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The Biology of Cholesterol and Related Steroids

The Biology of Cholesterol and Related Steroids
Author: N. B. Myant
Publisher: Butterworth-Heinemann
Total Pages: 925
Release: 2014-04-24
Genre: Science
ISBN: 148328123X
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The Biology of Cholesterol and Related Steroids focuses on the study of sterols in relation to living organisms. The publication first takes a look at the analysis of sterols and related steroids and the distribution of sterols and related steroids in nature, as well as the processes of extraction and separation and presence of sterols in plants, fungi, vertebrates, and invertebrates. The text then ponders on biosynthesis of sterols and metabolism of cholesterol. Topics include formation of fatty acid esters of cholesterol, steroid hormones, biosynthetic pathway to sterols, reaction mechanisms, and comparative aspects of sterol synthesis. The manuscript examines the developmental aspects of cholesterol metabolism and sterols in biological membranes. The book also reviews cholesterol synthesis in animal tissues, sterol metabolism in isolated cells, and epidemiology of the plasma cholesterol. Discussions focus on selection of statistical populations, genetic influences, regulation of sterol synthesis, general aspects of sterol metabolism, and removal of cell cholesterol in vivo. The publication is a dependable source of data for biochemists and readers interested in the biology of cholesterol and steroids.

Mammalian Sterols

Mammalian Sterols
Author: Damjana Rozman
Publisher: Springer Nature
Total Pages: 174
Release: 2020-08-10
Genre: Science
ISBN: 3030396843
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This book provides a comprehensive description of sterols and their novel biological roles in mammalian signaling, the book covers their biosynthesis and structure, describes sterol receptor -mediated actions, their tissue distribution and their role in disease. It offers insight into new research findings, focusing specifically on novel discoveries in bile acid and oxysterol signaling, including the lanosterol-to-cholesterol intermediates. Special attention is paid on the sex distribution of these sterols (male or female) and their sexually dimorphic roles in mammalian species, such as human, rat and mouse. Since sterols and drugs (xenobiotics) use many identical receptor-mediated signaling pathways, the book will be interesting for researchers working on the cross-road of endogenous and xenobiotic metabolism, it is intended for advanced students and scientists in molecular biology and biochemistry as well as for medical doctors in hepatology.

Physiology and Biochemistry of Sterols

Physiology and Biochemistry of Sterols
Author: Glenn W. Patterson
Publisher: The American Oil Chemists Society
Total Pages: 414
Release: 1991
Genre: Medical
ISBN: 9780935315387
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Introduction to Steroid Chemistry

Introduction to Steroid Chemistry
Author: J. R. Hanson
Publisher: Elsevier
Total Pages: 113
Release: 2016-06-23
Genre: Science
ISBN: 148313928X
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Introduction to Steroid Chemistry is a six-chapter introductory text of the analysis, conformation, and production of steroids. After providing a brief overview of steroid chemistry, this book goes on discussing the application of physical methods to the analysis of structural and stereochemical correlations in steroids, such as UV, infrared, NMR, and mass spectroscopy, optical rotary dispersion, and circular dichroism. The subsequent two chapters describe the influence of steroid conformation and molecular rearrangements on reactions rates and reaction products. The remaining chapters explore the improvements in the synthesis of the estrogenic hormones and the biosynthetic pathways and metabolism of cholesterol. This book will be of value to general and organic chemists, biochemists, and research workers in related subjects.

Analysis of Sterols and Other Biologically Significant Steroids

Analysis of Sterols and Other Biologically Significant Steroids
Author: W. David Nes
Publisher: Elsevier
Total Pages: 358
Release: 2012-12-02
Genre: Science
ISBN: 0323154441
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Analysis of Sterols and Other Biologically Significant Steroids provides the fundamental training for the analysis of selected sterols and steroids. The book is composed of chapters that review the spectroscopic and chromatographic properties of certain sterols and steroids. The text also teaches how to isolate and characterize sterols and steroid metabolites of plant, fungal, and insect origin. Lipoprotein analysis and the utilization of physical-analytical techniques are likewise provided. Biochemists, microbiologists, and medical physiologists will find the book useful.

Medicinal Chemistry of Steroids

Medicinal Chemistry of Steroids
Author: F. J. Zeelen
Publisher: Elsevier Publishing Company
Total Pages: 380
Release: 1990
Genre: Medical
ISBN:
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The many new and fascinating data which have been gathered in the period 1985-1990 have made molecular endocrinology into a mature discipline stimulating creative chemists to design innovative drugs. Within a few years, the primary structures of all the steroid receptor proteins and most of the steroid-converting enzymes have been determined and detailed studies of their mechanism of action at a molecular level have become possible. Medicinal chemists have developed steroidal affinity probes to examine the binding sites of enzymes and receptors, and these investigations were supplemented with studies of modified enzymes and receptors prepared with the aid of site-directed mutagenesis. In view of these rapid scientific developments, the author deemed it appropriate to review the present knowledge of the medicinal chemistry of the steroids. In this book, the discussion is supported by the addition of some chapters which summarize the available data on the biological counterparts of the steroids, the steroid-converting enzymes and the steroid receptors.

Principles of Endocrinology and Hormone Action

Principles of Endocrinology and Hormone Action
Author: Antonino Belfiore
Publisher: Springer
Total Pages: 0
Release: 2018-02-08
Genre: Medical
ISBN: 9783319446745
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This volume provides comprehensive coverage of the current knowledge of the physiology of the endocrine system and hormone synthesis and release, transport, and action at the molecular and cellular levels. It presents essential as well as in-depth information of value to both medical students and specialists in Endocrinology, Gynecology, Pediatrics, and Internal Medicine. Although it is well established that the endocrine system regulates essential functions involved in growth, reproduction, and homeostasis, it is increasingly being recognized that this complex regulatory system comprises not only hormones secreted by the classic endocrine glands but also hormones and regulatory factors produced by many organs, and involves extensive crosstalk with the neural and immune system. At the same time, our knowledge of the molecular basis of hormone action has greatly improved. Understanding this complexity of endocrine physiology is crucial to prevent endocrine disorders, to improve the sensitivity of our diagnostic tools, and to provide the rationale for pharmacological, immunological, or genetic interventions. It is such understanding that this book is designed to foster.

Cholesterol

Cholesterol
Author: Robert Bittman
Publisher: Springer Science & Business Media
Total Pages: 567
Release: 2013-11-11
Genre: Science
ISBN: 1461559014
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Experts investigate the biochemical and biomedical aspects of cholesterol, addressing its metabolism in normal and disease states. They discuss a broad range of topics, including key steps in the cholesterol biosynthetic pathway, and the role of cholesterol in cancer, atherosclerosis, and diseases of the nervous system. The book's comprehensive coverage also includes the pathological consequences and potential therapies for various disease states, and the development of new anti-atherogenic drugs.

Cholesterol

Cholesterol
Author: Anna N. Bukiya
Publisher: Academic Press
Total Pages: 1060
Release: 2022-04-26
Genre: Science
ISBN: 0323858589
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With Cholesterol, Drs. Anna Bukiya and Alex Dopico have compiled a comprehensive resource on biological and clinical aspects of cholesterol, spanning biophysics and biochemistry, as well as the latest pharmacological discoveries employed to tackle disorders associated with abnormal cholesterol levels. Early chapters on basic biology offer guidance in cholesterol lab chemistry, cholesterol metabolism and synthesis, molecular evolution of cholesterol and sterols, cholesterol peptides, and cholesterol modulation. Chapters on cellular and organismal development discuss cholesterol transport in blood, lipoproteins, and cholesterol metabolism; cholesterol detection in the blood; cellular cholesterol levels; hypercholesterolemia; and the role of cholesterol in early human development. Pathophysical specialists consider familial hypobetalipoproteinemia, critical illness and cholesterol levels, coronary artery disease, CESD, cholesterol and viral pathology, cholesterol and neurodegenerative disorders, and cholesterol and substance use disorders. A final section examines pharmacology of drug delivery systems targeting cholesterol related disorders, cholesterol receptors, cholesterol reduction, statins, citrate lyase, cyclodextrins, and clinical management. Cholesterol: From Biophysics and Biochemistry to Pathology and Pharmacology empowers researchers, students, and clinicians across various disciplines to advance new cholesterol-based studies, improve clinical management, and drive drug discovery. Ties basic biology to clinical application and drug discovery Provides methods and protocols for lab-based cholesterol research and clinical testing Examines the latest pharmacological discoveries employed to tackle cholesterol related disorders Includes chapter contributions from a wide range of specialists, uniting various disciplines

Chemistry and Biological Activity of Steroids

Chemistry and Biological Activity of Steroids
Author: Jorge António Ribeiro Salvador
Publisher: BoD – Books on Demand
Total Pages: 144
Release: 2020-02-26
Genre: Science
ISBN: 1789855152
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The steroid scaffold continues to be the structural basis of new drugs for a variety of targets and diseases. Indeed, steroids interact with enzymes and receptors in a strikingly specific manner. Chemistry and Biological Activity of Steroids aims to provide an updated overview of recent advances in the medicinal chemistry of steroids. Novel synthetic methods in the steroids field, including steroid biotransformations, new steroids able to tackle steroid receptors, and steroid enzymes with clinical relevance, are critically reviewed in this book. Furthermore, the diverse physiopathological roles of oxysterols and their therapeutic value are also discussed.