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| Author | : Caleb González (Ph.D.) |
| Publisher | : |
| Total Pages | : 374 |
| Release | : 2009 |
| Genre | : |
| ISBN | : |
| Author | : David Mittelman |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 284 |
| Release | : 2013-03-12 |
| Genre | : Medical |
| ISBN | : 1461462800 |
The discovery of stress-induced mutagenesis has changed ideas about mutation and evolution, and revealed mutagenic programs that differ from standard spontaneous mutagenesis in rapidly proliferating cells. The stress-induced mutations occur during growth-limiting stress, and can include adaptive mutations that allow growth in the otherwise growth-limiting environment. The stress responses increase mutagenesis specifically when cells are maladapted to their environments, i.e. are stressed, potentially accelerating evolution then. The mutation mechanism also includes temporary suspension of post-synthesis mismatch repair, resembling mutagenesis characteristic of some cancers. Stress-induced mutation mechanisms may provide important models for genome instability underlying some cancers and genetic diseases, resistance to chemotherapeutic and antibiotic drugs, pathogenicity of microbes, and many other important evolutionary processes. This book covers pathways of stress-induced mutagenesis in all systems. The principle focus is mammalian systems, but much of what is known of these pathways comes from non-mammalian systems.
| Author | : Richard A. Calderone |
| Publisher | : American Society for Microbiology Press |
| Total Pages | : 1222 |
| Release | : 2011-12-07 |
| Genre | : Medical |
| ISBN | : 1555815391 |
The underlying mechanisms of Candida and candidiasis and promising new directions in drug discovery and treatment. • Reviews all aspects of this common fungal pathogen and its impact on human health, from the basic biology of Candida albicans to the clinical management of candidiasis. • Reviews the latest basic and clinical research, focusing on findings in genome variability, host-pathogen interactions, antifungal resistance and drug discovery, and diagnostics to foster better understanding and treatment of candidiasis. • Examines recent discoveries that have shed light on morphogenesis and the cell cycle, including how new findings on host responses may have applications for the diagnosis of blood-borne candidiasis.
| Author | : Roderick D.M. Page |
| Publisher | : John Wiley & Sons |
| Total Pages | : 352 |
| Release | : 2009-07-14 |
| Genre | : Science |
| ISBN | : 1444313363 |
The study of evolution at the molecular level has given the subject of evolutionary biology a new significance. Phylogenetic 'trees' of gene sequences are a powerful tool for recovering evolutionary relationships among species, and can be used to answer a broad range of evolutionary and ecological questions. They are also beginning to permeate the medical sciences. In this book, the authors approach the study of molecular evolution with the phylogenetic tree as a central metaphor. This will equip students and professionals with the ability to see both the evolutionary relevance of molecular data, and the significance evolutionary theory has for molecular studies. The book is accessible yet sufficiently detailed and explicit so that the student can learn the mechanics of the procedures discussed. The book is intended for senior undergraduate and graduate students taking courses in molecular evolution/phylogenetic reconstruction. It will also be a useful supplement for students taking wider courses in evolution, as well as a valuable resource for professionals. First student textbook of phylogenetic reconstruction which uses the tree as a central metaphor of evolution. Chapter summaries and annotated suggestions for further reading. Worked examples facilitate understanding of some of the more complex issues. Emphasis on clarity and accessibility.
| Author | : Rhoda Grell |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 443 |
| Release | : 2012-12-06 |
| Genre | : Medical |
| ISBN | : 1468421336 |
This book contains the papers presented at the Twenty-Seventh Annual Biology Division Research Conference which was held April 1-4, 1974 in Gatlinburg, Tennessee. The topic of the symposium was Mechanisms in Recombination and it follows by exactly twenty years the previous Gatlinburg Symposium on Genetic Recombination. During this interval, and the preceding years as well, the process of recombination has remained a central and tantalizing problem for geneticists. The subject assumes added significance with the recent appeal by a committee of leading scientists for a moratorium on the construction of certain types of recombinant molecules. That autonomously replicating molecules linking portions of pro karyotic and eukaryotic DNA can now be produced in vitro attests to the technical advances that have taken place in this field. Nevertheless, the details underlying the process in vivo continue to be elusive. This symposium brought together individuals studying recombi nation in organisms as widely separated as bacteriophage and mammals and using disciplinary approaches of comparable diversity. Conse quently the present volume summarizes much of current strategies and concepts concerning the subject. The meeting was sponsored by the Biology Division of the Oak Ridge National Laboratory (operated by the Union Carbide Corporation for the U. S. Atomic Energy Commission) with the support and encour agement of its director, H. I. Adler. The organizing committee was chaired by J. K. Setlow and included R. F. Grell, R. D. Hotchkiss and E. Volkin. Special thanks are due to the speakers, to I. R.
| Author | : Georg T. Wondrak |
| Publisher | : Springer |
| Total Pages | : 450 |
| Release | : 2014-11-07 |
| Genre | : Medical |
| ISBN | : 9401794219 |
It is now established that dysregulated cell stress response pathways play a critical role in tumorigenesis, and a refined mechanistic understanding of this phenomenon at the molecular level promises to open new avenues for targeted therapeutic strategies that may benefit cancer patients in the near future. Coauthored by recognized leaders in cancer research from five continents, this novel book provides a comprehensive perspective on cell stress response pathways and therapeutic opportunities. Focusing on the role of genotoxic, proteotoxic, oxidative, metabolic, and inflammatory stress in tumorigenesis, the book is essential reading for students, basic researchers, and biomedical health care professionals interested in cancer and therapeutic development.
| Author | : Douglas Mayers |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 692 |
| Release | : 2009-07-14 |
| Genre | : Medical |
| ISBN | : 1603275959 |
This ? rst edition of Antimicrobial Drug Resistance grew out of a desire by the editors and authors to have a comprehensive resource of information on antimicrobial drug resistance that encompassed the current information available for bacteria, fungi, protozoa and viruses. We believe that this information will be of value to clinicians, epidemiologists, microbiologists, virologists, parasitologists, public health authorities, medical students and fellows in training. We have endeavored to provide this information in a style which would be accessible to the broad community of persons who are concerned with the impact of drug resistance in our cl- ics and across the broader global communities. Antimicrobial Drug Resistance is divided into Volume 1 which has sections covering a general overview of drug resistance and mechanisms of drug resistance ? rst for classes of drugs and then by individual microbial agents including bacteria, fungi, protozoa and viruses. Volume 2 addresses clinical, epidemiologic and public health aspects of drug resistance along with an overview of the conduct and interpretation of speci? c drug resistance assays. Together, these two volumes offer a comprehensive source of information on drug resistance issues by the experts in each topic.
| Author | : David E. Fisher |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 441 |
| Release | : 2000-10-26 |
| Genre | : Medical |
| ISBN | : 1592592309 |
David Fisher, MD, PhD, and an authoritative panel of academic, cutting-edge researchers review and summarize the current state of the field. Describing the broad roles of tumor suppressors from a perspective based in molecular biology and genetics, the authors detail the major suppressors and the pathways they regulate, including cell cycle progression, stress responses, apoptosis, and responses to DNA damage. Leading-edge and forward-looking, Tumor Suppressor Genes in Human Cancer illuminates what is currently known of tumor suppressor genes and their regulation, work that is already beginning to revolutionize cancer target elucidation, drug discovery, and treatment design.
| Author | : Elisabetta Baldi |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 206 |
| Release | : 2013-08-16 |
| Genre | : Medical |
| ISBN | : 1461477832 |
There are several types of damage that can be found in the male gamete. Genetic damage in spermatozoa can originate during spermatogenesis, or it can originate during transit in both male and female genital tracts. Damage can also be due to ageing, environmental or iatrogenic conditions, as well as to the protocols to cryopreserve and to select spermatozoa in assisted reproduction techniques. The purpose of this book is to provide a comprehensive resource for all possible DNA damages in sperm, the relation to fertility and infertility, and possible transgenerational heritable effects.
| Author | : Effie Tsakalidou |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 540 |
| Release | : 2011-09-06 |
| Genre | : Technology & Engineering |
| ISBN | : 0387927719 |
Beginning with the basics of lactic acid bacteria and stress response, then working into specific fields of research and current developments, Stress Responses of Lactic Acid Bacteria will serve as an essential guidebook to researchers in the field, industry professionals, and advanced students in the area. The exploration of stress responses in lactic acid bacteria began in the early 90s and revealed the differences that exist between LAB and the classical model microorganisms. A considerable amount of work has been performed on the main genera / species of LAB regarding the genes implicated and their actual role and regulation, and the mechanisms of stress resistance have also been elucidated. Recent genome and transcriptome analyses complement the proteome and genetic information available today and shed a new light on the perception of and the responses to stress by lactic acid bacteria.
