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Unravelling Cancer Signaling Pathways: A Multidisciplinary Approach

Unravelling Cancer Signaling Pathways: A Multidisciplinary Approach
Author: Kakoli Bose
Publisher: Springer Nature
Total Pages: 587
Release: 2019-11-25
Genre: Medical
ISBN: 9813298162
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Unravelling the intricate cell signalling networks and their significance in cancer poses major intellectual challenge. Keeping this in mind, the book aims at understanding the mechanism of action of different proteins and their complexes in the cancer signalling pathways. Hence, the proposed book that comprises 20 chapters provides a comprehensive introduction on cell signalling, its alterations in cancer, molecules that have been popular targets as well as the ones that are emerging as targets. In addition, it discusses different forms of therapy that are coming up for its treatment. Other than that, a major portion of the book is focused on studying different disciplines at the interface of biology and other areas of science that are being used to understand cancer biology in depth.

Pharmacotherapeutic Botanicals for Cancer Chemoprevention

Pharmacotherapeutic Botanicals for Cancer Chemoprevention
Author: Manish Kumar
Publisher: Springer Nature
Total Pages: 344
Release: 2020-07-20
Genre: Medical
ISBN: 9811559996
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The book presents a comprehensive and up-to-date overview of phytochemicals as efficient cancer therapeutics. Over the last few decades there has been a paradigm shift from conventional cancer therapeutic approaches to alternative and complementary medicinal approaches especially using phytoconstituents from natural products. As such, the book provides an in-depth understanding of phytochemicals targeting diverse signaling pathways involved in cancer along with the evaluation of the cancer modulatory effects of phytochemicals. It also highlights the potential modulatory effect of single nucleotide polymorphisms (SNPs) on the cancer-associated cellular pathways and their interactions with the phytochemicals. Further, it analyzes the drug delivery methods, bioavailability of active components of botanicals, and toxicity of phytochemicals. Lastly, the book elucidates the 3D cell culture and animal models systems to analyze the beneficial effects of phytochemicals in cancer.

Protein lipidation in health and disease

Protein lipidation in health and disease
Author: Rebeca M. Mejias Estevez
Publisher: Frontiers Media SA
Total Pages: 161
Release: 2023-11-15
Genre: Science
ISBN: 2832539122
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Protein Interactions

Protein Interactions
Author: Volkhard Helms
Publisher: John Wiley & Sons
Total Pages: 436
Release: 2022-11-08
Genre: Science
ISBN: 3527830529
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Protein Interactions A fundamental guide to the burgeoning field of protein interactions From enzymes to transcription factors to cell membrane receptors, proteins are at the heart of biological cell function. Virtually all cellular processes are governed by their interactions, with one another, with cell bodies, with DNA, or with small molecules. The systematic study of these interactions is called Interactomics, and research within this new field promises to shape the future of molecular cell biology. Protein Interactions goes beyond any existing guide to protein interactions, presenting the first truly comprehensive overview of the field. Edited by two leading scholars in the field of protein bioinformatics, this book covers all known categories of protein interaction, stable as well as transient, as well as the effect of mutations and post-translational modifications on the interaction behavior. Protein Interactions readers will also find: Introductory chapters on protein structure, conformational dynamics, and protein-protein binding interfaces A data-driven approach incorporating machine learning and integrating experimental data into computational models An outlook on the current challenges in the field and suggestions for future research Protein Interactions will serve as a fundamental resource for novice researchers who want a systematic introduction to interactomics, as well as for experienced cell biologists and bioinformaticians who want to gain an edge in this exciting new field.

Multidisciplinary Approach for Colorectal Cancer

Multidisciplinary Approach for Colorectal Cancer
Author: Keun-Yeong Jeong
Publisher: BoD – Books on Demand
Total Pages: 108
Release: 2019-12-18
Genre: Medical
ISBN: 1789843995
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A multidisciplinary understanding of the various processes leading to colorectal cancer progression is important for creating promising methods of therapy. Therefore it is necessary to scrutinize the progression of cancer and the therapeutic process through various academic theories. This book examines colorectal cancer - its prevention, pathogenesis, and treatment - through a multidisciplinary lens in an effort to advance understanding of the disease and improve therapeutic efficacy.

Epithelial-Mesenchymal Plasticity in Cancer Metastasis

Epithelial-Mesenchymal Plasticity in Cancer Metastasis
Author: Mohit Kumar Jolly
Publisher: MDPI
Total Pages: 512
Release: 2020-12-29
Genre: Medical
ISBN: 3039367242
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Recent studies have highlighted that epithelial-mesenchymal transition (EMT) is not only about cell migration and invasion, but it can also govern many other important elements such as immunosuppression, metabolic reprogramming, senescence-associated secretory phenotype (SASP), stem cell properties, therapy resistance, and tumor microenvironment interactions. With the on-going debate about the requirement of EMT for cancer metastasis, an emerging focus on intermediate states of EMT and its reverse process mesenchymal-epithelial transition (MET) offer new ideas for metastatic requirements and the dynamics of EMT/MET during the entire metastatic cascade. Therefore, we would like to initiate discussions on viewing EMT and its downstream signaling networks as a fulcrum of cellular plasticity, and a facilitator of the adaptive responses of cancer cells to distant organ microenvironments and various therapeutic assaults. We hereby invite scientists who have prominently contributed to this field, and whose valuable insights have led to the appreciation of epithelial-mesenchymal plasticity as a more comprehensive mediator of the adaptive response of cancer cells, with huge implications in metastasis, drug resistance, tumor relapse, and patient survival.

Optimizing Well-Being in Hypopharyngeal Cancer: A Comprehensive Guide for Patients and Caregivers

Optimizing Well-Being in Hypopharyngeal Cancer: A Comprehensive Guide for Patients and Caregivers
Author: Dr. Spineanu Eugenia
Publisher: Dr. Spineanu Eugenia
Total Pages: 137
Release: 2024-03-03
Genre: Medical
ISBN:
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Discover 'Optimizing Well-Being in Hypopharyngeal Cancer,' a comprehensive guide tailored to patients and caregivers navigating the challenges of this condition. Written by medical experts, this treatise offers a holistic approach to managing hypopharyngeal cancer, providing invaluable insights into its medical intricacies, anatomy, risk factors, and pathogenesis. Readers will delve into the world of hypopharyngeal cancer, gaining a profound understanding of its genetic and epigenetic alterations, the role of oncogenes and tumor suppressors, and the intricate cell signaling pathways involved. Explore the latest research on biomarkers, metabolism, and immunological aspects, empowering you with knowledge to make informed decisions about your treatment journey. With chapters dedicated to surgical techniques, radiation therapy, chemotherapy, targeted therapies, immunotherapy, and palliative care, this treatise equips you with a comprehensive toolkit to combat hypopharyngeal cancer effectively. Dive into the world of cutting-edge treatments and emerging therapies, guided by the expertise of medical professionals. Additionally, this guide delves into complementary and alternative therapies, offering insights into their safe integration alongside conventional treatments. Explore the benefits of mind-body practices, social support, and coping strategies that enhance your emotional and psychological well-being. As you navigate your cancer journey, this treatise provides crucial guidance on survivorship, quality of life assessment, and holistic approaches to well-being. Empower yourself with knowledge, resilience, and the support needed to optimize your well-being in the face of hypopharyngeal cancer. 'Optimizing Well-Being in Hypopharyngeal Cancer' is your indispensable companion on the path to recovery and a resource you can trust. Start your journey to well-being today, and let this guide be your beacon of hope and healing.

Targeted Therapies for Lung Cancer

Targeted Therapies for Lung Cancer
Author: Ravi Salgia
Publisher: Springer
Total Pages: 238
Release: 2019-06-26
Genre: Medical
ISBN: 3030178323
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This book contextualizes translational research and provides an up to date progress report on therapies that are currently being targeted in lung cancer. It is now well established that there is tremendous heterogeneity among cancer cells both at the inter- and intra-tumoral level. Further, a growing body of work highlights the importance of targeted therapies and personalized medicine in treating cancer patients. In contrast to conventional therapies that are typically administered to the average patient regardless of the patient’s genotype, targeted therapies are tailored to patients with specific traits. Nonetheless, such genetic changes can be disease-specific and/or target specific; thus, the book addresses these issues manifested in the somatically acquired genetic changes of the targeted gene. Each chapter is written by a leading medical oncologist who specializes in thoracic oncology and is devoted to a particular target in a specific indication. Contributors provide an in-depth review of the literature covering the mechanisms underlying signaling, potential cross talk between the target and downstream signaling, and potential emergence of drug resistance.

Research and Clinical Applications of Targeting Gastric Neoplasms

Research and Clinical Applications of Targeting Gastric Neoplasms
Author: Brendan Jenkins
Publisher: Elsevier
Total Pages: 370
Release: 2021-07-23
Genre: Science
ISBN: 0323855636
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Research and Clinical Applications of Targeting Gastric Neoplasms provides a comprehensive overview of gastrointestinal cancers, covering preclinical research and clinical findings related to risk factors, current treatment regimens (including immunotherapy), screening/detection methods, etiology of disease, precision medicine and future perspectives. Gastrointestinal cancers rank among the most lethal and common worldwide, and as such, there is intense research into their diverse causes and treatment options. This reference provides a consolidation of the research, making it a perfect resource for basic science and clinical researchers as well as oncologists who work in gastroenterology and GI tract cancer fields. Provides comprehensive coverage of preclinical research and the clinical aspects of gastric cancer Presents future perspectives from leading researchers in the field who provide the potential for furthering research topics Combines the expertise of researchers in GI tracts, cancer, immunity, immunology, infectious disease and microbiology for an interdisciplinary approach