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3D Cell-Based Biosensors in Drug Discovery Programs

3D Cell-Based Biosensors in Drug Discovery Programs
Author: William S. Kisaalita
Publisher: CRC Press
Total Pages: 404
Release: 2010-06-22
Genre: Medical
ISBN: 1420073508

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Advances in genomics and combinatorial chemistry during the past two decades inspired innovative technologies and changes in the discovery and pre-clinical development paradigm with the goal of accelerating the process of bringing therapeutic drugs to market. Written by William Kisaalita, one of the foremost experts in this field, 3D Cell-Based Bio


Biochemical Sensors (In 2 Volumes)

Biochemical Sensors (In 2 Volumes)
Author: Huangxian Ju
Publisher: World Scientific
Total Pages: 997
Release: 2021-06-08
Genre: Science
ISBN: 9811237727

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This book covers the full scope of biochemical sensors and offers a survey of the principles, design and applications of the most popular types of biosensing devices. It is presented in 19 chapters, written by 20 distinguished scientists as well as their co-workers. The topics include the design of signal transducers, signal tags and signal amplification strategies, the structure of biosensing interfaces with new biorecognition elements such as aptamers and DNAzymes, and different newly emerging nanomaterials such as Au nanoclusters, carbon nitride, silicon, upconversion nanoparticles and two-dimensional materials, and the applications in wearable detections, biofuel cells, biomarker analyses, bioimaging, single cell analysis and in vivo sensing.By discussing recent advances, it is hoped this book will bridge the common gap between research literature and standard textbooks. Research into biochemical sensors and their biomedical applications is proceeding in a number of exciting directions, as reflected by the content. This book is published in honor of the 90th birthday of Professor Shaojun Dong, who performed many pioneering studies on modified electrodes and biochemical sensors.


High Throughput Screening for Food Safety Assessment

High Throughput Screening for Food Safety Assessment
Author: Arun K. Bhunia
Publisher: Elsevier
Total Pages: 550
Release: 2014-09-06
Genre: Technology & Engineering
ISBN: 0857098071

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Recent advances in array-based detectors and imaging technologies have provided high throughput systems that can operate within a substantially reduced timeframe and other techniques that can detect multiple contaminants at one time. These technologies are revolutionary in terms of food safety assessment in manufacturing, and will also have a significant impact on areas such as public health and food defence. This book summarizes the latest research and applications of sensor technologies for online and high throughput screening of food. The book first introduces high throughput screening strategies and technology platforms, and discusses key issues in sample collection and preparation. The subsequent chapters are then grouped into four sections: Part I reviews biorecognition techniques; Part II covers the use of optical biosensors and hyperspectral imaging in food safety assessment; Part III focuses on electrochemical and mass-based transducers; and finally Part IV deals with the application of these safety assessment technologies in specific food products, including meat and poultry, seafood, fruits and vegetables. Summarises the latest research on sensor technologies for online and high-throughput screening of food Covers high-throughput screening and the current and forecast state of rapid contaminant detection technologies Looks at the use of optical and electrochemical biosensors and hyperspectral imaging in food safety assessment and the application of these technologies in specific food products


Cell-based Biosensors

Cell-based Biosensors
Author: Qingjun Liu
Publisher: Artech House
Total Pages: 291
Release: 2009-10
Genre: Medical
ISBN: 1596934409

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Written by recognized experts the field, this leading-edge resource is the first book to systematically introduce the concept, technology, and development of cell-based biosensors. You find details on the latest cell-based biosensor models and novel micro-structure biosensor techniques. Taking an interdisciplinary approach, this unique volume presents the latest innovative applications of cell-based biosensors in a variety of biomedical fields. The book also explores future trends of cell-based biosensors, including integrated chips, nanotechnology and microfluidics. Over 140 illustrations help clarify key topics throughout the book.


Development Engineering

Development Engineering
Author: William Kisaalita
Publisher: Cambridge Scholars Publishing
Total Pages: 307
Release: 2020-08-28
Genre: Business & Economics
ISBN: 1527558940

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This book details the development and evaluation of technological interventions designed to improve human and economic development within complex, low-resource settings, showing that a solution becomes an innovation when it reaches widespread use. The book shortens the time-gap between development and up-take of the intervention, especially for student solution-developers or innovators who are new to the cultural and geopolitical settings of the problem-source country or region. Technological interventions in development are sustainable if they meet a real need, are affordable by the users, fit within the cultural context and are ergonomically appropriate. Many interventions have failed because of inattentiveness to one or more of these factors. Each of the book’s points is backed up with scholarly research work, confidently guiding solution-developers confronted with issues such as acquiring intellectual property protections, among many others.


Whole Cell Sensing Systems I

Whole Cell Sensing Systems I
Author: Shimshon Belkin
Publisher: Springer
Total Pages: 208
Release: 2010-07-13
Genre: Science
ISBN: 3642123627

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Table of Contents Reporter cells: - Yeast Based Sensors by Mifumi Shimomura-Shimizu and Isao Karube - Mammalian Cell-Based Sensor Systems by Pratik Banerjee, Briana Franz, and Arun K. Bhunia - Fluorescent and Bioluminescent Cell-Based Sensors: Strategies for Their Preservation by Amol Date, Patrizia Pasini, and Sylvia Daunert - Electrochemical Cell-Based Sensors by Eliora Z. Ron and Judith Rishpon - Microbial Cell Arrays by Tal Elad, Jin Hyung Lee, Man Bock Gu, and Shimshon Belkin Devices: - Surface Functionalization for Protein and Cell Patterning by Pascal Colpo , Ana Ruiz , Laura Ceriotti , and François Rossi - Fiber-Optic Based Cell Sensors by Evgeni Eltzov and Robert S. Marks - Electronic Interfacing with Living Cells by James T. Fleming - On-Chip Detection of Cellular Activity by R. Almog , R. Daniel , S. Vernick , A. Ron , H. Ben-Yoav, and Y. Shacham-Diamand


Cell-based Biosensors

Cell-based Biosensors
Author: Ping Wang
Publisher: Artech House Publishers
Total Pages: 271
Release: 2010
Genre: Science
ISBN: 9781596934399

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In the 21st century, we are witnessing the integration of two dynamic disciplines electronics and biology. As a result bioelectronics and biosensors have become of particular interest to engineers and researchers working in related biomedical areas. Written by recognized experts the field, this leading-edge resource is the first book to systematically introduce the concept, technology, and development of cell-based biosensors. Readers find details on the latest cell-based biosensor models and novel micro-structure biosensor techniques. Taking an interdisciplinary approach, this unique volume presents the latest innovative applications of cell-based biosensors in a variety of biomedical fields. The book also explores future trends of cell-based biosensors, including integrated chips, nanotechnology and microfluidics. Over 140 illustrations help clarify key topics throughout the book.


Label-Free Biosensor Methods in Drug Discovery

Label-Free Biosensor Methods in Drug Discovery
Author: Ye Fang
Publisher: Humana
Total Pages: 0
Release: 2016-10-05
Genre: Medical
ISBN: 9781493949618

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This volume explores label-free biosensors, advantageous in part because this technology bypasses the need of labels, reporters, and cell engineering, all of which are common to labeled techniques but may introduce artifacts in assay results. Addressing several fundamental and practical aspects as to how to implement label-free methods in the drug discovery process, this book covers a wide range of topics, including binding kinetics determination, fragment screening, antibody epitope mapping, protein-protein interaction profiling and screening, receptor pathway deconvolution, drug pharmacology profiling and screening, target identification, drug toxicity assessment, and physical phenotype profiling and diagnostics based on various cellular processes such as cell adhesion, migration, invasion, infection, and inflammation. As part of the Methods in Pharmacology and Toxicology series, chapters aim to provide key detail and implementation advice to aid with progress in the lab. Practical and thorough, Label-Free Biosensor Methods in Drug Discovery provides a new avenue for rapid access to a focused collection of highly regarded contributions in the field.


Biomedical Product and Materials Evaluation

Biomedical Product and Materials Evaluation
Author: P.V. Mohanan
Publisher: Woodhead Publishing
Total Pages: 808
Release: 2022-01-22
Genre: Technology & Engineering
ISBN: 012824173X

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Biomedical Product and Materials Evaluation: Standards and Ethics provides a much-needed overview of the procedures, issues, standards and ethical issues in the early development of biomedical products. The book covers a range of key biomedical products, from 3D printed organs and blood derived products, to stem calls and decellularized tissue products. Each chapter reviews a single product type, associated materials, biomedical applications, proven development strategies, and potential challenges. The core focus of the book is on the standardization and ethical aspects of biomedical product development, with these elements addressed and discussed in chapters dedicated to product evaluation. This is a useful reference for academics, researchers and industry professionals in R&D groups with an interest in biomaterial research and production, as well as those working in the fields of biomedical engineering, biotechnology and toxicology. Covers a variety of biomedical products, including specific biomaterials, organs-on-chips, wound care products, combinational products, and more Delves into strategies and considerations for product evaluation, including cytotoxicity assays, microbial and blood compatibility studies Discusses standardization and ethical hurdles in biomedical product development and how to overcome them