The Dna Replication Machinery As Therapeutic Targets PDF Download
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Author | : Andrew F. Gardner |
Publisher | : Frontiers Media SA |
Total Pages | : 144 |
Release | : 2019-09-19 |
Genre | : |
ISBN | : 2889459276 |
Download The DNA Replication Machinery as Therapeutic Targets Book in PDF, ePub and Kindle
In all organisms, the DNA replication machinery is responsible for accurate and efficient duplication of the chromosome. Inhibitors of replication proteins are commonly used in anti-cancer and anti-viral therapies. This eBook on “The DNA Replication Machinery as Therapeutic Targets” examines the normal functions of replication proteins as well as strategies to target each step during the replication process including DNA unwinding, DNA synthesis, and DNA damage bypass and repair. Articles discuss current strategies to develop drugs targeting DNA replication proteins as well as future outlooks and needs.
Author | : D.J. McCance |
Publisher | : Gulf Professional Publishing |
Total Pages | : 212 |
Release | : 2002-09-13 |
Genre | : Medical |
ISBN | : 9780444506269 |
Download Human Papilloma Viruses Book in PDF, ePub and Kindle
This book describes up-to-date information on the pathogenesis and molecular biology of human papillomaviruses and describes the mechanistic role of the viruses in epithelial cancers. Included in the book are chapters on the epidemiology of human papillomaviruses, the factors that control replication and transcription and the viral proteins, which are involved in modulating the biology of the host cell leading to cancer. Details of the immune response to the viruses and potential vaccine strategies are discussed.
Author | : Muzafar Ahmad Macha |
Publisher | : Frontiers Media SA |
Total Pages | : 359 |
Release | : 2023-06-09 |
Genre | : Medical |
ISBN | : 2832526195 |
Download Emerging therapeutic targets, potential diagnostic or prognostic markers for colorectal cancer Book in PDF, ePub and Kindle
Author | : Ann Arvin |
Publisher | : Cambridge University Press |
Total Pages | : 1325 |
Release | : 2007-08-16 |
Genre | : Medical |
ISBN | : 1139461648 |
Download Human Herpesviruses Book in PDF, ePub and Kindle
This comprehensive account of the human herpesviruses provides an encyclopedic overview of their basic virology and clinical manifestations. This group of viruses includes human simplex type 1 and 2, Epstein–Barr virus, Kaposi's Sarcoma-associated herpesvirus, cytomegalovirus, HHV6A, 6B and 7, and varicella-zoster virus. The viral diseases and cancers they cause are significant and often recurrent. Their prevalence in the developed world accounts for a major burden of disease, and as a result there is a great deal of research into the pathophysiology of infection and immunobiology. Another important area covered within this volume concerns antiviral therapy and the development of vaccines. All these aspects are covered in depth, both scientifically and in terms of clinical guidelines for patient care. The text is illustrated generously throughout and is fully referenced to the latest research and developments.
Author | : |
Publisher | : Academic Press |
Total Pages | : 376 |
Release | : 2019-10-04 |
Genre | : Science |
ISBN | : 0128178698 |
Download Improving the Therapeutic Ratio in Head and Neck Cancer Book in PDF, ePub and Kindle
Improving the Therapeutic Ratio in Head and Neck Cancer provides a complete review of current approaches to modulating therapeutic sensitivity in head and neck cancer. It presents a broad background of current approaches and by highlighting the potential for clinical translational, introduces a roadmap for how to move promising preclinical findings into the clinic. The book discusses topics such as immunotherapy and molecularly targeted therapies in head and neck cancer, PI3k/mTOR pathway, autophagy inhibition to sensitize HNC to radiation and chemotherapy, TAM and Eph/Ephrin family proteins and metabolic reprogramming to modulate therapeutic sensitivity. Additionally, it details approaches to improve the response to immunotherapy, and Chk1/2 inhibition in radiation and cetuximab resistance. This book is a valuable source to head and neck cancer researchers and advanced students, and to those studying specific approaches in other model systems and disease sites. Provides key scientific background for clinicians when developing novel clinical trials and important examples for basic scientists of the types of work required to move a concept from the lab to the clinic Presents consistent pathway diagrams in each chapter, thus making it easier to understand complicated pathways Includes chapter summaries of the critical next steps needed to move studies from their current state into practice changing clinical data
Author | : Terrance Johns |
Publisher | : Frontiers Media SA |
Total Pages | : 197 |
Release | : 2022-05-25 |
Genre | : Medical |
ISBN | : 2889762211 |
Download Emerging Therapeutic Targets in Brain Cancer Book in PDF, ePub and Kindle
Author | : Terrence P. Kenakin |
Publisher | : Lippincott Williams & Wilkins |
Total Pages | : 491 |
Release | : 1997 |
Genre | : Medical |
ISBN | : 9780397518159 |
Download Pharmacologic Analysis of Drug-receptor Interaction Book in PDF, ePub and Kindle
The thoroughly revised, updated Third Edition of this highly acclaimed text reflects the past four years' groundbreaking developments in receptor pharmacology, particularly the use of human recombinant receptor systems in drug design and development. Whereas prior editions focused on the correspondence of animal to human receptor systems, this new edition examines drug effects on human receptors obtained by recombinant technology, as well as on physiological natural receptor systems in animals. Two new chapters explain how to produce and use human recombinant receptor systems and discuss the interpretation of data from human recombinant receptor studies. Other chapters describe the use of receptor studies to measure and characterize the biological actions of drugs.
Author | : Miral Dizdaroglu |
Publisher | : Springer Science & Business Media |
Total Pages | : 502 |
Release | : 2012-12-06 |
Genre | : Science |
ISBN | : 1461548659 |
Download Advances in DNA Damage and Repair Book in PDF, ePub and Kindle
In recent years the field of DNA repair has flourished due to new findings on DNA repair mechanisms and the molecular basis of cancer. This volume covers the most recent developments in this research field and contains contributions from scientists working in various fields.
Author | : Heinz-Peter Nasheuer |
Publisher | : Springer Science & Business Media |
Total Pages | : 346 |
Release | : 2009-12-11 |
Genre | : Medical |
ISBN | : 9048134714 |
Download Genome Stability and Human Diseases Book in PDF, ePub and Kindle
Since the establishment of the DNA structure researchers have been highly interested in the molecular basis of the inheritance of genes and of genetic disorders. Scientific investigations of the last two decades have shown that, in addition to oncogenic viruses and signalling pathways alterations, genomic instability is important in the development of cancer. This view is supported by the findings that aneuploidy, which results from chromosome instability, is one of the hallmarks of cancer cells. Chromosomal instability also underpins our fundamental principles of understanding tumourigenesis: It thought that cancer arises from the sequential acquisition of genetic alterations in specific genes. In this hypothesis, these rare genetic events represent rate-limiting ‘bottlenecks’ in the clonal evolution of a cancer, and pre-cancerous cells can evolve into neoplastic cells through the acquisition of somatic mutations. This book is written by international leading scientists in the field of genome stability. Chapters are devoted to genome stability and anti-cancer drug targets, histone modifications, chromatin factors, DNA repair, apoptosis and many other key areas of research. The chapters give insights into the newest development of the genome stability and human diseases and bring the current understanding of the mechanisms leading to chromosome instability and their potential for clinical impact to the reader.
Author | : Nina Parker |
Publisher | : |
Total Pages | : 1301 |
Release | : 2016-05-30 |
Genre | : Microbiology |
ISBN | : 9781938168147 |
Download Microbiology Book in PDF, ePub and Kindle
"Microbiology covers the scope and sequence requirements for a single-semester microbiology course for non-majors. The book presents the core concepts of microbiology with a focus on applications for careers in allied health. The pedagogical features of the text make the material interesting and accessible while maintaining the career-application focus and scientific rigor inherent in the subject matter. Microbiology's art program enhances students' understanding of concepts through clear and effective illustrations, diagrams, and photographs. Microbiology is produced through a collaborative publishing agreement between OpenStax and the American Society for Microbiology Press. The book aligns with the curriculum guidelines of the American Society for Microbiology."--BC Campus website.