Advances In Nanomedicine For The Delivery Of Therapeutic Nucleic Acids PDF Download
Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download Advances In Nanomedicine For The Delivery Of Therapeutic Nucleic Acids PDF full book. Access full book title Advances In Nanomedicine For The Delivery Of Therapeutic Nucleic Acids.
Author | : Surendra Nimesh |
Publisher | : Woodhead Publishing |
Total Pages | : 256 |
Release | : 2017-04-04 |
Genre | : Science |
ISBN | : 0081005636 |
Download Advances in Nanomedicine for the Delivery of Therapeutic Nucleic Acids Book in PDF, ePub and Kindle
Advances in Nanomedicine for the Delivery of Therapeutic Nucleic Acids addresses several issues related to safe and effective delivery of nucleic acids (NAs) using nanoparticles. A further emphasis would be laid on the mechanism of delivery of NAs, the barriers encountered and the strategies adapted to combat them. An exhaustive account of the advantages as well shortcomings of all the delivery vectors being employed in delivery of various NAs will be provided. On final note the regulatory aspects of nanoparticles mediated NA would be discussed, with focus on their clinical relevance. The design and development of nucleic acid-based therapeutics for the treatment of diseases arising from genetic abnormalities has made significant progress over the past few years. NAs have been widely explored for the treatment of cancer and infectious diseases or to block cell proliferation and thereby caused diseases. Advances in synthetic oligonucleotide chemistry resulted in synthesis of NAs that are relatively stable in in vivo environments. However, cellular targeting and intracellular delivery of NAs still remains a challenge. Further development of NA-based therapeutics depends on the progress of safe and effective carriers for systemic administration. Nanomedicine has facilitated availability of vectors with diminished cytotoxicity and enhanced efficacy which are rapidly emerging as systems of choice. These vectors protect NAs from enzymatic degradation by forming condensed complexes along with targeted tissue and cellular delivery. During the past few years, a myriad reports have appeared reporting delivery of NAs mediated by nanoparticles. This book will provide an overview of nanoparticles being employed in the in vitro and in vivo delivery of therapeutically relevant NAs like DNA, siRNA, LNA, PNA, etc. Provides a complete overview of the applicatiosn of nanomedicine in the delivery of nucleic acids, from characterization of nanoparticles, to in vitro and in vivo studies Discusses delivery issues of less well explored nucleic acids, like PNAs, Ribozymes, DNAzymes, etc. Summarizes the current state of research in nucleic acid delivery and underscores the future of nanomedicine in this field
Author | : Dan Peer |
Publisher | : CRC Press |
Total Pages | : 232 |
Release | : 2013-03-27 |
Genre | : Medical |
ISBN | : 9814411051 |
Download Nanotechnology for the Delivery of Therapeutic Nucleic Acids Book in PDF, ePub and Kindle
Nucleic acid (NA) therapeutics has been extensively studied both in the academia and in the pharmaceutical industry and is still considered the promise for new therapeutic modalities, especially in personalized medicine. The only hurdle that limits the translation of NA therapeutics from an academic idea to the new therapeutic modality is the lack
Author | : Loutfy H. Madkour |
Publisher | : Academic Press |
Total Pages | : 650 |
Release | : 2019-08-27 |
Genre | : Business & Economics |
ISBN | : 0128197781 |
Download Nucleic Acids as Gene Anticancer Drug Delivery Therapy Book in PDF, ePub and Kindle
Nucleic Acids as Gene Anticancer Drug Delivery Therapy highlights the most recent developments in cancer treatment using nucleic acids, nanoparticles and polymer nanoparticles for genomic nanocarriers as drug delivery, including promising opportunities for targeted and combination therapy. The development of a wide spectrum of nanoscale technologies is beginning to change the scientific landscape in terms of disease diagnosis, treatment, and prevention. This book presents the use of nanotechnology for medical applications, focusing on its use for anticancer drug delivery. Various intelligent drug delivery systems such as inorganic nanoparticles and polymer-based drug delivery are discussed. The use of smart drug delivery systems seems to be a promising approach for developing intelligent therapeutic systems for cancer immunotherapies and is discussed in detail along with nucleic acid-targeted drug delivery combination therapy for cancer. Nucleic Acids as Gene Anticancer Drug Delivery Therapy will be a useful reference for pharmaceutical scientists, pharmacologiests, and those involved in nanotechnology and cancer research. Discusses intelligent drug delivery systems such as inorganic nanoparticles and polymer-based drug delivery Contains a comprehensive comparison of various delivery systems, listing their advantages and limitations Presents combination therapy as a new hope for enhancing current gene-based treatment efficacy
Author | : Jens Kurreck |
Publisher | : Royal Society of Chemistry |
Total Pages | : 362 |
Release | : 2008 |
Genre | : Medical |
ISBN | : 0854041168 |
Download Therapeutic Oligonucleotides Book in PDF, ePub and Kindle
This book provides a compelling overall update on current status of RNA interference
Author | : Peixuan Guo |
Publisher | : CRC Press |
Total Pages | : 1013 |
Release | : 2022-07-18 |
Genre | : Medical |
ISBN | : 100055273X |
Download RNA Nanotechnology and Therapeutics Book in PDF, ePub and Kindle
Interest in RNA nanotechnology has increased in recent years as recognition of its potential for applications in nanomedicine has grown. Edited by the world's foremost experts in nanomedicine, this comprehensive, state-of-the-art reference details the latest research developments and challenges in the biophysical and single molecule approaches in RNA nanotechnology. In addition, the text also provides in-depth discussions of RNA structure for nanoparticle construction, RNA computation and modeling, single molecule imaging of RNA, RNA nanoparticle assembly, RNA nanoparticles in therapeutics, immunorecognition of RNA nanomaterials, RNA chemistry for nanoparticle synthesis, and conjugation and labeling. Presents the latest research and discoveries in RNA nanotechnology Features contributions from world-class experts in the field Covers RNA nanoparticles in therapeutics Describes self-assembled RNA nanoparticles
Author | : Marco Filice |
Publisher | : Elsevier |
Total Pages | : 0 |
Release | : 2019-02-28 |
Genre | : Technology & Engineering |
ISBN | : 9780128144701 |
Download Nucleic Acid Nanotheranostics Book in PDF, ePub and Kindle
Nucleic Acid Nanotheranostics: Biomedical Applications offers a comprehensive overview of improvements and new trends in fabrication of nanostructures as theranostic multifunctional carriers in gene therapy. With a strong focus on medical applications (comprising diagnosis, therapy and imaging), the book also examines gene therapy in an individual patient's cells or tissues to treat genetic diseases. Sections cover Biomedical and Diagnostic applications of Nucleic Acids, Biologic and Synthetic Advanced Nanostructures for nucleic acid delivery, and important considerations of nanomedicine. This book is a valuable guide for materials scientists, physicians, chemists and engineers, but is also ideal for clinicians wishing to expand their knowledge.
Author | : Marco Filice |
Publisher | : Elsevier |
Total Pages | : 491 |
Release | : 2019-02-26 |
Genre | : Technology & Engineering |
ISBN | : 0128144718 |
Download Nucleic Acid Nanotheranostics Book in PDF, ePub and Kindle
Nucleic Acid Nanotheranostics: Biomedical Applications offers a comprehensive overview of improvements and new trends in fabrication of nanostructures as theranostic multifunctional carriers in gene therapy. With a strong focus on medical applications (comprising diagnosis, therapy and imaging), the book also examines gene therapy in an individual patient’s cells or tissues to treat genetic diseases. Sections cover Biomedical and Diagnostic applications of Nucleic Acids, Biologic and Synthetic Advanced Nanostructures for nucleic acid delivery, and important considerations of nanomedicine. This book is a valuable guide for materials scientists, physicians, chemists and engineers, but is also ideal for clinicians wishing to expand their knowledge. Provides a unique source of knowledge (theoretical as well as practical) on nanotheranostic materials for gene therapy at all levels and related scientific areas Covers the pros and cons related to viral and nanomaterial-based delivery of nucleic acids in terms of biosafety, carrier selection, synthesis and bioimaging Presents the only book to include an analysis of nanoformulations approved for clinical use
Author | : Yunfeng Lin |
Publisher | : Springer Nature |
Total Pages | : 227 |
Release | : 2021-08-20 |
Genre | : Medical |
ISBN | : 9811626669 |
Download Advances in Nanomaterials-based Cell Biology Research Book in PDF, ePub and Kindle
This book aims to comprehensively summarize the current research status of nanomaterials and cell biology. It highlights the biological effects and biomedical applications of nanomaterials for specific diseases, bone tissue engineering, and skeletal muscle regeneration. It also provides the details of the biomedical applications of nucleic acid nanomaterials in drug delivery carriers, antimicrobial therapy, vaccine, and neurodegenerative diseases. Therefore, this book renders the audience a better understanding of nanomaterials along with the diverse applications in the cell biology field from recent works to perspectives.
Author | : Kirill A. Afonin |
Publisher | : CRC Press |
Total Pages | : 1229 |
Release | : 2021-07-21 |
Genre | : Medical |
ISBN | : 1000263177 |
Download Therapeutic RNA Nanotechnology Book in PDF, ePub and Kindle
This collection of research articles and reviews covers the latest work in the design, delivery, dynamic abilities, and immune stimulation of RNA nanoparticles which have driven the utilization of their immunomodulatory properties. The unknown immune properties of nucleic acid nanoparticles have been a major hurdle in their adaptation until the works herein began assessing their structure-activity relationships. This collection chronologically follows the path of investigating the recognition of design components to implementing them into nucleic acid nanostructures. RNA nanotechnology is an emerging platform for therapeutics with increasing clinical relevance as this approach becomes more widely used and approved for the treatment of various diseases. The latest research aims to take advantage of RNA’s modular nature for the design of nanostructures which can interact with their environments to communicate programmed messages with intracellular pathways. In doing so, nanoparticles can be used to elicit or elude responses by the immune system as desired in conjunction with their therapeutic applications.
Author | : Nathan Beals |
Publisher | : |
Total Pages | : 451 |
Release | : 2018 |
Genre | : Nanostructured materials |
ISBN | : |
Download Evaluation of the Delivery and Targeting of Nucleic Acid Based Nanomaterials for Therapeutic Application Book in PDF, ePub and Kindle
Nanotechnology is based around creating new materials with distinct and different properties for the advancement of applications in biosensing, cellular delivery, theranostics, bioelectronics, bio-computers among many others. As materials are modulated and created to be made on the nanoscale, altered physicochemical properties can be exploited for new functions. Nanomaterial application can change drastically based on the disposition of the material. Nucleic acids have been increasingly examined for pairing with nanomaterials or being used autonomously as a nanomaterial, due to the unique ability to control structure, size and function at the molecular level. Independently or in combination with nanomaterials, nucleic acids offer precise control and properties not commonly found in nanotechnology. My research will highlight this relationship in three distinctly different ways: 1) Using DNA aptamers within a multipart nanoparticle complex to target specific cells, not only improving efficacy of the delivered therapeutic agent but also reducing non-specific side effects 2) Examining intracellular hydrogel formation where a DNA sequence is used as potassium dependent switch, creating a new mechanism for targeted cytotoxicity 3) Nanomaterial drug delivery systems to overcome the negative attributes RNA and DNA therapeutics may have. The third arm of this work will explain the delivery of thiolated siRNAs, piRNAs and DNAs in gold nanoparticle complexes, but also expand upon a new strategy to incorporate modified nucleotides within DNA plasmid sequences as a tethering beacon for nanomaterial conjugation as a scaffold for protection and targeting. I hope to emphasize the diverse ways nucleic acids and nanotechnology can be paired which could lead into potential new insights and advancements for clinical application in the future.