The Ubiquitin System
| Author | : Milton J. Schlesinger |
| Publisher | : Cold Spring Harbor Laboratory Press |
| Total Pages | : 218 |
| Release | : 1988 |
| Genre | : Science |
| ISBN | : |
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Ubiquitin And Autophagy PDF Download
Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download Ubiquitin And Autophagy PDF full book. Access full book title Ubiquitin And Autophagy.
Ubiquitin and Autophagy
| Author | : Taras Y. Nazarko |
| Publisher | : MDPI |
| Total Pages | : 294 |
| Release | : 2021-08-18 |
| Genre | : Science |
| ISBN | : 3036513426 |
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This book is a collection of articles from the Cells Special Issue on “Ubiquitin and Autophagy”. It contains an Editorial and 13 articles at the intersection of ubiquitin- and autophagy-related processes. Ubiquitin is a small protein modifier that is widely used to tag proteins, organelles, and pathogens for their degradation by the ubiquitin–proteasome system and/or autophagy–lysosomal pathway. Interestingly, several ubiquitin-like proteins are at a core of the autophagy mechanism. This book dedicates a lot of attention to the crosstalk between the ubiquitin–proteasome system and autophagy and serves as a good starting point for the readers interested in the current state of the knowledge on ubiquitin and autophagy.
Autophagy: Biology and Diseases
| Author | : Zheng-Hong Qin |
| Publisher | : Springer Nature |
| Total Pages | : 727 |
| Release | : 2019-11-27 |
| Genre | : Science |
| ISBN | : 9811506027 |
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This book series consists of 3 volumes covering the basic science (Volume 1), clinical science (Volume 2) and the technology and methodology (Volume 3) of autophagy. Volume 1 focuses on the biology of autophagy, including the signaling pathways, regulating processes and biological functions. Autophagy is a fundamental physiological process in eukaryotic cells. It not only regulates normal cellular homeostasis, and organ development and function, but also plays an important role in the pathogenesis of a wide range of human diseases. Thanks to the rapid development of molecular biology and omic technologies, research on autophagy has boomed in recent decades, and more and more cellular and animal models and state-of the-art technologies are being used to shed light on the complexity of signaling networks involved in the autophagic process. Further, its involvement in biological functions and the pathogenesis of various diseases has attracted increased attention around the globe. Presenting cutting-edge knowledge, this book series is a useful reference resource for researchers and clinicians who are working on or interested in autophagy.
Membrane Biogenesis
| Author | : Jos A.F. Op den Kamp |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 474 |
| Release | : 2013-06-29 |
| Genre | : Science |
| ISBN | : 3642731848 |
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Many individual aspects of the dynamics and assembly of biological membranes have been studied in great detail. Cell biological approaches, advanced genetics, biophysics and biochemistry have greatly contributed to an increase in our knowledge in this field.lt is obvious however, that the three major membrane constituents - lipids, proteins and carbohydrates- are studied, in most cases separately and that a coherent overview of the various aspects of membrane biogenesis is not readily available. The NATO Advanced Study Institute on "New Perspectives in the Dynamics of Assembly of Biomembranes" intended to provide such an overview: it was set up to teach students and specialists the achievements obtained in the various research areas and to try and integrate the numerous aspects of membrane assembly into a coherent framework. The articles in here reflect this. Statting with detailed contributions on phospholipid structure, dynamics, organization and biogenesis, an up to date overview of the basic, lipidic backbone of biomembranes is given. Extensive progress is made in the research on membrane protein biosynthesis. In particular the post- and co-translational modification processes of proteins, the mechanisms of protein translocation and the sorting mechanisms which are necessary to direct proteins to their final, intra - or extracellular destination have been characterized in detail. Modern genetic approaches were indispensable in this research area: gene cloning, hybrid protein construction, site directed mutagenesis and sequencing techniques elucidated many functional aspects of specific nucleic acid and amino acid sequences.
Autophagy and Cancer
| Author | : Hong-Gang Wang |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 267 |
| Release | : 2013-03-30 |
| Genre | : Medical |
| ISBN | : 1461465613 |
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With the explosion of information on autophagy in cancer, this is an opportune time to speed the efforts to translate our current knowledge about autophagy regulation into better understanding of its role in cancer. This book will cover the latest advances in this area from the basics, such as the molecular machinery for autophagy induction and regulation, up to the current areas of interest such as modulation of autophagy and drug discovery for cancer prevention and treatment. The text will include an explanation on how autophagy can function in both oncogenesis and tumor suppression and a description of its function in tumor development and tumor suppression through its roles in cell survival, cell death, cell growth as well as its influences on inflammation, immunity, DNA damage, oxidative stress, tumor microenvironment, etc. The remaining chapters will cover topics on autophagy and cancer therapy. These pages will serve as a description on how the pro-survival function of autophagy may help cancer cells resist chemotherapy and radiation treatment as well as how the pro-death functions of autophagy may enhance cell death in response to cancer therapy, and how to target autophagy for cancer prevention and therapy − what to target and how to target it.
Cellular Proteolytic Systems
| Author | : Aaron J. Ciechanover |
| Publisher | : Wiley-Liss |
| Total Pages | : 256 |
| Release | : 1994-11-03 |
| Genre | : Medical |
| ISBN | : |
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The field of cellular proteolysis is advancing rapidly and has great potential impact in a variety of research and clinical areas, including AIDS and cancer research and treatment. The editors, pioneers in the field of cellular and protein research, describe our current understanding of the three major cellular proteolytic systems: the ubiquitin system, the lysosomal and vacuolar systems, and physiological and pathophysiological cellular proteolysis.
Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging
| Author | : M. A. Hayat |
| Publisher | : Academic Press |
| Total Pages | : 431 |
| Release | : 2016-12-28 |
| Genre | : Medical |
| ISBN | : 0128094273 |
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Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging is an eleven volume series that discusses in detail all aspects of autophagy machinery in the context of health, cancer, and other pathologies. Autophagy maintains homeostasis during starvation or stress conditions by balancing the synthesis of cellular components and their deregulation by autophagy. This series discusses the characterization of autophagosome-enriched vaccines and its efficacy in cancer immunotherapy. Autophagy serves to maintain healthy cells, tissues, and organs, but also promotes cancer survival and growth of established tumors. Impaired or deregulated autophagy can also contribute to disease pathogenesis. Understanding the importance and necessity of the role of autophagy in health and disease is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and forward-thinking, these books offer a valuable guide to cellular processes while also inciting researchers to explore their potentially important connections. Presents the most advanced information regarding the role of the autophagic system in life and death Examines whether autophagy acts fundamentally as a cell survivor or cell death pathway or both Introduces new, more effective therapeutic strategies in the development of targeted drugs and programmed cell death, providing information that will aid in preventing detrimental inflammation Features recent advancements in the molecular mechanisms underlying a large number of genetic and epigenetic diseases and abnormalities, including atherosclerosis and CNS tumors, and their development and treatment Includes chapters authored by leaders in the field around the globe—the broadest, most expert coverage available
Autophagy
| Author | : Kelsey B. Law |
| Publisher | : Elsevier Inc. Chapters |
| Total Pages | : 29 |
| Release | : 2013-09-03 |
| Genre | : Medical |
| ISBN | : 0128069317 |
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Macroautophagy is mainly considered to be a mechanism for the bulk degradation of the cytoplasm in times of nutrient depletion. However, growing evidence suggests that macroautophagy is more substrate-specific than originally considered. Numerous cytosolic components are selectively degraded by macroautophagy, including aggresomes, damaged mitochondria, peroxisomes, ribosomes, midbodies, and bacteria and viruses. Although the specific molecular components may differ for each substrate, the general mechanism of selective macroautophagy involves the targeted ubiquitination of the substrate and the recruitment of autophagy receptors. Autophagy receptors are proteins that act as an interface between the substrate and the nascent autophagosome, the double-membrane structure that sequesters the cytoplasm for delivery to lysosomes for degradation. In this chapter we will describe the general mechanism of selective autophagy in the mammalian system, focusing on the most described autophagy receptor, p62. The emerging data suggest that selective autophagy is not only necessary for cell survival during nutrient starvation, but also plays a critical role in cell development, cellular responses to oxidative stress, and innate immunity.
Non-Canonical Autophagy
| Author | : Giulia Petroni |
| Publisher | : Academic Press |
| Total Pages | : 184 |
| Release | : 2021-04-21 |
| Genre | : Science |
| ISBN | : 0128209119 |
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Non-canonical Autophagy: Mechanisms and Pathophysiological Implications outlines the differences between ‘canonical’ and ‘non-canonical’ forms of autophagy, highlighting the discoveries concerning the molecular mechanisms underlying these unconventional forms of autophagy and the advancements in pathophysiological features of ‘non-canonical’ autophagy. The book discusses all forms of ‘non-canonical’ autophagy and the complexity of autophagy-dependent cell death. Readers will gain a better understanding of mechanisms underlying ‘non-canonical’ autophagy so that they can interpret the biological effects of autophagy correctly and identify reliable, novel and effective treatment strategies. Presents the most advanced information surrounding the molecular mechanisms underlying non-canonical autophagy Outlines the increasing evidence regarding the involvement of non-canonical autophagy in multiple physiological and pathological processes Discusses the therapeutic potential of autophagy modulators and the obstacles that have limited their development
Autophagy
| Author | : Vladimir Rogov |
| Publisher | : Elsevier Inc. Chapters |
| Total Pages | : 51 |
| Release | : 2013-09-03 |
| Genre | : Medical |
| ISBN | : 0128069309 |
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Autophagy, the evolutionarily conserved lysosome-based degradation system, has been the topic of intensive investigation for the past two decades. The recent explosion of interest can be explained in part by the emerging role of autophagy in pathogenesis and progression of major human diseases, such as neurodegeneration, infection diseases, and cancer. One of the key aspects of autophagy, which is of great importance for the disease-related roles of autophagy and yet remains frequently overlooked, is its remarkable selectivity. Aggregated proteins, damaged mitochondria, superfluous peroxisomes, or invading bacteria are specifically recognized and targeted to the lysosome for destruction by selective autophagy. Research over the past 5 years has identified a number of receptor proteins that bind molecular determinants of the autophagic cargo, leading to nucleation and expansion of the autophagosome around the target structure. Ubiquitin, the small protein modifier, has proven to be one such determinant, which, in addition to protein substrates, earmarks organelles and microbes for selective recognition by the autophagosome. Ubiquitin-like members of the Atg8/LC3/GABARAP protein family are core components of the autophagic machinery that become instrumental in the assembly of target-induced autophagosomes. The understanding of molecular mechanisms of selective clearance of pathogenic structures (protein aggregates, damaged or obsolete organelles and microbes) holds promise for developing new strategies to fight infection, neurodegeneration, and cancer.
