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A Theory of the Basal Ganglia and Their Disorders

A Theory of the Basal Ganglia and Their Disorders
Author: Robert Miller
Publisher: CRC Press
Total Pages: 310
Release: 2007-08-08
Genre: Medical
ISBN: 1420058983

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The Basal ganglia, to adopt a phrase of Churchill's, are "a riddle wrapped in a mystery, inside an enigma." And although there is a wealth of information available on them, this research field remains controversial due in part to the diverse number of disciplines involved. A Theory of the Basal Ganglia and Their Disorders provides a clear, coherent


The Brain and Behavior

The Brain and Behavior
Author: David L. Clark
Publisher: Cambridge University Press
Total Pages: 290
Release: 2005-09-08
Genre: Medical
ISBN: 9780521840507

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New edition building on the success of previous one. Retains core aim of providing an accessible introduction to behavioral neuroanatomy.


Models of Information Processing in the Basal Ganglia

Models of Information Processing in the Basal Ganglia
Author: James C. Houk
Publisher: MIT Press
Total Pages: 414
Release: 1995
Genre: Basal ganglia
ISBN: 9780262082341

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This book brings together the biology and computational features of the basal ganglia and their related cortical areas along with select examples of how this knowledge can be integrated into neural network models. Recent years have seen a remarkable expansion of knowledge about the anatomical organization of the part of the brain known as the basal ganglia, the signal processing that occurs in these structures, and the many relations both to molecular mechanisms and to cognitive functions. This book brings together the biology and computational features of the basal ganglia and their related cortical areas along with select examples of how this knowledge can be integrated into neural network models. Organized in four parts - fundamentals, motor functions and working memories, reward mechanisms, and cognitive and memory operations - the chapters present a unique admixture of theory, cognitive psychology, anatomy, and both cellular- and systems- level physiology written by experts in each of these areas. The editors have provided commentaries as a helpful guide to each part. Many new discoveries about the biology of the basal ganglia are summarized, and their impact on the computational role of the forebrain in the planning and control of complex motor behaviors discussed. The various findings point toward an unexpected role for the basal ganglia in the contextual analysis of the environment and in the adaptive use of this information for the planning and execution of intelligent behaviors. Parallels are explored between these findings and new connectionist approaches to difficult control problems in robotics and engineering. Contributors James L. Adams, P. Apicella, Michael Arbib, Dana H. Ballard, Andrew G. Barto, J. Brian Burns, Christopher I. Connolly, Peter F. Dominey, Richard P. Dum, John Gabrieli, M. Garcia-Munoz, Patricia S. Goldman-Rakic, Ann M. Graybiel, P. M. Groves, Mary M. Hayhoe, J. R. Hollerman, George Houghton, James C. Houk, Stephen Jackson, Minoru Kimura, A. B. Kirillov, Rolf Kotter, J. C. Linder, T. Ljungberg, M. S. Manley, M. E. Martone, J. Mirenowicz, C. D. Myre, Jeff Pelz, Nathalie Picard, R. Romo, S. F. Sawyer, E Scarnat, Wolfram Schultz, Peter L. Strick, Charles J. Wilson, Jeff Wickens, Donald J. Woodward, S. J. Young


The Hidden Life of the Basal Ganglia

The Hidden Life of the Basal Ganglia
Author: Hagai Bergman
Publisher: MIT Press
Total Pages: 333
Release: 2021-10-12
Genre: Science
ISBN: 0262367297

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The anatomy and physiology of the basal ganglia and their relation to brain and behavior, disorders and therapies, and philosophy of mind and moral values. The main task of the basal ganglia—a group of subcortical nuclei, located at the base of the brain—is to optimize and execute our automatic behavior. In this book, Hagai Bergman analyzes the anatomy and physiology of the basal ganglia, discussing their relation to brain and behavior, to disorders and therapies, and even to moral values. Drawing on his forty years of studying the basal ganglia, Bergman presents new information on physiology and computational models, Parkinson’s disease and other ganglia-related disorders, and such therapies as deep brain stimulation. Focusing on studies of nonhuman primates and human basal ganglia and relying on system physiology and in vivo extra-cellular recording techniques, Bergman first describes the major brain structures that constitute the basal ganglia, the morphology of their cellular elements, their synaptic connectivity and their physiological function in health and disease. He discusses the computational physiology of the healthy basal ganglia, describing four generations of computational models, and then traces the computational physiology of basal ganglia–related disorders and their treatments, including Parkinson’s disease and its pharmacological and surgical therapies. Finally, Bergman considers the implications of these findings for such moral concerns as free will. Explaining this leap into domains rarely explored in neuroscientific accounts, Bergman writes that the longer he studies the basal ganglia, the more he is convinced that they are truly the base of both brain and mind.


The Integrative Functions of The Basal Ganglia

The Integrative Functions of The Basal Ganglia
Author: Henry Yin
Publisher: CRC Press
Total Pages: 337
Release: 2023-11-03
Genre: Medical
ISBN: 1498768709

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This volume is the first comprehensive and single-authored book on the functions of the basal ganglia. The goal is to provide a new synthesis of diverse areas of research on the basal ganglia, from cellular mechanisms of synaptic transmission and plasticity to neural circuit mechanisms underlying behavior. A global theory of basal ganglia function incorporating research from the last 40 years is presented. I hope to explain for the first time how the basal ganglia generate behavior, how they contribute to learning and memory, and how impairments in basal ganglia function can lead to neurological and psychiatric disorders. Features The only single-authored book on the basal ganglia with coverage of the latest literature Spans multiple levels of analysis, from cellular physiology to behavior Includes coverage of clinical symptoms, encompassing neuropsychology, movement disorders, and psychiatric disorders Discusses the role of the basal ganglia in learning and memory


Basal ganglia: physiological, behavioral, and computational studies

Basal ganglia: physiological, behavioral, and computational studies
Author: Ahmed A. Moustafa
Publisher: Frontiers Media SA
Total Pages: 495
Release: 2015-05-26
Genre: Basal ganglia
ISBN: 2889193888

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The basal ganglia has received much attention over the last two decades, as it has been implicated in many neurological and psychiatric disorders. Most of this research—in both animals and humans—attempt to understand the neural and biochemical substrates of basic motor and learning processes, and how these are affected in human patients as well as animal models of brain disorders. The current volume contains research articles and reviews describing basic, pre-clinical and clinical neuroscience research of the basal ganglia written by attendees of the 11th Triennial Meeting of the International Basal Ganglia Society (IBAGS) that was held March 3-7th, 2013 at the Princess Hotel, Eilat, Israel and by researchers of the basal ganglia. Specifically, articles in this volume include research reports on the biochemistry, computational theory, anatomy and physiology of single neurons and functional circuitry of the basal ganglia networks as well as the latest data on animal models of basal ganglia dysfunction and clinical studies in human patients.


Handbook of Basal Ganglia Structure and Function

Handbook of Basal Ganglia Structure and Function
Author: Heinz Steiner
Publisher: Academic Press
Total Pages: 729
Release: 2010-03-17
Genre: Medical
ISBN: 008091215X

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The Basal Ganglia comprise a group of forebrain nuclei that are interconnected with the cerebral cortex, thalamus and brainstem. Basal ganglia circuits are involved in various functions, including motor control and learning, sensorimotor integration, reward and cognition. The importance of these nuclei for normal brain function and behavior is emphasized by the numerous and diverse disorders associated with basal ganglia dysfunction, including Parkinson’s disease, Tourette’s syndrome, Huntington’s disease, obsessive-compulsive disorder, dystonia, and psychostimulant addiction. The Handbook of Basal Ganglia provides a comprehensive overview of the structural and functional organization of the basal ganglia, with special emphasis on the progress achieved over the last 10-15 years. Organized in six parts, the volume describes the general anatomical organization and provides a review of the evolution of the basal ganglia, followed by detailed accounts of recent advances in anatomy, cellular/molecular, and cellular/physiological mechanisms, and our understanding of the behavioral and clinical aspects of basal ganglia function and dysfunction. Synthesizes widely dispersed information on the behavioral neurobiology of the basal ganglia, including advances in the understanding of anatomy, cell-molecular and cell-physiological mechanisms, and behavioral/clinical aspects of function and dysfunction Features a truly international cast of the preeminent researchers in the field Fully explores the clinically relevant impact of the basal ganglia on various psychiatric and neurological diseases


Movement Disorders in Childhood

Movement Disorders in Childhood
Author: Harvey S. Singer
Publisher: Academic Press
Total Pages: 601
Release: 2015-10-27
Genre: Medical
ISBN: 0124115802

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Movement Disorders in Childhood, Second Edition, provides the most up-to-date information on the diseases and disorders that affect motor control, an important area of specialization within child neurology. Over the past several decades, advances in genetics, neuroimaging, neurophysiology, and other areas of neuroscience have provided new understanding of the underlying etiologies and mechanisms of these conditions as well as new opportunities for more accurate diagnosis and effective treatment. This new edition builds upon the success of the first edition, with comprehensive scientific and clinical updates of all chapters. In addition, there are new chapters on hereditary spastic paraplegia, quantitative motor assessments, autoimmune disorders, and movement disorders in the developmental neuropsychiatric disorders ADHD, OCD, and autism. Additional materials are provided on the latest in drug treatments, computer based strategies for genetic diagnosis, and helpful videos for phenomenology. Provides the only current reference specifically focused on childhood movement disorders Investigates the underlying etiologies and mechanisms of these disorders Completely revised and updated with new materials and a more disease-oriented approach New coverage of genetics and movement disorders, immunology and movement disorders, and an introduction to the latest quantitative analysis New videos of instructive and unusual childhood movement disorders 2016 BMA Medical Book Awards Highly Commended in Neurology


The Basal Ganglia V

The Basal Ganglia V
Author: International Basal Ganglia Society. Symposium
Publisher: Springer Science & Business Media
Total Pages: 550
Release: 1996
Genre: Medical
ISBN: 9780306453861

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Sixty-one proceedings papers from the May 1995 meeting updating research and presenting new ideas and data on the basal ganglia. The contributors addressed topics in the functional connectivity of the basal ganglia, the characteristics of its neurons, transmitters, and modulators, the neurophysiology of the basal ganglia and related nuclei, behavioral and physiological studies of its disorders, its neurochemistry and neuropharmacology, the characterization of basal ganglia disorders, and animal models of those disorders. Includes illustrations. Annotation copyrighted by Book News, Inc., Portland, OR


Hyperkinetic Movement Disorders

Hyperkinetic Movement Disorders
Author: Alberto Albanese
Publisher: John Wiley & Sons
Total Pages: 413
Release: 2012-03-07
Genre: Medical
ISBN: 1444346164

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Hyperkinetic movement disorders comprise a range of diseases characterized by unwanted and uncontrollable, or poorly controllable, involuntary movements. The phenomenology of these disorders is quite variable encompassing chorea, tremor, dystonia, myoclonus, tics, other dyskinesias, jerks and shakes. Discerning the underlying condition can be very difficult given the range and variability of symptoms. But recognizing the phenomenology and understanding the pathophysiology are essential to ensure appropriate treatment. Hyperkinetic Movement Disorders provides a clinical pathway for effective diagnosis and management of these disorders. The stellar international cast of authors distils the evidence so you can apply it into your practice. The judicious use of diagnostic criteria algorithms rating scales management guidelines Provides a robust framework for clear patient management. Throughout the text, QR codes* provide smartphone access to case-study videos of hyperkinetic symptoms. Purchase includes an enhanced Wiley Desktop Edition.* This is an interactive digital version featuring: all text and images in fully searchable form integrated videos of presentations View a sample video: www.wiley.com/go/albanese highlighting and note taking facilities book marking linking to additional references Hyperkinetic Movement Disorders provides you with the essential visual and practical tools you need to effectively diagnose and treat your patients. *Full instructions for using QR codes and for downloading your digital Wiley DeskTop Edition are inside the book.