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Aging

Aging
Author: Sean P. Curran
Publisher:
Total Pages: 277
Release: 2020
Genre: Aging
ISBN: 9781071605929

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This volume details the impact of aging on biological system and to understand the basis of this diversity with the goal of elucidating mechanisms to optimize health. Chapters guide readers through different animal models and methodologies to examine aging at the organism, tissue, cellular, and molecular levels across the lifespan. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Aging: Methods and Protocols aims to ensure successful results in the further study of this vital field.


Biological Aging

Biological Aging
Author: Trygve O. Tollefsbol
Publisher: Springer Science & Business Media
Total Pages: 844
Release: 2008-02-03
Genre: Science
ISBN: 1597453617

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This book investigates the various processes that are affected by the age of an organism. Several new tools for the analysis of biological aging have been introduced recently, and this volume provides methods and protocols for these new techniques in addition to its coverage of established procedures. Researchers seeking new technology and techniques will find this volume of tremendous benefit as they move towards new directions.


Stem Cells and Aging

Stem Cells and Aging
Author: Kursad Turksen
Publisher: Humana
Total Pages: 354
Release: 2020-09-19
Genre: Science
ISBN: 9781493997152

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This fully updated book collects protocols that reflect current investigations into how stem cell populations change during organismal aging. These methodologies are well-established and described in easy to follow fashion so as to be valuable for not only experts but novices in the ever-developing stem cell field. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Stem Cells and Aging: Methods and Protocols, Second Edition serves as an ideal guide for all researchers working in this very active area of study.


Aging Methods and Protocols

Aging Methods and Protocols
Author: Yvonne A. Barnett
Publisher: Springer Science & Business Media
Total Pages: 378
Release: 2008-02-01
Genre: Medical
ISBN: 1592590705

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Aging is an almost universal process within biological systems, one which leads to a decline in functional capacity, disease onset, and eventually death. There has been much interest in recent years to elucidate the molecular mec- nisms that underlie the aging process. Many theories have been proposed since the last century that aim to explain the causes of aging. There is no one theory that completely satisfies the phenotype of aging, but genetics and environm- tal factors play an important role in the etiology of age-related pathologies and the aging process. However, there is still much to be learned about the aging process which has been termed one of the last great frontiers in biology. De- graphic changes worldwide are leading to increased average life expectancies within our populations. These changes in population characteristics will impact upon the economies of the supporting society, with increasing healthcare and infrastructural costs arising from the prevalence of age-related pathologies and other physical disabilities associated with advancing years. Many researchers worldwide are working in the attempt to identify key cellular processes through which it might one day be possible to slow down the aging process and thus increase the health span of humans. Numerous research projects—from the cellular through to tissue, organ, and whole organism studies—are currently underway to investigate the mul- factorial aging process.


Methionine Dependence of Cancer and Aging

Methionine Dependence of Cancer and Aging
Author: Robert M. Hoffman
Publisher: Humana
Total Pages: 0
Release: 2019-02-07
Genre: Medical
ISBN: 9781493987955

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This book explores the methionine dependence of cancer and its effects on aging, a great story of science that is not widely known. The chapters in this book describe the discovery of methionine dependence of cancer; the molecular basis for the increased methionine demand of cancer cells and tumors; the clinical application of methionine dependence of cancer in PET imaging with [11C]methionine; the development of methioninases as cancer drugs; the anti-aging and anti-diabetes effects of methionine restriction; and the future of targeting methionine in the body for the elimination of cancer and for the extension of a healthy life-span. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Methionine Dependence of Cancer and Aging: Methods and Protocols is an important resource for researchers and scientists wishing to pursue this exciting and vital area of study."


Clinical and Preclinical Models for Maximizing Healthspan

Clinical and Preclinical Models for Maximizing Healthspan
Author: Paul C. Guest
Publisher: Humana
Total Pages: 0
Release: 2021-03-27
Genre: Science
ISBN: 9781071604731

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This book presents a series of protocols in multiple disease areas affected by the aging process along with several methods which have shown progress in nutrient- or intervention-based approaches to maximize the healthspan. Of interest to researchers in the areas of chronic disease, gerontology, physical exercise, and nutrition as well as to clinical scientists, physicians, and pharmacologists, this volume also provides important information on disease mechanisms and novel drug targets as each protocol will be presented in the context of specific chronic diseases or different therapeutic areas. Written for the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Clinical and Preclinical Models for Maximizing Healthspan: Methods and Protocols is an ideal guide for preclinical and clinical researchers working toward the discoveries needed to lead to a world society in which individuals are not only living longer lives but more productive and healthier ones.


Collagen

Collagen
Author: Irit Sagi
Publisher: Humana Press
Total Pages: 254
Release: 2019-04-06
Genre: Science
ISBN: 9781493990948

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This detailed volume compiles state-of-the-art protocols that will serve as recipes for scientists researching collagen, an abundant protein with great importance to health and disease, as well as in applications like food, cosmetics, pharmaceuticals, cosmetic surgery, artificial skin, and glue. Beginning with a section on in vitro models for the characterization of collagen formation, the book continues by highlighting large-scale analysis of collagen with mass spectrometry in order to elucidate the proteomics, degradomics, interactomes, and cross-linking of collagen, high resolution imaging approaches for collagen by the use of scanning electron microscopy and multiphoton imaging, as well as the role of collagen during physiological and pathological conditions. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Collagen: Methods and Protocols is an ideal guide to high quality and repeatable protocols in this vital field of study.


Studies of Aging

Studies of Aging
Author: Hal Sternberg
Publisher: Springer Science & Business Media
Total Pages: 214
Release: 2012-12-06
Genre: Science
ISBN: 3642599168

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This laboratory manual provides the researcher with a specific group of techniques, emphasising throughout hands-on information. A variety of protocols using molecular, cellular and physiological techniques are presented in detail and appropriate animal models have been selected for the study of ageing and ageing-related diseases. Non-invasive in vivo techniques are described for the study of Alzheimers dementia and cardiovascular diseases, while techniques for detection of oxidative processes are presented to explore the role of free radicals in causing cell damage and mutations as well as techniques to study apoptosis for its role in cell ageing. XXXXXXXXX Neuer Text This lab manual provides hands-on protocols using molecular, cellular, and physiological techniques and the appropriate animal models for the study of aging and aging-related diseases. Non-invasive in vivo techniques are described for the study of Alzheimers dementia and cardiovascular diseases. Techniques for detection of oxidative processes are presented to explore the role of free radicals in causing cell damage, as well as techniques to study apoptosis for its role in cell aging. A Springer Lab Manual


Methods in Aging Research

Methods in Aging Research
Author: Byung Pal Yu
Publisher:
Total Pages: 697
Release: 1998
Genre: MEDICAL
ISBN: 9780367803988

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Gerontological research is currently of great interest due to ever-increasing longevity of human life spans. Created to provide researchers and scientists with the technical methods essential to their work, Methods in Aging Research is a practical bench-top guide for everyone who plans, designs, or conducts research in aging. It highlights experimental procedures that are key to the investigation of the biological aging phenomena.Methods in Aging Research is a state-of-the-art reference that offers the most direct and clear cut descriptions available of methodological procedures used in aging research. Methods and protocols are critically evaluated and the advantages and disadvantages of each technique are explored. More than 70 expert contributors from around the world share their combined knowledge on a broad range of topics essential to everyone involved in cultivating and developing the gerontological research frontier.


Chemical Biology

Chemical Biology
Author: Jonathan E. Hempel
Publisher: Humana
Total Pages: 0
Release: 2015-01-24
Genre: Science
ISBN: 9781493922680

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This volume seeks to enable the discovery of tools in chemical biology by providing readers with various techniques ranging from initial chemical genetic screening to target identification. To successfully highlight the essential components of the chemical biology tool discovery process, the book is organizes into four parts that focus on platforms for molecular discovery in in vitro cellular systems, in vivo chemical genetic screening protocols, and methods used to discover functional protein targets. Written in the highly successful Methods of Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Practical and informative, Chemical Biology: Methods and Protocols seeks to improve the success rate of the chemical biology field through the dissemination of detailed and experiential knowledge.