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The Practice of Peptide Synthesis

The Practice of Peptide Synthesis
Author: Miklos Bodanszky
Publisher: Springer Science & Business Media
Total Pages: 268
Release: 2013-11-11
Genre: Science
ISBN: 364296835X

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During the years 1980-81, as guests of the Deutsches Woll forschungsinstitut in Aachen, Germany, we were working on a small book entitled, "Principles of Peptide Synthesis". In the library of the Institute we noted that the volumes of Houben-Weyl's Handbuch der Organischen Chemie dealing with peptide synthesis were so much in use that they were ready to fall apart because the researchers of the Institute consulted them with amazing regularity. They were looking for references, but even more for experimental details which could be adapted to the particular problem they happened to face. In planning a new synthetic endeavor they tried to lean on the experience of others in analogous situations. This suggested to us that a smaller and hence more tractable book may be needed, a volume which can be kept on or near the bench to make examples of funda mental methods readily available in the laboratory. Such a collection could save numerous short trips to the library, a point particularly important where a library well equipped with the sources of the literature of peptide synthesis is not near at hand. Also, we thought that the envisaged book may be welcome by those who are more versed in English than in German. To our best knowledge no similar publi cation is available.


The Practice of Peptide Synthesis

The Practice of Peptide Synthesis
Author: Miklos Bodanszky
Publisher:
Total Pages: 284
Release: 1984
Genre: Peptides
ISBN: 9780387134710

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Fmoc Solid Phase Peptide Synthesis

Fmoc Solid Phase Peptide Synthesis
Author: W. Chan
Publisher: OUP Oxford
Total Pages: 371
Release: 1999-12-16
Genre: Science
ISBN: 0199637245

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Since the publication of Atherton and Sheppard's volume, the technique of Fmoc solid-phase peptide synthesis has matured considerably and is now the standard approach for the routine production of peptides. The focus of this new volume is much broader, and covers the essential procedures.


Principles of Peptide Synthesis

Principles of Peptide Synthesis
Author: M. Bodanszky
Publisher: Springer Science & Business Media
Total Pages: 320
Release: 2012-12-06
Genre: Science
ISBN: 3642967639

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A look at the shelves of a major library awakens doubts in the author of this small volume about the importance of writing a new introduction to peptide synthesis. This rather narrow area of bio-organic chemistry already has received considerable attention. A whole series of books deals with the synthesis of peptides. Some of these are textbooks written to support lecture courses on peptide synthesis. Others try to help the beginner, otherwise well versed in organic chemistry, to embark on some experimental project that requires the construction of peptide chains. Not less useful are the monographs which were compiled to aid the adept practitioner and to provide him with references to the growing literature of a very active field. Is there any need for a new book on peptide synthesis? Should we add a new volume to an already impressive and certainly useful series? The answer is not obvious. The author has already participated in two similar en deavors. The first edition! of "Peptide Synthesis", with M. A. Ondetti as coauthor, was meant to serve as an introduction for the beginner. It was rather well received by researchers who joined the field of peptide chemistry and were looking for initiation. While working on the 2 second edition with Drs. Klausner and Ondetti, we became painfully aware of the impossibility of the task.


Peptide Chemistry

Peptide Chemistry
Author: Miklos Bodanszky
Publisher: Springer Science & Business Media
Total Pages: 209
Release: 2012-12-06
Genre: Science
ISBN: 364297886X

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Analysis of peptides and determination of their primary structure. Conformational analysis: secondary-tertiary structure. Peptide synthesis: protection, activation and coupling, undesired reactions and their prevention, design of synthetic schemes.


Peptide Synthesis and Applications

Peptide Synthesis and Applications
Author: Knud J. Jensen
Publisher: Humana
Total Pages: 0
Release: 2016-08-27
Genre: Science
ISBN: 9781493960040

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Peptides are used ubiquitously for studies in biology, biochemistry, chemical biology, peptide based medicinal chemistry, and many other areas of research. There is a number of marketed peptide drugs, and the prospects for the development of new peptide drugs are very encouraging. The second edition of Peptide Synthesis and Applications expands upon the previous editions with current, detailed methodologies for peptide synthesis. With new chapters on laboratory protocols for both the specialist and the non-specialist. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Peptide Synthesis and Application, Second Edition seeks to aid scientists in understanding different approaches to the synthesis of peptides by using a broad range of methods and strategies.


Life During a Golden Age of Peptide Chemistry

Life During a Golden Age of Peptide Chemistry
Author: Bruce Merrifield
Publisher:
Total Pages: 328
Release: 1993
Genre: Biography & Autobiography
ISBN:

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Thirteenth in a series of autobiographies of 22 eminent organic chemists, the present volume chronicles the life and contributions to the field of Bruce Merrifield, winner of the 1984 Nobel Prize for chemistry. Subtitled The Concept and Development of Solid-Phase Peptide Synthesis. Highly illustrated with diagrams, tables, graphs and (bandw) photographs. Annotation copyright by Book News, Inc., Portland, OR


Solid-Phase Peptide Synthesis

Solid-Phase Peptide Synthesis
Author: Gregg B. Fields
Publisher: Academic Press
Total Pages: 828
Release: 1997-10-21
Genre: Medical
ISBN:

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The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volumehas been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. More than 275 volumes have been published (all of them still in print) and much of the material is relevant even today-truly an essential publication for researchers in all fields of life sciences. Key Features * Solid-phase peptide synthesis * Applications of peptides for structural and biological studies * Characterization of synthetic peptides


Chemical Approaches to the Synthesis of Peptides and Proteins

Chemical Approaches to the Synthesis of Peptides and Proteins
Author: Paul Lloyd-Williams
Publisher: CRC Press
Total Pages: 306
Release: 1997-04-23
Genre: Medical
ISBN: 9780849391422

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Organic chemists working on the synthesis of natural products have long found a special challenge in the preparation of peptides and proteins. However, more reliable, more efficient synthetic preparation methods have been developed in recent years. This reference evaluates the most important synthesis methods available today, and also considers methods that show promise for future applications. This text describes the state of the art in efficient synthetic methods for the synthesis of both natural and artificial large peptide and protein molecules. Subjects include an introduction to basic topics, linear solid-phase synthesis of peptides, peptide synthesis in solution, convergent solid-phase synthesis, methods for the synthesis of branched peptides, formation of disulfide bridges, and more. The book emphasizes strategies and tactics that must be considered for the successful synthesis of peptides.


Peptides

Peptides
Author: Bernd Gutte
Publisher: Elsevier
Total Pages: 527
Release: 1995-10-24
Genre: Science
ISBN: 0080538592

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In recent years, research has shown the importance of peptides in neuroscience, immunology, and cell biology. Active research programs worldwide are now engaged in developing peptide-based drugs and vaccines using modification of natural peptides and proteins, design of artificial peptides and peptide mimetics, and screening of peptide and phage libraries. In this comprehensive book, the authors discuss peptide synthesis and application within the context of their increasing importance to the pharmaceutical industry. Peptides: Synthesis, Structures, and Applications explores the broad growth of information in modern peptide synthetic methods and the structure-activity relationships of synthetic polypeptides. The history of peptide chemistry Amide formation, deprotection, and disulfide formation in peptide synthesis Solid-phase peptide synthesis a-helix formation by peptides in water Stability and dynamics of peptide conformation An overview of structure-function studies of peptide hormones Neuropeptides:peptide and nonpeptide analogs Reversible inhibitors of serine proteinases Design of polypeptides Current capabilities and future possibilities of soluble chemical combinatorial libraries Epitope mapping with peptides Synthesis and applications of branched peptides in immunological methods and vaccines