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Therapy Approaches in Neurological Disorders

Therapy Approaches in Neurological Disorders
Author: Mario Bernardo-Filho
Publisher: BoD – Books on Demand
Total Pages: 168
Release: 2021-07-14
Genre: Medical
ISBN: 1839686685

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Neurological disorders are conditions affecting the central or peripheral nervous system, with undesirable consequences for the quality of life. This book highlights and discusses several approaches for managing these conditions and improving the functional capacity and quality of life of patients, including whole-body vibration exercise, biofeedback, sagittal plane spine alignment, allopathic and non-allopathic medications, phytotherapy, and more.


Gene Therapy in Neurological Disorders

Gene Therapy in Neurological Disorders
Author: Mingjie Li
Publisher: Academic Press
Total Pages: 450
Release: 2018-05-25
Genre: Medical
ISBN: 012809821X

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Gene therapy has tremendous potential for the treatment of neurological disorders. There has been substantial progress in the development of gene therapy strategies for neurological disorders over the last two decades. Gene Therapy in Neurological Disorders thoroughly reviews currently available gene therapy tools and presents examples of their application in a variety of neurological diseases. The book begins with general reviews of gene therapy strategies with a focus on neurological disorders. The remainder of the chapters present approaches to specific neurological disorders. Each chapter gives an in-depth introduction to the relevant field before diving into the specific tool or application. The book aims to help investigators, students and research staff better understand the principles of gene therapy and its application in the nervous system. Provides background information and experimental details of gene therapy tools applied for neuroscience research and neurological disorders Covers a broad range of gene delivery and regulation tools, therapeutic agents, and target cells, including emerging new technologies such as CRISPR/Cas9 genome editing Discusses applications of gene therapy tools to neurological disorders including neurodegeneration, muscular dystrophy, trauma and chronic pain, and neoplastic diseases


Gene Therapy for Neurological Disorders

Gene Therapy for Neurological Disorders
Author: Fredric P. Manfredsson
Publisher: Humana
Total Pages: 0
Release: 2015-11-26
Genre: Medical
ISBN: 9781493932702

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This volume provides a clear and detailed roadmap of how to design and execute a gene therapy experiment in order to obtain consistent results. Chapters in this book disseminate bits of unknown information that are important to consider during the course of experimentation and will answer questions such as: What delivery vehicle do you use?; How will you ensure that your vector retains stability?; What expression system best fits your needs?; What route will you choose to deliver your gene therapy agent?; How will you model the neurodegenerative disorder that you aim to investigate and what are the proven methods to treat these disorders in preclinical models? Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and tips on troubleshooting and avoiding known pitfalls. Authoritative and thorough, Gene Therapy for Neurological Disorders: Methods and Protocols, is a compilation of protocols and instructive chapters intended to give researchers, clinicians, and students of all levels, a foundation upon which future gene therapy experiments can be designed.


Developing Multimodal Therapies for Brain Disorders

Developing Multimodal Therapies for Brain Disorders
Author: National Academies of Sciences, Engineering, and Medicine
Publisher: National Academies Press
Total Pages: 97
Release: 2017-03-13
Genre: Medical
ISBN: 0309450268

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Multimodal therapy approaches that combine interventions aimed at different aspects of disease are emerging as potentialâ€"and perhaps essentialâ€"ways to enhance clinical outcomes for patients with psychiatric and neurological disorders. In order to examine the general principles underlying multimodal therapies and to explore challenges, potential barriers, and opportunities for their development, the National Academies of Sciences, Engineering, and Medicine convened a workshop in June 2016. Participants explored scientific, clinical, regulatory, and reimbursement issues related to multimodal approaches and potential opportunities to enhance clinical outcomes for individuals with nervous system disorders. This publication summarizes the presentations and discussions from the workshop.


Disease Control Priorities, Third Edition (Volume 4)

Disease Control Priorities, Third Edition (Volume 4)
Author: Vikram Patel
Publisher: World Bank Publications
Total Pages: 307
Release: 2016-03-10
Genre: Medical
ISBN: 1464804281

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Mental, neurological, and substance use disorders are common, highly disabling, and associated with significant premature mortality. The impact of these disorders on the social and economic well-being of individuals, families, and societies is large, growing, and underestimated. Despite this burden, these disorders have been systematically neglected, particularly in low- and middle-income countries, with pitifully small contributions to scaling up cost-effective prevention and treatment strategies. Systematically compiling the substantial existing knowledge to address this inequity is the central goal of this volume. This evidence-base can help policy makers in resource-constrained settings as they prioritize programs and interventions to address these disorders.


Drug Discovery Approaches for the Treatment of Neurodegenerative Disorders

Drug Discovery Approaches for the Treatment of Neurodegenerative Disorders
Author: Adeboye Adejare
Publisher: Academic Press
Total Pages: 310
Release: 2016-09-20
Genre: Medical
ISBN: 0128028114

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Drug Discovery Approaches for the Treatment of Neurodegenerative Disorders: Alzheimer’s Disease examines the drug discovery process for neurodegenerative diseases by focusing specifically on Alzheimer’s Disease and illustrating the paradigm necessary to ensure future research and treatment success. The book explores diagnosis, epidemiology, drug discovery strategies, current therapeutics, and much more to provide a holistic approach to the discovery, development, and treatment of Alzheimer’s Disease. Through its coverage of the latest research in targeted drug design, preclinical studies, and mouse and rat models, the book is a must-have resource for all pharmaceutical scientists, pharmacologists, neuroscientists, and clinical researchers working in this area. It illustrates why these drugs tend to fail at the clinical stage, and examines Alzheimer’s Disease within the overall context of improving the drug discovery process for the treatment of other neurodegenerative disorders. Provides a compilation of chemical considerations required in drug discovery for the treatment of neurodegenerative disorders Examines different classes of compounds currently being used in discovery and development stages Explores in vitro and in vivo models with respect to their ability to translate these models to human conditions Distills the most significant information across multiple areas of Alzheimer’s disease research to provide a single, comprehensive, and balanced resource


Translational Neuroscience

Translational Neuroscience
Author: Mark H. Tuszynski
Publisher: Springer
Total Pages: 584
Release: 2016-03-08
Genre: Medical
ISBN: 148997654X

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Translational Neuroscience offers a far-reaching and insightful series of perspectives on the effort to bring potentially revolutionary new classes of therapies to the clinic, thereby transforming the treatment of human nervous system disorders. Great advances in the fields of basic neuroscience, molecular biology, genomics, gene therapy, cell therapy, stem cell biology, information technology, neuro devices, rehabilitation and others over the last 20 years have generated unprecedented opportunities to treat heretofore untreatable disorders of the nervous system. This book provides a wide-ranging yet detailed sample of many of these efforts, together with the methods for pursuing clinical translation and assessing clinical outcomes. Among the topics covered are Alzheimer’s disease, Parkinson’s disease, stroke, multiple sclerosis, epilepsy, motor neuron disease, pain, inborn errors of metabolism, brain tumors, spinal cord injury, neuroprosthetics, rehabilitation and clinical trial design/consideration. Translational Neuroscience is aimed at basic neuroscientists, translational neuroscientists and clinicians who seek to gain a perspective on the nature and promise of translational therapies in the current era. Both students and established professionals will benefit from the content.


Occupational Therapy and Neurological Conditions

Occupational Therapy and Neurological Conditions
Author: Jenny Preston
Publisher: John Wiley & Sons
Total Pages: 232
Release: 2016-03-22
Genre: Medical
ISBN: 1118936132

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While diagnosis with a neurological condition may not be life-threatening, it can have significant impact on everyday life and on participation in activities. Occupational therapists must be able to fully consider the physical, cognitive, emotional, psychological and behavioural problems which may occur as a consequence of a neurological disorder, and understand the impact of diagnosis from a person-centred perspective. Occupational Therapy and Neurological Conditions incorporates theoretical, clinical and research evidence to support occupational therapists in the management of people with neurological conditions. Covers the key symptoms of neurological conditions and the biological basis of these within the ICF framework Provides an overview of therapy and management for all neurological conditions Includes key occupational therapy theory Case studies root concepts in real-life practice End-of-chapter self-evaluation questions help test understanding Occupational Therapy and Neurological Conditions is the ideal resource to support students, newly-qualified practitioners, and occupational therapists looking for an overview or introduction to this key area of practice.


Handbook of Neurological Therapy

Handbook of Neurological Therapy
Author: Carlo Colosimo
Publisher: Oxford University Press, USA
Total Pages: 481
Release: 2015
Genre: Medical
ISBN: 0199862923

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This is a practical book on neurological therapy. It is aimed at giving concise and updated answers to busy practicing clinicians in the clinic, ward, or emergency department. An evidence-based approach is used, but when there is no evidence or the data are inconclusive, an expert opinion is always given in order to meet the expectations of the reader. All neurological conditions, common and less common, are discussed; each chapter has a similar format, and contains an initial brief introduction on the epidemiology and clinical features of each disease. The therapy is then discussed, including pharmacological and non-pharmacological, with wide use of Tables & Figures. Flowcharts are also included in most of the chapters.