analysis and data management New expanded chapter on complex genetic interactions This latest edition of Genetic Analysis of Complex Diseases is a must-read resource for molecular biologists, human geneticists, genetic epidemiologists and pharmaceutical researchers. It is also invaluable for graduate students taking courses in statistical genetics or genetic epidemiology.
| Author | : National Research Council |
| Publisher | : National Academies Press |
| Total Pages | : 128 |
| Release | : 1988-01-01 |
| Genre | : Science |
| ISBN | : 0309038405 |
Download Mapping and Sequencing the Human Genome Book in PDF, ePub and Kindle
There is growing enthusiasm in the scientific community about the prospect of mapping and sequencing the human genome, a monumental project that will have far-reaching consequences for medicine, biology, technology, and other fields. But how will such an effort be organized and funded? How will we develop the new technologies that are needed? What new legal, social, and ethical questions will be raised? Mapping and Sequencing the Human Genome is a blueprint for this proposed project. The authors offer a highly readable explanation of the technical aspects of genetic mapping and sequencing, and they recommend specific interim and long-range research goals, organizational strategies, and funding levels. They also outline some of the legal and social questions that might arise and urge their early consideration by policymakers.
| Author | : Joseph Douglas Terwilliger |
| Publisher | : JHU Press |
| Total Pages | : 326 |
| Release | : 1994-04 |
| Genre | : Medical |
| ISBN | : 9780801848032 |
Download Handbook of Human Genetic Linkage Book in PDF, ePub and Kindle
"A good reference for statisticians and other analysts becoming involved in the popular field of 'gene mapping'." -- "American Journal of Human Genetics"
| Author | : Meredith S. Vaughan |
| Publisher | : |
| Total Pages | : 154 |
| Release | : 1991 |
| Genre | : Human gene mapping |
| ISBN | : |
Download A Distributed Approach to Human Genetic Linkage Analysis Book in PDF, ePub and Kindle
| Author | : Andrew R. Collins |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 529 |
| Release | : 2008-02-05 |
| Genre | : Medical |
| ISBN | : 1597453897 |
Download Linkage Disequilibrium and Association Mapping Book in PDF, ePub and Kindle
As researchers continue to make enormous progress in mapping disease genes, exciting, novel, and complex analyses have emerged. In this book, scientists from around the world, who are leaders in this field, contribute their vast experience and expertise to produce a comprehensive and fascinating text for researchers and clinicians alike. They provide cutting-edge analysis of the most up-to-date and preeminent information available.
| Author | : National Research Council |
| Publisher | : National Academies Press |
| Total Pages | : 101 |
| Release | : 1998-01-19 |
| Genre | : Science |
| ISBN | : 0309184746 |
Download Evaluating Human Genetic Diversity Book in PDF, ePub and Kindle
This book assesses the scientific value and merit of research on human genetic differencesâ€"including a collection of DNA samples that represents the whole of human genetic diversityâ€"and the ethical, organizational, and policy issues surrounding such research. Evaluating Human Genetic Diversity discusses the potential uses of such collection, such as providing insight into human evolution and origins and serving as a springboard for important medical research. It also addresses issues of confidentiality and individual privacy for participants in genetic diversity research studies.
| Author | : Benjamin Neale |
| Publisher | : Garland Science |
| Total Pages | : 608 |
| Release | : 2007-11-30 |
| Genre | : Science |
| ISBN | : 1134129335 |
Download Statistical Genetics Book in PDF, ePub and Kindle
Statistical Genetics is an advanced textbook focusing on conducting genome-wide linkage and association analysis in order to identify the genes responsible for complex behaviors and diseases. Starting with an introductory section on statistics and quantitative genetics, it covers both established and new methodologies, providing the genetic and statistical theory on which they are based. Each chapter is written by leading researchers, who give the reader the benefit of their experience with worked examples, study design, and sources of error. The text can be used in conjunction with an associated website (www.genemapping.org) that provides supplementary material and links to downloadable software.
| Author | : Robert C. Elston |
| Publisher | : Humana Press |
| Total Pages | : 564 |
| Release | : 2012-02-04 |
| Genre | : Science |
| ISBN | : 9781617795541 |
Download Statistical Human Genetics Book in PDF, ePub and Kindle
Recent advances in genetics over the last quarter of a century, especially in molecular techniques, have dramatically reduced the cost of determining genetic markers and hence opened up a field of research that is increasingly helping to detect, prevent and/or cure many diseases that afflict humans. In Statistical Human Genetics: Methods and Protocols expert researchers in the field describe statistical methods and computer programs in the detail necessary to make them more easily accessible to the beginner analyzing data. Written in the highly successful Methods in Molecular BiologyTM series format, with examples of running the programs and interpreting the program outputs, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results from human genetic data collected in the laboratory. Thorough and as much as possible intuitive, Statistical Human Genetics: Methods and Protocols aids scientists in understanding the computer programs and analytical procedures they need to use.
| Author | : Xiaoyi Raymond Gao |
| Publisher | : Academic Press |
| Total Pages | : 383 |
| Release | : 2019-09-12 |
| Genre | : Science |
| ISBN | : 0128167270 |
Download Genetics and Genomics of Eye Disease Book in PDF, ePub and Kindle
Genetics and Genomics of Eye Disease: Advancing to Precision Medicine thoroughly examines the latest genomics methods for studying eye disease, including complex eye disorders associated with multiple genes. GWAS, WES, WGS, RNA-sequencing, and transcriptome analysis as employed in ocular genomics are discussed in-depth, as are genomics findings tied to early-onset glaucoma, strabismus, age-related macular degeneration, adult-onset glaucoma, diabetic retinopathy, keratoconus, and leber congenital amaurosis, among other diseases. Research and clinical specialists offer guidance on conducting preventative screenings and counseling patients, as well as the promise of machine learning, computational statistics and artificial intelligence in advancing ocular genomics research. Offers thorough guidance on conducting genetic and genomic studies of eye disease Examines the genetic basis of a wide range of complex eye diseases and single-gene and Mendelian disorders Discusses the application of genetic testing and genetic risk prediction in eye disease diagnosis and patient counseling
