Allogeneic Stem Cell Transplantation Using Hla Matched Donors For Acute Myeloid Leukemia With Deletion 5q Or Monosomy 5 PDF Download
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| Author | : Xavier Poiré |
| Publisher | : |
| Total Pages | : |
| Release | : 2020 |
| Genre | : |
| ISBN | : |
Download Allogeneic Stem Cell Transplantation Using HLA-matched Donors for Acute Myeloid Leukemia with Deletion 5q Or Monosomy 5 Book in PDF, ePub and Kindle
Abstract: Deletion 5q or monosomy 5 (-5/5q-) in acute myeloid leukemia (AML) is a common high-risk feature that is referred to allogeneic stem cell transplantation. However, -5/5q- is frequently associated with other high-risk cytogenetic aberrations such as complex karyotype, monosomal karyotype, monosomy 7 (-7), or 17p abnormalities (abn (17p)), the significance of which is unknown. In order to address this question, we studied adult patients with AML harboring -5/5q- having their first allogeneic transplantation between 2000 and 2015. Five hundred and one patients with -5/5q- have been analyzed. Three hundred and thirty-eight patients (67%) were in first remission and 142 (28%) had an active disease at time of allogeneic transplantation. The 2-year probabilities of overall survival and leukemia-free survival were 27% and 20%, respectively. The 2-year probability of treatment-related mortality was 20%. We identified four different cytogenetic groups according to additional abnormalities with prognostic impact: -5/5q- without complex karyotype, monosomal karyotype or abn(17p), -5/5q- within a complex karyotype, -5/5q- within a monosomal karyotype and the combination of -5/5q- with abn(17p). In multivariate analysis, factors associated with worse overall survival and leukemia-free survival across the four groups were active disease, age, monosomal karyotype, and abn(17p). The presence of -5/5q- without monosomal karyotype or abn(17p) was associated with a significantly better survival rate while -5/5q- in conjunction with monosomal karyotype or abn(17p) translated into a worse outcome. The patients harboring the combination of -5/5q- with abn(17p) showed very limited benefit from allogeneic transplantation
| Author | : Eolia Brissot |
| Publisher | : |
| Total Pages | : |
| Release | : 2019 |
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| ISBN | : |
Download Haploidentical Versus Unrelated Allogeneic Stem Cell Transplantation for Relapsed/refractory Acute Myeloid Leukemia: a Report on 1578 Patients from the Acute Leukemia Working Party of the EBMT. Book in PDF, ePub and Kindle
Abstract: Primary refractory or relapsed acute myeloid leukemia is associated with a dismal prognosis. Allogeneic stem cell transplantation is the only therapeutic option that offers prolonged survival and cure in this setting. In the absence of a matched sibling donor, transplantation from unrelated 10/10 HLA allele-matched or 9/10 HLA allele-mismatched donors and haploidentical donors are potential alternatives. The current study aimed to compare the outcomes of acute myeloid leukemia patients with active disease who received allogeneic stem cell transplantation from a haploidentical donor with post-transplant cyclophosphamide (n=199) versus an unrelated 10/10-matched donor (n=1111) and versus an unrelated 9/10-mismatched donor (n=383) between 2007 and 2014 and who were reported to the European Society for Blood and Marrow Transplantation registry. Propensity score weighted analysis was conducted in order to control for disease risk imbalances between the groups. The leukemia-free survival rates at 2 years of recipients of grafts from a haploidentical donor, an unrelated 10/10-matched donor and an unrelated 9/10-mismatched donor were 22.8%, 28% and 22.2%, respectively (P=NS). In multivariate analysis, there were no significant differences in leukemia-free survival, overall survival, relapse incidence, non-relapse mortality, or graft-versus-host-disease-free relapse-free survival between the three groups. Two predictive factors were associated with a higher relapse incidence: transplantation during first or second relapse compared to primary refractory acute myeloid leukemia and poor cytogenetics. Allogeneic stem cell transplantation may rescue about 25% of acute myeloid leukemia patients with active disease. Importantly, the outcomes of transplants from haploidentical donors were comparable to those from 10/10-matched and 9/10-mismatched unrelated donors. Therefore, a haploidentical donor is a valid option for acute myeloid leukemia patients with active disease
| Author | : Mary J. Laughlin |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 448 |
| Release | : 2002-11-08 |
| Genre | : Medical |
| ISBN | : 159259333X |
Download Allogeneic Stem Cell Transplantation Book in PDF, ePub and Kindle
Internationally recognized physicians and researchers review both the basics of allogeneic stem cell transplantation and recent advances in the field, particularly as they relate to antitumor effects and graft-versus-host disease They also provide unique decision-tree analyses to guide clinicians in selecting and managing their allogeneic transplant patients. The innovations discussed cover a variety of areas, ranging from stem cell mobilization in normal donors, to indications for allogeneic transplantation other than hematologic malignancies, to the use of nonmyeloablative conditioning regimens. The authors also explore new developments in the optimal selection of unrelated allogeneic grafts (e.g., matched unrelated donor, partially mismatched family member, or umbilical cord blood), the use allogeneic peripheral blood stem cell vs marrow-derived grafts for transplantation, and the kinetics of immune reconstitution after transplantation.
| Author | : Hillard M. Lazarus |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 885 |
| Release | : 2010-03-02 |
| Genre | : Medical |
| ISBN | : 1597454788 |
Download Allogeneic Stem Cell Transplantation Book in PDF, ePub and Kindle
Since the original publication of Allogeneic Stem Cell Transplantation: Clinical Research and Practice, Allogeneic hematopoietic stem cell transplantation (HSC) has undergone several fast-paced changes. In this second edition, the editors have focused on topics relevant to evolving knowledge in the field in order to better guide clinicians in decision-making and management of their patients, as well as help lead laboratory investigators in new directions emanating from clinical observations. Some of the most respected clinicians and scientists in this discipline have responded to the recent advances in the field by providing state-of-the-art discussions addressing these topics in the second edition. The text covers the scope of human genomic variation, the methods of HLA typing and interpretation of high-resolution HLA results. Comprehensive and up-to-date, Allogeneic Stem Cell Transplantation: Clinical Research and Practice, Second Edition offers concise advice on today's best clinical practice and will be of significant benefit to all clinicians and researchers in allogeneic HSC transplantation.
| Author | : Laurent Garderet |
| Publisher | : |
| Total Pages | : 0 |
| Release | : 2018 |
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| ISBN | : |
Download Allogeneic Stem Cell Transplantation for Myelodysplastic Syndrome Patients with a 5q Deletion Book in PDF, ePub and Kindle
Abstract: The deletion (5q) karyotype (del [5q]) in patients with myelodysplastic syndrome (MDS) is the most common karyotypic abnormality in de novo MDS. An increased number of blasts and additional karyotypic abnormalities (del [5q]+) are associated with a poor outcome. We analyzed the outcome of allogeneic hematopoietic cell transplants (HCT) in patients suffering from MDS with only del (5q) or del (5q)+ . A total of 162 patients, of median age 54 years (range, 9 to 73), having MDS and del (5q) abnormalities received HCT from identical siblings (n = 87) or unrelated donors (n = 75). The cumulative incidence of nonrelapse mortality and relapse incidence at 4 years was 29% (95% CI, 22 to 36) and 46% (95% CI, 38 to 54), whereas the estimated 4 year survival, relapse-free and overall, was 25% (95% CI, 18 to 33) and 30% (95% CI, 23 to 38), respectively. In a multivariate analysis patients with del (5q) and a blast excess displayed poorer survival (hazard ratio, 2.38; 95% CI, 1.44 to 3.93; P
| Author | : Pier Paolo Piccaluga |
| Publisher | : BoD – Books on Demand |
| Total Pages | : 324 |
| Release | : 2021-03-24 |
| Genre | : Medical |
| ISBN | : 1838811680 |
Download Acute Leukemias Book in PDF, ePub and Kindle
Written by expert research teams, this book describes different aspects of both acute myeloid and acute lymphocytic leukemia, specifically their pathobiology, classification/diagnosis, and treatment. Chapters highlight current research as well as the gold standards for diagnosis and treatment of these diseases, examining recent advances in personalized approaches to acute leukemia.
| Author | : Taner Demirer |
| Publisher | : Humana Press |
| Total Pages | : 205 |
| Release | : 2017-10-27 |
| Genre | : Science |
| ISBN | : 3319653199 |
Download Haploidentical Stem Cell Transplantation Book in PDF, ePub and Kindle
This book discusses the aspects of haploidentical transplants and will shed light on the debates and questions on this burgeoning field and timely topic. Donor selection, graft failure, minimal CD34+ cell requirement, and conditioning regimens used for haploidentical transplants will be written by expert authors dealing with this type of transplants. Approximately one third of the books' chapters cover logic and basic aspects; the remaining two thirds of the book discuss clinical aspects, outcomes, and future perspectives, thus providing a comphrensive discussion of the topic. Haploidentical transplantation is extremely timely, rapidly-changing area and increasing its use will decrease the need for time-consuming, expensive, unrelated donor search. Moreover, Haploidentical Stem Cell Transplantation brings a set of clear answers to questions of feasibility, advantages over unrelated transplants, cost effectivity and outcome..
| Author | : Robert J. Soiffer |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 483 |
| Release | : 2004-01-29 |
| Genre | : Medical |
| ISBN | : 1592597335 |
Download Stem Cell Transplantation for Hematologic Malignancies Book in PDF, ePub and Kindle
A comprehensive survey of the current state-of-the-art in hematopoietic stem cell transplantation for malignant disease. The authors focus on the indications and results of transplantation for acute leukemia, chronic myelogenous leukemia, lymphoma, multiple myeloma, and breast cancer. Special attention is given to transplant-related complications, including the pathophysiology and clinical consequences of acute and chronic GVHD, delayed immune reconstitution leading to infectious complications, and organ damage to the lung and liver. Additional chapters address the sources of stem cells and the effects of graft manipulation used to eliminate residual contaminating tumor cells in autologous transplantation, or to reduce the number of T lymphocytes causing GVHD in allogenic transplantation.
| Author | : Richard K. Burt |
| Publisher | : Springer |
| Total Pages | : 419 |
| Release | : 2012-11-28 |
| Genre | : Medical |
| ISBN | : 1461549876 |
Download Advances in Allogeneic Hematopoietic Stem Cell Transplantation Book in PDF, ePub and Kindle
The field of hematopoietic stem cell transplantation is rapidly evolving. Realization that hematopoietic stem cells give rise to the immune compartment has resulted in clinical trials of hematopoietic stem cell transplantation for patients with autoimmune diseases. Allogeneic hematopoietic transplants are a form of adoptive immunotherapy resulting in beneficial graft versus tumor effects. Large numbers of hematopoietic cells can be collected with ease. Therefore, a renewable source of cells for ex vivo genetic manipulations is readily available. Multiple trials combining hematopoietic transplants and gene therapy are in progress. One such application is the infusion of allogeneic lymphocytes containing a suicide gene to abort graft versus host disease. Hematopoietic stem cell transplantation is in reality the clinical and practical application of cellular therapy. Hematopoietic transplant physicians are by design or by practical application evolving into cell and gene therapy specialists. The excitement and enthusiasm in hematopoietic transplantation is that it offers a door to the future. A future not of drugs or titrating poisonous chemotherapy but rather of cellular and gene therapy. 1 ALLOGENEIC PERIPHERAL BLOOD STEM CELL TRANSPLANTATION FOR HEMATOLOGIC DISEASES Martin Korbling University o/Texas MD. Anderson Cancer Center, Houston, Texas 77030 INTRODUCTION Circulating hematopoietic stem cells have emerged as an alternative to bone marrow (BM) stem cells for allografting. For many years the reconstitutive potential of circulating stem cells was questioned; peripheral blood stem cells (PBSC) were even characterized a waste product (1).
| Author | : Anke Delie |
| Publisher | : |
| Total Pages | : |
| Release | : 2017 |
| Genre | : |
| ISBN | : |
Download Donor Cell Derived Deletion 7q Occurring After Allogeneic Stem Cell Transplantation: a Case Report Book in PDF, ePub and Kindle
IntroductionDeletion 7q (del(7q)) is a non-reciprocal chromosomal abnormality frequently seen in patients with therapy related myeloid neoplasms. The resulting compound haploinsufficiency and dysregulation of gene expression is thought to play a key role in disease development and progression in myeloid malignancies. Deletion 7q has been found to be a recurrent genetic abnormality in donor cell leukemia (DCL) and u2013MDS. Case presentationWe present a case of donor cell derived del(7q) occurring in a 61 year old male 4 years after a matched related donor allogeneic stem cell transplantation for a poor risk acute myeloid leukemia (FLT3-ITD+, NPM-). Pre-transplant bone marrow aspirate showed a complete morphological and molecular remission without any cytogenetic abnormalities. On pre-donation screening, peripheral blood counts of the donor (the patients HLA-identical sister) showed no abnormalities. Post-transplant course was complicated by the occurrence of a primo CMV-infection and a transient clonal expansion of T-cell large granular lymphocytes. Routine bone marrow analysis 4 years post-transplant identified a del(7q) in 10 out of 20 cells, all of them with female karyotype (46,XX,del(7)(q21)[10]), alongside normal morphology and full donor chimerism. The donor was contacted and bone marrow analysis performed, showing no morphological or cytogenetic abnormalities. DiscussionThe mechanism of development of del(7q) in our patient is unclear. Taking into account the normal karyotype in the donor as well as the long latency between transplant and development of the abnormality, it seems likely that host factors such as an impaired bone marrow microenvironment, an underlying genetic predisposition or defective immune surveillance played a significant role in the development of the observed abnormality. ConclusionAs there is a high risk of further clonal evolution to donor cell derived MDS or DCL strict further follow-up is warranted. The detection of donor cell derived clonal abnormalities should warrant a thorough evaluation of the donor.
