An Integrated MEMS Syringe for Advanced Drug Delivery
Author | : Boris Stoeber |
Publisher | : |
Total Pages | : 414 |
Release | : 2002 |
Genre | : |
ISBN | : |
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Author | : Boris Stoeber |
Publisher | : |
Total Pages | : 414 |
Release | : 2002 |
Genre | : |
ISBN | : |
Author | : Richa Mishra |
Publisher | : CRC Press |
Total Pages | : 243 |
Release | : 2023-12-11 |
Genre | : Technology & Engineering |
ISBN | : 1003823416 |
This book introduces transdermal drug delivery and the developments that have taken place in various transdermal drug delivery techniques including the system-level design approach of a novel miniaturized medical device to offer precise and painless drug delivery via a skin-based transdermal route. It discusses the microelectromechanical systems (MEMS)-based fabrication technique and the design, fabrication and characterization of different MEMS-based components like microneedles and micropumps. It further includes a MEMS-based component micropump with design, analysis, fabrication and characterization of the transdermal drug delivery device and challenges encountered in the design improvements. Features: Summarizes transdermal drug delivery systems especially with a focus on MEMS and microneedles, including theoretical concepts Emphasizes system integration by describing simulation and design techniques as well as experimental fabrication Discusses system-level integration for miniaturized therapeutic devices Includes working simulation models covering microneedles and micropump analysis Explores future direction in development of pertinent devices. The book is aimed at researchers, professionals, and graduate students in biomedical engineering, microelectronics, micro-electro-mechanical-systems, and drug delivery.
Author | : Richa Mishra |
Publisher | : CRC Press |
Total Pages | : 267 |
Release | : 2023-12-11 |
Genre | : Technology & Engineering |
ISBN | : 1003823394 |
This book introduces transdermal drug delivery and the developments that have taken place in various transdermal drug delivery techniques including the system-level design approach of a novel miniaturized medical device to offer precise and painless drug delivery via a skin-based transdermal route. It discusses the microelectromechanical systems (MEMS)-based fabrication technique and the design, fabrication and characterization of different MEMS-based components like microneedles and micropumps. It further includes a MEMS-based component micropump with design, analysis, fabrication and characterization of the transdermal drug delivery device and challenges encountered in the design improvements. Features: Summarizes transdermal drug delivery systems especially with a focus on MEMS and microneedles, including theoretical concepts Emphasizes system integration by describing simulation and design techniques as well as experimental fabrication Discusses system-level integration for miniaturized therapeutic devices Includes working simulation models covering microneedles and micropump analysis Explores future direction in development of pertinent devices The book is aimed at researchers, professionals, and graduate students in biomedical engineering, microelectronics, micro-electro-mechanical-systems, and drug delivery.
Author | : Ryan F. Donnelly |
Publisher | : John Wiley & Sons |
Total Pages | : 349 |
Release | : 2018-08-20 |
Genre | : Science |
ISBN | : 1119305144 |
Provides comprehensive coverage of microneedles for delivering and monitoring patient drugs and vaccines Microneedles are an incredibly active research area and have the potential to revolutionize the way many medicines and vaccines are delivered. This comprehensive research book covers the major aspects relating to the use of microneedle arrays in enhancing both transdermal and intradermal drug delivery and provides a sound background to the use of microneedle arrays in enhanced delivery applications. Beginning with a history of the field and the various methods employed to produce microneedles from different materials, Microneedles for Drug and Vaccine Delivery and Patient Monitoring discusses the penetration of the stratum corneum by microneedles and the importance of application method and force and microneedle geometry (height, shape, inter-needle spacing). Transdermal and intradermal delivery research using microneedles is comprehensively and critically reviewed, focusing on the outcomes of in vivo animal and human studies. The book describes the important topics of safety and patient acceptability studies carried out to date. It also covers in detail the growing area for microneedle use in the monitoring of interstitial fluid contents. Finally, it reviews translational and regulatory developments in the microneedles field and describes the work ongoing in industry. The only book currently available on microneedles Filled with tables, graphs, and black and white images (photographs, micrographs) Authored by four experts in pharmaceutics Microneedles for Drug and Vaccine Delivery and Patient Monitoring is an ideal source for researchers in industry and academia working on drug delivery and transdermal delivery in particular, as well as for advanced students in pharmacy and pharmaceutical sciences.
Author | : Jaspreet Singh Kochhar |
Publisher | : Springer |
Total Pages | : 156 |
Release | : 2019-07-04 |
Genre | : Medical |
ISBN | : 3030154440 |
This monograph covers a novel technology to deliver drugs and cosmetics through the skin in a minimally invasive manner. Microneedles – a bed of miniaturized needles is one of the most studied topics in delivering actives through the skin barrier. This book enables readers to understand the delivery of ingredients through the skin, describes a novel and simple method to fabricate microneedles containing a range of small and large molecular weight compounds, studies their physical properties as well as delivery through the skin layers. Readers will discover this book to be extremely beneficial to help them understand the state of the field of transdermal drug delivery, with extensive coverage including experimental data on basics of microneedle fabrication technology using photolithography, encapsulation of drugs within the polymeric matrix of microneedles and studying their release patternsin vitro and ex vivo . Academic researchers, pharmaceutical and cosmeceutical industry as well as students of skin science will find this account very useful in their pursuits. As microneedles grow and develop into a commercial reality with more actives being delivered and significant clinical research being put in, this account will hold well in providing basic principles and knowledge together with rigorous experimental data.
Author | : Raja Kameswaran Sivamani |
Publisher | : |
Total Pages | : 94 |
Release | : 2004 |
Genre | : |
ISBN | : |
Author | : Rudolph Frederick Stapelberg |
Publisher | : Springer Science & Business Media |
Total Pages | : 842 |
Release | : 2009-02-17 |
Genre | : Technology & Engineering |
ISBN | : 1848001754 |
This handbook studies the combination of various methods of designing for reliability, availability, maintainability and safety, as well as the latest techniques in probability and possibility modeling, mathematical algorithmic modeling, evolutionary algorithmic modeling, symbolic logic modeling, artificial intelligence modeling and object-oriented computer modeling.
Author | : C.P. Wong |
Publisher | : Springer Science & Business Media |
Total Pages | : 761 |
Release | : 2009-12-23 |
Genre | : Technology & Engineering |
ISBN | : 1441900403 |
Nanotechnologies are being applied to the biotechnology area, especially in the area of nano material synthesis. Until recently, there has been little research into how to implement nano/bio materials into the device level. “Nano and Bio Electronics Packaging” discusses how nanofabrication techniques can be used to customize packaging for nano devices with applications to biological and biomedical research and products. Covering such topics as nano bio sensing electronics, bio device packaging, NEMs for Bio Devices and much more.
Author | : Andreas Dietzel |
Publisher | : Springer |
Total Pages | : 353 |
Release | : 2016-01-22 |
Genre | : Technology & Engineering |
ISBN | : 3319269208 |
This book provides a comprehensive, state-of-the-art review of microfluidic approaches and applications in pharmatechnology. It is appropriate for students with an interdisciplinary interest in both the pharmaceutical and engineering fields, as well as process developers and scientists in the pharmaceutical industry. The authors cover new and advanced technologies for screening, production by micro reaction technology and micro bioreactors, small-scale processing of drug formulations, and drug delivery that will meet the need for fast and effective screening methods for drugs in different formulations, as well as the production of drugs in very small volumes. Readers will find detailed chapters on the materials and techniques for fabrication of microfluidic devices, microbioreactors, microsystems for emulsification, on-chip fabrication of drug delivery systems, respiratory drug delivery and delivery through microneedles, organs-on-chip, and more.
Author | : Farshid Meshkinfam |
Publisher | : |
Total Pages | : 0 |
Release | : 2015 |
Genre | : |
ISBN | : |
One of the most effective treatments for diabetes type 1 and 2 is the administering Insulin. Single needle mechanical insulin pumps are heavy and painful. A generation of micro-needle-based MEMS-based drug delivery devices can be an excellent solution for insulin dosing. The stackable structure provides minimum dimensions and makes the final product to be patchable in any flat area of human skin and in combination with micro-needle array; it provides a safe, painless and robust injection application. In this study we address various aspects of design and simulation of a MEMS-based piezoelectric insulin micro-pump including PDMS micro-valves and micro-needle array. We investigate the micro-pump performance for different activating frequencies and different voltage at human skin interfacial pressure to match minimum to maximum deliver targets/requirements for total range of diabetic patients. COMSOL multiphysics is used to simulate and investigate the performance of a MEMS-based insulin micro-pump with a piezoelectric actuator pumping a viscous Newtonian fluid. The nature of this study is nonlinear therefore we use a fully coupled system with two-way boundary couplings. Fully coupling physics provide real time relationship between different parameters and pump's outputs. Three simulation modules; Structural Mechanic, Piezoelectric Device and Fluid-Structure Interaction are used to study the 2-D/3-D models of this MEMS based concept. Post processing and ODE also are used to create different required outputs.