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| Author | : Vijay Gyanani |
| Publisher | : |
| Total Pages | : 286 |
| Release | : 2013 |
| Genre | : Drug targeting |
| ISBN | : |
| Author | : D.D. Lasic |
| Publisher | : Elsevier |
| Total Pages | : 796 |
| Release | : 1998-07-22 |
| Genre | : Business & Economics |
| ISBN | : 0444829172 |
The development of liposomes as a drug delivery system has fluctuated since its introduction in the late 1960's by A.D. Bangham. While academic research of liposomes as a model membrane system has always flourished, as the exponential growth of papers can testify, the application of these findings to medically useful products has gone through several crises. Following the original optimism in the 70's and early 80's, a period of severe skepticism ensued at the end of the 80's and beginning of the 90's, culminating in a moderate but real optimism in the mid 90's, as a result of a successful launch of the first products in the US and Europe. In this collection of papers, the editors have gathered the most promising ideas, approaches, applications and commercial developments, thereby presenting an up-to-date compilation of the present status of the field. This includes such broad areas as anti-cancer chemotherapy immune stimulation and infectious diseases. Currently, the major areas of progress are in delivery of anti-fungal agents by conventional liposomes or lipid-based carriers and systemic anticancer therapy using long-circulating liposomes. The future applications as characterized by the direction of present day research is in specific targeting and delivery of informational molecules such as DNA plasmids (genes), antisense oligonucleotides or ribozymes. Other future developments may be in topical delivery, vaccination and in diagnostics. Features of this book: . Contributions from almost all the leading labs in the field . Up-to-date, critical reviews bridged by editors' introductions . Organized into a logical framework.
| Author | : Danilo D. Lasic |
| Publisher | : CRC Press |
| Total Pages | : 324 |
| Release | : 2018-05-04 |
| Genre | : Medical |
| ISBN | : 1351414011 |
This book examines stealth liposomes from a multidisciplinary approach, which includes theoretical polymer physics, organic synthesis, colloid science, and biology. Discussions include theory, chemistry, biochemistry, pharmacology, preclinical studies in model systems, and medical applications in humans.
| Author | : Sophia G. Antimisiaris |
| Publisher | : Elsevier |
| Total Pages | : 698 |
| Release | : 2024-04-15 |
| Genre | : Medical |
| ISBN | : 0443154929 |
Liposomes in Drug Delivery: What, Where, How and When to Deliver is a concise, well-structured reference covering all the important issues related to the potential of this technology. Organized to provide practical information to researchers from any discipline with a particular therapeutic or bio-active substance to deliver, this book helps readers understand if liposomes can be of benefit for their particular need, what is the best type of liposome to use according to what needs to be delivered, where/when to deliver it, and how to design/prepare/characterize/investigate/optimize liposome properties for a particular application. The book is structured in Four parts. The first covers in a concise but in-depth way, what liposomes are, which are the liposome types, advantages/disadvantages, and what is their stability, characterization methods, in vitro stability, and in vivo fate after different administration methods (routes). The second part focuses on the different mechanisms for liposomal drug delivery. Methodologies/technologies for manipulation of liposome structure/properties in order to design liposomes for particular delivery applications. Specific roadmaps for liposome design are discussed, including components to incorporate in liposomes for specific types of encapsulated molecules or specific routes of administration. The third part covers liposome applications for drug delivery. It focuses on specific delivery considerations for particular diseases. Finally, the fourth part covers methods of liposome fabrication. Focuses on key information - What, Where, How and When to deliver – needed for drug delivery researchers Covers all aspects of liposomes in drug delivery in one single volume Guides researchers through the decision process on whether and what liposomes are most applicable to their particular interest
| Author | : Jean R. Philippot |
| Publisher | : CRC Press |
| Total Pages | : 292 |
| Release | : 1994-11-11 |
| Genre | : Science |
| ISBN | : 9780849345692 |
This book is devoted to a broader understanding of liposomes as a versatile tool used in many domains, including basic research and applied technology, focusing on less common applications and recent developments. Over the past few years, new types of liposomes made of nonphospholipid molecules have opened new perspectives in applications. These lipid vesicles, already used in cosmetology, are being manufactured for industrial and agricultural uses. However, "Stealth" liposomes, pH-sensitive liposomes, and cationic liposomes have enlarged and improved the application field of liposomes in clinical research. The book covers these different uses of liposomes with particular attention to new formulations and new applications.
| Author | : Cyrus R Safinya |
| Publisher | : |
| Total Pages | : |
| Release | : 2017 |
| Genre | : |
| ISBN | : |
Cationic Liposomes (CLs) are synthetic vectors for nucleic acid (NA) and drug delivery applications. CLs may be complexed with nucleic acids (DNA or short interfering RNA) for gene delivery and silencing, or used as vectors of cytotoxic hydrophobic drugs in cancer therapeutics. Primary among hydrophobic drugs is paclitaxel (PTX) a mitotic inhibitor that halts the proliferation of tumor cells during the cell cycle and induces cell death. We will describe the effect of PEGylation of paclitaxel-loaded cationic liposome (CLPTX) nanoparticles (NPs) on structure and NP shape, which, in turn, lead to modified interactions with human cancer cells and a dramatic enhancement of PTX delivery and cytotoxicity compared to bare CLPTX NPs. This enhancement occurs even though the PEG-chain coating the NP is in the mushroom to brush transition regime. These results are in contrast to PEGylated CL-DNA NPs employed in gene therapeutics, where the PEG coat suppresses cell entry.
| Author | : Daphne Hsiao-Hua Da |
| Publisher | : |
| Total Pages | : 84 |
| Release | : 1994 |
| Genre | : Doxorubicin |
| ISBN | : |
| Author | : Letícia Rangel |
| Publisher | : |
| Total Pages | : 630 |
| Release | : 2013 |
| Genre | : |
| ISBN | : 9789535171409 |
Cancer Treatment: Conventional and Innovative Approaches is an attempt to integrate into a book volume the various aspects of cancer treatment, compiling comprehensive reviews written by an international team of experts in the field. The volume is presented in six sections: i) Section 1: Cancer treatment: Conventional and innovative pharmacological approaches; ii) Section 2: Combinatorial strategies to fight cancer: Surgery, radiotherapy, backytherapy, chemotherapy, and hyperthermia; iii) Section 3: The immunotherapy of cancer; iv) Section 4: Multidisciplinarity in cancer therapy: nutrition and beyond; v) Section 5: Supportive care for cancer patients; vi) Section 6: Perspectives in cancer biology and modeling. Ultimately, we hope this book can enlighten important issues involved in the management of cancer, summarizing the state-of-the-art knowledge regarding the disease control and treatment; thus, providing means to improve the overall care of patients that daily battle against this potentially lethal condition.
| Author | : Angel Catala |
| Publisher | : BoD – Books on Demand |
| Total Pages | : 104 |
| Release | : 2019-09-04 |
| Genre | : Science |
| ISBN | : 1789844940 |
Liposomes have received increased attention in recent years. Nevertheless, liposomes, due to their various forms and applications, require further investigation. These structures can deliver both hydrophilic and hydrophobic drugs. The preparation of liposomes results in different properties for these systems. In addition, there are many factors and difficulties that affect the development of liposome drug delivery structures.The purpose of this book is to concentrate on recent developments in liposomes. The articles collected in this book are contributions by invited researchers with long-standing experience in different research areas. We hope that the material presented here is understandable to a broad audience, not only scientists but also people with a general background in many different biological sciences. This volume offers up-to-date, expert reviews of the fast-moving field of liposomes and is divided in two major sections: 1. Introduction; 2. Liposomes general properties
| Author | : Wan-Liang Lu |
| Publisher | : Springer |
| Total Pages | : 0 |
| Release | : 2021-07-01 |
| Genre | : Technology & Engineering |
| ISBN | : 9783662493182 |
This volume describes the protocols for fabrication of liposomal drug delivery system, and consists of two parts. The first part emphasizes the basic protocols and concepts for fabrication of drug-loaded liposomes. For new investigators, laying the groundwork is the first step. This part focuses on the fabrication details in liposomes formulations, which are the so-called small tricks while usually not disclosed in mostly published research articles. However, these processing details are crucial for the preparation of liposomes. And the second part focuses on the strategies in modified and/or functionalized liposomes to adapt to pathophysiological environment, as well as their application in treating diseases. As new analytical and synthetic technologies become available, and improved understanding of pathophysiology, various functionalized drug liposomes are developing to fit the requirements of different therapeutic purposes, exhibiting a broad range of applications. Accordingly, the objectives of this part are aimed at deeply unearthing the formulation of drug-loaded liposomes, describing the detailed operation of liposomal formulation, and further demonstrating their potential applications. Therefore, this volume shows the features of experimental report or protocol for proving a guide to scientists, research students, and young investigators in pharmaceutical enterprises.
