Analysis Of Aggregates And Particles In Protein Pharmaceuticals PDF Download

Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download Analysis Of Aggregates And Particles In Protein Pharmaceuticals PDF full book. Access full book title Analysis Of Aggregates And Particles In Protein Pharmaceuticals.

Analysis of Aggregates and Particles in Protein Pharmaceuticals

Analysis of Aggregates and Particles in Protein Pharmaceuticals
Author: Hanns-Christian Mahler
Publisher: John Wiley & Sons
Total Pages: 480
Release: 2012-01-24
Genre: Medical
ISBN: 0470497181

Download Analysis of Aggregates and Particles in Protein Pharmaceuticals Book in PDF, ePub and Kindle

This book describes how to address the analysis of aggregates and particles in protein pharmaceuticals, provides a comprehensive overview of current methods and integrated approaches used to quantify and characterize aggregates and particles, and discusses regulatory requirements. Analytical methods covered in the book include separation, light scattering, microscopy, and spectroscopy.


Protein Pharmaceuticals

Protein Pharmaceuticals
Author: Hanns-Christian Mahler
Publisher:
Total Pages: 464
Release: 2010
Genre: Aufsatzsammlung
ISBN: 9783871933820

Download Protein Pharmaceuticals Book in PDF, ePub and Kindle


Methods for Structural Analysis of Protein Pharmaceuticals

Methods for Structural Analysis of Protein Pharmaceuticals
Author: Wim Jiskoot
Publisher: Springer Science & Business Media
Total Pages: 694
Release: 2005-12-05
Genre: Medical
ISBN: 9780971176720

Download Methods for Structural Analysis of Protein Pharmaceuticals Book in PDF, ePub and Kindle

Protein pharmaceuticals form a fast-growing category in the arsenal of drugs. This book explores the nature of different analytical techniques and the way in which they are related to pharmaceutical proteins. In addition to serving the analytical chemist, this book is needed by the formulation scientist who is responsible for design and formulation of a pharmaceutical protein that can be monitored during production and over time.


Aggregation of Therapeutic Proteins

Aggregation of Therapeutic Proteins
Author: Wei Wang
Publisher: John Wiley & Sons
Total Pages: 400
Release: 2010-12-28
Genre: Medical
ISBN: 1118043588

Download Aggregation of Therapeutic Proteins Book in PDF, ePub and Kindle

This book gives pharmaceutical scientists an up-to-date resource on protein aggregation and its consequences, and available methods to control or slow down the aggregation process. While significant progress has been made in the past decade, the current understanding of protein aggregation and its consequences is still immature. Prevention or even moderate inhibition of protein aggregation has been mostly experimental. The knowledge in this book can greatly help pharmaceutical scientists in the development of therapeutic proteins, and also instigate further scientific investigations in this area. This book fills such a need by providing an overview on the causes, consequences, characterization, and control of the aggregation of therapeutic proteins.


Protein Self-Assembly

Protein Self-Assembly
Author: Jennifer J. McManus
Publisher: Humana
Total Pages: 266
Release: 2020-08-08
Genre: Science
ISBN: 9781493996803

Download Protein Self-Assembly Book in PDF, ePub and Kindle

This volume explores experimental and computational approaches to measuring the most widely studied protein assemblies, including condensed liquid phases, aggregates, and crystals. The chapters in this book are organized into three parts: Part One looks at the techniques used to measure protein-protein interactions and equilibrium protein phases in dilute and concentrated protein solutions; Part Two describes methods to measure kinetics of aggregation and to characterize the assembled state; and Part Three details several different computational approaches that are currently used to help researchers understand protein self-assembly. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Thorough and cutting-edge, Protein Self-Assembly: Methods and Protocols is a valuable resource for researchers who are interested in learning more about this developing field.


Protein Instability at Interfaces During Drug Product Development

Protein Instability at Interfaces During Drug Product Development
Author: Jinjiang Li
Publisher: Springer Nature
Total Pages: 338
Release: 2021-02-12
Genre: Medical
ISBN: 3030571777

Download Protein Instability at Interfaces During Drug Product Development Book in PDF, ePub and Kindle

Proteins are exposed to various interfacial stresses during drug product development. They are subjected to air-liquid, liquid-solid, and, sometimes, liquid-liquid interfaces throughout the development cycle-from manufacturing of drug substances to storage and drug delivery. Unlike small molecule drugs, proteins are typically unstable at interfaces where, on adsorption, they often denature and form aggregates, resulting in loss of efficacy and potential immunogenicity. This book covers both the fundamental aspects of proteins at interfaces and the quantification of interfacial behaviors of proteins. Importantly, this book introduces the industrial aspects of protein instabilities at interfaces, including the processes that introduce new interfaces, evaluation of interfacial instabilities, and mitigation strategies. The audience that this book targets encompasses scientists in the pharmaceutical and biotech industry, as well as faculty and students from academia in the surface science, pharmaceutical, and medicinal chemistry areas.


Proteomics Sample Preparation

Proteomics Sample Preparation
Author: Jörg von Hagen
Publisher: John Wiley & Sons
Total Pages: 498
Release: 2011-08-24
Genre: Science
ISBN: 3527644695

Download Proteomics Sample Preparation Book in PDF, ePub and Kindle

This long-awaited first guide to sample preparation for proteomics studies overcomes a major bottleneck in this fast growing technique within the molecular life sciences. By addressing the topic from three different angles -- sample, method and aim of the study -- this practical reference has something for every proteomics researcher. Following an introduction to the field, the book looks at sample preparation for specific techniques and applications and finishes with a section on the preparation of sample types. For each method described, a summary of the pros and cons is given, as well as step-by-step protocols adaptable to any specific proteome analysis task.


Biophysical Characterization of Proteins in Developing Biopharmaceuticals

Biophysical Characterization of Proteins in Developing Biopharmaceuticals
Author: Damian J. Houde
Publisher: Elsevier
Total Pages: 586
Release: 2019-11-13
Genre: Medical
ISBN: 0444641742

Download Biophysical Characterization of Proteins in Developing Biopharmaceuticals Book in PDF, ePub and Kindle

Biophysical Characterization of Proteins in Developing Biopharmaceuticals, Second Edition, presents the latest on the analysis and characterization of the higher-order structure (HOS) or conformation of protein based drugs. Starting from the very basics of protein structure, this book explains the best way to achieve this goal using key methods commonly employed in the biopharmaceutical industry. This book will help today’s industrial scientists plan a career in this industry and successfully implement these biophysical methodologies. This updated edition has been fully revised, with new chapters focusing on the use of chromatography and electrophoresis and the biophysical characterization of very large biopharmaceuticals. In addition, best practices of applying statistical analysis to biophysical characterization data is included, along with practical issues associated with the concept of a biopharmaceutical’s developability and the technical decision-making process needed when dealing with biophysical characterization data. Presents basic protein characterization methods and tools applicable to (bio)pharmaceutical research and development Highlights the capabilities and limitations of each technique Discusses the underlining science of each tool Empowers industrial biophysical chemists by providing a roadmap for applying biophysical tools Outlines the needs for new characterization and analytical tools in the biopharmaceutical industry


Drying Technologies for Biotechnology and Pharmaceutical Applications

Drying Technologies for Biotechnology and Pharmaceutical Applications
Author: Satoshi Ohtake
Publisher: John Wiley & Sons
Total Pages: 394
Release: 2020-06-02
Genre: Medical
ISBN: 3527341129

Download Drying Technologies for Biotechnology and Pharmaceutical Applications Book in PDF, ePub and Kindle

A comprehensive source of information about modern drying technologies that uniquely focus on the processing of pharmaceuticals and biologicals Drying technologies are an indispensable production step in the pharmaceutical industry and the knowledge of drying technologies and applications is absolutely essential for current drug product development. This book focuses on the application of various drying technologies to the processing of pharmaceuticals and biologicals. It offers a complete overview of innovative as well as standard drying technologies, and addresses the issues of why drying is required and what the critical considerations are for implementing this process operation during drug product development. Drying Technologies for Biotechnology and Pharmaceutical Applications discusses the state-of-the-art of established drying technologies like freeze- and spray- drying and highlights limitations that need to be overcome to achieve the future state of pharmaceutical manufacturing. The book also describes promising next generation drying technologies, which are currently used in fields outside of pharmaceuticals, and how they can be implemented and adapted for future use in the pharmaceutical industry. In addition, it deals with the generation of synergistic effects (e.g. by applying process analytical technology) and provides an outlook toward future developments. -Presents a full technical overview of well established standard drying methods alongside various other drying technologies, possible improvements, limitations, synergies, and future directions -Outlines different drying technologies from an application-oriented point of view and with consideration of real world challenges in the field of drug product development -Edited by renowned experts from the pharmaceutical industry and assembled by leading experts from industry and academia Drying Technologies for Biotechnology and Pharmaceutical Applications is an important book for pharma engineers, process engineers, chemical engineers, and others who work in related industries.


Pharmaceutical Formulation Development of Peptides and Proteins

Pharmaceutical Formulation Development of Peptides and Proteins
Author: Lars Hovgaard
Publisher: CRC Press
Total Pages: 392
Release: 2012-11-14
Genre: Medical
ISBN: 1439853894

Download Pharmaceutical Formulation Development of Peptides and Proteins Book in PDF, ePub and Kindle

The rapid advances in recombinant DNA technology and the increasing availability of peptides and proteins with therapeutic potential are a challenge for pharmaceutical scientists who have to formulate these compounds as drug products. Pharmaceutical Formulation Development of Peptides and Proteins, Second Edition discusses the development of therap