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Acceleration and Improvement of Protein Identification by Mass Spectrometry

Acceleration and Improvement of Protein Identification by Mass Spectrometry
Author: Willy Vincent Bienvenut
Publisher: Springer Science & Business Media
Total Pages: 324
Release: 2005-04-19
Genre: Medical
ISBN: 9781402033186

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At present where protein identification and characterisation using mass spectrometry is a method of choice, this book is presenting a review of basic proteomic techniques. The second part of the book is related to the novel high throughput protein identification technique called the 'molecular scanner'. Several protein identification techniques are described, especially the peptide mass fingerprint with MALDI-MS based method. E.g. ionisation process, matrix available, signal reproducibility and suppression effect, as well as date treatment for protein identification using bioinformatics tools.


Protein Analysis using Mass Spectrometry

Protein Analysis using Mass Spectrometry
Author: Mike S. Lee
Publisher: John Wiley & Sons
Total Pages: 290
Release: 2017-06-19
Genre: Science
ISBN: 1118605195

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Presents Practical Applications of Mass Spectrometry for Protein Analysis and Covers Their Impact on Accelerating Drug Discovery and Development Covers both qualitative and quantitative aspects of Mass Spectrometry protein analysis in drug discovery Principles, Instrumentation, Technologies topics include MS of peptides, proteins, and ADCs , instrumentation in protein analysis, nanospray technology in MS protein analysis, and automation in MS protein analysis Details emerging areas from drug monitoring to patient care such as Identification and validation of biomarkers for cancer, targeted MS approaches for biomarker validation, biomarker discovery, and regulatory perspectives Brings together the most current advances in the mass spectrometry technology and related method in protein analysis


Computer-Supported Cooperative Work

Computer-Supported Cooperative Work
Author: Uwe M. Borghoff
Publisher: Springer Science & Business Media
Total Pages: 1342
Release: 2000-07-14
Genre: Business & Economics
ISBN: 9783540669845

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A detailed introduction to interdisciplinary application area of distributed systems, namely the computer support of individuals trying to solve a problem in cooperation with each other but not necessarily having identical work places or working times. The book is addressed to students of distributed systems, communications, information science and socio-organizational theory, as well as to users and developers of systems with group communication and cooperation as top priorities.


The Encyclopedia of Mass Spectrometry

The Encyclopedia of Mass Spectrometry
Author:
Publisher: Newnes
Total Pages: 407
Release: 2015-12-04
Genre: Science
ISBN: 0080913253

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Volume 9: Historical Perspectives, Part A: The Development of Mass Spectrometry of The Encyclopedia of Mass Spectrometry describes and analyzes the development of many aspects of Mass Spectrometry. Beginning with the earliest types of Mass Analyzers, Historical Perspectives explores the development of many different forms of analytical processes and methods. The work follows various instruments and interfaces, to the current state of detectors and computerization. It traces the use of Mass Spectrometry across many different disciplines, including Organic Chemistry, Biochemistry, and Proteomics; Environmental Mass Spectrometry; Forensic Science; Imaging; Medical Monitoring and Diagnosis; Earth and Planetary Sciences; and Nuclear Science. Finally, the book covers the history of manufacturers and societies as well as the professionals who form the Mass Spectrometry community. Also available: Volume 9: Historical Perspectives, Part B: Notable People in Mass Spectrometry briefly reviews the lives and works of many of the major people who carried out this development. Preserves the history and development of Mass Spectrometry for use across scientific fields Written and edited by Mass Spectrometry experts Coordinates with Volume 9: Historical Perspectives, Part B: Notable People in Mass Spectrometry, a collection of short biographies on many of the major people who carried out this development


Neuroproteomics

Neuroproteomics
Author: Oscar Alzate
Publisher: CRC Press
Total Pages: 356
Release: 2009-10-26
Genre: Medical
ISBN: 1420076264

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In this, the post-genomic age, our knowledge of biological systems continues to expand and progress. As the research becomes more focused, so too does the data. Genomic research progresses to proteomics and brings us to a deeper understanding of the behavior and function of protein clusters. And now proteomics gives way to neuroproteomics as we beg


Mass Spectrometry of Proteins and Peptides

Mass Spectrometry of Proteins and Peptides
Author: John R. Chapman
Publisher: Springer Science & Business Media
Total Pages: 539
Release: 2008-02-05
Genre: Science
ISBN: 1592590454

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Little more than three years down the line and I am already writing the Preface to a second volume to follow Protein and Peptide Analysis by Mass . What has happened in between these times to make this second venture worthwhile? New types of mass spectrometric instrumentation have appeared so that new techniques have become possible and existing techniques have become much more feasible. More particularly, however, the newer ionization te- niques, introduced for the analysis of high molecular weight materials, have now been thoroughly used and studied. As a result, there has been an en- mous improvement in the associated sample handling technology so that these methods are now routinely applied to much smaller sample amounts as well as to more intractable samples. Again, this particular community of mass spectrometry users has both increased in number and diversified. And, riding this wave of acceptance, leaders in the field have set their sights on more complex problems: molecular interaction, ion structures, quantitation, and kinetics are just a few of the newer areas reported in Mass Spectrometry of Proteins and Peptides. As with the first volume, one purpose of this collection, Mass Spectr- etry of Proteins and Peptides, is to show the reader what can be done by the application of mass spectrometry, and perhaps even to encourage the reader to venture down new paths.


Protein Sequencing and Identification Using Tandem Mass Spectrometry

Protein Sequencing and Identification Using Tandem Mass Spectrometry
Author: Michael Kinter
Publisher: John Wiley & Sons
Total Pages: 321
Release: 2005-04-12
Genre: Science
ISBN: 0471231886

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How to design, execute, and interpret experiments for protein sequencing using mass spectrometry The rapid expansion of searchable protein and DNA databases in recent years has triggered an explosive growth in the application of mass spectrometry to protein sequencing. This timely and authoritative book provides professionals and scientists in biotechnology research with complete coverage of procedures for analyzing protein sequences by mass spectrometry, including step-by-step guidelines for sample preparation, analysis, and data interpretation. Michael Kinter and Nicholas Sherman present their own high-quality, laboratory-tested protocols for the analysis of a wide variety of samples, demonstrating how to carry out specific experiments and obtain fast, reliable results with a 99% success rate. Readers will get sufficient experimental detail to apply in their own laboratories, learn about the proper selection and operation of instruments, and gain essential insight into the fundamental principles of mass spectrometry and protein sequencing. Coverage includes: * Peptide fragmentation and interpretation of product ion spectra * Basic polyacrylamide gel electrophoresis * Preparation of protein digests for sequencing experiments * Mass spectrometric analysis using capillary liquid chromatography * Techniques for protein identification by database searches * Characterization of modified peptides using tandem mass spectrometry And much more


Mass Spectrometry in Drug Discovery

Mass Spectrometry in Drug Discovery
Author: David T. Rossi
Publisher: CRC Press
Total Pages: 436
Release: 2001-11-07
Genre: Medical
ISBN: 9781420002478

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Mass Spectrometry in Drug Discovery summarizes the theory, instrumentation, techniques, and application of mass spectrometry and atmospheric pressure ionization to screening, evaluating, and improving the performance and quality of drug candidates. It provides time- and cost-efficient approaches for the generation and analysis of effective pharmaceuticals, covers advances in combinatorial chemistry, molecular biology, bioanalysis automation, and computing, and demonstrates the use of mass spectrometry in the assessment of disease states, drug targets, and potential drug agents.


Genetics, Genomics and Breeding of Stone Fruits

Genetics, Genomics and Breeding of Stone Fruits
Author: Chittaranjan Kole
Publisher: CRC Press
Total Pages: 432
Release: 2012-08-17
Genre: Science
ISBN: 1578088011

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The stone fruits—including peaches, apricots, almonds, plums, and cherries—have been bred and grown for thousands of years and today are significant agricultural crops in many local economies worldwide. This volume presents a comprehensive commentary on classical genetics and breeding, molecular mapping and breeding of agronomic traits, and the cloning of genes of interest. It also explores recent advances on omics sciences including structural and functional genomics, proteomics, nd metabolomics. The book enumerates the whole genome sequencing of the model fruit plant peach and discusses bioinformatic strategies and tools for stone fruit research


Quantitative Proteomics by Mass Spectrometry

Quantitative Proteomics by Mass Spectrometry
Author: Salvatore Sechi
Publisher: Springer Science & Business Media
Total Pages: 223
Release: 2008-02-05
Genre: Science
ISBN: 1597452556

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This volume is a compendium of cutting-edge protocols for quantitative proteomics, and presents the most significant methods used in the field today. The focus on mass spectrometry (MS) is integral. Attention is given to state-of-the-art techniques for the characterization of the phosphoproteome and tandem MS for detection of inborn errors of metabolism. This volume is an indispensable resource in the search for novel biomarkers.