Translational Toxicology PDF Download
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| Author | : Claude L. Hughes |
| Publisher | : Humana Press |
| Total Pages | : 384 |
| Release | : 2016-03-23 |
| Genre | : Medical |
| ISBN | : 331927449X |
Download Translational Toxicology Book in PDF, ePub and Kindle
Bringing together a distinguished interdisciplinary team of contributors, this volume provides a comprehensive exploration of translational toxicology—a systematic approach to developing therapeutic interventions that can protect against, mitigate, or reverse the effects of exposures. In particular, the book addresses modes of action and biomarkers, developmental risks of exposures, and potential translational toxicology therapeutics. The result is a compelling application of developmental toxicology in a new therapeutic discipline that is destined to become part of standard medical practice. Translational Toxicology: Defining a New Therapeutic Discipline is an essential text for regulatory authorities, scientists, and physicians who are concerned with environmental exposures, public health, nutrition, and pharmaceutical research and development. Basic science, epidemiological, and clinical investigators will also find this book a significant resource.
| Author | : Yvonne Will |
| Publisher | : John Wiley & Sons |
| Total Pages | : 899 |
| Release | : 2016-03-22 |
| Genre | : Medical |
| ISBN | : 1119053390 |
Download Drug Discovery Toxicology Book in PDF, ePub and Kindle
As a guide for pharmaceutical professionals to the issues and practices of drug discovery toxicology, this book integrates and reviews the strategy and application of tools and methods at each step of the drug discovery process. • Guides researchers as to what drug safety experiments are both practical and useful • Covers a variety of key topics – safety lead optimization, in vitro-in vivo translation, organ toxicology, ADME, animal models, biomarkers, and –omics tools • Describes what experiments are possible and useful and offers a view into the future, indicating key areas to watch for new predictive methods • Features contributions from firsthand industry experience, giving readers insight into the strategy and execution of predictive toxicology practices
| Author | : Michael D. Waters |
| Publisher | : John Wiley & Sons |
| Total Pages | : 790 |
| Release | : 2018-01-04 |
| Genre | : Medical |
| ISBN | : 1119023602 |
Download Translational Toxicology and Therapeutics Book in PDF, ePub and Kindle
Written by leading research scientists, this book integrates current knowledge of toxicology and human health through coverage of environmental toxicants, genetic / epigenetic mechanisms, and carcinogenicity. Provides information on lifestyle choices that can reduce cancer risk Offers a systematic approach to identify mutagenic, developmental and reproductive toxicants Helps readers develop new animal models and tests to assess toxic impacts of mutation and cancer on human health Explains specific cellular and molecular targets of known toxicants operating through genetic and epigenetic mechanisms
| Author | : Ernest Hodgson |
| Publisher | : Academic Press |
| Total Pages | : 452 |
| Release | : 2012-09-28 |
| Genre | : Medical |
| ISBN | : 0124158137 |
Download Toxicology and Human Environments Book in PDF, ePub and Kindle
Environmental toxicology is generally held to be the study of the potential of constituents of outdoor environments to impact either human health or the biological structure of the ecosystems involved. This volume is a first attempt to integrate toxicological studies of all of the many human environments, both indoor and outdoor, and their complex interrelationships. Included are considerations of natural environments, the agroecosystem, occupational, urban and domestic environments as well as the environment associated with Superfund sites and military deployments. The primary emphasis is on public health, including the potential health effects of toxicants found in different environments, the bioprocessing of such toxicants in humans and surrogate animals and the principles of risk analysis. Approaches the toxicology of human environments in a new and unique way, stressing the complex interrelationships of all human environments and the implication for human and environmental health Each chapter is written by an acknowledged expert and is addressed to those interested in the broader implications of the environmental modifications that are always associated with the activities of humans living and working in them
| Author | : Yvonne Will |
| Publisher | : John Wiley & Sons |
| Total Pages | : 602 |
| Release | : 2016-03-16 |
| Genre | : Medical |
| ISBN | : 1119053323 |
Download Drug Discovery Toxicology Book in PDF, ePub and Kindle
As a guide for pharmaceutical professionals to the issues and practices of drug discovery toxicology, this book integrates and reviews the strategy and application of tools and methods at each step of the drug discovery process. • Guides researchers as to what drug safety experiments are both practical and useful • Covers a variety of key topics – safety lead optimization, in vitro-in vivo translation, organ toxicology, ADME, animal models, biomarkers, and –omics tools • Describes what experiments are possible and useful and offers a view into the future, indicating key areas to watch for new predictive methods • Features contributions from firsthand industry experience, giving readers insight into the strategy and execution of predictive toxicology practices
| Author | : Claude L. Hughes |
| Publisher | : Royal Society of Chemistry |
| Total Pages | : 695 |
| Release | : 2022-04-27 |
| Genre | : Medical |
| ISBN | : 1839166789 |
Download The Coronavirus Pandemic and the Future: Virology, Epidemiology, Translational Toxicology and Therapeutics, Volume 2 Book in PDF, ePub and Kindle
This second volume chronicles the later stages of the outbreak of SARS-Cov-2 (COVID-19) and delineates the role of several disciplines in therapeutic and control measures highliting the response from specific coutries of note and efforts to repurpose and produce new therapeutics and vaccines. By addressing considerations of efficacy and safety of drugs and chemicals used to combat COVID-19, virtually in real-time, this book documents and highlights the advances in science and place the toxicology, pharmaceutical science, public health and medical community in a better position to advise in future epidemics.
| Author | : Michael D. Waters |
| Publisher | : Royal Society of Chemistry |
| Total Pages | : 595 |
| Release | : 2022-04-27 |
| Genre | : Medical |
| ISBN | : 1839163062 |
Download The Coronavirus Pandemic and the Future: Virology, Epidemiology, Translational Toxicology and Therapeutics, Volume 1 Book in PDF, ePub and Kindle
By addressing considerations of efficacy and safety of drugs and chemicals used to combat COVID-19, virtually in real-time, this book documents and highlights the advances in science and place the toxicology, pharmaceutical science, public health and medical community in a better position to advise in future epidemics.
| Author | : |
| Publisher | : Academic Press |
| Total Pages | : 451 |
| Release | : 2012-12-31 |
| Genre | : Science |
| ISBN | : 0124159087 |
Download Toxicology and Human Environments Book in PDF, ePub and Kindle
Environmental toxicology is generally held to be the study of the potential of constituents of outdoor environments to impact either human health or the biological structure of the ecosystems involved. This volume is a first attempt to integrate toxicological studies of all of the many human environments, both indoor and outdoor, and their complex interrelationships. Included are considerations of natural environments, the agroecosystem, occupational, urban and domestic environments as well as the environment associated with Superfund sites and military deployments. The primary emphasis is on public health, including the potential health effects of toxicants found in different environments, the bioprocessing of such toxicants in humans and surrogate animals and the principles of risk analysis. Approaches the toxicology of human environments in a new and unique way, stressing the complex interrelationships of all human environments and the implication for human and environmental health Each chapter is written by an acknowledged expert and is addressed to those interested in the broader implications of the environmental modifications that are always associated with the activities of humans living and working in them
| Author | : Martin Wehling |
| Publisher | : Academic Press |
| Total Pages | : 365 |
| Release | : 2015-04-02 |
| Genre | : Science |
| ISBN | : 0128007214 |
Download Principles of Translational Science in Medicine Book in PDF, ePub and Kindle
Principles of Translational Science in Medicine: From Bench to Bedside, Second Edition, provides an update on major achievements in the translation of research into medically relevant results and therapeutics. The book presents a thorough discussion of biomarkers, early human trials, and networking models, and includes institutional and industrial support systems. It also covers algorithms that have influenced all major areas of biomedical research in recent years, resulting in an increasing numbers of new chemical/biological entities (NCEs or NBEs) as shown in FDA statistics. The book is ideal for use as a guide for biomedical scientists to establish a systematic approach to translational medicine. Provides an in-depth description of novel tools for the assessment of translatability of trials to balance risk and improve projects at any given stage of product development New chapters deal with translational issues in the fastest growing population (the elderly), case studies, translatability assessment tools, and advances in nanotherapies Details IPR issues of translation, especially for public-private-partnerships Contains contributions from world leaders in translational medicine, including the former NIH director and authorities from various European regulatory institutions
| Author | : Rebecca Fry |
| Publisher | : Academic Press |
| Total Pages | : 366 |
| Release | : 2020-11-04 |
| Genre | : Medical |
| ISBN | : 0128199687 |
Download Environmental Epigenetics in Toxicology and Public Health Book in PDF, ePub and Kindle
Environmental Epigenetics in Toxicology and Public Health provides in-depth discussions of the suite of complex environmental factors shown to impact epigenetic components within the cell, as well as evidence that these epigenetic modifications are tied to early and later life health effects. This book offers a translational research perspective, highlighting both in vivo and human population-based evidence for ties between the environment, the epigenome, and health outcomes, with an emphasis on evidence for transgenerational effects of exposures, as well as developmental windows of susceptibility to environmentally-linked epigenetic effects. This volume in the Translational Epigenetics series aides in the development of new therapeutic options meant to reverse inappropriate epigenetic alterations, helping researchers in their efforts prevent and treat a variety of chronic diseases tied to environmental exposures. Offers a thorough discussion of the environmental factors influencing epigenetic mechanisms in early and late life, and in transgenerational inheritance Examines both animal model and human population-based research in environmental epigenetics, highlighting developmental windows of vulnerability to epigenetic modification Features contributions from international experts in the field
