A Structural Perspective On Respiratory Complex I PDF Download
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| Author | : Leonid Sazanov |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 281 |
| Release | : 2012-05-11 |
| Genre | : Medical |
| ISBN | : 9400741383 |
Download A Structural Perspective on Respiratory Complex I Book in PDF, ePub and Kindle
The book contains chapters written by leaders in the research on the structure and function of respiratory complex I. It will provide a concise and authoritative summary of the current knowledge on complex I of respiratory chains. This enzyme is central to energy metabolism and is implicated in many human neurodegenerative diseases, as well as in aging. Until recently it was poorly understood on a structural level, and this book will provide a timely reference resource. Such a book was not published previously. The last time a minireview series on complex I were published was in 2001, and since then complex I field changed quite dramatically.
| Author | : Mårten Wikström |
| Publisher | : |
| Total Pages | : 216 |
| Release | : 1981 |
| Genre | : Science |
| ISBN | : |
Download Cytochrome Oxidase Book in PDF, ePub and Kindle
| Author | : Bernhard Kadenbach |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 378 |
| Release | : 2012-06-23 |
| Genre | : Medical |
| ISBN | : 1461435730 |
Download Mitochondrial Oxidative Phosphorylation Book in PDF, ePub and Kindle
This book will describe the nuclear encoded genes and their expressed proteins of mitochondrial oxidative phosphorylation. Most of these genes occur in eukaryotic cells, but not in bacteria or archaea. The main function of mitochondria, the synthesis of ATP, is performed at subunits of proton pumps (complexes I, III, IV and V), which are encoded on mitochondrial DNA. The nuclear encoded subunits have mostly a regulatory function. However, the specific physiological functions of the nuclear encoded subunits of complexes I, III, IV, and V are mostly unknown. New data indicates that they are essential for life of higher organisms, which is characterized by an adult life without cell division (postmeiotic stage) in most tissues, after the juvenile growth. For complex IV (cytochrome c oxidase) some of these subunits occur in tissue-specific (subunits IV, VIa, VIb, VIIa, VIII), developmental-specific (subunits IV, VIa, and VIIa) as well as species-specific isoforms. Defective genes of some subunits were shown to induce mitochondrial diseases. Mitochondrial genes and human diseases will also be covered.
| Author | : Ewald R. Weibel |
| Publisher | : Harvard University Press |
| Total Pages | : 448 |
| Release | : 1984 |
| Genre | : Medical |
| ISBN | : 9780674657915 |
Download The Pathway for Oxygen Book in PDF, ePub and Kindle
It is rare indeed for one book to be both a first-rate classroom text and a major contribution to scholarship. The Pathway for Oxygen is such a book, offering a new approach to respiratory physiology and morphology that quantitatively links the two. Professionalism in science has led to a compartmentalization of biology. Function is the domain of the physiologist, structure that of the morphologist, and they often operate with vastly disparate concepts and procedures. Yet the performance of the respiratory system depends both on structural and on functional properties that cannot be separated. The first chapter of The Pathway for Oxygen engages the student with the design and function of the vertebrate respiratory organs from a comparative viewpoint. The second chapter adds to that foundation the link between cell energetics and oxygen needs of the whole animal. With Chapter 3 the excitement begins--new ideas, fresh attacks on old problems, and a fuller account of the power of the quantitative approach Dr. Weibel has pioneered. The Pathway for Oxygen will be read eagerly by medical students, graduate students, advanced undergraduates in zoology--and by their professors.
| Author | : J. Gordon Betts |
| Publisher | : |
| Total Pages | : 0 |
| Release | : 2013-04-25 |
| Genre | : |
| ISBN | : 9781947172807 |
Download Anatomy and Physiology Book in PDF, ePub and Kindle
| Author | : James Robin Harris |
| Publisher | : |
| Total Pages | : 459 |
| Release | : 2018 |
| Genre | : Membrane proteins |
| ISBN | : 9789811077586 |
Download Membrane Protein Complexes Book in PDF, ePub and Kindle
This edited book contains a compilation of 14 advanced academic chapters dealing with the structure and function of membrane protein complexes. This rapidly advancing important field of study closely parallels those on soluble protein complexes, and viral protein and nucleoprotein complexes. Diverse topics are included in this book, ranging from membrane-bound enzymes to ion channels, proton pumps and photosystems. Data from X-ray crystallography, cryo-electron microscopy and other biophysical and biochemical techniques are presented throughout the book. There is extensive use of colour figures of protein structures. Throughout the book structure and function are closely correlated. The two editors, Egbert Boekema and J. Robin Harris, have worked on aspects of membrane and soluble proteins throughout their scientific careers and also have much publishing experience. The Subcellular Biochemistry series has expanded considerably in recent years, including several related volumes. The theme of protein complexes will be continued within several future volumes, thereby creating encyclopaedic coverage. The chapter topics within this book are particularly relevant to those involved in the biological and biomedical sciences. It is aimed at the advanced undergraduates, postgraduates and established researchers within this broad field. It is hoped that the book will be of interest and use to those involved with the study of cellular membranes and their associated proteins.
| Author | : Mårten Wikström |
| Publisher | : Royal Society of Chemistry |
| Total Pages | : 416 |
| Release | : 2005 |
| Genre | : Medical |
| ISBN | : 0854043462 |
Download Biophysical and Structural Aspects of Bioenergetics Book in PDF, ePub and Kindle
This book provides a representative snapshot of the very latest key developments in this multidisciplinary subject.
| Author | : William A. Cramer |
| Publisher | : Springer |
| Total Pages | : 739 |
| Release | : 2016-06-14 |
| Genre | : Science |
| ISBN | : 9401774811 |
Download Cytochrome Complexes: Evolution, Structures, Energy Transduction, and Signaling Book in PDF, ePub and Kindle
An Introduction that describes the origin of cytochrome notation also connects to the history of the field, focusing on research in England in the pre-World War II era. The start of the modern era of studies on structure-function of cytochromes and energy-transducing membrane proteins was marked by the 1988 Nobel Prize in Chemistry, given to J. Deisenhofer, H. Michel, and R. Huber for determination of the crystal structure of the bacterial photosynthetic reaction center. An ab initio logic of presentation in the book discusses the evolution of cytochromes and hemes, followed by theoretical perspectives on electron transfer in proteins and specifically in cytochromes. There is an extensive description of the molecular structures of cytochromes and cytochrome complexes from eukaryotic and prokaryotic sources, bacterial, plant and animal. The presentation of atomic structure information has a major role in these discussions, and makes an important contribution to the broad field of membrane protein structure-function.
| Author | : Kapuganti Jagadis Gupta |
| Publisher | : John Wiley & Sons |
| Total Pages | : 398 |
| Release | : 2015-06-15 |
| Genre | : Science |
| ISBN | : 1118790464 |
Download Alternative Respiratory Pathways in Higher Plants Book in PDF, ePub and Kindle
Rapid developments in molecular and systems biology techniques have allowed researchers to unravel many new mechanisms through which plant cells switch over to alternative respiratory pathways. This book is a unique compendium of how and why higher plants evolved alternative respiratory metabolism. It offers a comprehensive review of current research in the biochemistry, physiology, classification and regulation of plant alternative respiratory pathways, from alternative oxidase diversity to functional marker development. The resource provides a broad range of perspectives on the applications of plant respiratory physiology, and suggests brand new areas of research. Other key features: written by an international team of reputed plant physiologists, known for their pioneering contributions to the knowledge of regular and alternative respiratory metabolism in higher plants includes step-by-step protocols for key molecular and imaging techniques advises on regulatory options for managing crop yields, food quality and environment for crop improvement and enhanced food security covers special pathways which are of key relevance in agriculture, particularly in plant post-harvest commodities Primarily for plant physiologists and plant biologists, this authoritative compendium will also be of great value to postdoctoral researchers working on plant respiration, as well as to graduate and postgraduate students and university staff in Plant Science. It is a useful resource for corporate and private firms involved in developing functional markers for breeding programs and controlling respiration for the prevention of post-harvest losses in fruit, vegetables, cut flowers and tubers.
| Author | : Martin Brüne |
| Publisher | : Oxford University Press |
| Total Pages | : 992 |
| Release | : 2019-01-31 |
| Genre | : Medical |
| ISBN | : 0192506781 |
Download The Oxford Handbook of Evolutionary Medicine Book in PDF, ePub and Kindle
Medicine is grounded in the natural sciences, among which biology stands out with regard to the understanding of human physiology and conditions that cause dysfunction. Ironically though, evolutionary biology is a relatively disregarded field. One reason for this omission is that evolution is deemed a slow process. Indeed, macroanatomical features of our species have changed very little in the last 300,000 years. A more detailed look, however, reveals that novel ecological contingencies, partly in relation to cultural evolution, have brought about subtle changes pertaining to metabolism and immunology, including adaptations to dietary innovations, as well as adaptations to the exposure to novel pathogens. Rapid pathogen evolution and evolution of cancer cells cause major problems for the immune system to find adequate responses. In addition, many adaptations to past ecologies have turned into risk factors for somatic disease and psychological disorder in our modern worlds (i.e. mismatch), among which epidemics of autoimmune diseases, cardiovascular diseases, diabetes and obesity, as well as several forms of cancer stand out. In addition, depression, anxiety and other psychiatric conditions add to the list. The Oxford Handbook of Evolutionary Medicine is a compilation of cutting edge insights into the evolutionary history of ourselves as a species, and how and why our evolved design may convey vulnerability to disease. Written in a classic textbook style emphasising physiology and pathophysiology of all major organ systems, the Oxford Handbook of Evolutionary Medicine will be valuable for students as well as scholars in the fields of medicine, biology, anthropology and psychology.
