Allogeneic Stem Cell Transplantation For Myelodysplastic Syndrome Patients With A 5q Deletion PDF Download
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Author | : Laurent Garderet |
Publisher | : |
Total Pages | : 0 |
Release | : 2018 |
Genre | : |
ISBN | : |
Download Allogeneic Stem Cell Transplantation for Myelodysplastic Syndrome Patients with a 5q Deletion Book in PDF, ePub and Kindle
Abstract: The deletion (5q) karyotype (del [5q]) in patients with myelodysplastic syndrome (MDS) is the most common karyotypic abnormality in de novo MDS. An increased number of blasts and additional karyotypic abnormalities (del [5q]+) are associated with a poor outcome. We analyzed the outcome of allogeneic hematopoietic cell transplants (HCT) in patients suffering from MDS with only del (5q) or del (5q)+ . A total of 162 patients, of median age 54 years (range, 9 to 73), having MDS and del (5q) abnormalities received HCT from identical siblings (n = 87) or unrelated donors (n = 75). The cumulative incidence of nonrelapse mortality and relapse incidence at 4 years was 29% (95% CI, 22 to 36) and 46% (95% CI, 38 to 54), whereas the estimated 4 year survival, relapse-free and overall, was 25% (95% CI, 18 to 33) and 30% (95% CI, 23 to 38), respectively. In a multivariate analysis patients with del (5q) and a blast excess displayed poorer survival (hazard ratio, 2.38; 95% CI, 1.44 to 3.93; P
Author | : Xavier Poiré |
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Total Pages | : |
Release | : 2020 |
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Download Allogeneic Stem Cell Transplantation Using HLA-matched Donors for Acute Myeloid Leukemia with Deletion 5q Or Monosomy 5 Book in PDF, ePub and Kindle
Abstract: Deletion 5q or monosomy 5 (-5/5q-) in acute myeloid leukemia (AML) is a common high-risk feature that is referred to allogeneic stem cell transplantation. However, -5/5q- is frequently associated with other high-risk cytogenetic aberrations such as complex karyotype, monosomal karyotype, monosomy 7 (-7), or 17p abnormalities (abn (17p)), the significance of which is unknown. In order to address this question, we studied adult patients with AML harboring -5/5q- having their first allogeneic transplantation between 2000 and 2015. Five hundred and one patients with -5/5q- have been analyzed. Three hundred and thirty-eight patients (67%) were in first remission and 142 (28%) had an active disease at time of allogeneic transplantation. The 2-year probabilities of overall survival and leukemia-free survival were 27% and 20%, respectively. The 2-year probability of treatment-related mortality was 20%. We identified four different cytogenetic groups according to additional abnormalities with prognostic impact: -5/5q- without complex karyotype, monosomal karyotype or abn(17p), -5/5q- within a complex karyotype, -5/5q- within a monosomal karyotype and the combination of -5/5q- with abn(17p). In multivariate analysis, factors associated with worse overall survival and leukemia-free survival across the four groups were active disease, age, monosomal karyotype, and abn(17p). The presence of -5/5q- without monosomal karyotype or abn(17p) was associated with a significantly better survival rate while -5/5q- in conjunction with monosomal karyotype or abn(17p) translated into a worse outcome. The patients harboring the combination of -5/5q- with abn(17p) showed very limited benefit from allogeneic transplantation
Author | : Silke Heidenreich |
Publisher | : |
Total Pages | : |
Release | : 2017 |
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ISBN | : |
Download Allogeneic Stem Cell Transplantation for Patients Age ≥ 70 Years with Myelodysplastic Syndrome: a Retrospective Study of the MDS Subcommittee of the Chronic Malignancies Working Party of the EBMT Book in PDF, ePub and Kindle
Abstract: In this retrospective analysis we evaluated the outcome of 313 patients aged ≥ 70 years in the registry of the European Group for Blood and Marrow Transplantation with myelodysplastic syndrome (MDS; n = 221) and secondary acute myeloid leukemia (n = 92) who underwent allogeneic hematopoietic stem cell transplantation (HSCT) from related (n = 79) or unrelated (n = 234) donors. Median age at HSCT was 72 years (range, 70 to 78). Conditioning regimen was nonmyeloablative (n = 54), reduced intensity (n = 207), or standard intensity (n = 52). Allogeneic HSCT for MDS patients ≥ 70 years was increasingly performed over time. Although during 2000 to 2004 only 16 patients received HSCT, during 2011 to 2013 the number of transplantations increased to 181. The cumulative incidence of nonrelapse mortality at 1 year and relapse at 3 years was 32% and 28%, respectively, with a 3-year overall survival rate of 34%. Good performance, determined by Karnofsky performance status, and recipients' seronegativity for cytomegalovirus was associated with 3-year estimated overall survival rates of 43% (P = .01) and 46% (P = .002), respectively. Conditioning intensity did not impact survival. After careful patient selection, allogeneic HSCT can be offered to patients older than 70 years with MDS
Author | : Alan List |
Publisher | : Springer Science & Business Media |
Total Pages | : 62 |
Release | : 2011-11-06 |
Genre | : Medical |
ISBN | : 1907673369 |
Download Clinician’s Manual on Myelodysplastic Syndromes Book in PDF, ePub and Kindle
An overview of diagnosis and current management of myelodysplastic syndromes. - Reviews the performance of the pharmacological treatments currently available and analyses the potential for new treatments - High quality clinical photos and figures to enhance descriptions and improve reader comprehension - Useful reference text for healthcare professionals needing to know more about myelodysplastic syndromes
Author | : M. Extermann |
Publisher | : Karger Medical and Scientific Publishers |
Total Pages | : 179 |
Release | : 2013-01-18 |
Genre | : Medical |
ISBN | : 3318023078 |
Download Cancer and Aging Book in PDF, ePub and Kindle
Cancer is clearly an age-related disease. Recent research in both aging and cancer has demonstrated the complex interaction between the two phenomena. This affects a wide spectrum of research and practice, anywhere from basic research to health care organization. Core examples of these close associations are addressed in this book. Starting with basic research, the first chapters cover cancer development, mTOR inhibition, senescent cells altering the tumor microenvironment, and immune senescence affecting cancer vaccine response. Taking into account the multidisciplinarity of geriatric oncology, several chapters focus on geriatric and oncologic aspects in patient assessment, treatment options, nursing and exercise programs. The book is rounded off by a discussion on the impact of the metabolic syndrome illustrating the interactions between comorbidity and cancer and a chapter on frailty.This book provides the reader with insights that will hopefully foster his or her reflection in their own research and practice to further the development of this most exciting field. Given the aging of the population worldwide and the high prevalence of cancer, it is essential reading not only for oncologists and geriatricians but for all health practitioners.
Author | : |
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Release | : 2014 |
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Download Clinical Advisory, Randomized, Multi-center, Phase III Study of Allogeneic Stem Cell Transplantation Comparing Regimen Intensity in Patients with Myelodysplastic Syndrome Or Acute Myeloid Leukemia (BMT CTN 0901) Book in PDF, ePub and Kindle
The National Institutes of Health's (NIH) National Heart, Lung, and Blood Institute (NHLBI) has suspended enrollment for the clinical study BMT CTN 0901 conducted by the Blood and Marrow Transplant Clinical Trials Network (BMT CTN) after preliminary data appeared to show benefit for one approach to the intensity of conditioning for allogeneic stem cell transplantations in patients eligible for the study.
Author | : |
Publisher | : ScholarlyEditions |
Total Pages | : 75 |
Release | : 2012-12-10 |
Genre | : Medical |
ISBN | : 1464973296 |
Download Myelodysplastic Syndromes: New Insights for the Healthcare Professional: 2012 Edition Book in PDF, ePub and Kindle
Myelodysplastic Syndromes: New Insights for the Healthcare Professional / 2012 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Myelodysplastic Syndromes in a concise format. The editors have built Myelodysplastic Syndromes: New Insights for the Healthcare Professional / 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Myelodysplastic Syndromes in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Myelodysplastic Syndromes: New Insights for the Healthcare Professional / 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Author | : Mahmoud Aljurf |
Publisher | : Springer Nature |
Total Pages | : 192 |
Release | : 2021-10-28 |
Genre | : Medical |
ISBN | : 3030820521 |
Download The Comprehensive Cancer Center Book in PDF, ePub and Kindle
This open access book provides a valuable resource for hospitals, institutions, and health authorities worldwide in their plans to set up and develop comprehensive cancer care centers. The development and implementation of a comprehensive cancer program allows for a systematic approach to evidence-based strategies of prevention, early detection, diagnosis, treatment, and palliation. Comprehensive cancer programs also provide a nexus for the running of clinical trials and implementation of novel cancer therapies with the overall aim of optimizing comprehensive and holistic care of cancer patients and providing them with the best opportunity to improve quality of life and overall survival. This book's self-contained chapter format aims to reinforce the critical importance of comprehensive cancer care centers while providing a practical guide for the essential components needed to achieve them, such as operational considerations, guidelines for best clinical inpatient and outpatient care, and research and quality management structures. Intended to be wide-ranging and applicable at a global level for both high and low income countries, this book is also instructive for regions with limited resources. The Comprehensive Cancer Center: Development, Integration, and Implementation is an essential resource for oncology physicians including hematologists, medical oncologists, radiation oncologists, surgical oncologists, and oncology nurses as well as hospitals, health departments, university authorities, governments and legislators.
Author | : Michele Malagola |
Publisher | : Frontiers Media SA |
Total Pages | : 193 |
Release | : 2022-03-15 |
Genre | : Medical |
ISBN | : 2889746925 |
Download Advances and Challenges of Allogeneic Stem Cell Transplantation Book in PDF, ePub and Kindle
Author | : Munir Shahjahan |
Publisher | : |
Total Pages | : 184 |
Release | : 2004 |
Genre | : |
ISBN | : |
Download Long-term Outcome and Quality of Life in Acute Myelogenous Leukemia (AML) and Myelodysplastic Syndrome (MDS) Patients Receiving Allogeneic Hematopoietic Stem Cell Transplantation Book in PDF, ePub and Kindle