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Mixture Toxicity

Mixture Toxicity
Author: Cornelis A. M. van Gestel
Publisher: CRC Press
Total Pages: 312
Release: 2016-04-19
Genre: Medical
ISBN: 1439830096

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In the last decade and a half, great progress has been made in the development of concepts and models for mixture toxicity, both in human and environmental toxicology. However, due to their different protection goals, developments have often progressed in parallel but with little integration. Arguably the first book to clearly link ecotoxicology an


Chemical Mixtures and Combined Chemical and Nonchemical Stressors

Chemical Mixtures and Combined Chemical and Nonchemical Stressors
Author: Cynthia V. Rider
Publisher: Springer
Total Pages: 554
Release: 2018-02-16
Genre: Medical
ISBN: 3319562347

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In this book, both basic and advanced concepts are discussed for considering mixtures from initial exposure characterization through evaluation of risk associated with combined exposures. This book will provide an introduction to key issues and multiple options for evaluating both the toxicity of mixtures as well as the risk associated with exposure to mixtures. Additionally, promising tools adapted from other disciplines will be discussed in the context of mixtures toxicology and risk assessment. Finally, the discussion will move beyond chemical mixtures to address incorporating non-chemical stressors into toxicity studies and cumulative risk assessments. Although exposure to multiple chemical and non-chemical stressors is the rule, not the exception, consideration of mixtures in toxicology and risk assessment continues to be a significant challenge. This book will be an essential resource for researchers and professionals in the fields of toxicology, epidemiology, exposure science, risk assessment, and statistics.


Human Toxicology of Chemical Mixtures

Human Toxicology of Chemical Mixtures
Author: Harold Zeliger
Publisher: William Andrew
Total Pages: 627
Release: 2008-07-25
Genre: Technology & Engineering
ISBN: 0815519842

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This book considers how exposure to toxic mixtures affects the different physiological systems and organs, including the respiratory, cardiovascular, immunological, musculoskeletal, nervous and reproductive systems, as well as the various organs, including the kidneys, liver and skin.The author evaluates various sources of exposure, including air, water, and soil pollution; in utero exposure; chemicals contained in foods, cosmetics, and domestic cleaning products; adhesives and paints; industrial chemicals; pesticides; electromagnetic radiation; and chemicals ingested or inhaled during the use of alcohol, tobacco and narcotics.The book also examines the interplay between exposure to these mixtures and the prevalence of various diseases and conditions, including autism, attention deficit hyperactivity disorder (ADHD), developmental neurotoxicology, multiple chemical sensitivity (MSC), chronic fatigue syndrome (CFS), fibromyalgia (FM), Gulf war syndrome, cancer and cancer clusters. The author also discusses how exposure to these mixtures yields the above diseases and conditions in different populations: fetuses, infants, pre-adolescent children, adolescents and adults.Finally, the book addresses the profound policy implications for formulation, labeling and use of chemical products, and it proposes more stringent exposure limits and warning requirements in light of the newly recognized toxic effects that are directly attributable to the mixture of toxic lipophilic and hydrophilic chemicals. Addresses chemical mixtures, while most literature only deals with single chemicals exposure Explains why certain toxicological effects are observed Discusses diagnosis and treatment of injuries resulting from exposure Explores consequences of effects on product formulation, use, handling and required warnings Provides guidelines for safer development of personal care, cosmetic, industrial and consumer use products


The Toxicity of Chemical Mixtures

The Toxicity of Chemical Mixtures
Author: J. K. Pollak
Publisher:
Total Pages: 77
Release: 1993
Genre: Toxicology
ISBN: 9780867587753

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Toxicology of Chemical Mixtures

Toxicology of Chemical Mixtures
Author: Raymond S.H. Yang
Publisher: Elsevier
Total Pages: 745
Release: 2013-10-22
Genre: Science
ISBN: 1483289400

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Although toxicologic studies in the laboratory often focus on a single chemical, in the larger world, mixtures of chemicals are routinely encountered. Toxicology of Chemical Mixtures examines the mechanisms of interactions and health effects stemming from chemical mixtures in the environment. Toxicologists, pharmacologists, environmental scientists, and professionals involved in environmental clean-ups will benefit from its content. Emphasis is on low-level, long-term exposure. Some of the issues addressed include Target organ toxicities in response to chemical mixture exposures Risk assessment and experimental approaches Case studies and special pollution problems Special pollution problems


Marine Anthropogenic Litter

Marine Anthropogenic Litter
Author: Melanie Bergmann
Publisher: Springer
Total Pages: 456
Release: 2015-06-01
Genre: Science
ISBN: 3319165100

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This book describes how man-made litter, primarily plastic, has spread into the remotest parts of the oceans and covers all aspects of this pollution problem from the impacts on wildlife and human health to socio-economic and political issues. Marine litter is a prime threat to marine wildlife, habitats and food webs worldwide. The book illustrates how advanced technologies from deep-sea research, microbiology and mathematic modelling as well as classic beach litter counts by volunteers contributed to the broad awareness of marine litter as a problem of global significance. The authors summarise more than five decades of marine litter research, which receives growing attention after the recent discovery of great oceanic garbage patches and the ubiquity of microscopic plastic particles in marine organisms and habitats. In 16 chapters, authors from all over the world have created a universal view on the diverse field of marine litter pollution, the biological impacts, dedicated research activities, and the various national and international legislative efforts to combat this environmental problem. They recommend future research directions necessary for a comprehensive understanding of this environmental issue and the development of efficient management strategies. This book addresses scientists, and it provides a solid knowledge base for policy makers, NGOs, and the broader public.


Complex Mixtures

Complex Mixtures
Author: National Research Council
Publisher: National Academies Press
Total Pages: 240
Release: 1988-02-01
Genre: Science
ISBN: 0309037786

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In the laboratory, testing the toxic effects for a single compound is a straightforward process. However, many common harmful substances occur naturally as mixtures and can interact to exhibit greater toxic effects as a mixture than the individual components exhibit separately. Complex Mixtures addresses the problem of identifying and classifying complex mixtures, investigating the effect of exposure, and the research problems inherent in testing their toxicity to human beings. A complete series of case studies is presented, including one that examines the cofactors of alcohol consumption and cigarette smoke.


Toxic Legacy

Toxic Legacy
Author: Patrick Sullivan
Publisher: Elsevier
Total Pages: 569
Release: 2010-07-27
Genre: Technology & Engineering
ISBN: 0080466478

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Any professional examination of existing or potential new toxins in a population must account for those already present from past problems and natural conditions.Toxic Legacy provides extensive information on the occurrence of chemical hazards and their potential dangers in combinations in the food, water and air in cities around the United States. The book illustrates consumer preferences for specific food and water products, as well as particular diets and discusses the toxicity and risks associated with our exposure to synthetic chemicals. The authors offer unique guidance to environmental engineers, scientists, process engineers, and planners and specify what steps can be taken to limit exposure to complex chemical mixtures. Includes strategies for minimizing our exposure to chemical mixtures Provides detailed analysis of hazards associated with exposure to chemical mixtures from multiple sources Presents chemical data on the food, water and air for 36 metropolitan areas in the United States


Human Toxicology of Chemical Mixtures

Human Toxicology of Chemical Mixtures
Author: Harold Zeliger
Publisher: William Andrew
Total Pages: 575
Release: 2011-06-24
Genre: Medical
ISBN: 1437734642

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In this important reference work, Zeliger catalogs the known effects of chemical mixtures on the human body and also proposes a framework for understanding and predicting their actions in terms of lipophile (fat soluble) / hydrophile (water soluble) interactions. The author’s focus is on illnesses that ensue following exposures to mixtures of chemicals that cannot be attributed to any one component of the mixture. In the first part the mechanisms of chemical absorption at a molecular and macromolecular level are explained, as well as the body’s methods of defending itself against xenobiotic intrusion. Part II examines the sources of the chemicals discusssed, looking at air and water pollution, food additives, pharmaceuticals, etc. Part III, which includes numerous case studies, examines specific effects of particular mixtures on particular body systems and organs and presents a theoretical framework for predicting what the effects of uncharacterized mixtures might be. Part IV covers regulatory requirements and the need to adjust recommended exposure levels for products containing mixtures. It also contains recommendations on how to limit exposure to mixtures in the products we use and on how to limit release of mixtures into the environment. Providing brief summaries of each mixture and its effects, Zeliger provides a comprehensive reference, a jumping off point for professionals (with extensive chapter bibliographies) and an introduction to the topic for those studying traditional toxicology. Addressing many inadequately understood illnesses and conditions such as asthma, infertility and cancer, it will also be of interest to health professionals, environmental scientists and lawyers. Presents a theoretical framework for predicting the effects of chemical mixtures for which no specific data exists (this predictive aspect is important due to the vast number of different potential chemical combinations – far too many to comprehensively catalog) A quick and convenient source of hard to come by data on the rapidly developing field of chemical mixtures, for groups including chemists and engineers, toxicologists, health professionals and environmental scientists New and updated material comprises over 30% of this timely new edition, which includes the latest research data alongside an expanded introduction to the science and art of predicting the toxicological properties of chemical mixtures


Aquatic Toxicology and Hazard Evaluation

Aquatic Toxicology and Hazard Evaluation
Author: F. L. Mayer
Publisher: ASTM International
Total Pages: 328
Release: 1977
Genre: Science
ISBN: 9780803102781

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