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Advances in the Development of Artificial Metalloenzymes

Advances in the Development of Artificial Metalloenzymes
Author: Tatjana N. Parac-Vogt
Publisher: Frontiers Media SA
Total Pages: 167
Release: 2019-11-05
Genre:
ISBN: 2889631532

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Reactions catalyzed by metalloenzymes have great potential for applications in the biotechnology and pharmaceutical industries. While only a few of these enzymes have yet been used in such applications, in the last few decades numerous efficient, selective, environmentally friendly and economical synthetic analogues have been described, including supramolecular, polymeric, nanoparticulate and lowmolecular- weight organometallic complexes, and metal organic frameworks. In this Research Topic, we present a collection of original research and review articles that show significant recent advances made in the rational design of such artificial metalloenzymes.


Artificial Metalloenzymes and MetalloDNAzymes in Catalysis

Artificial Metalloenzymes and MetalloDNAzymes in Catalysis
Author: Montserrat Diéguez
Publisher: John Wiley & Sons
Total Pages: 428
Release: 2018-06-05
Genre: Technology & Engineering
ISBN: 3527341781

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An important reference for researchers in the field of metal-enzyme hybrid catalysis Artificial Metalloenzymes and MetalloDNAzymes in Catalysis offers a comprehensive review of the most current strategies, developed over recent decades, for the design, synthesis, and optimization of these hybrid catalysts as well as material about their application. The contributors—noted experts in the field—present information on the preparation, characterization, and optimization of artificial metalloenzymes in a timely and authoritative manner. The authors present a thorough examination of this interesting new platform for catalysis that combines the excellent selective recognition/binding properties of enzymes with transition metal catalysts. The text includes information on the various applications of metal-enzyme hybrid catalysts for novel reactions, offers insights into the latest advances in the field, and contains an informative perspective on the future: Explores the development of artificial metalloenzymes, the modern and strongly evolving research field on the verge of industrial application Contains a comprehensive reference to the research area of metal-enzyme hybrid catalysis that has experienced tremendous growth in recent years Includes contributions from leading researchers in the field Shows how this new catalysis combines the selective recognition/binding properties of enzymes with transition metal catalysts Written for catalytic chemists, bioinorganic chemists, biochemists, and organic chemists, Artificial Metalloenzymes and MetalloDNAzymes in Catalysis offers a unique reference to the fundamentals, concepts, applications, and the most recent developments for more efficient and sustainable synthesis.


Protein Engineering

Protein Engineering
Author: Huimin Zhao
Publisher: John Wiley & Sons
Total Pages: 41
Release: 2021-08-23
Genre: Science
ISBN: 3527344705

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A one-stop reference that reviews protein design strategies to applications in industrial and medical biotechnology Protein Engineering: Tools and Applications is a comprehensive resource that offers a systematic and comprehensive review of the most recent advances in the field, and contains detailed information on the methodologies and strategies behind these approaches. The authors—noted experts on the topic—explore the distinctive advantages and disadvantages of the presented methodologies and strategies in a targeted and focused manner that allows for the adaptation and implementation of the strategies for new applications. The book contains information on the directed evolution, rational design, and semi-rational design of proteins and offers a review of the most recent applications in industrial and medical biotechnology. This important book: Covers technologies and methodologies used in protein engineering Includes the strategies behind the approaches, designed to help with the adaptation and implementation of these strategies for new applications Offers a comprehensive and thorough treatment of protein engineering from primary strategies to applications in industrial and medical biotechnology Presents cutting edge advances in the continuously evolving field of protein engineering Written for students and professionals of bioengineering, biotechnology, biochemistry, Protein Engineering: Tools and Applications offers an essential resource to the design strategies in protein engineering and reviews recent applications.


Enzymes for Solving Humankind's Problems

Enzymes for Solving Humankind's Problems
Author: José J. G. Moura
Publisher: Springer Nature
Total Pages: 507
Release: 2020-12-01
Genre: Science
ISBN: 3030583155

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This book presents specific key natural and artificial systems that are promising biocatalysts in the areas of health, agriculture, environment and energy. It provides a comprehensive account of the state of the art of these systems and outlines the significant progress made in the last decade using these systems to develop innovative, sustainable and environmentally friendly solutions. Chapters from expert contributors explore how natural enzymes and artificial systems tackle specific targets such as: climate change, carbon footprint and economy and carbon dioxide utilisation; nitrogen footprint and fixation and nitrous oxide mitigation; hydrogen production, fuel cells and energy from bacteria; biomass transformation and production of added-value compounds, as well as biosensors development. This book provides an important and inspiring account for the designing of new natural and artificial systems with enhanced properties, and it appeals not only to students and researchers working in the fields of energy, health, food and environment, but also to a wider audience of educated readers that are interested in these up-to-date and exciting subjects. Chapter “Carbon Dioxide Utilisation—The Formate Route” is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.


Comprehensive Asymmetric Catalysis

Comprehensive Asymmetric Catalysis
Author: Eric N. Jacobsen
Publisher: Springer Science & Business Media
Total Pages: 258
Release: 2003-09-22
Genre: Science
ISBN: 9783540003335

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The first supplement to the three volume reference work "Comprehensive Asymmetric Catalysis" critically reviews new developments to the hottest topics in the field written by recognised experts. Eleven chapters which are already in the major reference work have been supplemented and additionally five new chapters have been included. Thus the state-of-the art in this area is now re-established. Together with the basic three volume book set this supplement is not only the principal reference source for synthetic organic chemists, but also for all scientific researchers who use chiral compounds in their work (for example, in biochemical investigations and molecular medicine) as well as for pharmaceutical chemists and other industrial researchers who prepare chiral compounds.


Modern Developments in Catalysis

Modern Developments in Catalysis
Author: Graham Hutchings
Publisher: World Scientific
Total Pages: 348
Release: 2016-11-14
Genre: Science
ISBN: 1786341239

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The UK Catalysis Hub is a consortium of universities working together on fundamental and applied research to find out how catalysts work and to improve their effectiveness. The contribution of catalysis to manufacturing contributes to almost 40% of global GDP, making development and innovation within the field integral to industry. Modern Developments in Catalysis provides a review of current research and practise on catalysis, focussing on five main themes: catalysis design, environmental catalysis, catalysis and energy, chemical transformation and biocatalysis and biotransformations. Topics range from complex reactions to the intricacies of catalyst preparation for supported nanoparticles, while chapters illustrate the challenges facing catalytic science and the directions in which the field is developing. Editor leaders of the UK Hub, this book provides insight into one of the most important areas of modern chemistry — it represents a unique learning opportunity for students and professionals studying and working towards speeding-up, improving and increasing the rate of catalytic reactions in science and industry.


Iron Catalysis: Design And Applications

Iron Catalysis: Design And Applications
Author: Jose M Palomo
Publisher: World Scientific
Total Pages: 350
Release: 2021-03-15
Genre: Science
ISBN: 1786349639

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Iron Catalysis: Design and Applications is an exciting new book that takes readers inside the world of iron catalysis guided by international catalysis expert, Dr Jose M Palomo. Iron is the most abundant metal in the planet, cost-effective, environmentally friendly, with an easily manipulated remediation process. In the last few years the use of this nonprecious metal has gained extraordinary attention particularly for its potential as a catalyst in different areas. This book compiles a series of chapters describing the most significant advances in the last few years since the design of different iron catalysts and nanocatalysts and iron-containing artificial and natural enzymes. The chapters also cover its application in different areas of interest such as organic synthesis, environmental remediation, enzyme-like activities or the creation of novel types of electrodes for battery design.


Advances in Metallodrugs

Advances in Metallodrugs
Author: Shahid Ul-Islam
Publisher: John Wiley & Sons
Total Pages: 432
Release: 2020-07-08
Genre: Science
ISBN: 1119640423

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This book is organized into 12 important chapters that focus on the progress made by metal-based drugs as anticancer, antibacterial, antiviral, anti-inflammatory, and anti-neurodegenerative agents, as well as highlights the application areas of newly discovered metallodrugs. It can prove beneficial for researchers, investigators and scientists whose work involves inorganic and coordination chemistry, medical science, pharmacy, biotechnology and biomedical engineering.


Transition Metal-Catalyzed Carbene Transformations

Transition Metal-Catalyzed Carbene Transformations
Author: Jianbo Wang
Publisher: John Wiley & Sons
Total Pages: 450
Release: 2022-05-16
Genre: Science
ISBN: 3527347992

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Presents an up-to-date overview of the rapidly growing field of carbene transformations Carbene transformations have had an enormous impact on catalysis and organometallic chemistry. With the growth of transition metal-catalyzed carbene transformations in recent decades, carbene transformations are today an important compound class in organic synthesis as well as in the pharmaceutical and agrochemical industries. Edited by leading experts in the field, Transition Metal-Catalyzed Carbene Transformations is a thorough summary of the most recent advances in the rapidly expanding research area. This authoritative volume covers different reaction types such as ring forming reactions and rearrangement reactions, details their conditions and properties, and provides readers with accurate information on a wide range of carbene reactions. Twelve in-depth chapters address topics including carbene C-H bond insertion in alkane functionalization, the application of engineered enzymes in asymmetric carbene transfer, progress in transition-metal-catalyzed cross-coupling using carbene precursors, and more. Throughout the text, the authors highlight novel catalytic systems, transformations, and applications of transition-metal-catalyzed carbene transfer. Highlights the dynamic nature of the field of transition-metal-catalyzed carbene transformations Summarizes the catalytic radical approach for selective carbene cyclopropanation, high enantioselectivity in X-H insertions, and bio-inspired carbene transformations Introduces chiral N,N'-dioxide and chiral guanidine-based catalysts and different transformations with gold catalysis Discusses approaches in cycloaddition reactions with metal carbenes and polymerization with carbene transformations Outlines multicomponent reactions through gem-difunctionalization and transition-metal-catalyzed cross-coupling using carbene precursors Transition Metal-Catalyzed Carbene Transformations is essential reading for all chemists involved in organometallics, including organic and inorganic chemists, catalytic chemists, and chemists working in industry.


Organic Synthesis with Enzymes in Non-Aqueous Media

Organic Synthesis with Enzymes in Non-Aqueous Media
Author: Giacomo Carrea
Publisher: John Wiley & Sons
Total Pages: 328
Release: 2008-04-09
Genre: Science
ISBN: 3527621733

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Closing a gap in the literature, this comprehensive book examines and discusses different non-aqueous systems from organic solvents to ionic liquids for synthetic applications, thus opening the door to new successful methods for biocatalytic reactions. It gathers into one handy source the information otherwise widely spread throughout the literature, combining useful background information with a number of synthetic examples, including industrial scale processes for pharmaceutical and fine chemicals. Extremely well structured, the text introduces the fundamentals of non-aqueous enzymology, before going on to new reaction media and synthetic applications using hydrolases and non-hydrolytic enzymes. The one-stop reference for everyone working in this hot field.