A Kinetic And Mechanistic Study On The Substitution Behaviour Of Mononuclear And Dinuclear Platinum Ii Complexes PDF Download
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Author | : Grace Kinunda |
Publisher | : |
Total Pages | : |
Release | : 2013 |
Genre | : Antineoplastic agents |
ISBN | : |
Download A Kinetic and Mechanistic Study on the Substitution Behaviour of Mononuclear and Dinuclear Platinum (II) Complexes Book in PDF, ePub and Kindle
Author | : Isaac Masika Wekesa |
Publisher | : |
Total Pages | : |
Release | : 2014 |
Genre | : Ligands |
ISBN | : |
Download The Influence of Ligand Moiety on the Substitution Behaviour of Mononuclear Platinum (II) Complexes Book in PDF, ePub and Kindle
Author | : Peter Olengo Ongoma |
Publisher | : |
Total Pages | : |
Release | : 2012 |
Genre | : Chemotherapy |
ISBN | : |
Download Tuning Reactivity of Platinum(II) Complexes Book in PDF, ePub and Kindle
Author | : Varvara I. Nikolayenko |
Publisher | : |
Total Pages | : 316 |
Release | : 2012 |
Genre | : Antineoplastic agents |
ISBN | : |
Download A Kinetic and Mechanistic Study of Dinuclear Platinum (II) Complexes with Bis-(4'-terpyridyl)-a,w-alkyldiol Ligands Book in PDF, ePub and Kindle
Author | : Aishath Shaira |
Publisher | : |
Total Pages | : 438 |
Release | : 2010 |
Genre | : Platinum compounds |
ISBN | : |
Download A Kinetic and Mechanistic Study Into the Substition Behaviour of Platinum (II) Polypyridyl Complexes with a Series of Azole Ligands Book in PDF, ePub and Kindle
Author | : Carol Penelope Jill Viuk |
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Total Pages | : |
Release | : 1974 |
Genre | : |
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Download Substitution reactions of platinum metal complexes Book in PDF, ePub and Kindle
Author | : |
Publisher | : |
Total Pages | : 246 |
Release | : 1994 |
Genre | : |
ISBN | : |
Download Kinetic and Mechanistic Study of Aquated Forms of Platinum (II) Complexes with Nucleic Acid Derivatives Book in PDF, ePub and Kindle
Author | : Robert A. Stockland (Jr.) |
Publisher | : |
Total Pages | : |
Release | : 1999 |
Genre | : Organometallic compounds |
ISBN | : |
Download Preparation and Characterization of Mononuclear and Dinuclear Organopalladium Complexes Book in PDF, ePub and Kindle
Author | : Slindokuhle V. Nkabinde |
Publisher | : |
Total Pages | : 326 |
Release | : 2014 |
Genre | : Azoles |
ISBN | : |
Download Tuning the Reactivity of Mononuclear Tridentate Platinum (II) Complexes Book in PDF, ePub and Kindle
Author | : Thomas A. Wells |
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Total Pages | : |
Release | : 2020 |
Genre | : Chemotherapy |
ISBN | : |
Download Substitution Inert Platinum (II) Complexes and Their Non-covalent Interactions with Proteins Book in PDF, ePub and Kindle
Traditional platinum complexes are commonplace in chemotherapeutics. While effective, the toxicity of these complexes and development of resistance are inherent drawbacks that need to be addressed. This work focuses on the development of a new class of platinum (II) complexes designed for non-covalent, electrostatic interactions with proteins relevant to cancer and HIV-1. Chapter two focuses on mono and dinuclear substitution-inert platinum complexes and their selectivity for the N-terminal of the HIV-1 NCp7 protein. Chapters three and four investigate a second phenotype of mononuclear platinum complexes with bis conformations and their interactions with the p53-MDM2 interface. Chapter five provides insight into isoelectronic gold (III) complexes and an aryl-transfer mechanism to NCp7. Chapter six explains the recovery of platinum from laboratory wastes. Overall, the work presented in this dissertation expands on the class of substitution-inert platinum(II) complexes and assesses their viability to interact with specific active-site residues of the HIV-1 NCp7 protein and the p53-MDM2 interface.