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Disease Control Priorities, Third Edition (Volume 6)

Disease Control Priorities, Third Edition (Volume 6)
Author: King K. Holmes
Publisher: World Bank Publications
Total Pages: 1027
Release: 2017-11-06
Genre: Medical
ISBN: 1464805253

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Infectious diseases are the leading cause of death globally, particularly among children and young adults. The spread of new pathogens and the threat of antimicrobial resistance pose particular challenges in combating these diseases. Major Infectious Diseases identifies feasible, cost-effective packages of interventions and strategies across delivery platforms to prevent and treat HIV/AIDS, other sexually transmitted infections, tuberculosis, malaria, adult febrile illness, viral hepatitis, and neglected tropical diseases. The volume emphasizes the need to effectively address emerging antimicrobial resistance, strengthen health systems, and increase access to care. The attainable goals are to reduce incidence, develop innovative approaches, and optimize existing tools in resource-constrained settings.


Guidelines for the Psychosocially Assisted Pharmacological Treatment of Opioid Dependence

Guidelines for the Psychosocially Assisted Pharmacological Treatment of Opioid Dependence
Author: World Health Organization. Department of Mental Health and Substance Abuse
Publisher: World Health Organization
Total Pages: 133
Release: 2009
Genre: Medical
ISBN: 9241547545

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"These guidelines were produced by the World Health Organization (WHO), Department of Mental Health and Substance Abuse, in collaboration with the United Nations Office on Drugs and Crime (UNODC) a Guidelines Development Group of technical experts, and in consultation with the International Narcotics Control Board (INCB) secretariat and other WHO departments. WHO also wishes to acknowledge the financial contribution of UNODC and the Joint United Nations Programme on HIV/AIDS (UNAIDS) to this project. " - p. iv


HIV Oral Pre-exposure Prophylaxis (PrEP) Trials

HIV Oral Pre-exposure Prophylaxis (PrEP) Trials
Author: Madzouka B. Kokolo
Publisher:
Total Pages: 340
Release: 2010
Genre: University of Ottawa theses
ISBN:

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Pre-exposure prophylaxis (PrEP) is an experimental HIV prevention approach whereby antiretroviral pills are used 'before' anticipated exposure. It is unclear how ethical considerations have been addressed by investigators. METHODS. A systematic review of PrEP controlled prospective studies was conducted. Pre-determined data items were extracted from registries, protocols, reports, and consent forms. Study characteristics, methods, and ethics considerations were synthesized. RESULTS. Among sixteen studies included, twelve involved resource-limited countries. Quality scores were generally high and overall risk of bias was low. Considerations for social value were the least reported whereas considerations for the 'fair selection of study population ' were the most reported. More ethics considerations tend to be reported with time. No meta-analysis was performed, as few data were available. CONCLUSION. As critical as clinical data generation is for scientific progress, ethics should be monitored and adequately reported, lest lack of consideration for key principles be uncovered after the facts.


Consolidated Guidelines on the Use of Antiretroviral Drugs for Treating and Preventing HIV Infection

Consolidated Guidelines on the Use of Antiretroviral Drugs for Treating and Preventing HIV Infection
Author: World Health Organization
Publisher:
Total Pages: 429
Release: 2016
Genre: AIDS (Disease)
ISBN: 9789241549684

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These guidelines provide guidance on the diagnosis of human immunodeficiency virus (HIV) infection, the use of antiretroviral (ARV) drugs for treating and preventing HIV infection and the care of people living with HIV. They are structured along the continuum of HIV testing, prevention, treatment and care. This edition updates the 2013 consolidated guidelines on the use of antiretroviral drugs following an extensive review of evidence and consultations in mid-2015, shared at the end of 2015, and now published in full in 2016. It is being published in a changing global context for HIV and for health more broadly.


WHO implementation tool for pre-exposure prophylaxis (PrEP) of HIV infection. Module 13. Integrating STI services

WHO implementation tool for pre-exposure prophylaxis (PrEP) of HIV infection. Module 13. Integrating STI services
Author: World Health Organization
Publisher: World Health Organization
Total Pages: 50
Release: 2022-09-05
Genre: Medical
ISBN: 9240057420

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WHO's pre-exposure prophylaxis (PrEP) for HIV infection implementation tool contains modules for a range of stakeholders to support them in the consideration, planning, introduction, implementation and roll-out of PrEP services. The modules can be used on their own or in combination. In addition, there is a module for individuals interested in or already taking oral PrEP. The STI integration module compiles existing WHO recommendations, systematic scientific literature reviews and other relevant publications to provide suggested implementation approaches. It is the product of collaboration among many experts, community organizations and networks, providers, implementers, researchers and partners from all regions. The STI integration module is divided into 2 parts: the first focuses on programme managers and other decision-makers, and the second on health care workers. People who use PrEP will also benefit from it.


Pre-exposure Prophylaxis for the Prevention of HIV Infection

Pre-exposure Prophylaxis for the Prevention of HIV Infection
Author: Roger Chou
Publisher:
Total Pages: 220
Release: 2019
Genre:
ISBN:

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BACKGROUND: Effective prevention strategies for HIV infection are an important public health priority. Pre-exposure prophylaxis (PrEP) involves use of antiretroviral therapy (ART) regularly (e.g., daily) or before and after HIV exposure events to decrease the risk of acquiring HIV infection. PURPOSE: To synthesize evidence for the U.S. Preventive Services Task Force (USPSTF) on effects of PrEP on risk of HIV acquisition, mortality, harms, and other clinical outcomes; effects of adherence on PrEP-associated outcomes; and accuracy of methods for identifying potential candidates for PrEP. DATA SOURCES: We searched the Cochrane Central Register of Controlled Trials and Cochrane Database of Systematic Reviews, MEDLINE, and Embase from inception to June 2018 and manually reviewed reference lists; additional surveillance for new literature was conducted through January 25, 2019. STUDY SELECTION: Randomized, controlled trials on the benefits and harms of PrEP versus placebo or no PrEP in adults without HIV infection at high risk of becoming infected; studies on the diagnostic accuracy of instruments for predicting incident HIV infection; studies on effects of adherence to PrEP on risk of HIV infection; and studies on rates of adherence to PrEP in U.S. populations. DATA EXTRACTION: One investigator abstracted data and a second investigator checked data abstraction for accuracy. Two investigators independently assessed study quality using methods developed by the USPSTF. DATA SYNTHESIS (RESULTS): In populations at higher risk of acquiring HIV infection, PrEP was associated with decreased risk of HIV infection versus placebo or no PrEP (11 trials; relative risk [RR], 0.46 [95% confidence interval (CI), 0.33 to 0.66; I2=67%; absolute risk reduction, −2.0% [95% CI, −2.8% to −1.2%] after 4 months to 4 years). Effects were consistent across HIV risk categories and for PrEP with tenofovir disoproxil fumarate plus emtricitabine or tenofovir alone. There was a strong association between higher adherence and greater efficacy (adherence ≥70%: 6 trials; RR, 0.27 [95% CI, 0.19 to 0.39]; I2=0%; adherence >40% to


Missing Voices

Missing Voices
Author: Stephanie Brown
Publisher: Oxford University Press, USA
Total Pages: 316
Release: 1994
Genre: Family & Relationships
ISBN:

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Motherhood is often portrayed as one of the most fulfilling experiences in a woman's life. Books on pregnancy, birth and motherhood not only tell women what they should do, they also encourage them to have high expectations of what is inevitably a 'journey into the unknown'. Missing Voices isdifferent: its authors offer no prescriptions. Instead they tell the stories of 800 recent mothers. We hear about what happened to them during pregnancy and childbirth, what contributed to good and bad experiences of birth, and what women thought of the care they received. Ninety of the women went on to participate in interviews two years later. The result is a moving and powerful account of what it is like to be a mother in Australia in the 1990s. How do mothers' daily lives compare with accepted wisdom about 'good mothers'? How is the work of caring for children,running the household and providing financial support divided within the family? How do women feel about the care of children and work - both paid and unpaid? One in seven women was depressed in the year after birth. In Missing Voices they talk candidly about the origins of this depression and howthey coped with it. This is a book for all mothers (and fathers), for anyone contemplating having children, and for all those concerned about the health and well-being of mothers, children and families.


Cherokee Narratives

Cherokee Narratives
Author: Durbin Feeling
Publisher: University of Oklahoma Press
Total Pages: 241
Release: 2018-01-04
Genre: Foreign Language Study
ISBN: 0806160624

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The stories of the Cherokee people presented here capture in written form tales of history, myth, and legend for readers, speakers, and scholars of the Cherokee language. Assembled by noted authorities on Cherokee, this volume marks an unparalleled contribution to the linguistic analysis, understanding, and preservation of Cherokee language and culture. Cherokee Narratives spans the spectrum of genres, including humor, religion, origin myths, trickster tales, historical accounts, and stories about the Eastern Cherokee language. These stories capture the voices of tribal elders and form a living record of the Cherokee Nation and Eastern Band of Cherokee Indians' oral tradition. Each narrative appears in four different formats: the first is interlinear, with each line shown in the Cherokee syllabary, a corresponding roman orthography, and a free English translation; the second format consists of a morpheme-by-morpheme analysis of each word; and the third and fourth formats present the entire narrative in the Cherokee syllabary and in a free English translation. The narratives and their linguistic analysis are a rich source of information for those who wish to deepen their knowledge of the Cherokee syllabary, as well as for students of Cherokee history and culture. By enabling readers at all skill levels to use and reconstruct the Cherokee language, this collection of tales will sustain the life and promote the survival of Cherokee for generations to come.


Private Choices and Public Health

Private Choices and Public Health
Author: Tomas J. Philipson
Publisher: Harvard University Press
Total Pages: 290
Release: 1993
Genre: AIDS (Disease)
ISBN: 9780674707382

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An economics professor and a federal judge point out that engaging in unprotected sex is a dangerous but pleasurable activity, like downhill skiing and mountain climbing, and that people weigh the risks and benefits when deciding whether or not to do it. The people setting up public health measures to combat the spread of AIDS, they say, are not taking this informed and often rational decision-making into account. Therefore, their predictions are off and their information campaigns are not only in effective, but may well be encouraging the disease's spread. They also look at the cost and benefits of research and education for the society as a whole. The book is bound to be controversial. Annotation copyright by Book News, Inc., Portland, OR


A Project Using Pre-exposure Prophylaxis (PrEP) in the Urgent Care Setting

A Project Using Pre-exposure Prophylaxis (PrEP) in the Urgent Care Setting
Author: Tanya Clesie Cavallaro-Moretti
Publisher:
Total Pages: 152
Release: 2018
Genre: AIDS (Disease)
ISBN:

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The Pre-Exposure Prophylaxis (PrEP) guidelines 2014, supported by scientific evidence, recommends the use of antiviral therapy (ART) prophylaxis to prevent human immunodeficiency virus (HIV) infection in patients at high-risk for HIV infection. The literature is limited on PrEP guidelines use in the urgent care (UC) settings. The purpose of this project was to determine the knowledge of urgent care providers regarding the PrEP guidelines and their practices of assess patients at high-risk for HIV infection. Additionally, the project aimed to determine the feasibility of providers to prescribe, implement and follow patients to whom they have prescribed the PrEP guidelines. The diffusion of innovation theory was used as the framework of this project to assist in process of the adoption of the PrEP in the urgent care settings. This project used quantitative descriptive methodology using a survey and chart review that identified the current HIV preventive practice in the UC in Arizona. There were four clinical questions (CQs) that investigated the healthcare provider's knowledge, practice, and attitude toward HIV prevention. There were 208 HIV screening tests ordered in 2016 in the UC, and there were 20 patients that received ART prophylaxis prescribed by nurse practitioner and from those, only six prescribed Truvada® were for PrEP. Truvada® was given to 2.88% of 208 of the patients screened for HIV. The project identified barriers to implementation of the PrEP guidelines in UC and the DIT can assist with diffusion of PrEP guidelines. The project identified algorithms to facilitate the application of prep guidelines into urgent care. The applicability of the PrEP guidelines into the UC settings was investigated and the UC is prepared to indicate ART to those who have clinical indications for PrEP, in addition to HIV screening and education.