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| Author | : Cyril Corbet |
| Publisher | : Frontiers Media SA |
| Total Pages | : 192 |
| Release | : 2020-04-03 |
| Genre | : |
| ISBN | : 288963647X |
| Author | : Cyril Corbet |
| Publisher | : |
| Total Pages | : 0 |
| Release | : 2020 |
| Genre | : |
| ISBN | : |
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
| Author | : Khalid Shah |
| Publisher | : John Wiley & Sons |
| Total Pages | : 497 |
| Release | : 2013-08-01 |
| Genre | : Science |
| ISBN | : 1118660625 |
Stem Cell Therapeutics for Cancer covers the application of stem cells in various cancers, with an emphasis on the aspects of these strategies that are critical to the success of future stem cell-based therapies for cancer. Topics covered in the book include stem cell sources, tumor specificity, targeted therapeutics, visualizing the stem cell, and therapeutic agent pharmacokinetics. Each chapter contains a brief introduction to the cancer, followed by an exploration of how engineered stem cells have been utilized to cure the disease in mouse models and in early phase clinical trials. Comprises of sections on stem cell therapy in brain cancers, lung cancers, breast cancers, as well as stem cells in combination with other therapies Focuses on the practical applications of using stem cells as gene delivery agents to treat cancer Includes coverage of cutting-edge molecular imaging techniques in stem cell therapeutics for a variety of tumour types
| Author | : Farhadul Islam |
| Publisher | : Springer Nature |
| Total Pages | : 375 |
| Release | : 2023-07-26 |
| Genre | : Medical |
| ISBN | : 9819931851 |
This book comprehensively reviews the role of cancer stem cells (CSCs) in cancer initiation, progression, and resistance to anticancer therapies. The initial chapters examine the methods and procedure of the detection, isolation, and characterization of CSCs. It also introduces various epigenetic pathways that contribute to cancer initiation and tumorigenesis, particularly regarding the maintenance and survival of CSCs. It also explores the role of CSCs metabolism and the mechanisms of metabolic plasticity of CSCs in cancer biology. Further, it also presents the implications of CSCs on the origin of tumor heterogeneity and on heterogeneity of the therapeutic response. Towards the end, this book highlights the different immunotherapeutic approaches targeting CSCs with the potential of strongly improving cancer outcomes. This book offers a broad framework to scientists and clinicians into the state-of-the-art knowledge on cancer stem cell biology and highlights their therapeutic implications.
| Author | : Cristina Maccalli |
| Publisher | : Springer |
| Total Pages | : 256 |
| Release | : 2019-06-04 |
| Genre | : Medical |
| ISBN | : 3030166244 |
This book represents an up-dated summary of the state of the art of the characterization of cancer stem cell/ cancer initiating cell (CSC/CIC) properties. An overview of the definition and biological properties of CSCs/CICs as well as the role of these cells in determining the resistance to standard and immune-based therapies is provided. It also discusses limitations in the achievement of a definitive biological characterization of CSCs/CICs due to their high extent of plasticity and heterogeneity that is also mutually driven by the interaction of these cells with the tumor microenvironment. The limitations in targeting CSCs/CICs with immunotherapy are also explained together with explorative combination approaches that could increase the susceptibility of these cells to the recognition by immune cells. This book is conceived for a broad audience, including students, teachers, scientific experts. The critical revision of available results in terms of immunological profile of CSCs/CICs and the efficacy in targeting these cells by immunological approaches, results in a comprehensive and up to date recapitulation of the field and provides interesting suggestions on how to focus future investigations in order to assess the role of CSCs/CICs as prognostic and predictive biomarkers of responsiveness to therapies for cancer patients.
| Author | : William L. Farrar |
| Publisher | : Cambridge University Press |
| Total Pages | : 191 |
| Release | : 2009-08-24 |
| Genre | : Science |
| ISBN | : 1139483617 |
A remarkable paradigm shift has occurred in recent years regarding the biological origins of cancer. The cancer stem cell hypothesis challenged the foundational notions of cancer, and the therapeutic implications have been profound. Compelling evidence indicates that errors in the development of a small subset of adult stem cells can lead to cancer. Only this small sub-population of cells has the inherent ability to form tumours and metastasize. This book discusses the emerging field of cancer stem cell research, with contributions from leading experts on the basic biology, genetic pathways, and potentials for therapeutic targeting of cancer stem cells. It also covers clinical challenges for these new discoveries, namely, that cancer stem cells might be resistant to conventional chemotherapeutic and radiological treatments and may be at the biological core of relapse and therapeutic resistance. This book is an essential concise guide to the latest discoveries and therapies in cancer research.
| Author | : Sharmila A. Bapat |
| Publisher | : John Wiley & Sons |
| Total Pages | : 274 |
| Release | : 2008-10-03 |
| Genre | : Science |
| ISBN | : 0470391561 |
Because the concept and discoveries of cancer stem cells are relatively new, scientists and researchers need an introduction to this dynamic area. Cancer Stem Cells presents a consolidated account of the research done to date and recent progresses in the studies of cancer stem cells. Such a presentation facilitates a better understanding of and draws attention to stem cell and cancer biology - two fields that enhance, move, and evolve into each other continuously. It provides an informative study in designing approaches to apply stem cell principles to cancer biology while offering an overview of the challenges in developing combination stem and cancer biology targets for therapeutics. This book serves as a primer for new researchers in the field of cancer biology.
| Author | : Sadegh Babashah |
| Publisher | : Springer |
| Total Pages | : 576 |
| Release | : 2015-11-12 |
| Genre | : Medical |
| ISBN | : 3319210300 |
The concept of cancer stem cells has great clinical implications. This is due to the fact that small subpopulations of these cells have been identified in a variety of neoplastic conditions ranging from solid tumors to liquid malignancies. Although there are some huge gaps in our current understanding of the role played by cancer stem cells in cancer biology, a growing body of evidence provides strong support for the principal functions of these cells in tumorigenesis. This has represented the potential of cancer stem cells in the development of novel and innovative tools for the treatment of metastatic tumors. This book aims to offer a broad framework for obtaining insight into the state-of-the-art knowledge on cancer stem cell biology and highlight the therapeutic implications of these cells in the future of clinical oncology.
| Author | : Thomas Dittmar |
| Publisher | : CRC Press |
| Total Pages | : 334 |
| Release | : 2013-03-01 |
| Genre | : Medical |
| ISBN | : 1466577355 |
This book summarizes the latest findings about the role of cancer stem cells (CSCs) in cancer biology and how this knowledge could be used for novel anticancer therapies. It provides an overview of CSCs in selected malignancies with particular emphasis on hematopoietic neoplasias. It then reviews the role of CSCs in metastasis formation and initiation of cancer relapses. It also examines the dark side of cancer therapy such as conventional cancer therapies that may lead to the origin of recurrence CSCs. Finally, it supplies a brief overview of current concepts that may allow for a selective eradication of CSCs.
| Author | : Khawaja Husnain Haider |
| Publisher | : Walter de Gruyter GmbH & Co KG |
| Total Pages | : 340 |
| Release | : 2018-12-17 |
| Genre | : Medical |
| ISBN | : 3110586916 |
This book is a compilation of the bench experience of leading experts from various research labs involved in the cutting edge area of research. The authors describe the use of stem cells both as part of the combinatorial therapeutic intervention approach and as tools (disease model) during drug development, highlighting the shift from a conventional symptomatic treatment strategy to addressing the root cause of the disease process. The book is a continuum of the previously published book entitled "Stem Cells: from Drug to Drug Discovery" which was published in 2017.
