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| Author | : Michael Christian Dobelbower |
| Publisher | : |
| Total Pages | : 438 |
| Release | : 1997 |
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| Author | : Andrew E. Hawk |
| Publisher | : |
| Total Pages | : 236 |
| Release | : 2003 |
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| Author | : M. Frederick Hawthorne |
| Publisher | : Springer |
| Total Pages | : 1389 |
| Release | : 2013-11-11 |
| Genre | : Medical |
| ISBN | : 1461512859 |
Frontiers in Neutron Capture Therapy contains current research results originally presented at the Eighth International Symposium on Neutron Capture Therapy for Cancer in La Jolla, CA. This comprehensive collection of peer-reviewed manuscripts is showcased in two volumes covering all aspects of the development of this multidisciplinary approach to cancer therapy. Volume I of this work includes clinical results and current progress in treatment planning, neutron sources and dosimetry, while Volume II presents the synthesis, pharmacology and tissue-targeting design of boron compounds, including work on preclinical dosimetry and radiobiology. Intended for researchers and clinicians involved with or interested in new modes of cancer therapy, this volume will also serve as a useful guideline for scientists, students, and practitioners in the field.
| Author | : Otto K. Harling |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 340 |
| Release | : 2013-03-08 |
| Genre | : Medical |
| ISBN | : 1468458027 |
For this Workshop, the organizers have attempted to invite experts from all known centers which are engaged in neutron beam development for neutron capture therapy. The Workshop was designed around a series of nineteen invited papers which dealt with neutron source design and development and beam characterization and performance. Emphasis was placed on epithermal beams because they offer clinical advantages and are more challenging to implement than thermal beams. Fission reactor sources were the basis for the majority of the papers; however three papers dealt with accelerator neutron sources. An additional three invited papers provided a summary of clinical results of Ncr therapy in Japan between 1968 and 1989 and overviews of clinical considerations for neutron capture therapy and of the status of tumor targeting chemical agents for Ncr. Five contributed poster papers dealing with NCT beam design and performance were also presented. A rapporteurs' paper was prepared after the Workshop to attempt to summarize the major aspects, issues, and conclusions which resulted from this Workshop. Many people contributed to both the smooth functioning of the Workshop and to the preparation of these proceedings. Special thanks are reserved for Ms. Dorothy K.
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| Total Pages | : |
| Release | : 1989 |
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We present a conceptual design of a low-energy neutron generator for treatment of brain tumors by boron neutron capture theory (BNCT). The concept is based on a 2.5-MeV proton beam from a radio-frequency quadrupole (RFQ) linac, and the neutrons are produced by the 7Li(p, n)7Be reaction. A liquid lithium target and modulator assembly are designed to provide a high flux of epithermal neutrons. The patient is administered a tumor-specific 1°Be-enriched compound and is irradiated by the neutrons to create a highly localized dose from the reaction 1°B(n, .cap alpha.)7Li. An RFQ accelerator-based neutron source for BNCT is compact, which makes it practical to site the facility within a hospital. 11 refs., 5 figs., 1 tab.
| Author | : |
| Publisher | : |
| Total Pages | : 628 |
| Release | : 2006 |
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The overall goal of this project was to develop an accelerator-based neutron source (ABNS) for Boron Neutron Capture Therapy (BNCT). Specifically, our goals were to design, and confirm by measurement, a target assembly and a moderator assembly that would fulfill the design requirements of the ABNS. These design requirements were 1) that the neutron field quality be as good as the neutron field quality for the reactor-based neutron sources for BNCT, 2) that the patient treatment time be reasonable, 3) that the proton current required to treat patients in reasonable times be technologially achievable at reasonable cost with good reliability, and accelerator space requirements which can be met in a hospital, and finally 4) that the treatment be safe for the patients.
| Author | : International Atomic Energy Agency |
| Publisher | : |
| Total Pages | : 0 |
| Release | : 2023-07-31 |
| Genre | : |
| ISBN | : 9789201327239 |
Boron neutron capture therapy (BNCT) is a neutron-based technique that allows selective cancer treatment at the tumour cellular level. BNCT is especially suitable for the treatment of brain, head, neck and skin cancers. Using the reaction between a neutron and boron to selectively destroy cancer cells, BNCT is a treatment that differs radically from conventional radiotherapy and promises to become a more widely adopted option for cancer treatment. BNCT is undergoing a major resurgence of interest around the world as some recent progress in accelerator technology allows the procedure to be undertake in clinics. In addition, the approval of BNCT in Japan as a routine clinical treatment for certain tumour types offers valuable insights for other states considering a similar approach. This publication comprehensively reports on the current state of the science as well as the supporting technology. It covers accelerator-based neutron sources, beam design, physical dosimetry, facility design and operation, pharmaceuticals, radiobiology, dose calculation, treatment planning and clinical trials. It has been written to assist in decision making at the national level as well as offering practical guidance for all those involved in implementation and ongoing management of BNCT programmes.
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| Total Pages | : 5 |
| Release | : 2003 |
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There were three objectives to this project: (1) The development of the 2-D Swan code for the optimization of the nuclear design of facilities for medical applications of radiation, radiation shields, blankets of accelerator-driven systems, fusion facilities, etc. (2) Identification of the maximum beam quality that can be obtained for Boron Neutron Capture Therapy (BNCT) from different reactor-, and accelerator-based neutron sources. The optimal beam-shaping assembly (BSA) design for each neutron source was also to e obtained. (3) Feasibility assessment of a new neutron source for NCT and other medical and industrial applications. This source consists of a state-of-the-art proton or deuteron accelerator driving and inherently safe, proliferation resistant, small subcritical fission assembly.
| Author | : Cristian G. Marciulescu |
| Publisher | : |
| Total Pages | : 152 |
| Release | : 2002 |
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| ISBN | : |
| Author | : Xiao-Lin Zhou |
| Publisher | : |
| Total Pages | : 422 |
| Release | : 1990 |
| Genre | : |
| ISBN | : |
