A Guide To Sample Size For Animal Based Studies PDF Download
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Author | : Penny S. Reynolds |
Publisher | : John Wiley & Sons |
Total Pages | : 294 |
Release | : 2023-08-29 |
Genre | : Medical |
ISBN | : 1119799988 |
Download A Guide to Sample Size for Animal-based Studies Book in PDF, ePub and Kindle
A Guide to Sample Size for Animal-based Studies Understand a foundational area of experimental design with this innovative reference Animal-based research is an essential part of basic and preclinical research, but poses a unique set of experimental design challenges. The most important of these are the 3Rs − Replacement, Reduction and Refinement − the principles comprising the ethical framework for humane animal-based studies. However, many researchers have difficulty navigating the design trade-offs necessary to simultaneously minimize animal use, and produce scientific information that is both rigorous and reliable. A Guide to Sample Size for Animal-based Studies meets this need with a thorough, accessible reference work to the subject. This book provides a straightforward systematic approach to “rightsizing” animal-based experiments, with sample size estimates based on the fundamentals of statistical thinking: structured research questions, variation control and appropriate design of experiments. The result is a much-needed guide to planning animal-based experiments to ensure scientifically valid and reliable results. This book offers: Step-by-step guidance in diverse methods for approximating and refining sample size Detailed treatment of research topics specific to animal-based research, including pilot, feasibility and proof-of-concept studies Sample size approximation methods for different types of data − binary, continuous, ordinal, time to event − and different study types − description, comparison, nested designs, reference interval construction and dose-response studies Numerous worked examples, using real data from published papers, together with SAS and R code A Guide to Sample Size for Animal-based Studies is a must-have reference for preclinical and veterinary researchers, as well as ethical oversight committees and policymakers.
Author | : Penny S. Reynolds |
Publisher | : John Wiley & Sons |
Total Pages | : 294 |
Release | : 2023-12-11 |
Genre | : Medical |
ISBN | : 111979997X |
Download A Guide to Sample Size for Animal-based Studies Book in PDF, ePub and Kindle
Understand a foundational area of experimental design with this innovative reference Animal-based research is an essential part of basic and preclinical research, but poses a unique set of experimental design challenges. The most important of these are the 3Rs Replacement, Reduction and Refinement the principles comprising the ethical framework for humane animal-based studies. However, many researchers have difficulty navigating the design trade-offs necessary to simultaneously minimize animal use, and produce scientific information that is both rigorous and reliable. A Guide to Sample Size for Animal-Based Studies meets this need with a thorough, accessible reference work to the subject. This book provides a straightforward systematic approach to "right-sizing" animal-based experiments, with sample size estimates based on the fundamentals of statistical thinking: structured research questions, variation control and appropriate design of experiments. The result is a much-needed guide to planning animal-based experiments to ensure scientifically valid and reliable results. This book offers: Step-by-step guidance in diverse methods for approximating and refining sample size Detailed treatment of research topics specific to animal-based research, including pilot, feasibility and proof-of-concept studies Sample size approximation methods for different types of data binary, continuous, ordinal, time to event and different study types description, comparison, nested designs, reference interval construction and dose-response studies Numerous worked examples, using real data from published papers, together with SAS and R code A Guide to Sample Size for Animal-Based Studies is a must-have reference for preclinical and veterinary researchers, as well as ethical oversight committees and policymakers.
Author | : National Research Council |
Publisher | : National Academies Press |
Total Pages | : 223 |
Release | : 2003-08-22 |
Genre | : Science |
ISBN | : 030916785X |
Download Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research Book in PDF, ePub and Kindle
Expanding on the National Research Council's Guide for the Care and Use of Laboratory Animals, this book deals specifically with mammals in neuroscience and behavioral research laboratories. It offers flexible guidelines for the care of these animals, and guidance on adapting these guidelines to various situations without hindering the research process. Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research offers a more in-depth treatment of concerns specific to these disciplines than any previous guide on animal care and use. It treats on such important subjects as: The important role that the researcher and veterinarian play in developing animal protocols. Methods for assessing and ensuring an animal's well-being. General animal-care elements as they apply to neuroscience and behavioral research, and common animal welfare challenges this research can pose. The use of professional judgment and careful interpretation of regulations and guidelines to develop performance standards ensuring animal well-being and high-quality research. Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research treats the development and evaluation of animal-use protocols as a decision-making process, not just a decision. To this end, it presents the most current, in-depth information about the best practices for animal care and use, as they pertain to the intricacies of neuroscience and behavioral research.
Author | : National Research Council |
Publisher | : National Academies Press |
Total Pages | : 42 |
Release | : 2011-09-16 |
Genre | : Science |
ISBN | : 030921954X |
Download Guidance for the Description of Animal Research in Scientific Publications Book in PDF, ePub and Kindle
The publication of research articles involving animal studies is central to many disciplines in science and biomedicine. Effective descriptions in such publications enable researchers to interpret the data, evaluate and replicate findings, and move the science forward. Analyses of published studies with research animals have demonstrated numerous deficiencies in the reporting of details in research methods for animal studies. Considerable variation in the amount of information required by scientific publications and reported by authors undermines this basic scientific principle and results in the unnecessary use of animals and other resources in failed efforts to reproduce study results. Guidance for the Description of Animal Research in Scientific Publications outlines the information that should be included in scientific papers regarding the animal studies to ensure that the study can be replicated. The report urges journal editors to actively promote effective and ethical research by encouraging the provision of sufficient information. Examples of this information include: conditions of housing and husbandry, genetic nomenclature, microbial status, detailed experimental manipulations, and handling and use of pharmaceuticals. Inclusion of this information will enable assessment and interpretation of research findings and advancement of knowledge based on reproducible results.
Author | : Michael Festing |
Publisher | : SAGE Publications Limited |
Total Pages | : 0 |
Release | : 2016-12-14 |
Genre | : Science |
ISBN | : 9781473974630 |
Download The Design of Animal Experiments Book in PDF, ePub and Kindle
Where there is no alternative to the use of animals in biomedical research, it is important that experiments are well designed and correctly analysed in order to minimise pain and maximize the chance of getting scientifically valid results. Experiments that use too few animals may fail to pick up biologically important effects, while those who use them incorrectly or wastefully may get invalid results while subjecting the animals to unnecessary pain, distress or lasting harm. The Design of Animal Experiments is intended for all research scientists who use laboratory animals, with the aim of helping them to design their own experiments more effectively and/or to improve their ability to communicate with professional statisticians when necessary. It covers all randomised controlled experimental designs likely to be needed in laboratory animal research, with worked examples showing how they can be statistically analysed. It suggests the more widespread use of randomised block designs and shows how both males and females can be included in an experiment without the need to increase the total number of animals by using factorial designs. It also includes guidance on the choice of experimental animals. The book covers the learning outcomes of Module 10 and part (ii) of Module 11 of education and training under Directive 2010/63/EU.
Author | : Simon T. Bate |
Publisher | : Cambridge University Press |
Total Pages | : 327 |
Release | : 2014-03-13 |
Genre | : Computers |
ISBN | : 1107030781 |
Download The Design and Statistical Analysis of Animal Experiments Book in PDF, ePub and Kindle
This book will provide scientists with a better understanding of statistics, improving their decision-making and reducing animal use.
Author | : |
Publisher | : |
Total Pages | : 232 |
Release | : 2002 |
Genre | : Animal experimentation |
ISBN | : |
Download Institutional Animal Care and Use Committee Guidebook Book in PDF, ePub and Kindle
Author | : Anton Bespalov |
Publisher | : Springer Nature |
Total Pages | : 424 |
Release | : 2020-01-01 |
Genre | : Cardiology |
ISBN | : 3030336565 |
Download Good Research Practice in Non-Clinical Pharmacology and Biomedicine Book in PDF, ePub and Kindle
This open access book, published under a CC BY 4.0 license in the Pubmed indexed book series Handbook of Experimental Pharmacology, provides up-to-date information on best practice to improve experimental design and quality of research in non-clinical pharmacology and biomedicine.
Author | : Richard Colin Campbell |
Publisher | : |
Total Pages | : 264 |
Release | : 1967-11-02 |
Genre | : Medical |
ISBN | : |
Download Statistics for Biologists Book in PDF, ePub and Kindle
Author | : D.R. Cox |
Publisher | : CRC Press |
Total Pages | : 337 |
Release | : 2000-06-06 |
Genre | : Mathematics |
ISBN | : 1420035835 |
Download The Theory of the Design of Experiments Book in PDF, ePub and Kindle
Why study the theory of experiment design? Although it can be useful to know about special designs for specific purposes, experience suggests that a particular design can rarely be used directly. It needs adaptation to accommodate the circumstances of the experiment. Successful designs depend upon adapting general theoretical principles to the spec