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Improving and Accelerating Therapeutic Development for Nervous System Disorders

Improving and Accelerating Therapeutic Development for Nervous System Disorders
Author: Institute of Medicine
Publisher: National Academies Press
Total Pages: 107
Release: 2014-02-06
Genre: Medical
ISBN: 0309292492

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Improving and Accelerating Therapeutic Development for Nervous System Disorders is the summary of a workshop convened by the IOM Forum on Neuroscience and Nervous System Disorders to examine opportunities to accelerate early phases of drug development for nervous system drug discovery. Workshop participants discussed challenges in neuroscience research for enabling faster entry of potential treatments into first-in-human trials, explored how new and emerging tools and technologies may improve the efficiency of research, and considered mechanisms to facilitate a more effective and efficient development pipeline. There are several challenges to the current drug development pipeline for nervous system disorders. The fundamental etiology and pathophysiology of many nervous system disorders are unknown and the brain is inaccessible to study, making it difficult to develop accurate models. Patient heterogeneity is high, disease pathology can occur years to decades before becoming clinically apparent, and diagnostic and treatment biomarkers are lacking. In addition, the lack of validated targets, limitations related to the predictive validity of animal models - the extent to which the model predicts clinical efficacy - and regulatory barriers can also impede translation and drug development for nervous system disorders. Improving and Accelerating Therapeutic Development for Nervous System Disorders identifies avenues for moving directly from cellular models to human trials, minimizing the need for animal models to test efficacy, and discusses the potential benefits and risks of such an approach. This report is a timely discussion of opportunities to improve early drug development with a focus toward preclinical trials.


Accelerating New Food Product Design and Development

Accelerating New Food Product Design and Development
Author: Jacqueline H. Beckley
Publisher: John Wiley & Sons
Total Pages: 416
Release: 2017-10-23
Genre: Technology & Engineering
ISBN: 1119149304

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Written primarily for directors and managers of food design and development, food scientists, technologists, and product developers, this book explains all the necessary information in order to help meet the increasing demands for innovation in an industry that is providing fewer resources. This updated edition, by a group of seasoned food industry business professionals and academics, provides a real-world perspective of what is occurring in the food industry right now, offers strategic frameworks for problem solving and R&D strategies, and presents methods needed to accelerate and optimize new product development. Accelerating New Food Product Design and Development, Second Edition features five brand new chapters covering all the changes that have occurred within the last decade: A Flavor Supplier Perspective, An Ingredient Supplier Perspective, Applying Processes that Accelerate New Product Development, Looking at How the University Prepares Someone for a Career in Food, and Innovative Packaging and Its Impact on Accelerated Product Development. Offers new perspectives on what really goes on during the development process Includes updated chapters fully describing the changes that have occurred in the food industry, both from a developer’s point of view as well as the consumer requirements Features a completely rewritten chapter covering the importance of packaging which is enhanced through 3D printing All of this against the impact on speed to market Filled with unique viewpoints of the business from those who really know and a plethora of new information, Accelerating New Food Product Design and Development, Second Edition will be of great interest to all professionals engaged in new food product design and development.


Accelerate

Accelerate
Author: Nicole Forsgren, PhD
Publisher: IT Revolution
Total Pages: 251
Release: 2018-03-27
Genre: Business & Economics
ISBN: 1942788355

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Winner of the Shingo Publication Award Accelerate your organization to win in the marketplace. How can we apply technology to drive business value? For years, we've been told that the performance of software delivery teams doesn't matter―that it can't provide a competitive advantage to our companies. Through four years of groundbreaking research to include data collected from the State of DevOps reports conducted with Puppet, Dr. Nicole Forsgren, Jez Humble, and Gene Kim set out to find a way to measure software delivery performance―and what drives it―using rigorous statistical methods. This book presents both the findings and the science behind that research, making the information accessible for readers to apply in their own organizations. Readers will discover how to measure the performance of their teams, and what capabilities they should invest in to drive higher performance. This book is ideal for management at every level.


Development

Development
Author: Ian Goldin
Publisher: Oxford University Press
Total Pages: 217
Release: 2018
Genre: Business & Economics
ISBN: 0198736258

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What is development -- How does development happen? -- Why are some countries rich and others poor? -- What can be done to accelerate development? -- The evolution of development aid -- Sustainable development -- Globalization and development -- The future of development.


Accelerating the Development of Biomarkers for Drug Safety

Accelerating the Development of Biomarkers for Drug Safety
Author: Institute of Medicine
Publisher: National Academies Press
Total Pages: 101
Release: 2009-07-20
Genre: Medical
ISBN: 0309142318

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Biomarkers can be defined as indicators of any biologic state, and they are central to the future of medicine. As the cost of developing drugs has risen in recent years, reducing the number of new drugs approved for use, biomarker development may be a way to cut costs, enhance safety, and provide a more focused and rational pathway to drug development. On October 24, 2008, the IOM's Forum on Drug Discovery, Development, and Translation held "Assessing and Accelerating Development of Biomarkers for Drug Safety," a one-day workshop, summarized in this volume, on the value of biomarkers in helping to determine drug safety during development.


Accelerating Innovation

Accelerating Innovation
Author: Marvin L. Patterson
Publisher: Van Nostrand Reinhold Company
Total Pages: 184
Release: 1993
Genre: Business & Economics
ISBN:

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"The time for rehashing America's lost battles on the world market has passed." "Now it's time to address a critical component of the economic battle plan: the product development process that creates the products that satisfy customer needs. How quickly these weapons of economic war are developed, how competitive they are, how timely they are deployed, and how supportable they are will determine the failure or success of American business in the 1990s." "Here is the right book at the right time...a concise blueprint to transform product development from a collection of ad hoc activities into an integrated, smoothly operating process. Written by the Director of Corporate Engineering for Hewlett-Packard, one of the most successfully innovative companies in America today, Accelerating Innovation shows how successful, well-tested concepts from the manufacturing domain can be readily transformed into the needy world of new product innovation." "Filled with clear-sighted analysis and practical explanations, this book will help management unleash innovation and creativity in development processes to meet the urgent need for bringing new technology to customers faster and more effectively than the competition." "Discover how to cope with the limited life span of today's products...anticipate changing consumer needs and desires...close the gap between new technology and products that apply it...bring leading-edge products to market fast...eliminate profit-threatening gaps between the "death" of obsolete products and the introduction of new ones...and enjoy higher returns on investment." "Accelerating Innovation provides a results-oriented model for transferring to product development the strategies that are moving manufacturers from the old era to the new one. Numerous real-life examples give you powerful insights into the time-based factoring and total quality management principles used so successfully in manufacturing and shows how to implement them in the product development cycle. Key chapters address how to shorten the innovation cycle time, applying the principle that success springs from focusing on the right issues; manage organization change so that change goes where you want it to go - and quickly, transfer quality principles used on the assembly line to the process of developing raw information and adding value to it, reduce innovation time by implementing the cost of quality principle (cost as a function of when an error is detected), manage information flow and bottlenecks, minimize changeover time; and much, much more." "Does your organization really have a handle on new product development? Are goals, objectives, processes, metrics, and controls in place? Are you equipped to create new products rationally and systematically, while continuously reducing innovation cycle times?" "Accelerating Innovation presents new thinking that will help you answer these questions with a resounding "yes." In product development, doing business the same old way is a formula for disaster. The time to act is long before the livelihood of the product development function is ever threatened. And if a company is trying to catch up, then it has to improve faster than its toughest competition if it ever expects to win." "Finally, here is a guide that can give you the critical advantage you need for success in product development - success that is no longer a luxury, but a necessity for survival."--BOOK JACKET.Title Summary field provided by Blackwell North America, Inc. All Rights Reserved


Rare Diseases and Orphan Products

Rare Diseases and Orphan Products
Author: Institute of Medicine
Publisher: National Academies Press
Total Pages: 442
Release: 2011-04-03
Genre: Medical
ISBN: 0309158060

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Rare diseases collectively affect millions of Americans of all ages, but developing drugs and medical devices to prevent, diagnose, and treat these conditions is challenging. The Institute of Medicine (IOM) recommends implementing an integrated national strategy to promote rare diseases research and product development.


Accelerating Your Development as a Leader

Accelerating Your Development as a Leader
Author: Robert Barner
Publisher: John Wiley & Sons
Total Pages: 165
Release: 2011-09-14
Genre: Business & Economics
ISBN: 0470937033

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An invaluable resource for HR professionals and executive coaches, this book focuses on how to reduce the time needed to prepare high-potential (HIPO) leaders for next-level positions. Providing the leading trends, tools, and techniques in the industry, the book demystifies the process of HIPO development. It includes a powerful five-step process for increasing leaders' readiness, as well as a complete set of tools for running workshops on developmental planning and coaching. This text also serves as a core text for the author's Executive Coaching Certificate Programs.


Accelerating Sustainable Energy Transition(s) in Developing Countries

Accelerating Sustainable Energy Transition(s) in Developing Countries
Author: Laurence L Delina
Publisher: Routledge
Total Pages: 207
Release: 2017-10-19
Genre: Business & Economics
ISBN: 1351726846

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Accelerating sustainable energy transitions away from carbon-based fuel sources needs to be high on the agendas of developing countries. It is key in achieving their climate mitigation promises and sustainable energy development objectives. To bring about rapid transitions, simultaneous turns are imperative in hardware deployment, policy improvements, financing innovation, and institutional strengthening. These systematic turns, however, incur tensions when considering the multiple options available and the disruptions of entrenched power across pockets of transition innovations. These heterogeneous contradictions and their trade-offs, and uncertainties and risks have to be systematically recognized, understood, and weighed when making decisions. This book explores how the transitions occur in fourteen developing countries and broadly surveys their technological, policy, financing, and institutional capacities in response to the three key aspects of energy transitions: achieving universal energy access, harvesting energy efficiency, and deploying renewable energy. The book shows how fragmented these approaches are, how they occur across multiple levels of governance, and how policy, financing, and institutional turns could occur in these complex settings. This book will be of interest to students and scholars of energy and climate policy, development studies, international relations, politics, strategic studies, and geography. It is also useful to policymakers and development practitioners.