The Role Of Nitric Oxide And Adrenomedullin In Cardiovascular Failure In Septic Shock PDF Download
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Author | : Qixian Shan |
Publisher | : |
Total Pages | : |
Release | : 2017-01-27 |
Genre | : |
ISBN | : 9781374791459 |
Download The Role of Nitric Oxide and Adrenomedullin in Cardiovascular Failure in Septic Shock Book in PDF, ePub and Kindle
This dissertation, "The Role of Nitric Oxide and Adrenomedullin in Cardiovascular Failure in Septic Shock" by Qixian, Shan, 單綺嫻, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. DOI: 10.5353/th_b3124226 Subjects: Nitric oxide - Physiological aspects Adrenomedullin - Physiological aspects Septic shock Heart failure
Author | : Qixian Shan |
Publisher | : |
Total Pages | : 386 |
Release | : 2001 |
Genre | : Adrenomedullin |
ISBN | : |
Download The Role of Nitric Oxide and Adrenomedullin in Cardiovascular Failure in Septic Shock Book in PDF, ePub and Kindle
Author | : Günther Schlag |
Publisher | : Springer Science & Business Media |
Total Pages | : 461 |
Release | : 2012-12-06 |
Genre | : Medical |
ISBN | : 3642586309 |
Download Shock, Sepsis, and Organ Failure Book in PDF, ePub and Kindle
At the Sixth Wiggers Bernard Conference, a group of scientists from various disciplines discussed new findings relating to nitric oxide synthase inhibitor in shock, sepsis, and organ failure. Dedicated to the presentation and discussion of both positive and negative findings related to the use of NOS inhibitors, the meeting served as a forum for issues relating to specific and non-specific inhibitors, as well as the role of nitric oxide-oxygen radical interactions. Both experimental and clinical data were presented in the trauma and sepsis field.
Author | : Günther Schlag |
Publisher | : Springer Science & Business Media |
Total Pages | : 566 |
Release | : 2012-12-06 |
Genre | : Medical |
ISBN | : 3642793436 |
Download Shock, Sepsis, and Organ Failure — Nitric Oxide Book in PDF, ePub and Kindle
International experts examine the role of nitric oxide in various metabolic events such as septic shock, cardiovascular dysfunction, and trauma and hemorrhagic shock. The nitric oxide pathway and nitric oxide synthesis regulation are also discussed.
Author | : M.P. Fink |
Publisher | : Springer Science & Business Media |
Total Pages | : 435 |
Release | : 2012-12-06 |
Genre | : Medical |
ISBN | : 3642799205 |
Download Role of Nitric Oxide in Sepsis and ARDS Book in PDF, ePub and Kindle
Nitric Oxide (NO) is a free radical, a gas, and a pluripotent product of mammalian cells. Only a few years ago, scientific discussions of NO were largely held in the context of the chemistry of air pollution. Now, however, the great significance of NO as a signalling and cytotoxic molecule has captured the attention of the biomedical community. This book provides a very up-to-date review of the role of NO in sepsis and ARDS. Consideration is given to NO both as a pathophysiologic mediator as well as a therapeutic agent. An internationally recognized group of scientists and clinicians have contributed chapters dealing with cutting-edge science and practical clinical strategies. Numerous tables and charts have been included to aid the reader in understanding this fascinating and important subject.
Author | : Bodh I. Jugdutt |
Publisher | : Springer Science & Business Media |
Total Pages | : 248 |
Release | : 2007-05-08 |
Genre | : Medical |
ISBN | : 1402079605 |
Download The Role of Nitric Oxide in Heart Failure Book in PDF, ePub and Kindle
Research on nitric oxide (NO) is a very hot topic since 1998, when three prominent researchers were recognized by Nobel prize awards. Addresses clinically pertinent issues related to nitric oxide in the pathophysiology and therapeutics of heart failure. Chapters written by basic scientists and clinicians to emphasize translation character of research in nitric oxide. An excellent reference source for researchers, practitioners and students.
Author | : Mandar S. Joshi |
Publisher | : |
Total Pages | : |
Release | : 2005 |
Genre | : Genetic polymorphisms |
ISBN | : |
Download Mechanisms of Nitric Oxide Control in Endothelial and Cardiac Dysfunction Book in PDF, ePub and Kindle
Abstract: The primary focus of this work is to investigate the role of nitric oxide control in cardiac and endothelial dysfunction. Intact endothelial function is a major regulator of cardiovascular function. Alterations in nitric oxide (NO) production via endothelial nitric oxide synthase (eNOS, NOS3) have been implicated in cardiovascular dysfunction. NOS3 genetic polymorphisms have been linked to enhanced cardiovascular disease risk but functional implications are not identified. We tested the hypothesis that the NOS3 Glu298Asp polymorphism is associated with altered endothelial cell functional responses with respect to wound healing, responses to high shear, toxic stress and altered protein-protein interactions. We provide the first evidence that presence of NOS3 exon7 Glu298Asp polymorphism alters the endothelial cell (EC) responses to high shear. These alterations are due to differences in interactions between NOS3 and Cav-1. The NOS3 Glu298Asp polymorphism significantly delays the wound closure response in ECs. Moreover, these effects were significantly altered by different VEGF isoforms. Genetic polymorphisms in NOS3 gene and ACE gene have been identified and linked to enhanced vascular susceptibility. We demonstrate the functional importance of NOS3 genetic polymorphism but not the ACE genetic polymorphism. In this section we provide first time evidence for a role of NOS3 Glu298Asp polymorphism in EC function. Reactive oxygen and nitrogen species and mitochondrial dysfunction have all been individually implicated in sepsis related organ failure. Their roles in cardiac failure associated with sepsis are less completely understood. We developed a novel method for measuring mitochondrial morphological alterations and tested the hypothesis that increased NO production and altered mitochondrial functions are implicated as contributing mechanisms to sepsis-induced cardiac dysfunction. We also investigated the potential role of calcineurin inhibitors in attenuation of dysfunction. LPS treatment resulted in reduced contractility and prolonged relaxation times, altered myocardial mitochondrial morphology, and increases in NOS2 protein expression and protein nitration. Enhanced myocardial protein nitration was associated with increased mitochondrial swelling and cardiac dysfunction. Thus, altered reactive nitrogen species apparently play an important role in sepsis related cardiac failure. Moreover, calcineurin inhibitors attenuated the sepsis related dysfunction, providing preliminary evidence for their role as potential therapeutic strategy in sepsis-related organ failure.
Author | : Michel Félétou |
Publisher | : Morgan & Claypool Publishers |
Total Pages | : 309 |
Release | : 2011 |
Genre | : Science |
ISBN | : 1615041230 |
Download The Endothelium Book in PDF, ePub and Kindle
The endothelium, a monolayer of endothelial cells, constitutes the inner cellular lining of the blood vessels (arteries, veins and capillaries) and the lymphatic system, and therefore is in direct contact with the blood/lymph and the circulating cells. The endothelium is a major player in the control of blood fluidity, platelet aggregation and vascular tone, a major actor in the regulation of immunology, inflammation and angiogenesis, and an important metabolizing and an endocrine organ. Endothelial cells controls vascular tone, and thereby blood flow, by synthesizing and releasing relaxing and contracting factors such as nitric oxide, metabolites of arachidonic acid via the cyclooxygenases, lipoxygenases and cytochrome P450 pathways, various peptides (endothelin, urotensin, CNP, adrenomedullin, etc.), adenosine, purines, reactive oxygen species and so on. Additionally, endothelial ectoenzymes are required steps in the generation of vasoactive hormones such as angiotensin II. An endothelial dysfunction linked to an imbalance in the synthesis and/or the release of these various endothelial factors may explain the initiation of cardiovascular pathologies (from hypertension to atherosclerosis) or their development and perpetuation. Table of Contents: Introduction / Multiple Functions of the Endothelial Cells / Calcium Signaling in Vascular Cells and Cell-to-Cell Communications / Endothelium-Dependent Regulation of Vascular Tone / Conclusion / References
Author | : Jeremie Joffre |
Publisher | : Frontiers Media SA |
Total Pages | : 111 |
Release | : 2023-02-10 |
Genre | : Science |
ISBN | : 2832514383 |
Download Endothelial activation and microcirculatory disorders in sepsis and critical illness Book in PDF, ePub and Kindle
Author | : |
Publisher | : |
Total Pages | : 1796 |
Release | : 2000 |
Genre | : Medicine |
ISBN | : |
Download Cumulated Index Medicus Book in PDF, ePub and Kindle