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An Introduction to Biological Aging Theory

An Introduction to Biological Aging Theory
Author: Theodore Goldsmith
Publisher: Azinet
Total Pages: 31
Release: 2011-05-08
Genre: Medical
ISBN: 0978870913
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Why do we age? The answer to this question is critical to our ability to prevent and treat highly age-related diseases such as cancer and heart disease that now cause the deaths of most people in the developed world. This short book provides an overview of biological aging theories including history, current status, major scientific controversies, and implications for the future of medicine. Major topics include: human mortality as a function of age, aging mechanisms and processes, the programmed vs. non-programmed aging controversy, empirical evidence on aging, and the feasibility of anti-aging and regenerative medicine. Evolution theory is essential to aging theories. Theorists have been struggling for 150 years to explain how aging, deterioration, and consequent death fit with Darwin’s survival of the fittest concept. This book explains how continuing genetics discoveries have produced changes in the way we think about evolution that in turn lead to new thinking about the nature of aging.

Handbook of Theories of Aging, Second Edition

Handbook of Theories of Aging, Second Edition
Author: Merril Silverstein, PhD
Publisher: Springer Publishing Company
Total Pages: 817
Release: 2008-10-27
Genre: Medical
ISBN: 0826162525
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The field of gerontology has often been criticized for being "data-rich but theory-poor." The editors of this book address this issue by stressing the importance of theory in gerontology. While the previous edition focused on multidisciplinary approaches to aging theory, this new edition provides cross-disciplinary, integrative explanations of aging theory: The contributors of this text have reached beyond traditional disciplinary boundaries to partner with researchers in adjacent fields in studying aging and age-related phenomena. This edition of the Handbook consists of 39 chapters written by 67 internationally recognized experts in the field of aging. It is organized in seven sections, reflecting the major theoretical developments in gerontology over the past 10 years. Special Features: Comprehensive coverage of aging theory, focusing on the biological, psychological, and social aspects of aging A section dedicated to discussing how aging theory informs public policy A concluding chapter summarizing the major themes of aging, and offering predictions about the future of theory development Required reading for graduate students and post doctoral fellows, this textbook represents the current status of theoretical development in the study of aging.

A Means to an End

A Means to an End
Author: William R. Clark
Publisher: Oxford University Press
Total Pages: 252
Release: 2002-02-28
Genre: Science
ISBN: 0195348397
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Why do we age? Is aging inevitable? Will advances in medical knowledge allow us to extend the human lifespan beyond its present limits? Because growing old has long been the one irreducible reality of human existence, these intriguing questions arise more often in the context of science fiction than science fact. But recent discoveries in the fields of cell biology and molecular genetics are seriously challenging the assumption that human lifespans are beyond our control. With such discoveries in mind, noted cell biologist William R. Clark clearly and skillfully describes how senescence begins at the level of individual cells and how cellular replication may be bound up with aging of the entire organism. He explores the evolutionary origin and function of aging, the cellular connections between aging and cancer, the parallels between cellular senescence and Alzheimer's disease, and the insights gained through studying human genetic disorders--such as Werner's syndrome--that mimic the symptoms of aging. Clark also explains how reduction in caloric intake may actually help increase lifespan, and how the destructive effects of oxidative elements in the body may be limited by the consumption of antioxidants found in fruits and vegetables. In a final chapter, Clark considers the social and economic aspects of living longer, the implications of gene therapy on senescence, and what we might learn about aging from experiments in cloning. This is a highly readable, provocative account of some of the most far-reaching and controversial questions we are likely to ask in the next century.

An Introduction to Gerontology

An Introduction to Gerontology
Author: Ian Stuart-Hamilton
Publisher: Cambridge University Press
Total Pages: 459
Release: 2011-03-31
Genre: Psychology
ISBN: 1139500171
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With the world's population getting increasingly older, there has never been a more pressing need for the study of old age and ageing. An Introduction to Gerontology provides a wide-ranging introduction to this important topic. By assuming no prior expert knowledge and avoiding jargon, this book will guide students through all the main subjects in gerontology, covering both traditional areas, such as biological and social ageing, and more contemporary areas, such as technology, the arts and sexuality. An Introduction to Gerontology is written by a team of international authors with multidisciplinary backgrounds who draw evidence from a variety of different perspectives and traditions.

Human Aging

Human Aging
Author: Calogero Caruso
Publisher: Academic Press
Total Pages: 382
Release: 2021-05-11
Genre: Science
ISBN: 0128227370
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Human Aging: From Cellular Mechanisms to Therapeutic Strategies offers an exhaustive picture of all the biological aspects of human aging by describing the key mechanisms associated with human aging and covering events that could disrupt the normal course of aging. Each chapter includes a summary of the salient points covered, along with futures prospects. The book provides readers with the information they need to gain or deepen the skills needed to evaluate the mechanisms of aging and age-related diseases and to monitor the effectiveness of therapies aimed at slowing aging. The book encourages PhD and Postdoc students, researchers, health professionals and others interested in the biology of aging to explore the fascinating and challenging questions about why and how we age as well as what can and cannot be done about it. Concentrates on different processes, e.g., oxidative stress, cellular senescence and Inflammaging Offers the ability to access cross-sectional knowledge more easily Written by expert researchers in biogerontology who are actively involved in various fields within aging research

Health, Illness, and Optimal Aging

Health, Illness, and Optimal Aging
Author: Carolyn M. Aldwin
Publisher: SAGE
Total Pages: 446
Release: 2004
Genre: Social Science
ISBN: 9780761922599
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The authors undertake the difficult task of assembling an objective and holistic picture of human aging, including the physical aspects of aging, chronic disease and health promotion in the later years, for students and professionals.

Introduction to Aging

Introduction to Aging
Author: Judith A. Sugar, PhD
Publisher: Springer Publishing Company
Total Pages: 366
Release: 2019-08-08
Genre: Psychology
ISBN: 0826162940
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The second edition of this engaging text reflects a welcome new paradigm for aging—that of aging as a positive stage of life. Written for undergraduate and masters-level students, it provides an interdisciplinary perspective on the wide variety of subject areas within gerontology, and combines research with engrossing narratives, new trends, and controversial topics. Substantially updated, the second edition features integrated content on the diversity of the aging population. State-of-the-art information includes new science on the biology of aging; chronic conditions; integrated care; changing roles for older adults; new demographics; and critical policy issues. The second edition examines career opportunities in gerontology and includes Practical Applications and Student Activities, new scenarios, and many more charts and graphs. Qualified instructors have access to supplementary material, including PowerPoint slides, a test bank, and an instructor’s manual. Key Features: Conceptualizes a positive approach to aging, with an emphasis on the advantages and opportunities presented by the large and growing number of older Americans Delivers comprehensive, interdisciplinary coverage of aging topics Dispels negative myths about aging Engages the reader with vivid narratives and thought-provoking activities Offers a broad range of subject areas in the field, from biological aging processes, to economics and living arrangements Provides instructor’s manual, PowerPoint slides, and test bank for additional learning Includes access to student activities answer key New to the Second Edition: Presents a new chapter on careers in aging, which explores expanding opportunities Explores new and updated demographics Includes new information on personality, palliative care, age-friendly communities, homelessness, social networks, Medicaid, and more Presents a new approach to elder abuse focusing on solutions to social isolation, a major cause of abuse

Lifespan

Lifespan
Author: David A. Sinclair
Publisher: Atria Books
Total Pages: 432
Release: 2019-09-10
Genre: Science
ISBN: 1501191977
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A NEW YORK TIMES BESTSELLER “Brilliant and enthralling.”​ —The Wall Street Journal A paradigm-shifting book from an acclaimed Harvard Medical School scientist and one of Time’s most influential people. It’s a seemingly undeniable truth that aging is inevitable. But what if everything we’ve been taught to believe about aging is wrong? What if we could choose our lifespan? In this groundbreaking book, Dr. David Sinclair, leading world authority on genetics and longevity, reveals a bold new theory for why we age. As he writes: “Aging is a disease, and that disease is treatable.” This eye-opening and provocative work takes us to the frontlines of research that is pushing the boundaries on our perceived scientific limitations, revealing incredible breakthroughs—many from Dr. David Sinclair’s own lab at Harvard—that demonstrate how we can slow down, or even reverse, aging. The key is activating newly discovered vitality genes, the descendants of an ancient genetic survival circuit that is both the cause of aging and the key to reversing it. Recent experiments in genetic reprogramming suggest that in the near future we may not just be able to feel younger, but actually become younger. Through a page-turning narrative, Dr. Sinclair invites you into the process of scientific discovery and reveals the emerging technologies and simple lifestyle changes—such as intermittent fasting, cold exposure, exercising with the right intensity, and eating less meat—that have been shown to help us live younger and healthier for longer. At once a roadmap for taking charge of our own health destiny and a bold new vision for the future of humankind, Lifespan will forever change the way we think about why we age and what we can do about it.

Biology of Aging

Biology of Aging
Author: Robert Arking
Publisher: Oxford University Press
Total Pages: 619
Release: 2006-02-02
Genre: FAMILY & RELATIONSHIPS
ISBN: 0195167392
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Robert Arking's Biology of Aging is an introductory text to the biology of aging which gives advanced undergraduate and graduate students a thorough review of the entire field. The mass of data related to aging is summarized into fifteen focused chapters, each dealing with some particular aspect of the problem. His prior two editions have also served admirably as a reference text for clinicians and scientists. This new edition captures the extraordinary recent advances in our knowledge of the ultimate and proximal mechanisms underlying the phenomenon of aging.

Aging and Health - A Systems Biology Perspective

Aging and Health - A Systems Biology Perspective
Author: A.I. Yashin
Publisher: Karger Medical and Scientific Publishers
Total Pages: 208
Release: 2014-10-14
Genre: Medical
ISBN: 3318027308
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Aging is a major risk factor for chronic diseases, which in turn can provide information about the aging of a biological system. This publication serves as an introduction to systems biology and its application to biological aging. Key pathways and processes that impinge on aging are reviewed, and how they contribute to health and disease during aging is discussed. The evolution of this situation is analyzed, and the consequences for the study of genetic effects on aging are presented. Epigenetic programming of aging, as a continuation of development, creates an interface between the genome and the environment. New research into the gut microbiome describes how this interface may operate in practice with marked consequences for a variety of disorders. This analysis is bolstered by a view of the aging organism as a whole, with conclusions about the mechanisms underlying resilience of the organism to change, and is expanded with a discussion of circadian rhythms in aging. Finally, the book presents an outlook for the development of interventions to delay or to reverse the features of aging. The publication is recommended to students, researchers as well as professionals dealing with public health and public policy related to an aging society.