Advances In Nucleic Acid Therapeutics PDF Download
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Author | : Michael J Gait |
Publisher | : Royal Society of Chemistry |
Total Pages | : 566 |
Release | : 2019-02-11 |
Genre | : Science |
ISBN | : 1788012097 |
Download Advances in Nucleic Acid Therapeutics Book in PDF, ePub and Kindle
The sequencing of the human genome and subsequent elucidation of the molecular pathways that are important in the pathology of disease have provided unprecedented opportunities for the development of new therapeutics. Nucleic acid-based drugs have emerged in recent years to yield extremely promising candidates for drug therapy to a wide range of diseases. Advances in Nucleic Acid Therapeutics is a comprehensive review of the latest advances in the field, covering the background of the development of nucleic acids for therapeutic purposes to the array of drug development approaches currently being pursued using antisense, RNAi, aptamer, immune modulatory and other synthetic oligonucleotides. Nucleic acid therapeutics is a field that has been continually innovating to meet the challenges of drug discovery and development; bringing contributions together from leaders at the forefront of progress, this book depicts the many approaches currently being pursued in both academia and industry. A go-to volume for medicinal chemists, Advances in Nucleic Acid Therapeutics provides a broad overview of techniques of contemporary interest in drug discovery.
Author | : Surendra Nimesh |
Publisher | : Woodhead Publishing |
Total Pages | : 258 |
Release | : 2017-04-04 |
Genre | : Medical |
ISBN | : 0081005636 |
Download Advances in Nanomedicine for the Delivery of Therapeutic Nucleic Acids Book in PDF, ePub and Kindle
Advances in Nanomedicine for the Delivery of Therapeutic Nucleic Acids addresses several issues related to safe and effective delivery of nucleic acids (NAs) using nanoparticles. A further emphasis would be laid on the mechanism of delivery of NAs, the barriers encountered and the strategies adapted to combat them. An exhaustive account of the advantages as well shortcomings of all the delivery vectors being employed in delivery of various NAs will be provided. On final note the regulatory aspects of nanoparticles mediated NA would be discussed, with focus on their clinical relevance. The design and development of nucleic acid-based therapeutics for the treatment of diseases arising from genetic abnormalities has made significant progress over the past few years. NAs have been widely explored for the treatment of cancer and infectious diseases or to block cell proliferation and thereby caused diseases. Advances in synthetic oligonucleotide chemistry resulted in synthesis of NAs that are relatively stable in in vivo environments. However, cellular targeting and intracellular delivery of NAs still remains a challenge. Further development of NA-based therapeutics depends on the progress of safe and effective carriers for systemic administration. Nanomedicine has facilitated availability of vectors with diminished cytotoxicity and enhanced efficacy which are rapidly emerging as systems of choice. These vectors protect NAs from enzymatic degradation by forming condensed complexes along with targeted tissue and cellular delivery. During the past few years, a myriad reports have appeared reporting delivery of NAs mediated by nanoparticles. This book will provide an overview of nanoparticles being employed in the in vitro and in vivo delivery of therapeutically relevant NAs like DNA, siRNA, LNA, PNA, etc. Provides a complete overview of the applicatiosn of nanomedicine in the delivery of nucleic acids, from characterization of nanoparticles, to in vitro and in vivo studies Discusses delivery issues of less well explored nucleic acids, like PNAs, Ribozymes, DNAzymes, etc. Summarizes the current state of research in nucleic acid delivery and underscores the future of nanomedicine in this field
Author | : Paloma H. Giangrande |
Publisher | : Academic Press |
Total Pages | : 474 |
Release | : 2022-04-10 |
Genre | : Science |
ISBN | : 0128217391 |
Download RNA Therapeutics Book in PDF, ePub and Kindle
RNA Therapeutics: The Evolving Landscape of RNA Therapeutics provides a comprehensive overview of RNA therapeutic modalities, from bench-to-bedside, with an emphasis on the increasingly impactful areas of gene therapy, oligonucleotide therapeutics, gene editing and delivery. International leaders in the field examine RNA-based therapeutics tools that have been developed to-date to modulate cellular processes such as transcription, translation and protein function. Approved RNA-based therapies and lessons learned from failed therapies are discussed in-depth, as are evolving advances in RNA biochemical analysis, and similar advances that are enabling clinical application of RNA-based therapies. Later sections discuss delivery technologies, remaining hurdles in research and translation, the therapy development process from the lab to the clinic, and novel RNA-based therapies currently in development. Features leading experts in the field of RNA therapeutics, spanning all classes of RNA therapies Provides a detailed examination of approved RNA therapies and lessons learned from failed therapeutics Covers all aspects of therapeutic discovery and preclinical development, as well as clinical translation, manufacturing and regulatory aspects
Author | : Jens Kurreck |
Publisher | : Royal Society of Chemistry |
Total Pages | : 362 |
Release | : 2008 |
Genre | : Medical |
ISBN | : 0854041168 |
Download Therapeutic Oligonucleotides Book in PDF, ePub and Kindle
This book provides a compelling overall update on current status of RNA interference
Author | : |
Publisher | : |
Total Pages | : |
Release | : 2015 |
Genre | : |
ISBN | : |
Download Recent Advances in Nucleic Acid Therapeutics Book in PDF, ePub and Kindle
Author | : Alan M. Gewirtz |
Publisher | : Springer Science & Business Media |
Total Pages | : 300 |
Release | : 2004-03-25 |
Genre | : Medical |
ISBN | : 1592597777 |
Download Nucleic Acid Therapeutics in Cancer Book in PDF, ePub and Kindle
A cutting-edge review of the important issues underlying the therapeutic use of nucleic acid-mediated gene silencing. Topics range from basic methodology and delivery to targeting and clinical targets. The authors thoroughly explain the latest developments in RNA biology, as well as the underpinnings of RNA interference, oligodeoxynucleotide delivery into cells, and strategies for targeting these molecules to accessible regions within the mRNA. They also provide some examples of how these new therapeutic compounds are being used clinically.
Author | : Olga N. Ilinskaya |
Publisher | : Frontiers Media SA |
Total Pages | : 251 |
Release | : 2020-06-04 |
Genre | : RNA targeting |
ISBN | : 2889637751 |
Download New Advances in RNA Targeting Book in PDF, ePub and Kindle
Author | : |
Publisher | : |
Total Pages | : |
Release | : 2015 |
Genre | : |
ISBN | : 9781910419946 |
Download Advances and challenges in the delivery of nucleic acid therapeutics Book in PDF, ePub and Kindle
Author | : Marco Filice |
Publisher | : Elsevier |
Total Pages | : 0 |
Release | : 2019-02-28 |
Genre | : Technology & Engineering |
ISBN | : 9780128144701 |
Download Nucleic Acid Nanotheranostics Book in PDF, ePub and Kindle
Nucleic Acid Nanotheranostics: Biomedical Applications offers a comprehensive overview of improvements and new trends in fabrication of nanostructures as theranostic multifunctional carriers in gene therapy. With a strong focus on medical applications (comprising diagnosis, therapy and imaging), the book also examines gene therapy in an individual patient's cells or tissues to treat genetic diseases. Sections cover Biomedical and Diagnostic applications of Nucleic Acids, Biologic and Synthetic Advanced Nanostructures for nucleic acid delivery, and important considerations of nanomedicine. This book is a valuable guide for materials scientists, physicians, chemists and engineers, but is also ideal for clinicians wishing to expand their knowledge.
Author | : Akira Murakami |
Publisher | : Springer |
Total Pages | : 189 |
Release | : 2012-07-04 |
Genre | : Technology & Engineering |
ISBN | : 364230463X |
Download Nucleic Acid Drugs Book in PDF, ePub and Kindle
New Antisense Strategies: Chemical Synthesis of RNA Oligomers, by Junichi Yano und Gerald E. Smyth Development and Modification of Decoy Oligodeoxynucleotides for Clinical Application, by Mariana Kiomy Osako, Hironori Nakagami und Ryuichi Morishita Modulation of Endosomal Toll-Like Receptor-Mediated Immune Responses by Synthetic Oligonucleotides, by Ekambar R. Kandimalla und Sudhir Agrawal Delivery of Nucleic Acid Drugs, by Yan Lee und Kazunori Kataoka Aptamer: Biology to Applications, by Yoshikazu Nakamura Development and Clinical Applications of Nucleic Acid Therapeutics, by Veenu Aishwarya, Anna Kalota und Alan M. Gewirtz