Amyloid Fibrils And Prefibrillar Aggregates PDF Download
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Author | : Daniel Erik Otzen |
Publisher | : John Wiley & Sons |
Total Pages | : 496 |
Release | : 2013-06-04 |
Genre | : Science |
ISBN | : 3527654208 |
Download Amyloid Fibrils and Prefibrillar Aggregates Book in PDF, ePub and Kindle
Summing up almost a decade of biomedical research, this topical and eagerly awaited handbook is the first reference on the topic to incorporate recent breakthroughs in amyloid research. The first part covers the structural biology of amyloid fibrils and pre-fibrillar assemblies, including a description of current models for amyloid formation. The second part looks at the diagnosis and biomedical study of amyloid in humans and in animal models, while the final section discusses pharmacological approaches to manipulating amyloid and also looks at its physiological roles in lower and higher organisms. For Biochemists, Molecular Biologists, Neurobiologists, Neurophysiologists and those working in the Pharmaceutical Industry.
Author | : Gregory R. Bock |
Publisher | : John Wiley & Sons |
Total Pages | : 266 |
Release | : 2008-04-30 |
Genre | : Medical |
ISBN | : 0470514930 |
Download The Nature and Origin of Amyloid Fibrils Book in PDF, ePub and Kindle
Amyloid fibrils are associated with a range of pathological disorders including Alzheimer's Disease, Down's syndrome, diabetes, cardiomyopathies, and transmissible spongiform encephalopathies. This volume is a comprehensive account of recent developments in the understanding of the process of amyloid fibrils. Contains up-to-date data on all of the clinical problems which, despite their pathological significance, are still largely unsolved.
Author | : |
Publisher | : Elsevier |
Total Pages | : 412 |
Release | : 2006-10-06 |
Genre | : Science |
ISBN | : 0080468977 |
Download Amyloid, Prions, and Other Protein Aggregates, Part C Book in PDF, ePub and Kindle
The ability of polypeptides to form alternatively folded, polymeric structures such as amyloids and related aggregates is being increasingly recognized as a major new frontier in protein research. This new volume of Methods in Enzymology along with Part B (volume 412) on Amyloid, Prions and other Protein Aggregates continue in the tradition of the first volume (309) in containing detailed protocols and methodological insights, provided by leaders in the field, into the latest methods for investigating the structures, mechanisms of formation, and biological activities of this important class of protein assemblies. Presents detailed protocols Includes troubleshooting tips Provides coverage on structural biology, computational methods, and biology
Author | : |
Publisher | : Elsevier |
Total Pages | : 861 |
Release | : 1999-09-22 |
Genre | : Science |
ISBN | : 0080496679 |
Download Amyloid, Prions, and Other Protein Aggregates Book in PDF, ePub and Kindle
This volume includes a core of methodologies to attack the unique experimental problems presented by protein misassembly. Emphasis is on human biology applications, the area in which there is the most interest, in which most of the work has already been done, and in which there is the best evidence for the structural sophisitication of the protein aggregates.The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences.
Author | : |
Publisher | : Academic Press |
Total Pages | : 322 |
Release | : 2017-01-18 |
Genre | : Science |
ISBN | : 0128122528 |
Download Early Stage Protein Misfolding and Amyloid Aggregation Book in PDF, ePub and Kindle
Early Stage Protein Misfolding and Amyloid Aggregation, Volume 329, the latest in the International Review of Cell and Molecular Biology series presents comprehensive reviews and current advances in cell and molecular biology, including articles that address the structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. The series has a worldwide readership and maintains a high standard by publishing invited articles on important and timely topics as authored by prominent cell and molecular biologists. Provides comprehensive reviews and current advances Presents a wide range of perspectives on specific subjects Includes valuable reference material for advanced undergraduates, graduate students, and professional scientists
Author | : Ana Maria Fernandez-Escamilla |
Publisher | : BoD – Books on Demand |
Total Pages | : 348 |
Release | : 2016-08-24 |
Genre | : Medical |
ISBN | : 9535126180 |
Download Exploring New Findings on Amyloidosis Book in PDF, ePub and Kindle
Amyloid protein aggregates are involved in ''protein-misfolding diseases'' of enormous social and economic impact, still with no effective therapies. The most prevalent amyloid pathologies are related to neurodegenerative diseases, but amyloidosis also affects other organs. The majority of the studies includes serious health connotations on amyloids. However, not all amyloid fibers play a detrimental role in host. An increasing number of studies shows an important beneficial role as ''functional amyloids''. This book opens an exciting door to provide up-to-date information about the function and the mechanisms of the amyloid formation process from the structural, biophysical, biomedical, and nanotechnological perspective, combining the new findings on toxic and functional amyloids studies using theoretical and experimental approaches to fight against amyloid-based diseases.
Author | : |
Publisher | : Elsevier |
Total Pages | : 530 |
Release | : 2024-05-30 |
Genre | : Science |
ISBN | : 0443293414 |
Download The Hidden World of Protein Aggregation Book in PDF, ePub and Kindle
The Hidden World of Protein Aggregation, Volume 206 provides a comprehensive exploration of protein aggregation, uncovering the factors behind the formation of amorphous aggregates and ordered structures called amyloid fibrils. It delves into the advantages and disadvantages of protein aggregates, addressing topics such as cytotoxicity and disorders linked to misfolding. Specific chapters in this release include Protein Aggregation: An Overview, Pathways of Amyloid Fibril Formation and Aggregation, Factors Influencing Amyloid Fibril Formation, Morphological Features and Types of Aggregated Structures, Each big journey starts with a first step: Importance of Oligomerization, Liquid-Liquid Phase Separation as Triggering Factor of Fibril Formation, and more. Additional sections cover Experimental Techniques for Detecting and Evaluating the Amyloid Fibrils, Prediction of Protein Aggregation, Amyloid Fibril Cytotoxicity and Associated Disorders, Inhibitors of Amyloid Fibril Formation, Therapeutic Approaches in Proteinopathies, Functional Amyloids, Biotechnological Applications of Amyloid Fibrils, and The Hidden World of Protein Aggregation. Provides an introduction to the folding of protein and associated conditions leading to aggregation and linked pathology Discusses structural biology and computational methodologies for analysis of protein (mis)folding and aggregation Describes functional amyloids and their biotechnological applications
Author | : John M. Squire |
Publisher | : Elsevier |
Total Pages | : 329 |
Release | : 2006-12-12 |
Genre | : Science |
ISBN | : 0080468950 |
Download Fibrous Proteins: Amyloids, Prions and Beta Proteins Book in PDF, ePub and Kindle
Amyloids, Prions and Beta Proteins is the last volume of the three-part thematic series on Fibrous Proteins in the Advances in Protein Chemistry serial. Fibrous proteins act as molecular scaffolds in cells providing the supporting structures of our skeletons, bones, tendons, cartilage, and skin. They define the mechanical properties of our internal hollow organs such as the intestines, heart, and blood vessels. This volume covers such topics as Beta-Structures in Fibrous Proteins; B-Silks: Enhancing and Controlling Aggregation; Beta-Rolls, Beta-Helices and Other Beta-Solenoid Proteins; Natural Triple B-Stranded Fibrous Folds; Structure, Function and Amyloidogenesis of Fungal Prions: Filament Polymorphism and Prion Variants; X-Ray Fiber and powder Diffraction of PRP Prion Peptides; From the Polymorphism of Amyloid Fibrils to Their Assembly Mechanism and Cytotoxicity; Structural Models of Amyloid-like Fibrils.
Author | : Einar M. Sigurdsson |
Publisher | : Springer Science & Business Media |
Total Pages | : 390 |
Release | : 2008-02-02 |
Genre | : Science |
ISBN | : 1592598749 |
Download Amyloid Proteins Book in PDF, ePub and Kindle
A proven collection of readily reproducible techniques for studying amyloid proteins and their involvement in the etiology, pathogenesis, diagnosis, and therapy of amyloid diseases. The contributors provide methods for the preparation of amyloid and its precursors (oligomers and protofibrils), in vitro assays and analytical techniques for their study, and cell culture models and assays for the production of amyloid proteins. Additional chapters present readily reproducible techniques for amyloid extraction from tissue, its detection in vitro and in vivo, as well as nontransgenic methods for developing amyloid mouse models. The protocols follow the successful Methods in Molecular BiologyTM series format, each offering step-by-step laboratory instructions, an introduction outlining the principle behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls.
Author | : Paul M. Gorman |
Publisher | : |
Total Pages | : 348 |
Release | : 2006 |
Genre | : |
ISBN | : 9780494219225 |
Download Analysis of Beta-amyloid Aggregation and Amyloid Precursor Protein Dimerization Book in PDF, ePub and Kindle
Alzheimer's Disease (AD) is a neuropathological disorder characterized by the progressive deposition of insoluble amyloid plaques and vascular deposits consisting primarily of 4.5 kDa amyloid beta peptides (Abeta). There is increasing evidence that the deposition of Abeta fibrils in the brain, an invariable feature of AD, and/or prefibrillar aggregates likely cause neurodegeneration in AD. While Abeta fibrils were a previous research focus, recent experiments implicate prefibrillar aggregates as the toxic species. The identification and characterization of prefibrillar aggregates is of great importance to understanding AD and the development of therapeutic strategies. Biophysical and spectroscopic techniques were used to examine the effects of electrostatic interactions on Abeta oligomerization. Experimental work demonstrated that, while salt bridges likely provide stability to preformed Abeta aggregates, these interactions are not essential for the early stages of aggregation. Abeta oligomerization is driven by the formation of pH-independent interactions and is impeded by electrostatic repulsion at pH values away from the isoelectric point. Diffuse plaques, containing only the 42-residue form of Abeta, are unstructured and non-toxic; they appear before toxic senile plaques containing both 40 and 42-residue forms. Through incubation, Abeta40 and Abeta42 were shown to co-incorporate into unstructured aggregates early during fibrillogenesis later leading to tightly packed aggregates with secondary structure. Previously, the stage at which the Abeta variants co-incorporated during the fibrillogenic process was unknown. After observing that the amyloid precursor protein transmembrane (APP-TM) domain contains two known dimerization motifs (GXXXG/A), oligomerization of the APP-TM domain was examined. A model system was developed to investigate the effects of familial AD mutations on the dimerization propensity of APP-TM domains. This work culminated in the first experimentally supported mechanism to explain how genetic mutations within the APP gene lead to the observed phenotype and predisposition to AD. Further experimentation led to the discovery of non-denaturing detergents that stabilize suspected on-pathway spherical Abeta aggregates. These detergent-stabilized Abeta oligomers share many of the structural features and biological activities of both membrane bound Abeta and spherical oligomers of Abeta formed in solution. Thus, these stabilizing detergents may prove useful in high-resolution structural analysis of spherical oligomers.