The Comet Assay In Toxicology PDF Download
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Author | : Alok Dhawan |
Publisher | : Royal Society of Chemistry |
Total Pages | : 610 |
Release | : 2016-10-07 |
Genre | : Medical |
ISBN | : 178262287X |
Download The Comet Assay in Toxicology Book in PDF, ePub and Kindle
Concerns about the adverse effects of chemicals present in the environment have created a need for better systems to assess their potential consequences on human health. One potential solution is the versatile and state-of-the-art Comet assay. Simple, sensitive, rapid and visual, this modern toxicological method allows quantitative and qualitative assessment of DNA damage in single cells. This unique reference is devoted exclusively to the Comet assay and addresses, in-depth, the different protocols, statistical analyses and applications being used worldwide. It also includes the guidelines recommended by the working group on Comet assay. The book is aimed at students as well as scientists in the area of molecular epidemiology and genetic toxicology.
Author | : OECD |
Publisher | : OECD Publishing |
Total Pages | : 27 |
Release | : 2016-07-29 |
Genre | : |
ISBN | : 9264264884 |
Download OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 489: In Vivo Mammalian Alkaline Comet Assay Book in PDF, ePub and Kindle
The in vivo alkaline single cell gel electrophoresis assay, also called alkaline Comet Assay is a method measuring DNA strand breaks in eukaryotic cells.
Author | : Ray Proudlock |
Publisher | : Academic Press |
Total Pages | : 458 |
Release | : 2016-05-28 |
Genre | : Medical |
ISBN | : 0128010061 |
Download Genetic Toxicology Testing Book in PDF, ePub and Kindle
Genetic Toxicology Testing: A Laboratory Manual presents a practical guide to genetic toxicology testing of chemicals in a GLP environment. The most commonly used assays are described, from laboratory and test design to results analysis. In a methodical manner, individual test methods are described step-by-step, along with equipment, suggested suppliers, recipes for reagents, and evaluation criteria. An invaluable resource in the lab, this book will help to troubleshoot any assay problems you may encounter to optimise quality and efficiency in your genetic toxicology tests. Genetic Toxicology Testing: A Laboratory Manual is an essential reference for those new to the genetic toxicology laboratory, or anyone involved in setting up their own. Offers practical and consistent guidance on the most commonly-performed tests and procedures in a genetic toxicology lab Describes standard genetic toxicology assays, their methodology, reagents, suppliers, and analysis of their results Includes guidance on general approaches: formulation for in vitro assays, study monitoring, and Good Laboratory Practice (GLP) Serves as an essential reference for those new to the genetic toxicology laboratory, or anyone involved in setting up their own lab
Author | : Alok Dhawan |
Publisher | : Humana Press |
Total Pages | : 0 |
Release | : 2013-07-30 |
Genre | : Medical |
ISBN | : 9781627035286 |
Download Genotoxicity Assessment Book in PDF, ePub and Kindle
Genetic toxicology is recognized by geneticists and researchers concerned with the genetic impact of man-made chemicals. In Genotoxicity Assessment: Methods and Protocols, expert researchers in the field provide comprehensive genetic toxicology protocols. These include in vitro and in vivo protocols on mutation assays, cytogenetic techniques, and primary DNA damage, assays in alternate to animal models, and updated ICH guidelines. Written in the highly successful Methods in Molecular Biology series format, the chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, as well as key tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Genotoxicity Assessment: Methods and Protocols seeks to aid research students and scientists working in regulatory toxicology as well as biomedical, biochemical and pharmaceutical sciences.
Author | : Jesús del Mazo |
Publisher | : Springer Science & Business Media |
Total Pages | : 248 |
Release | : 1998-10-31 |
Genre | : Medical |
ISBN | : 9780306460258 |
Download Reproductive Toxicology Book in PDF, ePub and Kindle
Reviews the current practices of analyzing germ and interacting cell in vitro culture systems to investigate toxicological damage on germ cells and reproductive systems. Focuses on methodology rather than findings, interpretations, or clinical applications. Covers advances in improving human risk estimation, new approaches to analyzing the exposure of germ cells to toxicological agents in vitro, molecular and developmental approaches to assessing reproductive toxicity, and comparing the assessment of animal risk in vivo and in vitro. Among specific topics are assays to measure estrogen and androgen agonists and antagonists, flow cytometry to evaluate testicular toxicity, current and future contributions of transgenic mice in analyzing germline toxicology, and a new assay to assess aneuploidy in human-hamster embryos. The 25 papers are from an October 1997 workshop in Granada, Spain. Annotation copyrighted by Book News, Inc., Portland, OR
Author | : Micah J. Smith |
Publisher | : |
Total Pages | : |
Release | : 1999 |
Genre | : Aflatoxins |
ISBN | : |
Download The Comet Assay Book in PDF, ePub and Kindle
Author | : Daryl S. Henderson |
Publisher | : Springer Science & Business Media |
Total Pages | : 498 |
Release | : 2008-02-03 |
Genre | : Science |
ISBN | : 1592599737 |
Download DNA Repair Protocols Book in PDF, ePub and Kindle
The first edition of this book, published in 1999 and called DNA Repair Protocols: Eukaryotic Systems, brought together laboratory-based methods for studying DNA damage and repair in diverse eukaryotes: namely, two kinds of yeast, a nematode, a fruit fly, a toad, three different plants, and human and murine cells. This second edition of DNA Repair Protocols covers mammalian cells only and hence its new subtitle, Mammalian Systems. There are two reasons for this fresh emphasis, both of them pragmatic: to cater to the interests of what is now a largely mammalocentric DNA repair field, and to expedite editing and prod- tion of this volume. Although DNA Repair Protocols: Mammalian Systems is a smaller book than its predecessor, it actually contains a greater variety of methods. Fourteen of the book’s thirty-two chapters are entirely new and areas of redundancy present in the first edition have been eliminated here (for example, now just two chapters describe assays for nucleotide excision repair [NER], rather than seven). All eighteen returning chapters have been revised, many of them ext- sively. In order to maintain a coherent arrangement of topics, the four-part p- titioning seen in the first edition was dispensed with and chapters concerned with ionizing radiation damage and DNA strand breakage and repair were re- cated to near the front of the book. Finally, an abstract now heads each chapter.
Author | : James M. Parry |
Publisher | : Humana Press |
Total Pages | : 433 |
Release | : 2011-12-07 |
Genre | : Medical |
ISBN | : 9781617794209 |
Download Genetic Toxicology Book in PDF, ePub and Kindle
The evaluation of potential mutagenic activity is a critical step in the assessment of the safety of both new and pre-existing chemical types. In Genetic Toxicology: Principles and Methods, expert contributors help to satisfy the demand for education in this tremendously important area of study. The volume covers three basic areas: the scientific basis of the discipline, the methodologies of the main test assays, and the application of the methods, all aimed primarily at scientists in the safety departments of the industries working with both natural and synthetic chemicals. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Intuitive and cutting-edge, Genetic Toxicology: Principles and Methods provides crucial support to both laboratory workers in providing quality information on the appropriate application of techniques and to study directors in their assay selection and protocol design in this vital field.
Author | : Marcelo Larramendy |
Publisher | : BoD – Books on Demand |
Total Pages | : 124 |
Release | : 2018-07-11 |
Genre | : Medical |
ISBN | : 1789234182 |
Download Genotoxicity Book in PDF, ePub and Kindle
This book is designed to provide an overview of the different genotoxicants and their effects on living organisms, including humans. The contributions made by the specialists in this field of research are gratefully acknowledged. We hope that the information presented in this book will meet the expectations and needs of all those interested in the different aspects of the genotoxicity field. The publication of this book is of great importance to those scientists, pharmacologists, physicians and veterinarians, as well as engineers, teachers, graduate students and administrators of environmental programmes, who make use of these investigations to understand both the basic and applied genotoxic aspects of known and new xenobiotics, and to guide them in their future investigations.
Author | : OECD |
Publisher | : OECD Publishing |
Total Pages | : 16 |
Release | : 2011-07-28 |
Genre | : |
ISBN | : 9264122818 |
Download Test No. 488: Transgenic Rodent Somatic and Germ Cell Gene Mutation Assays Book in PDF, ePub and Kindle
This Test Guideline describes an in vivo assay that detects chemicals that may induce gene mutations. In this assay, transgenic rats or mice that contain multiple copies of chromosomally integrated plasmid or phage shuttle vectors are used. The ...