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An increasingly important and often overlooked issue in science and technology policy is recognizing the role that philanthropies play in setting the direction of research. In an era where public and private resources for science are strained, the practices that foundations adopt to advance basic and applied research needs to be better understood. This first-of-its-kind study provides a detailed assessment of the current state of science philanthropy. This examination is particularly timely, given that science philanthropies will have an increasingly important and outsized role to play in advancing responsible innovation and in shaping how research is conducted. Philanthropy and the Future of Science and Technology surveys the landscape of contemporary philanthropic involvement in science and technology by combining theoretical insights drawn from the responsible research and innovation (RRI) framework with empirical analysis investigating an array of detailed examples and case studies. Insights from interviews conducted with foundation representatives, scholars, and practitioners from a variety of sectors add real-world perspective. A wide range of philanthropic interventions are explored, focusing on support for individuals, institutions, and networks, with attention paid to the role that science philanthropies play in helping to establish and coordinate multi-sectoral funding partnerships. Novel approaches to science philanthropy are also considered, including the emergence of crowdfunding and the development of new institutional mechanisms to advance scientific research. The discussion concludes with an imaginative look into the future, outlining a series of lessons learned that can guide how new and established science philanthropies operate and envisioning alternative scenarios for the future that can inform how science philanthropy progresses over the coming decades. This book offers a major contribution to the advancement of philanthropic investment in science and technology. Thus, it will be of considerable interest to researchers and students in public policy, public administration, political science, science and technology studies, sociology of science, and related disciplines.