The Journal Of Biological Chemistry 1905 Vol 10 Classic Reprint PDF Download

Excerpt from The Journal of Biological Chemistry, 1917, Vol. 31 In a recent publication Anderson has reviewed the literature on the utilization of inosite by animals and has reported the results of his own experiments. All investigators who have worked with inosite have found that it is not readily utilized by animals. After administration by mouth, a considerable amount of inosite may disappear but, after subcutaneous administration, most of it is found in the urine. The destruction of inosite given by mouth has generally been ascribed to the action of the intestinal flora. In man, Anderson found that of 0.5 gm. of inosite per kilo of body weight given by mouth, only 9 percent was found in the urine and none in the feces. In the dog, however, with doses of 2 gm. per kilo, apparently very little was absorbed from the intestine. A large part of the inosite administered could be recovered from the feces but only a small amount was found in the urine. Ingestion of inosite did not raise the respiratory quotient and Anderson concluded that "inosite is not utilized to any extent by the dog." At the time Anderson's experiments were published we had already been engaged with an investigation of the same subject. Our first experiments were planned to ascertain whether or not inosite was, physiologically, related to the carbohydrates. Previous work had indicated that it was not. Kulz and Mayer had failed to observe a formation of glycogen from inosite. About the Publisher Forgotten Books publishes hundreds of thousands of rare and classic books. Find more at www.forgottenbooks.com This book is a reproduction of an important historical work. Forgotten Books uses state-of-the-art technology to digitally reconstruct the work, preserving the original format whilst repairing imperfections present in the aged copy. In rare cases, an imperfection in the original, such as a blemish or missing page, may be replicated in our edition. We do, however, repair the vast majority of imperfections successfully; any imperfections that remain are intentionally left to preserve the state of such historical works."