Advanced Cell Culture Technologies To Boost Cell Based Therapies PDF Download
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| Author | : Dominik Egger |
| Publisher | : Frontiers Media SA |
| Total Pages | : 183 |
| Release | : 2021-09-15 |
| Genre | : Science |
| ISBN | : 288971330X |
Download Advanced Cell Culture Technologies to Boost Cell-Based Therapies Book in PDF, ePub and Kindle
Dr. Correa is the founder of Lumos Biomed Consulting and holds shares in Cryovida Stem Cell Bank (Mexico). Dr O’Brien holds patents related to regeneration technology and was a co-founder of SurgaColl Technologies. All other Topic Editors declare no competing interests with regard to the Research Topic subject.
| Author | : Sadettin Ozturk |
| Publisher | : CRC Press |
| Total Pages | : 788 |
| Release | : 2005-08-30 |
| Genre | : Medical |
| ISBN | : 0849351065 |
Download Cell Culture Technology for Pharmaceutical and Cell-Based Therapies Book in PDF, ePub and Kindle
Edited by two of the most distinguished pioneers in genetic manipulation and bioprocess technology, this bestselling reference presents a comprehensive overview of current cell culture technology used in the pharmaceutical industry. Contributions from several leading researchers showcase the importance of gene discovery and genomic technology devel
| Author | : |
| Publisher | : |
| Total Pages | : 320 |
| Release | : 1989 |
| Genre | : Cell culture |
| ISBN | : |
Download Advances in Cell Culture Book in PDF, ePub and Kindle
| Author | : Yi-Chen Ethan Li |
| Publisher | : CRC Press |
| Total Pages | : 346 |
| Release | : 2023-12-01 |
| Genre | : Science |
| ISBN | : 1003822746 |
Download Stem Cell-based Biosystems Book in PDF, ePub and Kindle
Stem cell science has emerged as a novel discipline in biomedical research over the past decade. With advancements in this field, stem cells have demonstrated versatile applications ranging from basic research to clinical case studies. Recognizing the demand for knowledge in stem cell applications, this book aims to provide comprehensive information on stem cell technology and its application in biosystems. It covers fundamental culture methods, advanced stem cell-based biosystems, and clinical case studies of stem cell therapy. This book is intended for individuals with an interest in stem cell science, offering valuable insights into this rapidly evolving field.
| Author | : Radwa Ali Mehanna |
| Publisher | : BoD – Books on Demand |
| Total Pages | : 294 |
| Release | : 2019-01-23 |
| Genre | : Science |
| ISBN | : 1789848660 |
Download Cell Culture Book in PDF, ePub and Kindle
Cell culture is one of the major tools used in cellular and molecular biology, delivering an excellent model for studying the normal physiology and biochemistry of cells. This book covers some advanced aspects in cell culture methodologies. The book has four sections discussing different types of cell culture models, including 3D cell culture techniques, their advantages, and limitations in comparison to traditional 2D culturing; cell viability, autophagy, in vitro toxicity tests and live cell imaging; stem cell culture for cell-based therapeutics; and specific applications and methodologies for hybrid cell lines and cancer models. This book provides a comprehensive overview of some of the advanced cell culture methodologies and applications. It serves as a valuable source for scientists, researchers, clinicians and students.
| Author | : Joaquim M. S. Cabral |
| Publisher | : Elsevier |
| Total Pages | : 340 |
| Release | : 2016-07-24 |
| Genre | : Medical |
| ISBN | : 0444632662 |
Download Stem Cell Manufacturing Book in PDF, ePub and Kindle
Stem Cell Manufacturing discusses the required technologies that enable the transfer of the current laboratory-based practice of stem cell tissue culture to the clinic environment as therapeutics, while concurrently achieving control, reproducibility, automation, validation, and safety of the process and the product. The advent of stem cell research unveiled the therapeutic potential of stem cells and their derivatives and increased the awareness of the public and scientific community for the topic. The successful manufacturing of stem cells and their derivatives is expected to have a positive impact in the society since it will contribute to widen the offer of therapeutic solutions to the patients. Fully defined cellular products can be used to restore the structure and function of damaged tissues and organs and to develop stem cell-based cellular therapies for the treatment of cancer and hematological disorders, autoimmune and other inflammatory diseases and genetic disorders. Presents the first ‘Flowchart‘ of stem cell manufacturing enabling easy understanding of the various processes in a sequential and coherent manner Covers all bioprocess technologies required for the transfer of the bench findings to the clinic including the process components: cell signals, bioreactors, modeling, automation, safety, etc. Presents comprehensive coverage of a true multidisciplinary topic by bringing together specialists in their particular area Provides the basics of the processes and identifies the issues to be resolved for large scale cell culture by the bioengineer Addresses the critical need in bioprocessing for the successful delivery of stem cell technology to the market place by involving professional engineers in sections of the book
| Author | : Xiao-Dong Chen |
| Publisher | : Academic Press |
| Total Pages | : 544 |
| Release | : 2018-08-31 |
| Genre | : Science |
| ISBN | : 0128119217 |
Download A Roadmap to Nonhematopoietic Stem Cell-Based Therapeutics Book in PDF, ePub and Kindle
A Roadmap to Non-hematopoietic Stem Cell-Based Therapeutics: From the Bench to the Clinic is a resource that provides an overview of the principles of stem cell therapy, the promises and challenges of using stem cells for treating various clinical conditions, and future perspectives. The overall goal is to facilitate the translation of basic research on stem cells to clinical applications. The properties of stem cells from various sources are reviewed and the advantages and disadvantages of each for clinical use are discussed. Modifying stem cell properties through preconditioning strategies using physical, chemical, genetic, and molecular manipulation to improve cell survival, increase cell differentiation potential, enhance production of paracrine factors, and facilitate homing to the site of injury or disease upon transplantation are reviewed. Various routes of stem cell administration and dosing, and the duration of effects, are explored. Individual chapters are written by experts in the field and focus on the use of stem cells in treating various degenerative diseases, autoimmune diseases, wound healing, cardiovascular disease, spinal cord injury, oral and dental diseases, and skeletal disorders. Finally, experts in the regulatory arena discuss mechanisms used in different countries for approving the use of stem cells to treat diseases and many common issues that are typically encountered while seeking approval for this class of therapeutic agent. Offers advanced students, as well as new researchers, an overview of the principles of stem cell therapy Discusses a wide array of pressing clinical issues with stem cell-based therapies so that new ideas in the laboratory can be efficiently translated to the clinic through better designed clinical trials Helps clarify current regulatory mechanisms so that the safe use of stem cells for treating a variety of diseases can move forward Fosters cross-disciplinary dialogue between research scientists and physicians to accelerate the safe implementation of efficacious cell therapies
| Author | : Wei-Shu Hu |
| Publisher | : Springer |
| Total Pages | : 179 |
| Release | : 2006-08-16 |
| Genre | : Science |
| ISBN | : 3540340076 |
Download Cell Culture Engineering Book in PDF, ePub and Kindle
Since the introduction of recombinant human growth hormone and insulin a quarter century ago, protein therapeutics has greatly broadened the ho- zon of health care. Many patients suffering with life-threatening diseases or chronic dysfunctions, which were medically untreatable not long ago, can attest to the wonder these drugs have achieved. Although the ?rst generation of p- tein therapeutics was produced in recombinant Escherichia coli, most recent products use mammalian cells as production hosts. Not long after the ?rst p- duction of recombinant proteins in E. coli, it was realized that the complex tasks of most post-translational modi?cations on proteins could only be ef?ciently carried out in mammalian cells. In the 1990s, we witnessed a rapid expansion of mammalian-cell-derived protein therapeutics, chie?y antibodies. In fact, it has been nearly a decade since the market value of mammalian-cell-derived protein therapeutics surpassed that of those produced from E. coli. A common characteristic of recent antibody products is the relatively large dose required for effective therapy, demanding larger quantities for the treatment of a given disease. This, coupled with the broadening repertoire of protein drugs, has rapidly expanded the quantity needed for clinical applications. The increasing demand for protein therapeutics has not been met exclusively by construction of new manufacturing plants and increasing total volume capacity. More - portantly the productivity of cell culture processes has been driven upward by an order of magnitude in the past decade.
| Author | : Cornelia Kasper |
| Publisher | : |
| Total Pages | : 168 |
| Release | : 2018 |
| Genre | : Cell culture |
| ISBN | : 9783319748559 |
Download Cell Culture Technology Book in PDF, ePub and Kindle
This textbook provides an overview on current cell culture techniques, conditions, and applications specifically focusing on human cell culture. This book is based on lectures, seminars and practical courses in stem cells, tissue engineering, regenerative medicine and 3D cell culture held at the University of Natural Resources and Life Sciences Vienna BOKU and the Gottfried Wilhelm Leibniz University Hannover, complemented by contributions from international experts, and therefore delivers in a compact and clear way important theoretical, as well as practical knowledge to advanced graduate students on cell culture techniques and the current status of research.
| Author | : Mohamed Al-Rubeai |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 259 |
| Release | : 2009-08-11 |
| Genre | : Medical |
| ISBN | : 9048122457 |
Download Cell Line Development Book in PDF, ePub and Kindle
Mammalian cell lines command an effective monopoly for the production of therapeutic proteins that require post-translational modifications. This unique advantage outweighs the costs associated with mammalian cell culture, which are far grater in terms of development time and manufacturing when compared to microbial culture. The development of cell lines has undergone several advances over the years, essentially to meet the requirement to cut the time and costs associated with using such a complex hosts as production platforms. This book provides a comprehensive guide to the methodology involved in the development of cell lines and the cell engineering approach that can be employed to enhance productivity, improve cell function, glycosylation and secretion and control apoptosis. It presents an overall picture of the current topics central to expression engineering including such topics as epigenetics and the use of technologies to overcome positional dependent inactivation, the use of promoter and enhancer sequences for expression of various transgenes, site directed engineering of defined chromosomal sites, and examination of the role of eukaryotic nucleus as the controller of expression of genes that are introduced for production of a desired product. It includes a review of selection methods for high producers and an application developed by a major biopharmaceutical industry to expedite the cell line development process. The potential of cell engineering approch to enhance cell lines through the manipulation of single genes that play important roles in key metabolic and regulatory pathways is also explored throughout.
